Article
Biochemistry & Molecular Biology
Palsa Kondaiah, Ravindranadh Palika, Purnachandra Mashurabad, Puneeta Singh Yaduvanshi, Paul Sharp, Raghu Pullakhandam
Summary: The study demonstrates that zinc depletion leads to reduced intestinal iron absorption, body weight, and tissue iron levels, while zinc repletion can reverse these effects but may cause a decrease in hemoglobin levels and red blood cell number. Zinc status plays a significant role in influencing growth, iron absorption, and systemic iron utilization.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Jiaxi Lu, Yichun Hu, Min Li, Xiaobing Liu, Rui Wang, Deqian Mao, Xiaoguang Yang, Lichen Yang
Summary: The study analyzed the serum zinc nutrition status of Chinese elderly, finding an overall prevalence of zinc deficiency of 8.68%. Factors such as gender, age, and BMI were significantly associated with zinc deficiency.
Article
Nutrition & Dietetics
Marlene Fabiola Escobedo-Monge, Maria Carmen Torres-Hinojal, Enrique Barrado, Maria Antonieta Escobedo-Monge, Jose Manuel Marugan-Miguelsanz
Summary: This study evaluated the zinc nutritional status of children with chronic diseases and found that 69% of participants had a zinc intake lower than recommended, which may put them at high risk of zinc deficiency.
Article
Limnology
Shannon M. M. Burns, Randelle M. M. Bundy, William Abbott, Zuzanna Abdala, Alexa R. R. Sterling, P. Dreux Chappell, Bethany D. D. Jenkins, Kristen N. N. Buck
Summary: This study examined the relationship between phytoplankton growth and dissolved concentrations of iron, manganese, cobalt, nickel, copper, zinc, and cadmium in the Southern Ocean. The results showed that manganese was a secondary limiting nutrient both onshore and offshore, and there was no co-limitation of iron and vitamin B-12. The uptake of metals relative to soluble reactive phosphorus was closely related to initial dissolved metal to phosphorus ratio.
LIMNOLOGY AND OCEANOGRAPHY
(2023)
Article
Nutrition & Dietetics
Jacquelyn Cheng, Haim Bar, Elad Tako
Summary: Zinc deficiency affects over one billion people globally, with challenges in accurately assessing zinc physiological status. The Zinc Status Index (ZSI), incorporating LA:DGLA ratio, mRNA gene expression of zinc-related proteins, and gut microbiome profiling, offers a clear evaluation of zinc physiological status.
Article
Food Science & Technology
Tongtong Ma, Qian Sun, Gen-na Ba, Xuan Wu, Xingwu Pei, Chao Sun, Shengjie Tan, Zhongxiao Wan
Summary: This study compared the effects of low phytate soymilk and regular soymilk consumption on long-term mineral status using rodent models. The results showed that both soymilk and low phytate soymilk increased serum calcium, hemoglobin, transferrin, and femur zinc levels compared to the control group. However, the soymilk group had decreased serum iron, red cell distribution width, and zinc levels. In addition, the low phytate soymilk group had significantly higher serum and liver zinc levels compared to the soymilk group. Furthermore, low phytate soymilk improved bone quality, maintained circulating iron and zinc levels, and increased liver iron storage compared to regular soymilk. Further studies on human subjects are needed to explore the effects of low phytate soymilk consumption on calcium, iron, and zinc status.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Armando Garcia-Guerra, Juan A. Rivera, Lynnette M. Neufeld, Amado D. Quezada-Sanchez, Clara Dominguez Islas, Ana Cecilia Fernandez-Gaxiola, Anabelle Bonvecchio Arenas
Summary: This study compared the effects of three micronutrient products on iron and zinc status of Mexican children aged 6-12 months. The results showed that both zinc and hemoglobin concentrations significantly increased in the syrup and micronutrient powders groups, while the prevalence of anemia significantly decreased only in the micronutrient powders group.
Article
Agronomy
Antonio Rafael Sanchez-Rodriguez, Maria Marin-Paredes, Adrian Gonzalez-Guzman, Jose Maria Mendez, Monica Sanchez-Parra, Daniel Sacristan, Mariano Fuentes-Garcia, Vidal Barron, Jose Torrent, Maria Carmen del Campillo
Summary: The study aimed to find a soil indicator for predicting durum wheat response to Zn fertilization, compare different Zn fertilization strategies, and assess the impact on crop P uptake. Results showed that only one Zn fertilization strategy increased wheat yield, with foliar spraying being more effective for wheat biofortification. Soil applications had lower zinc use efficiency and minimal impact on grain Zn concentrations compared to foliar treatments. Additionally, none of the Zn fertilization strategies influenced P uptake in crops.
