Article
Oncology
Jennifer X. Ji, Dawn R. Cochrane, Gian Luca Negri, Shane Colborne, Sandra E. Spencer Miko, Lynn N. Hoang, David Farnell, Basile Tessier-Cloutier, Jutta Huvila, Emily Thompson, Samuel Leung, Derek Chiu, Christine Chow, Monica Ta, Martin Kobel, Lucas Feil, Michael Anglesio, Ellen L. Goode, Kelly Bolton, Gregg B. Morin, David G. Huntsman
Summary: Clear cell ovarian carcinoma (CCOC) has distinct proteomic differences compared with other subtypes of epithelial ovarian carcinoma, and potentially significant proteomic subgroups within CCOC, suggesting the possibility of stratified treatment for this cancer.
JOURNAL OF PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tsukuru Amano, Atsushi Murakami, Takashi Murakami, Tokuhiro Chano
Summary: Ovarian clear cell carcinomas (OCCCs) are resistant to conventional anti-cancer drugs and often arise from endometriosis associated with strong oxidative stress. The oxidative stress tolerance properties are involved in the survival and cancer stemness of OCCC cells. Therapeutic approaches need improvement, with multi-combinatorial treatments expected to improve patient outcomes.
Article
Oncology
Sarah A. Ackroyd, David Arguello, Pilar Ramos, Haider Mahdi, Adam ElNaggar, Ira Winer, Rob Holloway, Thomas Krivak, Nathaniel Jones, Valerie Galvan Turner, Thomas Herzog, Christina Chu, Jubilee Brown, Gina Mantia-Smaldone
Summary: This study analyzed ovarian and endometrial clear cell carcinomas using comprehensive sequencing technology and compared their molecular profiles to clear cell renal cell carcinoma. The results showed that these malignancies have different mutation profiles, but ovarian and endometrial clear cell carcinomas share similar molecular features. The study also suggested that a subset of ovarian clear cell carcinoma may benefit from immunotherapy. Evaluation: 7 out of 10.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Jocelyn C. Reader, Cong Fan, Eleanor Claire-Higgins Ory, Julia Ju, Rachel Lee, Michele I. Vitolo, Paige Smith, Sulan Wu, Mc Millan Nicol Ching, Emmanuel B. Asiedu, Christopher M. Jewell, Gautam G. Rao, Amy Fulton, Tonya J. Webb, Peixin Yang, Alessandro D. Santin, Huang-Chiao Huang, Stuart S. Martin, Dana M. Roque
Summary: Ovarian cancer can spread within the peritoneal cavity through exfoliation of malignant cells into ascites. Microtentacles (McTNs) are microtubule-based protrusions that may influence the metastatic potential and chemoresistance profile of free-floating cells. This study highlights the importance of McTNs as a therapeutic target for ovarian cancer and suggests that understanding their biology could lead to improved treatments.
Article
Endocrinology & Metabolism
Kaitlyn E. Collins, Xiyin Wang, Yuliya Klymenko, Noah B. Davis, Maria C. Martinez, Chi Zhang, Kaman So, Aaron Buechlein, Douglas B. Rusch, Chad J. Creighton, Shannon M. Hawkins
Summary: Endometriosis is a risk factor for endometriosis-associated ovarian cancers. Analysis of OCCC samples with concurrent endometriosis revealed upregulation of cell cycle regulation and DNA replication pathways, and downregulation of cytokine receptor signaling and matrisome pathways. MiR-10a-5p was identified as a potentially oncogenic molecule with significant impact.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Tadahiro Shoji, Shunsuke Tatsuki, Marina Abe, Hidetoshi Tomabechi, Eriko Takatori, Yoshitaka Kaido, Takayuki Nagasawa, Masahiro Kagabu, Tsukasa Baba, Hiroaki Itamochi
Summary: Ovarian clear cell and mucinous carcinomas show lower sensitivity to chemotherapy, leading to a poor prognosis. Recent focus has shifted to molecular target drugs and immune checkpoint inhibitors for treatment, with many clinical studies planned. Challenges include finding the best treatment combinations, identifying patients who will benefit from each therapy, and integrating results into standard care for these carcinomas.
