Article
Biology
Amit Kumar Singh, Harvesh Kumar Rana, Vishal Singh, Tara Chand Yadav, Pritish Varadwaj, Abhay Kumar Pandey
Summary: Chlorogenic acid effectively inhibits glucose metabolising enzymes and decreases hyperglycemia, hyperlipidemia, and hepatorenal damage associated with diabetes in rats, making it a potential functional food ingredient and drug candidate for diabetes management.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Applied
Shan Wang, Yue Li, Dejian Huang, Shangwei Chen, Yongmei Xia, Song Zhu
Summary: This study demonstrated that the inhibitory activities of CA derivatives on enzymes were enhanced as lipophilicity increased, with C12-CA showing the strongest inhibitory effects. The effects of C12-CA on the microenvironments and secondary structures of the enzymes were greater than those of CA and other derivatives.
Article
Plant Sciences
Ivana Carev, Cengiz Sarikurkcu
Summary: The study demonstrated the significant antioxidant activity of the endemic Stachys species S. cretica ssp. anatolica in Turkey. The extracts of this plant are rich in polyphenols, showing strong activity against antioxidant enzymes and potential therapeutic effects for skin disorders and diabetes.
Article
Biochemistry & Molecular Biology
Natalia Escobar-Beiza, Jose R. Perez-Correa, Wendy Franco
Summary: This study found that fermented murta juice enhances its antioxidant activity, releases more polyphenols, and inhibits alpha-glucosidase. These findings highlight the potential health benefits of fermented murta juice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Cengiz Sarikurkcu, Mehmet Sabih Ozer, Erman Salih Istifli, Saliha Seyma Sahinler, Bektas Tepe
Summary: Sideritis species have been traditionally used for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. This study focused on evaluating the chemical composition and bioactivities of solvent extracts from S. leptoclada, revealing high antioxidant activity in the water extract and potent inhibitory effects on tyrosinase by the MeOH extract. Docking analysis suggested that verbascoside could be a promising inhibitory agent for tyrosinase and alpha-amylase.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Chemistry, Physical
Irina Georgiana Munteanu, Constantin Apetrei
Summary: The purpose of this research was to develop a new enzymatic biosensor for sensitive detection of chlorogenic acid (CGA). The modified electrode showed a great catalytic effect on the electrochemical redox of CGA, leading to a linear peak current response. The detection limit and quantification limit were determined, and the method proved suitable for the detection of CGA in nutraceutical formulations. The correlation between the voltammetric method and the spectrophotometric one was good, and the antioxidant activity of CGA was demonstrated.
Article
Integrative & Complementary Medicine
Vladislava Nebrigic, Milena Terzic, Sasa Durovic, Darko Micic, Gokhan Zengin, Aleksandra Cvetanovic Kljakic, Marija Radojkovic
Summary: This study investigates the influence of drying technique on the chemical composition and biological activity of immortelle essential oil, and finds that the oil extracted from fresh plants exhibits the highest antioxidant and amylase inhibition activities.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Chemistry, Applied
Maria Alessia Schouten, Silvia Tappi, Simone Angeloni, Manuela Cortese, Giovanni Caprioli, Sauro Vittori, Santina Romani
Summary: The study found that during the coffee roasting process, acrylamide levels and antioxidant activity reached a peak at lower roasting degrees, then decreased as heating time increased. The thermal reduction had a greater impact on acrylamide compared to antioxidant activity, as there was a balance between the degradation and formation of antioxidant compounds.
Article
Chemistry, Applied
Shan Wang, Yue Li, Xiangyong Meng, Shangwei Chen, Dejian Huang, Yongmei Xia, Song Zhu
Summary: In this study, chlorogenic acid was acylated with different carbon chain lengths to produce derivatives with varying lipophilicities, which were found to have enhanced antioxidant activities in cellular antioxidant activity tests. The results indicated that the lipophilicities of the derivatives positively correlated with their digestive stabilities and cellular antioxidant activities. Among the derivatives, C12-CA exhibited the best antioxidant activity with a significantly lower effective dose compared to CA.