Article
Nutrition & Dietetics
Xiao-Bing Liu, Jia-Xi Lu, Li-Juan Wang, Yi-Chun Hu, Rui Wang, De-Qian Mao, Jian Huang, Li-Yun Zhao, Xiao-Guang Yang, Li-Chen Yang
Summary: The study evaluated the serum zinc status of 7147 pregnant women in the China Adult Chronic Disease and Nutrition Surveillance (CACDNS) in 2015-2016, finding a higher serum zinc concentration and lower prevalence of zinc deficiency. While differences in serum zinc status were observed in different categories, there was no significant difference in the prevalence of zinc deficiency.
Article
Chemistry, Multidisciplinary
Robin Grun, Moneesha Samanta, Michael J. Ellwood
Summary: This study investigated the impact of iron limitation on zinc uptake and the delta 66Zn composition in Southern Ocean phytoplankton. The results showed that iron and zinc availability regulate the zinc content of phytoplankton and the delta 66Zn composition of the Southern Ocean.
Article
Plant Sciences
Jan Stefaniak, Barbara Lata
Summary: The uptake of N can impact kiwiberry yield and quality, but the relationship between increasing N dose and micronutrient accumulation in leaves and fruit is still unclear.
Article
Agriculture, Dairy & Animal Science
A. Winiarska-Mieczan, M. Kwiecien, T. Mieczan, K. Kwiatkowska, K. Jachimowicz
Summary: The study aimed to investigate the impact of Cu, Zn, and Fe glycine chelates on the antioxidative status in broiler chicken thigh meat. Results showed that Zn and Cu chelates increased antioxidant enzyme activity in muscles, while Fe chelates decreased antioxidative stability by raising malondialdehyde levels. Hence, administering Zn or Cu in glycine chelate form can enhance antioxidative properties in chicken meat.
Article
Biochemistry & Molecular Biology
Hua Wang, Xian-Bao Li, Rong-Gui Huang, Nv-Wei Cao, Hong Wu, Kai-Di Li, Yi-Yu Wang, Bao-Zhu Li
Summary: This meta-analysis comprehensively assessed the levels of zinc, copper, iron, and selenium in systemic lupus erythematosus (SLE) patients and healthy controls. The results showed that SLE patients had lower levels of zinc and iron, higher levels of copper, and no significant difference in selenium compared to healthy controls. Further studies are needed to investigate the mechanisms of zinc, copper, and iron in SLE patients.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Nutrition & Dietetics
Oraporn Dumrongwongsiri, Pattanee Winichagoon, Nalinee Chongviriyaphan, Umaporn Suthutvoravut, Veit Grote, Berthold Koletzko
Summary: Maternal nutritional status and mode of delivery are significantly associated with zinc and iron stores at birth, highlighting the importance of ensuring adequate nutrition during preconception and pregnancy to build sufficient nutrient stores for infants.
Review
Biochemistry & Molecular Biology
Elahe Nirooei, Seyyed Mohammad Amin Kashani, Soroor Owrangi, Fatemeh Malekpour, Maryam Niknam, Fatemeh Moazzen, Peyman Nowrouzi-Sohrabi, Somaye Farzinmehr, Hamed Akbari
Summary: This meta-analysis revealed that the circulating levels of Zn and Fe were significantly lower in MS patients and that Mn level was significantly higher than those in the control group. However, it was found that there was no significant difference between MS patients and controls with regard to levels of Mg, Se, and Cu.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Environmental Sciences
Miguel Rodriguez-Barranco, Lorenzo Rivas-Garcia, Jose L. Quiles, Daniel Redondo-Sanchez, Pilar Aranda-Ramirez, Juan Llopis-Gonzalez, Maria Jose Sanchez Perez, Cristina Sanchez-Gonzalez
Summary: The study on the COVID-19 pandemic in Spain found that factors such as living with a COVID-19 patient, walking the dog, and disinfecting purchased products at home were linked to increased infection risk. Working on site at the workplace and using home delivery for basic commodities were identified as factors increasing the prevalence of the disease.
