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Biochemistry & Molecular Biology
Colin G. Miller, Jean A. Kundert, Justin R. Prigge, Julie A. Amato, Allison E. Perez, Lucia Coppo, Gabrielle N. Rizzo, Michael P. Kavanaugh, David J. Orlicky, Colin T. Shearn, Edward E. Schmidt
Summary: While ascorbate supplementation did not protect against liver failure in TrxR1/Gsr-null livers, it unexpectedly increased the death rate. However, it was found that ascorbate treatment reduced basal DNA damage and oxidative stress markers despite depleting GSH in the stressed livers.
Article
Biochemistry & Molecular Biology
Michele C. Larsen, Catherine M. Rondelli, Ahmed Almeldin, Yong-Seok Song, Alhaji N'Jai, David L. Alexander, E. Camilla Forsberg, Nader Sheibani, Colin R. Jefcoate
Summary: This study reveals the regulation of bone marrow cells by polycyclic aromatic hydrocarbon (PAH) pollutants and microbiome products through the aryl hydrocarbon receptor (AhR). The absence of Cyp1b1 and activation of AhR by PAH result in similar gene stimulations in these cells. Specific sources of Cyp1b1 are found to be linked to AhR and an OLFR network to modulate BM inflammation through diverse microbiome products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Daniel C. Moreira, Debora P. Paula, Marcelo Hermes-Lima
Summary: Insect diapause involves biochemical adaptations, including reduced oxidative capacity and increased enzymatic activities in preparation for oxidative stress. These changes occur early in diapausing animals, within the first 24 hours to 20 days of diapause, indicating a complex response to metabolic depression and stress resistance in tropical insects like C. lacinia.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Edward R. Pennington, Syed Masood, Steven O. Simmons, Lisa Dailey, Philip A. Bromberg, Rebecca L. Rice, Avram Gold, Zhenfa Zhang, Weidong Wu, Yi Yang, James M. Samet
Summary: This study investigates the effects of air pollutants on intracellular redox homeostasis in human airway cells. The results show that isoprene hydroxy hydroperoxide (ISOPOOH), an atmospheric oxidation product, can disrupt the redox balance in cells, but this imbalance can be restored by glucose. Additionally, glucose-6-phosphate dehydrogenase (G6PD) plays a regulatory role in this process.
Article
Pharmacology & Pharmacy
Masaaki Ishibashi, Masakazu Ishii, Shinichiro Yamamoto, Yasuo Mori, Shunichi Shimizu
Summary: The study demonstrates that 5-FU enhances the activation of TRPM2 channel, and inhibition of H2O2-induced Ca2+ concentration increase by 5-FU in Trpm2 KO mice, alleviating the reduction of blood cells induced by 5-FU.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alvaro Santana-Garrido, Claudia Reyes-Goya, Pablo Espinosa-Martin, Luis Sobrevia, Luis M. Beltran, Carmen M. Vazquez, Alfonso Mate
Summary: This study investigates the role of the NADPH oxidase system in a rodent model of preeclampsia. The results suggest that NADPH oxidase mediates oxidative stress and inflammation in the placenta and kidney, providing important insights into the pathogenesis and potential treatment of preeclampsia.
Article
Pharmacology & Pharmacy
Felipe Zecchinati, Maria Manuela Barranco, Guillermo Nicolas Tocchetti, Camila Juliana Dominguez, Maite Rocio Arana, Virginia Gabriela Perdomo, Aldo Domingo Mottino, Fabiana Garcia, Silvina Stella Maris Villanueva
Summary: This study demonstrated that oxidative stress negatively regulates the intestinal barrier protein Mrp2 posttranslationally, leading to impaired barrier function. The altered distribution and function of Mrp2 caused by oxidative stress may have implications in xenobiotic absorption and toxicity in various human diseases associated with oxidative stress, affecting the safety and efficacy of therapeutic agents.
