Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Agriculture, Multidisciplinary
Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, Xiaoxiao Wang, Xiuli Li, Jinsong Zhang
Summary: The study found that L-theanine in tea can inhibit the oxidation of tea catechins by chelating copper, thereby protecting the liver from damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Ling Lin, Li Zeng, An Liu, Dongyin Yuan, Yingqi Peng, Sheng Zhang, Yinhua Li, Jinhua Chen, Wenjun Xiao, Zhihua Gong
Summary: The study found that EGCG can regulate nutrient metabolism in rats by activating the AMPK and insulin pathways, while LTA cooperates with EGCG to promote glycogen metabolism and suppress the effects of EGCG on fatty acid and protein synthesis.
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jaganmay Sarkar, Manjusri Das, Md Sariful Islam Howlader, Prateeksha Prateeksha, Derek Barthels, Hiranmoy Das
Summary: EGCG inhibits osteoclast differentiation through modulating mitophagy and ROCK-mediated pathways. This study provides important theoretical support for the development of new therapies for arthritis.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi
Summary: This study found that EGCG can prevent the occurrence of hepatic fibrosis by suppressing oxidative stress and reducing OPN expression. Treatment with EGCG significantly alleviated liver injury and fibrogenesis, and reduced collagen deposition in liver tissue.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Tatsuya Kawasaki, Masaki Kondo, Rioka Hiramatsu, Tomohiro Nabekura
Summary: OAT1 and OAT3 are highly expressed drug transporters in the renal proximal tubules, affecting drug metabolism and toxicity, and are also susceptible to drug-drug interactions. The tea catechin EGCG inhibits OAT1 and OAT3, reducing the renal elimination of 6-CF in rats.
Article
Multidisciplinary Sciences
Sarah L. Millington-Burgess, Matthew T. Harper
Summary: The study found that epigallocatechin gallate (EGCG) does not inhibit phosphatidylserine (PS) exposure in procoagulant platelets, but does inhibit the release of extracellular vesicles (EVs).
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shih-Chung Huang, Yung-Hsi Kao, Shao-Fu Shih, Min-Chien Tsai, Chin-Sheng Lin, Liv Weichien Chen, Yi-Ping Chuang, Pi-Fen Tsui, Ling-Jun Ho, Jenn-Haung Lai, Sy-Jou Chen
Summary: EGCG can suppress cytokine secretion in activated human primary T cells, likely mediated by AP-1 inactivation through the ERK and JNK pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Wen-Ting Chen, Meei-Ju Yang, Yi-Wei Tsuei, Tsung-Chen Su, An-Ci Siao, Yow-Chii Kuo, Ling-Ru Huang, Yi Chen, Sy-Jou Chen, Po-Chuan Chen, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: This study investigates the effect of epigallocatechin gallate (EGCG) on the growth of white and beige preadipocytes by modulating the miR-let-7a and HMGA2 pathways. The results show that EGCG inhibits the growth of 3T3-L1 and D12 preadipocytes, upregulates miR-let-7a expression, and downregulates HMGA2 mRNA and protein levels. Overexpression of miR-let-7a and HMGA2 antagonizes the inhibitory effects of EGCG on cell growth. Therefore, EGCG acts on preadipocytes through the miR-let-7a/HMGA2 pathway to inhibit their growth.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Agriculture, Multidisciplinary
Seokho Hong, Sang Hwan Seo, Sun-Je Woo, Yonghoon Kwon, Manki Song, Nam-Chul Ha
Summary: SARS-CoV-2 and its variants present challenges to vaccine development and treatment. Natural compounds like EGCG, baicalin, and quercetin have been identified as potential inhibitors against the virus, with EGCG showing potent antiviral activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Changchao Huan, Weiyin Xu, Bo Ni, Tingting Guo, Haochun Pan, Luyao Jiang, Lin Li, Jingting Yao, Song Gao
Summary: The natural molecule EGCG, found in green tea, is effective against PEDV infection at the cellular level by inhibiting attachment, entry, replication, and assembly processes of the virus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lisa Henss, Arne Auste, Christoph Schuermann, Christin Schmidt, Christine von Rhein, Michael D. Muehlebach, Barbara S. Schnierle
Summary: EGCG showed antiviral activity against SARS-CoV-2 by blocking virus entry and inhibiting infections, suggesting it could be a lead structure for developing more effective anti-COVID-19 drugs.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Oncology