ENVIRONMENTAL RESEARCH
(2021)
Review
Food Science & Technology
Lorenzo Rivas-Garcia, Maria D. Navarro-Hortal, Jose M. Romero-Marquez, Tamara Y. Forbes-Hernandez, Alfonso Varela-Lopez, Juan Llopis, Cristina Sanchez-Gonzalez, Jose L. Quiles
Summary: Edible flowers are rich in phenolic compounds and antioxidants, offering positive effects on oxidative stress-related diseases. They also exhibit hepatoprotective, neuroprotective, and cardioprotective actions, as well as anticancer, metabolic disorder-improving, and microbiocidal effects. Further in vivo studies are needed to validate these effects and elucidate the mechanisms behind them, highlighting the potential of edible flowers in developing nutraceutical products or functional foods.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lorenzo Rivas-Garcia, Jose Luis Quiles, Alfonso Varela-Lopez, Francesca Giampieri, Maurizio Battino, Jorg Bettmer, Maria Montes-Bayon, Juan Llopis, Cristina Sanchez-Gonzalez
Summary: The application of metallic nanoparticles as a therapeutic tool can improve the diagnosis and treatment of diseases by targeting mitochondria, affecting cellular function, and triggering autophagy processes. Nanoparticles have the potential to be used as therapeutic agents for cancer and other diseases dependent on mitochondria.
Article
Chemistry, Applied
Lorenzo Rivas-Garcia, Jose M. Romero-Marquez, M. D. Navarro-Hortal, Adelaida Esteban-Munoz, Francesca Giampieri, Sandra Sumalla-Cano, Maurizio Battino, Jose L. Quiles, Juan Llopis, Cristina Sanchez-Gonzalez
Summary: This study evaluated the methanolic extract of Tulbaghia violacea and found 11 individual phenolic compounds. The extract exhibited antioxidant activity and anti-tumor effects against ovarian cancer cells in vitro. In vivo tests on Caenorhabditis elegans showed that the extract reduced beta amyloid peptide formation and prevented oxidative stress. These findings suggest that Tulbaghia violacea could be a potential source of phenolic compounds for nutraceuticals and functional food development.
Article
Pharmacology & Pharmacy
Miguel Navarro-Alarcon, Fernando Gil-Hernandez, Cristina Sanchez-Gonzalez, Juan Llopis, Marina Villalon-Mir, Pablo Olmedo, Pablo Alarcon-Guijo, Diego Salagre, Lorena Gaona, Mario Paredes, Ahmad Agil
Summary: The study found that melatonin can improve metabolic issues associated with obesity and diabetes (diabesity) in an animal model by increasing the levels of zinc and copper in muscle cells, thus ameliorating blood sugar, insulin levels, and oxidative stress.
Article
Food Science & Technology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Victoria Jimenez-Trigo, Laura Vera-Ramirez, Tamara J. Forbes-Hernandez, Adelaida Esteban-Munoz, Francesca Giampieri, Pedro Bullon, Maurizio Battino, Cristina Sanchez-Gonzalez, Jose L. Quiles
Summary: This study characterized an olive leaf extract enriched in oleuropein and found that it exhibited no toxicity and improved oxidative stress and proteotoxicity. The study also identified potential molecular mechanisms involving multiple signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Applied
Maria D. Navarro-Hortal, Jose M. Romero-Marquez, Adelaida Esteban-Munoz, Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Juan Llopis, Danila Cianciosi, Francesca Giampieri, Sandra Sumalla-Cano, Maurizio Battino, Jose L. Quiles
Summary: Bioactive compounds from strawberries, such as ellagic acid and pelargonidin-3-glucoside, along with minerals like K, Mg, P, and Ca, were found in a methanolic extract of Romina strawberry variety. The extract showed antioxidant properties, prevented oxidative stress and delayed amyloid-13 induced paralysis in an experimental model. Molecular mechanisms involving DAF-16/FOXO and SKN-1/NRF2 signaling pathways were partially responsible for the observed effects.
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Victoria Jimenez-Trigo, Pedro Munoz-Ollero, Tamara Y. Forbes-Hernandez, Adelaida Esteban-Munoz, Francesca Giampieri, Irene Delgado Noya, Pedro Bullon, Laura Vera-Ramirez, Maurizio Battino, Cristina Sanchez-Gonzalez, Jose L. Quiles
Summary: This study investigated the effects of an olive fruit extract rich in hydroxytyrosol on Alzheimer disease features using Caenorhabditis elegans model. The extract showed antioxidant properties and delayed Aβ-induced paralysis, and the observed effects were mechanistically associated with the regulation of SKN-1/NRF2 transcription factor and the overexpression of HSP-16.2.