Article
Reproductive Biology
Ling Zhou, Liqing Yao, Lin Dai, Honglan Zhu, Xue Ye, Shang Wang, Hongyan Cheng, Ruiqiong Ma, Huiping Liu, Heng Cui, Xiaohong Chang
Summary: The study identified distinct clinical characteristics of Chinese patients with ovarian endometrioid carcinoma (EC) and clear cell carcinoma (CCC), showing that EC patients tend to be younger while CCC has two peaks in disease onset. EC patients are more likely to have concurrent endometrial cancer and express estrogen and progesterone receptors, with more patients in a premenopausal state. The study also found that in the pure group, the correlation with endometriosis is associated with worse outcomes, while mixed endometrioid histology in mixed cancer patients is linked to better survival rates.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Michael-John Devilin, Rowan Miller, Florian Laforets, Panoraia Kotantaki, Dale W. Garsed, Rebecca Kristeleit, David D. Bowtell, Jacqueline McDermott, Eleni Maniati, Frances R. Balkwill
Summary: The tumor microenvironment (TME) of clear-cell ovarian cancer (CCOC) was analyzed in this study, revealing differences in immune cell populations, collagen matrix, and cytokine expression between different areas of the tumor. Advanced CCOC showed increased fibroblasts and a more complex collagen matrix compared to early CCOC. Differences in immune cell populations, collagen matrix, and cytokine expression were also observed between different genetic subtypes of CCOC. Increased infiltration of specific T cell subpopulations was associated with decreased overall survival.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Chenchen Zhu, Zhihao Xu, Tianjiao Zhang, Lili Qian, Weihua Xiao, Haiming Wei, Tengchuan Jin, Ying Zhou
Summary: Ovarian clear cell carcinoma (OCCC) is a special pathological type of epithelial ovarian carcinoma (EOC), with a high prevalence in Asia, often associated with endometriosis and platinum resistance. Current research focuses on targeted therapy and immunotherapy for OCCC.
Article
Medicine, General & Internal
Henry Zou, Maggi Forgue
Summary: Ovarian cysts are usually asymptomatic and self-resolvable, but large cysts can increase the risk of complications. In this case, laparoscopic left salpingo-oophorectomy was challenging due to the presence of an overlying sigmoid colon and dense adhesions. Drainage of the cyst was performed instead, with postoperative monitoring for recurrence recommended. This case highlights the difficulties in treating left-sided adnexal masses in post-hysterectomy patients and emphasizes the importance of preoperative ovarian cancer screening and conservative treatment options whenever possible.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Oncology
Kazuaki Takahashi, Masataka Takenaka, Aikou Okamoto, David D. L. Bowtell, Takashi Kohno
Summary: Ovarian clear cell carcinoma (OCCC) is a histological subtype of ovarian cancer prevalent in Asian countries, with deleterious mutations in SWI/SNF chromatin remodeling genes like ARID1A being common. Therapeutic strategies based on SWI/SNF deficiency, such as gemcitabine-based chemotherapy, synthetic lethal therapy, and immune checkpoint blockade therapy, have the potential to improve patient prognosis by targeting vulnerabilities unique to OCCC.
Review
Oncology
Yue Sun, Guoyan Liu
Summary: Endometriosis is an estrogen-dependent disease that can precede ovarian cancer, especially OCCC. The exact carcinogenic mechanism is unclear, but several key genes and pathways have been implicated. OCCC patients usually present with large, unilateral pelvic masses, have a worse prognosis, and are often resistant to chemotherapy.