Camilla Bove, Silvia Arcangeli, Laura Falcone, Barbara Camisa, Rita El Khoury, Beatrice Greco, Anna De Lucia, Alice Bergamini, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci
Summary: This study investigated the role of CD4 and CD8 T cells in CD19 CAR-T cell responses and the development of cytokine release syndrome (CRS). CD4 CAR-T cells exhibited superior proliferation and activation potential compared to CD8 CAR-T cells. CD4 CAR-T cells were found to play a key role in the development of CRS, and CD4 CAR-T cells with embedded 4-1BB were associated with a safer profile. CD4 cells were crucial for maintaining long-term responses and the combination of CD4.BBz with CD8.28z CAR-T cells resulted in the lowest toxicity without compromising antitumor efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Ga Young Lee, Chan Yoon Park, Kyeong Sun Cha, Seung Eun Lee, Munkyong Pae, Sung Nim Han
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Junpeng Wang, Ying Qi, Xinli Niu, Hua Tang, Simin Nikbin Meydania, Dayong Wu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Xinli Niu, Chunfang Wu, Mengyue Li, Qing Zhao, Simin Nikbin Meydani, Junpeng Wang, Dayong Wu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Munkyong Pae, Yunjung Baek, Seungeun Lee, Dayong Wu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Immunology
Yu Xie, Zhengyi Li, Yong Wang, Xiaoxu Xue, Wenhai Ma, Yijie Zhang, Junpeng Wang
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Article
Medicine, Research & Experimental
Xing Su, Kun Liu, Yu Xie, Mengdi Zhang, Yong Wang, Min Zhao, Yilin Guo, Yijie Zhang, Junpeng Wang
Article
Nutrition & Dietetics
Chan Yoon Park, Tae Yeon Kim, Ji Su Yoo, Yeonkyung Seo, Munkyong Pae, Sung Nim Han
Article
Nutrition & Dietetics
Hongzhen Sang, Yu Xie, Xing Su, Mengdi Zhang, Yijie Zhang, Kun Liu, Junpeng Wang
FRONTIERS IN NUTRITION
(2020)
Article
Medicine, Research & Experimental
Xing Su, Kun Liu, Yu Xie, Mengdi Zhang, Xiao Wu, Yijie Zhang, Junpeng Wang
Summary: Inonotus sanghuang extract (ISE) has been found to effectively attenuate bleomycin-induced lung fibrosis in mice by reducing inflammation and fibrosis, suppressing TGF-beta signaling, and inhibiting EMT process. These findings suggest that ISE may have potential health benefits in improving lung fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xinli Niu, Hongzhen Sang, Junpeng Wang
Summary: The study demonstrated that naringenin could attenuate experimental autoimmune encephalomyelitis (EAE) by maintaining the blood-brain barrier, reducing immune cell infiltration, and inhibiting the infiltration of pathogenic T cells into the central nervous system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mi Nam Lee, Youngyoon Lee, Dayong Wu, Munkyong Pae
Summary: The NLRP3 inflammasome is an important component in the pathogenesis of various diseases, and luteolin may potentially suppress NLRP3 activation to combat inflammatory diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Shican Zhou, Hang Wu, Wenjuan Ning, Xiao Wu, Xiaoxiao Xu, Yuanqiao Ma, Xingwang Li, Junhong Hu, Chenyu Wang, Junpeng Wang
Summary: Ivermectin inhibits colorectal cancer cell growth by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest, suggesting its potential as a novel anticancer drug therapy for human colorectal cancer and other cancers.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Youngyoon Lee, Yelim Kim, Minam Lee, Dayong Wu, Munkyong Pae
Summary: Studies suggest that time-restricted feeding (TRF) may prevent obesity and its related diseases by improving immune cell composition in obese mice, resulting in reduced weight gain and fat deposition, as well as enhanced insulin sensitivity.
Review
Nutrition & Dietetics
Jung Hyun Kim, Hyoung Su Park, Munkyong Pae, Kyung Hee Park, Oran Kwon
Summary: Vitamin D plays an important role in the prevention and management of various diseases, and Koreans are susceptible to vitamin D deficiency due to spending most of their time indoors. This study establishes the dietary reference intake of vitamin D in Korea by reviewing the evidence against various diseases and risks.
NUTRITION RESEARCH AND PRACTICE
(2022)
Article
Immunology
Mengdi Zhang, Yu Xie, Xing Su, Kun Liu, Yijie Zhang, Wuyan Pang, Junpeng Wang
FRONTIERS IN IMMUNOLOGY
(2019)