Article
Biology
Cristina Sanchez-Gonzalez, Laura Moreno, Pilar Aranda, Maria Montes-Bayon, Juan Llopis, Lorenzo Rivas-Garcia
Summary: The study found that diabetes alters the metabolism of zinc, copper, and manganese, and treatment with vanadium(IV) can reverse the changes in zinc and copper homeostasis caused by hyperglycemia. This effect is possibly mediated by a decrease in DMT1 gene expression.
Review
Food Science & Technology
Maria D. Navarro-Hortal, Jose M. Romero-Marquez, Victoria Jimenez-Trigo, Jianbo Xiao, Francesca Giampieri, Tamara Y. Forbes-Hernandez, Giuseppe Grosso, Maurizio Battino, Cristina Sanchez-Gonzalez, Jose L. Quiles
Summary: The growing number of older people has led to increased research on new approaches to manage or delay aging. Diet is a crucial factor in healthy aging and prevention of age-related diseases. Foods such as berries, curcumin, and virgin olive oil have shown positive effects on certain aspects of aging.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Chemistry, Applied
Francesca Giampieri, Luca Mazzoni, Danila Cianciosi, Jose M. Alvarez-Suarez, Lucia Regolo, Cristina Sanchez-Gonzalez, Franco Capocasa, Jianbo Xiao, Bruno Mezzetti, Maurizio Battino
Summary: Organic farming prohibits the use of chemical synthetic fertilizers, pesticides, etc., and applies sustainable agricultural technologies. While consumers believe that organic products are more nutritious and safer, there is controversy in academic circles. This study aims to summarize the impact of organic foods and the differences with conventional foods.
Article
Nutrition & Dietetics
Elena Nebot, Rosario Martinez, Garyfallia Kapravelou, Cristina Sanchez, Juan Llopis, Pilar Aranda, Jesus M. Porres, Maria Lopez-Jurado, Peter Pietschmann
Summary: This study found that implementing caloric restriction and a mixed training protocol as weight loss strategies can effectively counteract some of the detrimental effects caused by obesity, particularly in terms of trabecular bone morphometric parameters and bone mineral content.
Article
Biochemistry & Molecular Biology
Rocio Barragan, Cristina Sanchez-Gonzalez, Pilar Aranda, Jose Sorli, Eva M. Asensio, Olga Portoles, Carolina Ortega-Azorin, Laura V. Villamil, Oscar Coltell, Juan Llopis, Lorenzo Rivas-Garcia, Dolores Corella
Summary: This study aimed to investigate the association between trace elements and cardiovascular risk factors in a Mediterranean population. The results showed that higher plasma levels of trace elements (primarily Se, Cu, and Zn) were directly associated with elevated plasma lipids, while the mixture effect in urine was primarily associated with plasma glucose.
Review
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Tamara Y. Forbes-Hernandez, Maria D. Navarro-Hortal, Rosa Quirantes-Pine, Giuseppe Grosso, Francesca Giampieri, Vivian Lipari, Cristina Sanchez-Gonzalez, Maurizio Battino, Jose L. Quiles
Summary: Alzheimer's Disease (AD) is a major cause of global dementia cases, affecting around 50 million people worldwide. The leaves of olive trees contain bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT), which have shown medicinal properties in fighting AD. Olive leaf (OL), OLE, and HT can reduce amyloid-beta and neurofibrillary tangles formation, and OL has exhibited high cholinergic inhibitory activity. These compounds may also decrease neuroinflammation and oxidative stress, potentially promoting autophagy and restoring loss of proteostasis in AD models. Therefore, olive phytochemicals hold promise as an adjuvant in AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Francisco J. Orantes, Adelaida Esteban-Munoz, Cristina M. Perez-Oleaga, Maurizio Battino, Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Francesca Giampieri, Jose L. Quiles, Tamara Y. Forbes-Hernandez
Summary: This study aims to characterize monofloral avocado honey (AH) and evaluate its phenolic profile and antioxidant capacity. The results show that AH exhibits high antioxidant capacity in vitro and in vivo, which is relevant for the prevention of Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)