Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Maria Grazia Morgese, Stefania Schiavone, Maria Bove, Anna Laura Colia, Stefania Dimonte, Paolo Tucci, Luigia Trabace
Summary: The study investigated the protective role of lifelong exposure to n-3 PUFA-enriched or n-6/n-3 balanced diets in a rat model of A beta-induced toxicity. Both diets were found to reduce ROS production and oxidative stress, while affecting neurotransmitter levels.
Article
Biochemistry & Molecular Biology
Nadine Rohwer, Julia Jelleschitz, Annika Hoehn, Daniela Weber, Anja A. Kuehl, Chaoxuan Wang, Rei-Ichi Ohno, Nadja Kampschulte, Anne Pietzner, Nils Helge Schebb, Karsten-H. Weylandt, Tilman Grune
Summary: Inflammatory bowel disease (IBD) is associated with liver inflammation, and omega-3 polyunsaturated fatty acids (n-3 PUFA) can reduce the severity of IBD. This study found that increasing n-3 PUFA levels in mice also reduced liver inflammation and oxidative damage caused by colon inflammation. The anti-inflammatory effects of n-3 PUFA were accompanied by an increase in specific lipid compounds derived from n-3 PUFA. These findings demonstrate a correlation between the lipidome of n-3 PUFA and inflammatory changes in the liver during colitis, suggesting the potential of n-3 PUFA in reducing liver stress.
Article
Medicine, Research & Experimental
Maria Bove, Stefania Schiavone, Paolo Tucci, Lisa Pia Agosti, Stefania Dimonte, Maria Adelaide Palmieri, Vladyslav Sikora, Maria Matteo, Luigia Trabace, Maria Grazia Morgese
Summary: Low intake of n-3 polyunsaturated fatty acids (PUFA) during adolescence is associated with increased risk of depressive-like symptoms in both males and females. In this study, we found that adolescent rats fed with a low n-3 PUFA diet showed anxiety-like behavior, but immune activation was different between males and females.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Guixing Zeng, Dongxin You, Lingyan Ye, Yuchi Wu, Hualin Shi, Jiarong Lin, Ziyan Jiang, Junping Wei
Summary: This study examined the relationship between n-3 PUFA poor/rich seafood consumption and gout. The results showed that n-3 PUFA poor seafood consumption was associated with a higher risk of gout, while n-3 PUFA rich seafood consumption was not.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Nazek Noureddine, Ivan Hartling, Paulina Wawrzyniak, Pakeerathan Srikanthan, Phing-How Lou, Eliana Lucchinetti, Stefanie D. Kraemer, Gerhard Rogler, Michael Zaugg, Martin Hersberger
Summary: Through the study of mouse models and human cells, it was found that lipid emulsions rich in n-3 PUFA have more favorable clinical outcomes in total parenteral nutrition, which is associated with the generation of lipid mediators, especially SPMs and endocannabinoids in the spleen.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Stephen M. Cornish, Dean M. Cordingley, Keely A. Shaw, Scott C. Forbes, Taylor Leonhardt, Ainsley Bristol, Darren G. Candow, Philip D. Chilibeck
Summary: Supplementing with omega-3 fatty acids may improve lower-body strength and functionality in older adults, but has no impact on lean tissue mass.
Review
Food Science & Technology
Dan Xie, Ye Chen, Junwen Yu, Zhuangzhuang Yang, Xiaosan Wang, Xingguo Wang
Summary: This review discusses the applications of n-3 PUFA in foods and pharmaceutical products, as well as various methods for enriching lipids with n-3 PUFA. Lipases play a crucial role in the production of high-quality n-3 PUFA concentrates, but their high cost limits industrial-scale production. Further research should focus on discovering biological enzymes with exceptional catalytic ability and exploring novel technologies to improve lipases’ selectivity, catalytic ability, and reusability.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Long He, Shuting Wen, Zhuotai Zhong, Senhui Weng, Qilong Jiang, Hong Mi, Fengbin Liu
Summary: The combination of 5-ASA and SAHA showed lower toxicity and alleviated inflammation more effectively in the treatment of UC. One possible mechanism of synergy is the synergistic inhibition of the NF-kB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Ana Radanovic, Gordana Kralik, Ines Drenjancevic, Olivera Galovic, Manuela Kosevic, Zlata Kralik
Summary: This research elaborates the process of enriching table eggs with n-3 polyunsaturated fatty acids (n-3 PUFA) and presents the effect of such enriched eggs on human health. The experiment showed that the enriched eggs had higher levels of n-3 PUFA and better fatty acid profiles compared to conventional eggs. The consumption of these enriched eggs had a positive effect on some blood biochemical indicators. However, it was not confirmed that the short-term consumption of these eggs has a significant positive effect on human health.
