Article
Biochemistry & Molecular Biology
Zhen Li, Zhaoyi Yin, Baosheng Li, Jie He, Yanqun Liu, Ni Zhang, Xiaoyu Li, Qing Cai, Weiyan Meng
Summary: Peri-implantitis, characterized by peri-implant mucosal inflammation and loss of supporting bone tissue, is the most common cause of implant failure. In this study, a novel nanostructured lipid carrier (NLC) loaded with squalene and docosahexaenoic acid (DHA) (DHA-loaded NLC) was developed. DHA-loaded NLC showed enhanced anti-inflammatory effects and better prevention of alveolar bone resorption in a rat peri-implantitis model, providing a new approach for the treatment of peri-implantitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Karine Charriere, Imen Ghzaiel, Gerard Lizard, Anne Vejux
Summary: Neurodegenerative diseases pose a significant public health issue, with inflammatory component and microglia as potential therapeutic targets. Docosahexaenoic acid (DHA), an omega-3 fatty acid, shows inhibitory effects on microglial cell death and oxidative stress, as well as inflammatory activity. Nanomedicine offers new tools for delivering DHA to the brain, making it a promising therapeutic molecule for neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Aleena Francis Valookaran, Jenny Bouchard, Basma Milad Aloud, Sijo Joseph Thandapilly, Thomas Netticadan
Summary: This article reviews in detail the antihypertensive and cardio-protective effects of five food-derived bioactive compounds and their proposed mechanisms of action.
Article
Multidisciplinary Sciences
Jiqu Xu, Ben Ni, Congcong Ma, Shuang Rong, Hui Gao, Li Zhang, Xia Xiang, Qingde Huang, Qianchun Deng, Fenghong Huang
Summary: This study found that DHA improves hippocampal insulin sensitivity and cognitive function in aged rats fed a high-fat diet. The therapeutic effects of DHA are achieved by reducing systemic glucose homeostasis dysregulation, hippocampal neuroinflammation, and oxidative stress. In addition, DHA treatment breaks the cycle of hippocampal insulin resistance, Ab burden, and tau hyperphosphorylation, leading to enhanced cognitive capacity.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Patricia Monge, Alma M. Astudillo, Laura Pereira, Maria A. Balboa, Jesus Balsinde
Summary: This study investigates the incorporation and redistribution of DHA in mouse macrophages. DHA is initially taken up by choline glycerophospholipids and transferred to ethanolamine glycerophospholipids through prolonged incubation. Mass spectrometry analysis reveals a high abundance of DHA in ether phospholipids. Stimulation of macrophages leads to decreases in DHA-containing PC and PI species, while an unusual DHA-containing species, PI(20:4/22:6), markedly increases.
Article
Biochemistry & Molecular Biology
Ran Wei, Zhucheng Su, Gerardo G. Mackenzie
Summary: This study evaluated the gut protecting effect of CGA and EGCG, major constituents of coffee and green tea, on d-galactose-induced aging mice. CGA plus EGCG improved cognition deficits and protected gut barrier function more effectively compared to the agents alone. Additionally, CGA and EGCG modulated the gut microbiome and reduced gut inflammation.
Article
Immunology
Guo Mu, Changhe Ren, Yue Zhang, Bin Lu, Jianguo Feng, Dan Wu, Xinxin Xu, Cehua Ou
Summary: Trigeminal neuralgia is a complex neuropathic pain with a risk of central neurodegeneration. This study explored central neurodegeneration in TN rats and found that cognitive impairment is related to decreased docosahexaenoic acid (DHA) content in the central nervous system. By supplementing DHA, cognitive impairment was improved, possibly through the regulation of microglial polarization and neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elvira Verduci, Patrizia Rise, Elisabetta Di Profio, Laura Fiori, Sara Vizzuso, Dario Dilillo, Savina Mannarino, Elena Zoia, Valeria Calcaterra, Christian Pinna, Angelo Sala, Gianvincenzo Zuccotti
Summary: MIS-C is a pathological state linked to SARS-CoV-2 infection in children, characterized by inflammation, multisystem involvement, and altered inflammatory markers. The study reveals significant alterations in fatty acid levels in children with MIS-C, suggesting a potential contribution of omega-6 fatty acids to the observed inflammatory state.
