Article
Chemistry, Medicinal
Minji Choi, Sulagna Mukherjee, Jong Won Yun
Summary: Trigonelline, a major alkaloid component of fenugreek, has potential as an anti-obesity compound by inducing browning of white adipocytes and improving lipid metabolism through regulation of gene and protein expression, as well as mitochondrial biogenesis pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Food Science & Technology
Huong Giang Pham, Trang Thi Huyen Dang, Jong Won Yun
Summary: Salvianolic acid B (Sal B) promotes white fat browning, suppresses lipogenesis, and enhances lipolysis in white adipocytes, suggesting its beneficial effects in preventing and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Mueller, Anke Toenjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Bluher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer
Summary: This study reveals that inosine, a metabolite released during apoptosis, enhances the thermogenic program in healthy adipocytes and regulates energy expenditure. The equilibrative nucleoside transporter 1 (ENT1) controls inosine levels in brown adipose tissue, affecting thermogenic capacity. In humans, a loss of function mutation in ENT1 is associated with lower body mass index and reduced odds of obesity.
Article
Pharmacology & Pharmacy
Lu Zhang, Xuehong Ma, Rongmei Shi, Libo Zhang, Ruolin Zhao, Ran Duan, Yuanyuan Qin, Sijia Gao, Xinxia Li, Jingjing Duan, Jianguang Li
Summary: Allicin improves psoriasis by inhibiting excessive proliferation and apoptosis of keratinocytes, reducing the secretion of inflammatory factors, and breaking the positive inflammatory feedback. Moreover, topical application of allicin is safe and effective for long-term treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Minji Choi, Sulagna Mukherjee, Jong Won Yun
Summary: The microbial fermentation of grape-skin extracts can synthesize anthocyanin oligomers that are more effective than monomeric anthocyanins in treating metabolic diseases like diabetes and obesity. Specifically, the study showed that anthocyanin oligomers promote the browning of white adipocytes and increase thermogenic activity, suggesting potential benefits for obesity treatment.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aditya Sharma, Sushmita Singh, Shadab Ahmad, Farah Gulzar, Jonathan D. Schertzer, Akhilesh K. Tamrakar
Summary: Our study indicates that activation of NOD1 triggers oxidative stress in adipocytes through NOX1/4, contributing to the induction of inflammatory response.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chad C. Doucette, Davide Barteselli, Daniel C. Nguyen, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Summary: In this study, an optogenetic approach was used to activate UCP1-dependent thermogenesis in brown adipocytes. This system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can contribute to our understanding of brown adipocyte biology and the development of therapies for obesity-related disorders.
Article
Biotechnology & Applied Microbiology
Yufei He, Zhuokai Liang, Jing Wang, Haojing Tang, Jian Li, Junrong Cai, Yunjun Liao
Summary: Excess and dysfunctional adipose tissue plays an important role in metabolic diseases. This study describes a novel ceiling culture-based model of human mature white adipocytes that can transdifferentiate into beige adipocytes. The use of rosiglitazone and rapamycin can modulate transdifferentiation and enhance the expression of beige adipocyte-specific genes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emi Tanaka, Takakazu Mitani, Momona Nakashima, Eito Yonemoto, Hiroshi Fujii, Hitoshi Ashida
Summary: Theobromine (TB) induces browning in subcutaneous white adipose tissue in mice, increasing UCP1 expression and potentially offering a treatment for obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Diego Salagre, Meriem Chayah, Antonio Molina-Carballo, Maria-Jesus Oliveras-Lopez, Antonio Munoz-Hoyos, Miguel Navarro-Alarcon, Gumersindo Fernandez-Vazquez, Ahmad Agil
Summary: The role of melatonin in obesity control is widely accepted, but its mechanism of action is still unclear. This study demonstrated that melatonin increases brown fat in obese diabetic rats by both adipocyte transdifferentiation and de novo differentiation, and also promotes beige MSC adipogenesis in humans.