Article
Environmental Sciences
Pimchanok Nuchniyom, Ketsarin Intui, Jiraporn Laoung-on, Churdsak Jaikang, Ranida Quiggins, Kornravee Photichai, Paiwan Sudwan
Summary: This study aimed to determine the effects of Nelumbo nucifera extract on hepatotoxicity and oxidative stress induced by mancozeb. The results showed that the extract could suppress the toxicity of mancozeb, reduce liver injury, and regulate oxidative stress, making it a safe and effective natural antioxidant supplement.
Article
Biochemistry & Molecular Biology
Jiuchun Qiu, Daiqi Liu, Pengsha Li, Lingling Zhou, Lu Zhou, Xing Liu, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li, Tong Liu
Summary: Oxidative stress and mitochondrial dysfunction play important roles in the development of diabetic cardiomyopathy in type 2 diabetes mellitus. This study established a type 2 diabetes model and found that inhibiting NADPH oxidase can improve ventricular remodeling and reduce the incidence of DCM.
Article
Biochemistry & Molecular Biology
T. Etelainen, V Kulmala, R. Svarcbahs, M. Jantti, T. T. Myohanen
Summary: Oxidative stress is a common toxic feature in various neurodegenerative diseases, and reducing ROS production by inhibiting PREP can provide neuroprotection.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Francesca Beretti, Francesca Farnetani, Luca Reggiani Bonetti, Luca Fabbiani, Manuela Zavatti, Antonino Maiorana, Giovanni Pellacani, Tullia Maraldi
Summary: This study reveals a correlation between high positivity for Nox4 and c-met in BRAF mutated patients with melanoma, and metastasis occurring at least one year later than diagnosis. In vitro experiments demonstrate that the HGF/c-met/Nox4/ROS axis triggers epithelial-mesenchymal transition. The findings suggest that Nox4 inhibitors could be a potential addition to current therapies for treating melanoma patients with BRAF mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Qing Li, Yushi Du, Panyin Xiang, Guanyu Chen, Xiaoxian Qian, Shuangshuang Li, Yihui Mao, Wenhua Ling, Dongliang Wang
Summary: Brussels chicory, a typical vegetable in Mediterranean diets, has been found to stabilize advanced atherosclerotic plaques in the brachiocephalic artery of apoE-deficient mice. This study investigated the mechanism behind this effect and found that Brussels chicory improved oxidative stress, leading to the stabilization of aortic plaques and inhibition of monocyte adhesion.
Article
Medicine, Research & Experimental
Xiao-Fan Hu, Geng Xiang, Tian-Ji Wang, Yu-Bo Ma, Yang Zhang, Ya-Bo Yan, Xiong Zhao, Zi-Xiang Wu, Ya-Fei Feng, Wei Lei
Summary: The study revealed that abnormalities in the vascular system in the bone, particularly type H vessels, caused uncoupling of angiogenesis and osteogenesis, leading to diabetic osteopathy in type 1 diabetes mellitus (T1DM) mice. The severity of osteopathy was positively correlated with glycemic levels. Treatment with antioxidants and NOX2 inhibitors showed improvement in bone vessel impairments and bone mass quality.
Article
Nutrition & Dietetics
Annamaria D'Alessandro, Giovina Di Felice, Melania Manco, Anna Pastore, Simona Pezzi, Michela Mariani, Danilo Fintini, Andrea Onetti Muda, Ottavia Porzio
Summary: Obesity is a serious public health challenge that is closely linked to oxidative stress and metabolic disorders. This study analyzed serum samples from children with obesity and found abnormal levels of oxidative stress markers, which were positively correlated with obesity-related indices. Age was also found to be associated with oxidative stress.
Article
Neurosciences
Shuji Wakatsuki, Yoko Takahashi, Megumi Shibata, Toshiyuki Araki
Summary: In this study, we demonstrate that the NADPH oxidase subunit p47-phox regulates the activity of ZNRF1, and pS345 may serve as an important checkpoint to initiate ZNRF1-mediated neurite degeneration.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)