Article
Pediatrics
Kristina Wendel, Helle Cecilie Viekilde Pfeiffer, Drude Merete Fugelseth, Eirik Nestaas, Magnus Domelloef, Bjorn Steen Skalhegg, Katja Benedikte Presto Elgstoen, Helge Rootwelt, Rolf Dagfinn Pettersen, Are Hugo Pripp, Tom Stiris, Sissel J. Moltu
Summary: This study aims to investigate the effects of early supply of ARA and DHA on brain maturation and neonatal outcomes in infants born before 29 weeks of gestation. Infants will receive a fatty acid supplement from the second day of life to 36 weeks' postmenstrual age, with the primary outcome being brain maturation assessed by MRI.
Article
Multidisciplinary Sciences
Hirotaka Yamada, Jun Saegusa, Sho Sendo, Yo Ueda, Takaichi Okano, Masakazu Shinohara, Akio Morinobu
Summary: The study found that resolvins play a role in regulating inflammation in rheumatoid arthritis by suppressing inflammation cell differentiation, promoting regulatory T cell differentiation, and inhibiting T cell proliferation. The research suggests that resolvins could be a novel treatment approach for rheumatoid arthritis.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Melinda H. Spooner, Donald B. Jump
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic fatty liver disease, especially in obese and type 2 diabetic individuals. Currently, there are no approved therapies for NAFLD. This study examines the potential of omega 3 polyunsaturated fatty acids (PUFAs) in treating NAFLD based on their role in hepatic function regulation. The evidence from clinical and preclinical studies suggests that dietary supplementation of C20-22 omega 3 PUFAs may decrease NAFLD severity by reducing hepatosteatosis and liver injury.
ANNUAL REVIEW OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Haidy A. Saleh, Eman Ramdan, Mohey M. Elmazar, Hassan M. E. Azzazy, Anwar Abdelnaser
Summary: The study suggests that DOX alone does not stimulate inflammatory response in RAW 264.7 macrophages, but in combination with LPS/IFN-gamma it significantly increases the expression of inflammatory markers, while SFN exhibits a potent inhibitory effect on inflammation, potentially serving as a treatment for DOX-associated inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Sarah E. Hancock, Michael G. Friedrich, Todd W. Mitchell, Roger J. W. Truscott, Paul L. Else
Summary: This study examined the changes in phospholipid composition in the mitochondrial and microsomal membranes of the human cerebellum and motor cortex with age, comparing the results with previous analyses of other brain regions.
Article
Neurosciences
Grace Y. Sun, Michael K. Appenteng, Runting Li, Taeseon Woo, Bo Yang, Chao Qin, Meixia Pan, Magdalena Cieslik, Jiankun Cui, Kevin L. Fritsche, Zezong Gu, Matthew Will, David Beversdorf, Agata Adamczyk, Xianlin Han, C. Michael Greenlief
Summary: The study found that a DHA-enriched diet altered phospholipid species and led to a significant increase in the lipid peroxidation product 4-HHE in the brain and other organs of mice. Particularly, the hippocampus showed a notable response to the DHA-enriched diet.
NEUROMOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Liyuan Ran, Jinhui Yu, Rui Ma, Qing Yao, Mingjie Wang, Yuping Bi, Zichao Yu, Yingjie Wu
Summary: Omega-3 PUFAs rich in fish oil are believed to prevent obesity by improving lipid metabolism and regulating gut microbiota. Microalgae oil, particularly Schizochytrium microalgae oil (SMO) with a high DHA proportion, is shown to have comparable weight-loss effects to commercial fish oil and a weight-loss drug. In addition, SMO has different effects on gut microbiota, increasing the abundance of beneficial bacteria and inhibiting obesity-promoting bacteria. SMO also helps restore the disturbed metabolic capability of gut microbiota caused by a high-fat diet.