Article
Biochemistry & Molecular Biology
Fatema R. Saber, Rehab M. Ashour, Ali M. El-Halawany, Mohamad Fawzi Mahomoodally, Gunes Ak, Gokhan Zengin, Engy A. Mahrous
Summary: Metabolites from Feijoa sellowiana leaves exhibited inhibitory activity against various enzymes, with potential antioxidant and anti-enzyme properties. Compounds like alpha-tocopherol and primetin showed strong inhibition against AChE and BChE, as well as tyrosinase.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sakina Yagi, Abdullahi Ibrahim Uba, Kouadio Ibrahime Sinan, Diletta Piatti, Gianni Sagratini, Giovanni Caprioli, Sayadat M. Eltigani, Irina Lazarova, Gokhan Zengin
Summary: This study investigated the chemical profile, antioxidant activity, and enzyme inhibition properties of extracts from red roselle and white roselle varieties grown in Sudan. The results showed that the chemical composition and biological activities varied between the two varieties, highlighting their potential as valuable sources for various industries.
Article
Plant Sciences
Kishor Mazumder, Tahamina Sultana Sumi, Mimi Golder, Biswajit Biswas, Maknoon, Philip G. Kerr
Summary: The study revealed that the Phragmites karka extract is toxic at the cellular level after oral administration and cytotoxic when tested on HeLa cells. The plant also showed hypoglycemic properties, possibly through the inhibition of the alpha-amylase enzyme and recovery of pancreatic beta cells along with improvement in the lipid profile of diabetic mice. Further research is needed to isolate bioactive compounds, elucidate their structures, and evaluate their mechanism of actions to support these findings.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Ekkarat Tangkhawanit, Sirithon Siriamornpun
Summary: This study found that the bioactive components in soybean residues significantly increased after hot-air drying, with improved antioxidant properties and reduced starch digestion. These findings suggest that soybean residues could be utilized as functional food ingredients.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Physical
He Liu, Min Liu, Danfeng Wang, Lu Wang, Yanna Zhao, Jie Liu, Yushu Wu, Bin Sun, Yongfang Zhang
Summary: The binding of EGCG and CGA to lysozyme was studied, revealing different driving forces and resulting effects on lysozyme activity. Combination of EGCG and CGA showed synergistic antioxidant activity and cytotoxicity to HeLa cells. Response surface methodology was used to analyze the maximum synergistic antioxidant activity between EGCG and CGA.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Xuejiao Qie, Wenpu Chen, Maomao Zeng, Zhaojun Wang, Jie Chen, H. Douglas Goff, Zhiyong He
Summary: This study found that beta-lactoglobulin has a significant impact on the antioxidant properties of chlorogenic acid, and the stability of the complex is influenced by thermal treatments. Both covalent and non-covalent beta-lactoglobulin-chlorogenic acid complexes help maintain the antioxidant properties of CGA, while enhancing the thermal stability of beta-lactoglobulin in solutions.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Analytical
Nizar Tlili, Rifat Tayyib Sarikurkcu, Mehmet Sabih Ozer, Cengiz Sarikurkcu
Summary: This study investigated the impact of different solvents on phenolics extracted from Onosma mitis, evaluating their antioxidant capabilities and enzyme inhibitory properties. The results suggest that Onosma mitis has promising industrial applications as a potential source of bioactive compounds.
ANALYTICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Erman Salih Istiflia, Paulo A. Netz, Arzuhan Sihoglu Tepe, Cengiz Sarikurkcu, Bektas Tepe
Summary: This study compared the interaction between the RBD of E484K, N501Y and South Africa triple spike variants with ACE2, and found that these mutants interacted more strongly with ACE2 than the wild-type spike. Molecular dynamics and MM-PBSA results showed that E484K and spike triple mutant complexes were more stable than the N501Y variant, with E484K and South Africa triple mutants triggering greater conformational changes in the spike glycoprotein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Plant Sciences
Mustafa Cuce, Ersin Demir, Arzuhan Sihoglu Tepe, Cengiz Sarikurkcu
Summary: This study evaluated the chemical compositions and biological activities of roots, leaves, and seeds of D. cemileae. The results showed that the leaf and seed extracts had abundant phenolics and flavonoids. The leaf extract exhibited high activity in multiple tests, while the seed extract was superior in scavenging activity tests.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Chemistry, Analytical
Cengiz Sarikurkcu, Nizar Tlili
Summary: This study aimed to investigate the phytochemical content of Onosma inexspectata and O. armenum, identifying 27 compounds using liquid chromatography-electrospray ionization tandem mass spectrometry. Significant differences were found in antioxidant properties and enzyme inhibitory capacities between the two species.