Article
Nutrition & Dietetics
Peiwen Zhang, Yuheng Pan, Shuang Wu, Yuxu He, Jinyong Wang, Lei Chen, Shunhua Zhang, Hui Zhang, Ye Zhao, Lili Niu, Mailin Gan, Yan Wang, Linyuan Shen, Li Zhu
Summary: Polycystic ovary syndrome (PCOS) is an endocrine disorder that severely affects women's fertility and quality of life. Adding n-3 PUFA to the diet can slightly reduce body weight and greatly alleviate disturbed blood hormone levels in PCOS mice. In this study, we found that n-3 PUFA inhibited the over proliferation of granulosa cells in ovarian follicles by activating Hippo, promoting YAP1 exocytosis, weakening the cross-talk between YAP1 and Nrf2, and ultimately activating the ferroptosis sensitivity of ovarian granulosa cells. These findings reveal the molecular mechanisms by which n-3 PUFA attenuates PCOS and identify YAP1-Nrf2 as a potential therapeutic target for regulating granulosa cells in PCOS.
Article
Nutrition & Dietetics
Paulina Wawrzyniak, Barbara Hubeli, Marcin Wawrzyniak, Nazek Noureddine, Asa Walberg, Sylvie Scharl, Matthias Turina, Michael Scharl, Michael Zaugg, Stefanie D. Kramer, Gerhard Rogler, Martin Hersberger
Summary: This study compares the effects of two commonly used lipid emulsions, Omegaven (n-3-rich) and Intralipid (n-6-rich), on inflammation in human peripheral blood mononuclear cells (PBMCs). The results show that Omegaven has anti-inflammatory effects and increases the number of regulatory T cells, making it suitable for patients with inflammatory conditions. However, it may not be suitable for patients with cancer.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Yron Joseph Yabut Manaig, Silvia Sandrini, Sara Panseri, Gabriella Tedeschi, Josep M. Folch, Armand Sanchez, Giovanni Savoini, Alessandro Agazzi
Summary: Elevated ratios of omega-6 and omega-3 polyunsaturated fatty acids in swine diets can increase the risk of inflammatory and metabolic diseases. Lower ratios of these fatty acids have beneficial effects on sows and piglets. There is limited research on how sow nutrition directly affects protein and fat deposition in suckling piglets.
Review
Nutrition & Dietetics
Davide Decandia, Eugenia Landolfo, Stefano Sacchetti, Francesca Gelfo, Laura Petrosini, Debora Cutuli
Summary: Women approaching menopause may experience increased risk of cognitive impairment and emotional disorders, with intake of n-3 PUFA potentially benefiting depressive symptoms, reducing anxiety, and improving cognition. However, current research on the effects of n-3 PUFA in this area remains controversial, and further studies are needed to validate its effectiveness.
Article
Agriculture, Multidisciplinary
Dizhi Xie, Junfeng Guan, Xiaoping Huang, Chao Xu, Qing Pan, Yuanyou Li
Summary: The study demonstrates that farmed tilapia can be a beneficial source of n-3 LC-PUFA due to its high biosynthetic capacity of n-3 LC-PUFA in the intestine and liver.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Guillaume Pineton de Chambrun, Aurelien Amiot, Guillaume Bouguen, Stephanie Viennot, Romain Altwegg, Edouard Louis, Michael Collins, Mathurin Fumery, Florian Poullenot, Laura Armengol, Anthony Buisson, Vered Abitbol, David Laharie, Philippe Seksik, Stephane Nancey, Pierre Blanc, Yoram Bouhnik, Benjamin Pariente, Laurent Peyrin-Biroulet, Maria Nachury, Gilles Boschetti, Bernard Flourie, Pauline Danion, Guillaume Savoye, Franck Brazier, Julien Loreau, Laurent Beaugerie, Harry Sokol, I. Nion-Larmurier, A. Bourrier, C. Landman, J. Lefevre, N. Chafai, Najima Bouta, Natalie Funakoshi
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Michael Genin, Mathurin Fumery, Florent Occelli, Guillaume Savoye, Benjamin Pariente, Luc Dauchet, Jonathan Giovannelli, Cecile Vignal, Mathilde Body-Malapel, Helene Sarter, Corinne Gower-Rousseau, Gregoire Ficheur
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Marie Danielou, Helene Sarter, Benjamin Pariente, Mathurin Fumery, Delphine Ley, Christel Mamona, Mael Barthoulot, Cloe Charpentier, Laurent Siproudhis, Guillaume Savoye, Corinne Gower-Rousseau
JOURNAL OF CROHNS & COLITIS
(2020)
Article
Gastroenterology & Hepatology