Article
Anthropology
Mark D. Lucock, Patrice R. Jones, Martin Veysey, Rohith Thota, Manohar Garg, John Furst, Charlotte Martin, Zoe Yates, Christopher J. Scarlett, Nina G. Jablonski, George Chaplin, Emma L. Beckett
Summary: The study shows that ultraviolet radiation and pigmentation genes interact to affect blood vitamin levels. Individuals with light skin IRF4-TT genotype lose the most folate, while those with light skin HERC2-GG genotype synthesize the most vitamin D-3 (reflected in both TOMS and seasonal data). Additionally, dietary antioxidants interact with UVR and pigmentation genes to prevent oxidative loss of labile reduced folate vitamers.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jessica J. A. Ferguson, Christopher Oldmeadow, Gita D. Mishra, Manohar L. Garg
Summary: This study investigated the relationship between plant-based diets and overweight/obesity in older women. The results showed that women following plant-based diets had lower body weight, BMI, and waist circumference compared to regular meat eaters. On the other hand, increasing meat consumption was positively associated with higher body weight and other obesity-related measures.
PUBLIC HEALTH NUTRITION
(2022)
Article
Nutrition & Dietetics
Katerina Sarapis, Elena S. George, Wolfgang Marx, Hannah L. Mayr, Jane Willcox, Tammy Esmaili, Katie L. Powell, Oladayo S. Folasire, Anna E. Lohning, Manohar Garg, Colleen J. Thomas, Catherine Itsiopoulos, George Moschonis
Summary: This study found that consumption of high polyphenol extra-virgin olive oil (HPOO) can significantly reduce plasma oxidized low-density lipoprotein (ox-LDL) levels and increase total antioxidant capacity (TAC), especially in cardiovascular disease high-risk adults with abdominal obesity and inflammation.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Geriatrics & Gerontology
Dona P. W. Jayatunga, Eugene Hone, W. M. A. D. Binosha Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide. Nutraceuticals have become attractive compounds for their potential neuroprotective capabilities in AD prevention. This study aimed to derive a synergistic nutraceutical combination in vitro for potential preventative therapy. The combination of three compounds (DHA, LUT, and UA) was found to be the most effective in inhibiting AD-induced toxicity.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Dona P. W. Jayatunga, Eugene Hone, W. M. A. D. Binosha Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins
Summary: Current evidence suggests that consuming food rich in bioactive compounds may potentially slow down age-related cognitive decline. For neurodegenerative diseases like Alzheimer's disease (AD), which lack definitive treatments, the focus has shifted towards prevention strategies. Nutraceuticals have shown promise as potential compounds for their neuroprotective properties, particularly when combined with multiple bioactive components. The present study aimed to investigate the inhibitory effects and underlying mechanisms of a previously determined nutraceutical combination D5L5U5 for AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Nora A. Kalagi, Rohith N. Thota, Elizabeth Stojanovski, Khalid A. Alburikan, Manohar L. Garg
Summary: This study compared plasma TMAO levels in people with or without T2D and explored the association between TMAO and T2D. The results showed a significant association between higher plasma TMAO levels and T2D, with red meat consumption being a contributing factor. Further research is needed to assess the correlation between TMAO and T2D.
Article
Nutrition & Dietetics
Rohith N. Thota, Paul J. Moughan, Harjinder Singh, Manohar L. Garg
Summary: This study tested GlucoTRIG as a measure for ranking composite meals based on their metabolic effects. The results showed that meals with high fiber, low fat, and less processed foods had lower GlucoTRIG values, indicating a lower risk for metabolic diseases. Further research on the application of GlucoTRIG to foods, meals, and diets is warranted.