Article
Oncology
Se Ik Kim, Hyeong In Ha, Kyung Jin Eoh, Jiwon Lim, Young-Joo Won, Myong Cheol Lim
Summary: This nationwide registry-based study demonstrates the significant increase in the incidence of primary ovarian clear cell carcinoma (OCCC) in Korea from 1999 to 2018. Early-stage OCCC has a relatively good prognosis, but advanced-stage OCCC has a worse overall survival (OS) compared to ovarian serous carcinoma (OSC). Therefore, the development of optimal treatment strategies for OCCC is necessary.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yanhua An, Qiumei Cao, Yixin Liu, Luping Lei, Dawei Wang, Yanjie Yang, Weijie Kong, Dali An, Dan Liu
Summary: A colovesical fistula is a pathological communication between the colon and bladder. The diagnosis is challenging due to non-specific symptoms. In this case study, a 70-year-old woman presented with symptoms of recurrent urinary tract infection, and urine cultures showed Lactococcus lactis infection. Abdominopelvic CT scan revealed bladder wall thickening and gas in the bladder. Cystoscopic and colonoscopic examinations confirmed sigmoid colon cancer and a sigmoido-vesical fistula.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ha-Yeon Shin, Wookyeom Yang, Doo Byung Chay, Eun-ju Lee, Joon-Yong Chung, Hyun-Soo Kim, Jae-Hoon Kim
Summary: The study identified TSPAN1 as a key gene in the malignant transformation of endometriosis to ovarian clear cell carcinoma. Upregulation of TSPAN1 enhances cell growth and invasion, potentially serving as a screening candidate for high-risk endometriosis.
MOLECULAR ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Kei Tanaka, Kenji Yamada, Miho Matsushima, Tomoko Izawa, Seishi Furukawa, Yoichi Kobayashi, Mitsutoshi Iwashita
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2018)
Article
Cell Biology
Kei Tanaka, Momoe Watanabe, Miho Matsushima, Yukiko Matsuzawa, Tomoko Izawa, Takashi Nagashima, Yoichi Kobayashi, Mitsutoshi Iwashita
GROWTH HORMONE & IGF RESEARCH
(2018)
Article
Oncology
Mikio Mikami, Masae Ikeda, Hidetaka Sato, Haruko Iwase, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2018)
Article
Obstetrics & Gynecology
Kei Tanaka, Miho Matsushima, Tomoko Izawa, Seishi Furukawa, Yoichi Kobayashi, Mitsutoshi Iwashita
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2018)
Article
Obstetrics & Gynecology
Kei Tanaka, Yuma Muraoka, Riku Honda, Tomoko Izawa, Shinji Tanigaki, Yoichi Kobayashi, Mitsutoshi Iwashita
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2018)
Article
Obstetrics & Gynecology
Yoshiko Nishigaya, Yoichi Kobayashi, Yukiko Matsuzawa, Kiyoshi Hasegawa, Ichio Fukasawa, Yoh Watanabe, Hideki Tokunaga, Nobuo Yaegashi, Mitsutoshi Iwashita
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Oncology
Yasuhiko Ebina, Mikio Mikami, Satoru Nagase, Tsutomu Tabata, Masanori Kaneuchi, Hironori Tashiro, Masaki Mandai, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Daisuke Aoki
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Developmental Biology
Kei Tanaka, Momoe Watanabe, Shinji Tanigaki, Mitsutoshi Iwashita, Yoichi Kobayashi
Article
Oncology
Hiroko Machida, Koji Matsuo, Wataru Yamagami, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kanauchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami
GYNECOLOGIC ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Rumiko Yamamoto, Kentaro Sekiyama, Toshihiro Higuchi, Masae Ikeda, Mikio Mikami, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Takayuki Enomoto, Hidetaka Katabuchi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Oncology
Wataru Yamagami, Mikio Mikami, Satoru Nagase, Tsutomu Tabata, Yoichi Kobayashi, Masanori Kaneuchi, Hiroaki Kobayashi, Hidekazu Yamada, Kiyoshi Hasegawa, Hiroyuki Fujiwara, Hidetaka Katabuchi, Daisuke Aoki
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2020)
Article
Obstetrics & Gynecology
Seishi Furukawa, Yoichi Kobayashi
JOURNAL OF PREGNANCY
(2019)
Meeting Abstract
Oncology
M. Yasaka, M. Ikeda, M. Shida, T. Hirasawa, M. Mikami, Y. Kobayashi, S. Nagase, M. Yokoyama, T. Enomoto, H. Katabuchi
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Meeting Abstract
Oncology
T. Narayama, M. Ikeda, M. Shida, T. Hirasawa, M. Mikami, Y. Kobayashi, S. Nagase, M. Yokoyama, T. Enomoto, H. Katabuchi
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Meeting Abstract
Developmental Biology
Kei Tanaka, Yoichi Kobayashi, Mitsutoshi Iwashita