Parambir S. Dulai, Aurelien Amiot, Laurent Peyrin-Biroulet, Vipul Jairaith, Melanie Serrero, Jerome Filippi, Siddharth Singh, Benjamin Pariente, Edward V. Loftus, Xavier Roblin, Sunanda Kane, Anthony Buisson, Corey A. Siegel, Yoram Bouhnik, William J. Sandborn, Karen Lasch, Maria Rosario, Brian G. Feagan, Daniela Bojic, Caroline Trang-Poisson, Bo Shen, Romain Altwegg, Bruce E. Sands, Jean-Frederic Colombel, Franck Carbonnel, Gursimran Kochhar, Joseph Meserve, Maria Barsky, Brigid S. Boland, Charlotte Gagniere, Marc-Andre Bigard, Camille Zallot, Jean-Charles Grimaud, Xavier Hebuterne, Maria Nachury, Pierre Desreumaux, Emilie Del Tedesco, Gilles Bommelaer, Jenna L. Koliani-Pace, Carmen Stefanescu, Arnaud Boureille, Robert Hirten, Ryan Ungaro, Thibaud Vaysse, Matthew Bohm, Sashidhar Varma, Monika Fischer, David Hudesman, Shannon Chang, Anne Bourrier, Philippe Seksik, Laurent Beaugerie, Jacques Cosnes, Harry Sokol, Cecilia Landman, Dana Lukin, Aaron Weiss, Philippe Marteau, Xavier Dray, Stephane Nancey, Gilles Boschetti, David Laharie, Florian Poullenot, Matthieu Allez, Jean-Marc Gornet, Clautilde Baudry, Guillaume Savoye, Jacques Moreau, Lucine Vuitton, Stephane Koch, Stephanie Viennot, Alexandre Aubourg, Laurence Picon, Anne-Laure Pelletier, Gaelle Sickersen, Guillaume Bouguen, Vered Abitbol, Stanislas Chaussade, Stephane Nahon, Mathurin Fumery, Betsy Winkfield, Hedia Brixi-Benmansour, Rodica Gincul, Jean-Christophe Barberis, Bruno Bonaz, Christophe Michiels, Frank Zerbib, Marie Bourrier de Beauregard, Christophe Locher, Sophie Davin-Couve, Armelle Poirette, Laurence Guillem, Monica Stetiu-Mocanu, Beau Philippe, Sylvain Beorchia, Jawad Al Qaddi, Arun Swaminath
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Pauline Vasseur, Emmanuelle Dugelay, Robert Benamouzig, Guillaume Savoye, Annaig Lan, Bernard Srour, Serge Hercberg, Mathilde Touvier, Jean-Pierre Hugot, Chantal Julia, Camille Buscail
Summary: This study investigated the associations among dietary patterns, ultra-processed food, and the incidence of inflammatory bowel diseases. The results show no significant associations between dietary patterns, ultra-processed food proportion, and the risk of incident IBD after adjustments for covariates. Further research is needed to explore the long-term relationship between diet and IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Antoine Martin, Maria Nachury, Laurent Peyrin-Biroulet, Yoram Bouhnik, Stephane Nancey, Anne Bourrier, Melanie Serrero, Mathurin Fumery, Anthony Buisson, David Laharie, Cyrielle Gilletta, Jerome Filippi, Matthieu Allez, Guillaume Bouguen, Xavier Roblin, Romain Altwegg, Nina Dib, Guillaume Pineton de Chambrun, Guillaume Savoye, Franck Carbonnel, Stephanie Viennot, Aurelien Amiot
JOURNAL OF CROHNS & COLITIS
(2020)
Article
Gastroenterology & Hepatology
David Laharie, Arnaud Bourreille, Julien Branche, Matthieu Allez, Yoram Bouhnik, Jerome Filippi, Frank Zerbib, Guillaume Savoye, Lucine Vuitton, Jacques Moreau, Aurelien Amiot, Laurent Beaugerie, Elena Ricart, Olivier Dewit, Antonio Lopez-Sanroman, Mathurin Fumery, Franck Carbonnel, Anthony Buisson, Benoit Coffin, Xavier Roblin, Gert van Assche, Maria Esteve, Martti Farkkila, Javier P. Gisbert, Philippe Marteau, Stephane Nahon, Martine de Vos, Laurent Peyrin-Biroulet, Jean-Yves Mary
Summary: In patients with steroid-refractory ASUC responding to second-line medical therapy, the process of endoscopic remission started with bleeding remission and was not achieved in half the patients at day 98 for vascular pattern. Infliximab provided a higher endoscopic remission rate than cyclosporine at day 98.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
J. Moreau, N. Hammoudi, L. Marthey, C. Trang-Poisson, M. Nachury, R. Altwegg, J-C Grimaud, S. Orempuller, X. Hebuterne, A. Aubourg, C. Baudry, P. Seksik, X. Roblin, S. Nahon, G. Savoye, B. Mesnard, C. Stefanescu, M. Simon, B. Coffin, M. Fumery, F. Carbonnel, L. Peyrin-Biroulet, K. Desseaux, M. Allez
Summary: An education programme for IBD patients led to a significant increase in their disease knowledge over 6 months, with a higher improvement in the educated group compared to the control group. 46% of the educated group and 24% of the control group met the primary endpoint, indicating the effectiveness of education programmes in improving patients' skills in managing their disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Sara Tadbiri, Maria Nachury, Yoram Bouhnik, Melanie Serrero, Xavier Hebuterne, Xavier Roblin, Julien Kirchgesner, Guillaume Bouguen, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Edouard Louis, Stephane Nancey, Vered ABitbol, Jean-Marie Reimund, Olivier DeWit, Lucine Vuitton, Nicolas Matthieu, Laurent Peyrin-Biroulet, Cyrielle Gilletta, Matthieu Allez, Stephanie Viennot, Caroline Trang-Poisson, Nina Dib, Hedia Brixi, Medina Boualit, Laurianne Plastaras, Lucile Boivineau, Mathurin Fumery, Ludovic Caillo, David Laharie, Aurelien Amiot, GETAID-IBD-disk Study Group