FRONTIERS IN NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Jessica J. A. Ferguson, Christopher Oldmeadow, David Bentley, Shaun Eslick, Manohar L. Garg
Summary: This study investigated the effects of a polyphenols rich dietary supplement containing Pinus massoniana bark extract (PMBE) for modulating blood pressure (BP) in healthy Australian adults. The results showed that the supplement significantly reduced systolic blood pressure (SBP), especially in individuals with normal-high SBP. However, there was no significant effect on diastolic blood pressure (DBP).
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Review
Nutrition & Dietetics
Carolina B. Castro, Cintia B. Dias, Heidi Hillebrandt, Hamid R. Sohrabi, Pratishtha Chatterjee, Tejal M. Shah, Stephanie J. Fuller, Manohar L. Garg, Ralph N. Martins
Summary: This systematic review and meta-analysis examined the effects of medium-chain fatty acid (MCFA) supplementation on circulating ketone bodies and cognition in individuals with cognitive decline and Alzheimer's disease. The results showed that MCFA supplementation increases blood ketone levels and enhances brain energy metabolism. However, the effects on cognition varied and further research is needed to determine if MCFA-mediated increase in brain energy metabolism can improve cognition.
Article
Nutrition & Dietetics
Nora A. A. Kalagi, Rohith N. N. Thota, Elizabeth Stojanovski, Khalid A. A. Alburikan, Manohar L. L. Garg
Summary: This study investigated the association between plasma trimethylamine N-oxide (TMAO) levels and chronic kidney disease (CKD) in patients with type 2 diabetes (T2D). The findings suggest a significant association between elevated plasma TMAO levels and CKD in patients with T2D.
Article
Nutrition & Dietetics
Vidit V. Satokar, Jose G. B. Derraik, Matire Harwood, Karaponi Okesene-Gafa, Kathryn Beck, David Cameron-Smith, Manohar L. Garg, Justin M. O'Sullivan, Gerhard Sundborn, Shikha Pundir, R. Preston Mason, Wayne S. Cutfield, Benjamin B. Albert
Summary: A study found that supplementation with fish oil during pregnancy in overweight or obese mothers may not affect infant body fat percentage and metabolism, but it can lower maternal triglyceride levels and reduce the risk of emergency cesarean section. Further follow-up studies are needed to determine whether the observed metabolic effects persist in the offspring.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Jessica J. A. Ferguson, Grace Austin, Christopher Oldmeadow, Manohar L. Garg
Summary: Plant-based diets are associated with reduced cardiovascular morbidity/mortality and lower cardiovascular disease risk factors. However, limited evidence exists regarding their dietary profile, diet quality, and nutritional adequacy compared to traditional meat-eating diets in Australians. The PBDS study aims to investigate these factors and compare cardiovascular disease risk between different dietary patterns in 240 adults recruited from the Hunter region, through questionnaires, blood samples, physical measures, and dietary intake assessments. Statistical analyses, including ANOVA, Kruskal-Wallis tests, and regression and mediation analyses, will be used to evaluate the data.
Article
Gastroenterology & Hepatology
Rohith N. Thota, Katie Wynne, Shyamala Pradeepan, Peter A. B. Wark, Manohar L. Garg
Summary: The study found that the ratio of islet amyloid polypeptide to C-peptide was significantly higher in patients with CFRD compared to those without CFRD. This ratio could potentially serve as a marker for predicting CFRD in adults with CF, but further validation in longitudinal cohort studies is needed.
Meeting Abstract
Chemistry, Applied
Carolina Castro, Cintia Dias, Hamid Sohrabi, Tejal Shah, Pratishtha Chatterjee, Heidi Hillebrandt, Stephanie Fuller, Manohar Garg, Ralph Martins
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2022)
Review
Rheumatology
Vidhu Sethi, Manohar Garg, Maxime Herve, Ali Mobasheri
Summary: Boswellia serrata and Curcuma longa have been used in Aryuvedic medicine for thousands of years to treat various inflammatory conditions. Studies have shown that the combination of boswellic acids and curcumin can effectively reduce pain and potentially replace the use of nonsteroidal anti-inflammatory drugs or other medications.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)