ANALYTICAL LETTERS
(2022)
Article
Environmental Sciences
Feyyaz Keskin, Cengiz Sarikurkcu, Ahmet Demirak, Ilgaz Akata, Arzuhan Sihoglu Tepe
Summary: This study determined the element contents of various edible, inedible, and poisonous mushroom species collected from Ilgaz Mountain National Park in Turkey. The results showed that most species had metal contents within the legal limits, but some species had iron and cadmium contents exceeding the limits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Bulent Kirkan, Cengiz Sarikurkcu, Gokhan Zengin
Summary: This study evaluated the biological and chemical properties of two Onosma (O. trapezuntea and O. rigidum) species. The results showed that O. trapezuntea exhibited stronger antioxidant abilities and O. rigidum had better metal chelating ability. Additionally, O. rigidum showed higher activity against cholinesterase and a-glucosidase. The findings suggest that these Onosma species could be valuable sources of natural antioxidants and enzyme inhibitors.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Cengiz Sarikurkcu, Bulent Kirkan, Saliha Seyma Sahinler, Bektas Tepe
Summary: This study investigated the chemical compositions and in vitro antioxidant and enzyme inhibitory activities of plant polyphenols obtained from Acanthus spinosus L. The methanol extract was rich in phenolics and flavonoids, while the ethyl acetate extract showed good results in chelating effect and phosphomolybdenum tests. These extracts exhibited remarkable antioxidant and enzyme inhibitory activities, making them a potential alternative source of phytochemicals in the food, cosmetic, and medical industries.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Chemistry, Applied
Cengiz Sarikurkcu, Mehmet Halil Solak, Petr Tarkowski, Sanja Cavar Zeljkovic
Summary: This study focuses on the chemical composition and biological activities of a wild edible mushroom, Morchella steppicola Zerova. The results show that this mushroom is rich in beneficial elements and contains high levels of gallic acid, protocatechuic acid, 4-hydroxybenzoic acid, and vanillic acid. Statistical analysis indicates that 4-hydroxybenzoic and vanillic acids are mainly responsible for antioxidant and enzyme inhibition effects. The findings suggest that Morchella steppicola has significant potential for treating human disorders.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Radjassegarin Arumugam, Balachandravinayagam Elanchezhian, Cengiz Sarikurkcu, Samidurai Jayakumar, Kaliyamoorthy Amirthaganesan, Selvendiran Sudhakar
Summary: This study assessed the nutritional and elemental composition of 27 leafy vegetables commonly used in Tamil Nadu, India, in order to ensure food and nutritional security. The results showed significant differences in the nutritional makeup of the leaves, with carbohydrates being the main component, followed by ash, protein, and fiber. Lipid was the least significant component. Elemental analysis revealed higher concentrations of K, Na, Mg, and Fe, as well as considerable amounts of Zn, Mn, and Cu in the leaves. The research also concluded that all the leafy vegetables were safe for human consumption based on health risk assessment.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Sanja Cavar Zeljkovic, Saliha Seyma Sahinler, Cengiz Sarikurkcu, Bulent Kirkan, Riza Binzet, Petr Tarkowski
Summary: This study reports for the first time on the phenolic profile and biological activity of Onosma riedliana. The methanolic extract shows exceptional antioxidant properties, while the ethyl acetate extract demonstrates significant inhibition of cholinesterase and tyrosinase enzymes, and the methanolic extract displays potent activity against carbohydrate hydrolytic enzymes.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Chemistry, Applied
Bulent Kirkan, Cengiz Sarikurkcu, Arzuhan Sihoglu Tepe
Summary: This study analyzed the chemical composition and biological activities of the methanol extracts of O. cappadocica and O. rutilum. The extracts showed high antioxidant and enzyme inhibitory activities, making them potential alternative agents in the food, cosmetic, and medical industries.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Article
Chemistry, Applied
Bulent Kirkan, Cengiz Sarikurkcu, Riza Binzet, Bektas Tepe
Summary: This study investigated the chemical composition and biological activities of different extracts from Onosma microcarpum DC. and O. nana DC. It was found that both extracts exhibited inhibitory effects on enzymes related to digestion, cholinergic systems, and melanogenesis. O. nana showed higher phenolic and flavonoid concentrations, as well as stronger antioxidant and enzyme inhibitory activities, compared to O. microcarpum. The findings suggest that O. nana could be a potential source of phytochemicals for various industries.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Erman Salih Istifli, Paulo A. Netz, Arzuhan Sihoglu Tepe, Mehmet Tahir Husunet, Cengiz Sarikurkcu, Bektas Tepe
Summary: This study investigated the interactions between twenty-three phytochemicals belonging to different flavonoid subgroups and the spike glycoprotein of 2019-nCoV. The results showed that (-)-epicatechin gallate had strong interactions with all the proteins studied.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)