Summary: In this study, the IBD-disk score was found to be well correlated with IBD daily-life burden, demonstrating its potential for clinical use in assessing IBD-related disability. The high completion rate of the IBD-disk questionnaire suggests that it could be a valuable tool in evaluating the impact of IBD on patients' daily lives. The study also showed that an optimal cut-off of 40 for the IBD-disk score could effectively identify patients with high IBD daily-life burden.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Maria Nachury, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, Xavier Roblin, Julien Kirchgesner, Guillaume Bouguen, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Edouard Louis, Stephane Nancey, Vered Abitbol, Jean-Marie Reimund, Olivier DeWit, Lucine Vuitton, Nicolas Matthieu, Laurent Peyrin-Biroulet, Cyrielle Gilletta, Sara Tadbiri, Matthieu Allez, Stephanie Viennot, Arnaud Bourreille, David Laharie, Aurelien Amiot
Summary: The study assessed the experience of inflammatory bowel disease (IBD) patients with their disease, treatment, and physician relationship. Results indicated a good doctor-patient relationship, but room for improvement in patients' knowledge of the disease and treatment, along with concerns about treatment efficacy and adverse events. Additionally, there was a high demand for alternative healthcare professionals.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Nutrition & Dietetics
Rachel Marion-Letellier, Mathilde Leboutte, Asma Amamou, Maitreyi Raman, Guillaume Savoye, Subrata Ghosh
Summary: Intestinal fibrosis is a major complication of inflammatory bowel diseases, especially Crohn's disease, for which effective treatments are lacking. Diet may play a role in influencing the predisposition to develop intestinal fibrosis or alter its natural history by modifying the host immune response and intestinal microbial composition. Further studies are needed to investigate the effects of dietary factors on IBD-induced intestinal fibrosis and potential therapies to inhibit or promote fibrosis factors in the gut.
Article
Multidisciplinary Sciences
Asma Amamou, Matthieu Rouland, Linda Yaker, Alexis Goichon, Charlene Guerin, Moutaz Aziz, Guillaume Savoye, Rachel Marion-Letellier
Summary: The study suggests that high salt diet may exacerbate intestinal fibrosis and contribute to worsen chronic inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Asma Amamou, Cian O'Mahony, Mathilde Leboutte, Guillaume Savoye, Subrata Ghosh, Rachel Marion-Letellier
Summary: Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD), and macrophages play a key role in the inflammatory response and wound healing. Different subtypes of macrophages may be involved in the development of intestinal fibrosis, and the gut microbiota and diet may influence the characteristics and functions of macrophages, thus affecting the development of intestinal fibrosis.
Article
Gastroenterology & Hepatology
Marion Tilmant, Melanie Serrero, Florian Poullenot, Guillaume Bouguen, Benjamin Pariente, Romain Altwegg, Paul Basile, Jerome Filippi, Pierre Vanelslander, Anthony Buisson, Ariane Desjeux, David Laharie, Eric Le Balch, Maria Nachury, Lucile Boivineau, Guillaume Savoye, Xavier Hebuterne, Laurent Poincloux, Lucine Vuitton, Franck Brazier, Clara Yzet, Adnane Lamrani, Laurent Peyrin-Biroulet, Mathurin Fumery
Summary: Endoscopic balloon dilation of Crohn's disease-associated colorectal strictures is feasible, with high rates of technical and clinical success. With longer follow-up, over 40% of patients can become asymptomatic without the need for surgery.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Psychology, Multidisciplinary
Ingrid Banovic, Louise Montreuil, Marie Derrey-Bunel, Fabrizio Scrima, Guillaume Savoye, Laurent Beaugerie, Marie-Claire Gay
FRONTIERS IN PSYCHOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)