Article
Biochemistry & Molecular Biology
Yuelei Zhao, Xuexin Li, Ye Tian, Jindi Zhao, Wensai Yu, Lifan Zhang, Wei Wei, Jie Chen
Summary: This study found that nonivamide can induce browning of porcine adipocytes, inhibit adipogenesis and promote lipolysis, as well as up-regulate thermogenesis gene markers and mitochondrial biogenesis-related genes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Peiwen Zhang, Shuang Wu, Yuxu He, Xinrong Li, Yan Zhu, Xutao Lin, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Xuewei Li, Li Zhu, Linyuan Shen
Summary: This article reviews the roles and molecular mechanisms of long-chain noncoding RNAs (lncRNAs) in adipogenesis. lncRNAs regulate adipogenesis at multiple levels of gene expression through various mechanisms. Abnormal accumulation of adipose tissue can lead to metabolic diseases, therefore understanding the roles of lncRNAs in adipogenesis is of great importance for the prevention and treatment of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lilan Zhang, Silu Hu, Chunwei Cao, Chuanhe Chen, Jiali Liu, Yu Wang, Jianfeng Liu, Jianguo Zhao, Cong Tao, Yanfang Wang
Summary: This study compares the gene expression profiles between white and beige adipocytes from Tibetan piglets and identifies two genes involved in beige adipocyte differentiation and thermogenesis. Understanding the genetic basis of beige adipogenesis in pigs will have implications for molecular breeding in pigs and large animal models of human diseases.
Article
Nutrition & Dietetics
Boglarka Agnes Vinnai, Rini Arianti, Ferenc Gyory, Zsolt Bacso, Laszlo Fesus, Endre Kristof
Summary: This study investigated how the availability of extracellular thiamine affects the expression of thermogenic marker genes and proteins during adipocyte differentiation. Higher thiamine levels led to increased expression of thiamine transporters and enhanced thermogenic competency in differentiated adipocytes from the neck area. Gradually increasing concentrations of thiamine resulted in elevated mitochondrial biogenesis and thermogenic gene expression in a concentration-dependent manner.
FRONTIERS IN NUTRITION
(2023)
Article
Cell Biology
Lilla Nagy, Boglarka Rauch, Tamas Szerafin, Karen Uray, Attila Toth, Peter Bai
Summary: This study found that supplementation with nicotinamide riboside (NR) can induce the conversion of human white adipocytes to beige adipocytes, and enhance uncoupled respiration. This is beneficial for regulating organismal energy and metabolic balance, and combating metabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Hee-Weon Lee, Chung Gi Lee, Dong-Kwon Rhee, Sung Hee Urn, Sukneung Pyo
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Article
Plant Sciences
Ii-Seal Kwon, Jong Hwan Kwak, Suhkneung Pyo, Hee-Weon Lee, AeRyon Kim, Francis J. Schmitz
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Chemistry, Organic
Yongguk Oh, Yeon Jeong Jang, Mijin Jeon, Hyung Sik Kim, Jong Hwan Kwak, Kyu Hyuck Chung, Suhkneung Pyo, Young Hoon Jung, In Su Kim
JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Pharmacology & Pharmacy
Ii-Seul Kwon, Jinwook Kim, Dong-Kwon Rhee, Byung-Oh Kim, Suhkneung Pyo
Correction
Chemistry, Medicinal
Kyung-Ho Kim, Bongkyun Park, Dong-Kwon Rhee, Suhkneung Pyo
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Hee-Weon Lee, Suhkneung Pyo
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Correction
Agriculture, Multidisciplinary
Yun Joo Jung, Byung Oh Kim, Jong Hwan Kwak, Suhkneung Pyo
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Yoon Hee Kim, Suhkneung Pyo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Jinwook Kim, Hee-Weon Lee, Dong Kwon Rhee, James C. Paton, Suhkneung Pyo
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)
Article
Biochemistry & Molecular Biology
Yeon Jeong Jang, Bongkyun Park, Hee-Weon Lee, Hye Jin Park, Hyun Jung Koo, Byung Oh Kim, Eun-Hwa Sohn, Sung Hee Um, Suhkneung Pyo
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)