Article
Biochemistry & Molecular Biology
Benya Nontaleerak, Chatchakorn Eurtivong, Churat Weeraphan, Hansuk Buncherd, Daranee Chokchaichamnankit, Chantragan Srisomsap, Jisnuson Svasti, Rojana Sukchawalit, Skorn Mongkolsuk
Summary: This study found that oxidation of C104 in the NieR protein under NaOCl stress leads to the formation of a disulfide-linked dimer, altering the protein's conformation and thereby abolishing its DNA-binding ability and repressing the expression of target genes.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Danielle M. Beaupre, Richard G. Weiss
Summary: The review focuses on the properties and applications of synthetic thiol- and disulfide-based materials, particularly polymers. The emphasis is on soft and self-assembling materials, where interconversion of thiol and disulfide groups can trigger stimulus-responses and self-healing, for both biomedical and non-biomedical applications.
Article
Electrochemistry
Daria A. Burmistrova, Andrey Galustyan, Ivan V. Smolyaninov, Nadezhda T. Berberova
Summary: A range of substituted o-aminophenols have been investigated as redox mediators for thiol oxidation to disulfides. The electrooxidation of o-aminophenols leads to the formation of o-iminobenzoquinones, which react with thiols in solution to form disulfides. The use of 4,6-di-tert-butyl-2-(tert-butylamino)phenol as a redox mediator was found to reduce the overpotential of thiol oxidation, resulting in unsymmetrical disulfides with alkyl, aryl, and heteroaryl substituents.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Zamorano Cuervo, Nathalie Grandvaux
Summary: Protein disulfide isomerases (PDIs) are enzymes that catalyze redox reactions and have chaperone functions in protein folding. PDIs have catalytic thioredoxin (TRX)-like domains with CXXC motifs for redox reactions, as well as non-catalytic TRX-like domains. Strategies for identifying cysteine oxidative post-translational modifications (Cys ox-PTMs) have been optimized, and analysis of a Cys redoxome dataset suggests the presence of a non-catalytic thiol-disulfide motif in PDIs. Further structural analysis and exploration of other PDIs are needed to understand the role of these motifs.
Article
Chemistry, Multidisciplinary
Xi-Yao Li, Shuai Feng, Meng Zhao, Chang-Xin Zhao, Xiang Chen, Bo-Quan Li, Jia-Qi Huang, Qiang Zhang
Summary: This study identified surface gelation on disulfide electrocatalysts for the first time, which reduces their electrocatalytic activity, and introduced TEA as a competitive inhibitor to enhance the performance of Li-S batteries. The research provides new insights into the actual surface structure of electrocatalysts in Li-S batteries.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Rebecca L. Charles, Giancarlo Abis, Beatriz F. Fernandez, Sebastian Guttzeit, Roberto Buccafusca, Maria R. Conte, Philip Eaton
Summary: The study revealed that H2O2 activates sEH by forming an intra-disulfide bond, increasing its catalytic efficiency. This oxidative activation mechanism also sensitizes sEH to inhibition by lipid electrophiles. The renin-angiotensin system regulates the intra-disulfide bond activation of sEH, leading to a decrease in EET/DHET ratio and an increase in blood pressure.
Article
Chemistry, Physical
Xun Zhang, Bin Yang, Wenlong Zhou, Zhenqi Zhu, Yujing Bian, Ruonan Zeng
Summary: This study utilized FT-Raman and THz-TDS spectroscopy techniques to measure the TRS, showing a good correlation between disulfide concentration and characteristic peak intensities, with correlation coefficients of 92.2% and 95.4% for FT-Raman and THz-TDS data, respectively. Solid-state density functional theory analysis revealed that both Raman and terahertz vibrational spectroscopy techniques can quantitatively analyze the ratio of cysteine/cystine, providing a new method for biological analysis of sulfur-containing amino acids and related mixtures in basic science.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Medicine, Research & Experimental
Jie Lei, Qian Zhang, Xuan Jin, Huiru Lu, Shuxiang Wang, Tingting Li, Yanmei Sheng, Fangyan Zhang, Yaxin Zheng
Summary: The drug release mechanism and rate of camptothecin-oleic acid prodrugs linked by disulfide bonds were found to be highly dependent on the reactivity between the disulfide bonds and thiol agents, affecting the release rate of the drug. The extracellular release of CPT was significantly faster than intracellular release, attributed to different release mechanisms.
MOLECULAR PHARMACEUTICS
(2021)
Article
Emergency Medicine
Daniel Sas, Fan Jim Yang, Nestor Agbayani, Siu Fai Li
Summary: A 44-year-old woman presented to the Emergency Department with abdominal pain. Imaging revealed small bowel obstruction and massive uterine fibroids. Surgical intervention was required after conservative therapy failed. Massive uterine fibroids is a rare cause of small bowel obstruction that requires the vigilance of Emergency Medicine physicians.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Moua Yang, Robert Flaumenhaft
Summary: Oxidative stress is a characteristic of many systemic diseases associated with thrombosis, and thiol isomerases play a key role in protein folding. Recent studies show that the oxidoreductase activity of thiol isomerases in thrombus formation is controlled by the redox environment and may potentially control thrombotic potential by modifying substrate networks.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Pramod Subedi, Jason J. Paxman, Geqing Wang, Lilian Hor, Yaoqin Hong, Anthony D. Verderosa, Andrew E. Whitten, Santosh Panjikar, Carlos F. Santos-Martin, Jennifer L. Martin, Makrina Totsika, Begona Heras
Summary: This study identified and characterized a novel Dsb-like protein, BcfH, from Salmonella that has a trimeric structure and unconventional catalytic sites, contributing to fimbrial biogenesis. The structural and functional flexibility in the TRX-fold protein family was demonstrated, with BcfH showing multiple redox functions mimicking eukaryotic PDI activity in bacteria.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Multidisciplinary Sciences
Yunlong Shi, Ari Zeida, Caitlin E. Edwards, Michael L. Mallory, Santiago Sastre, Matias R. Machado, Raymond J. Pickles, Ling Fu, Keke Liu, Jing Yang, Ralph S. Baric, Richard C. Boucher, Rafael Radi, Kate S. Carroll
Summary: This study demonstrates the potential of thiol-based chemical probes in inhibiting coronavirus infections, providing a new strategy for drug development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Roshan Kumar, Ruma Banerjee
Summary: The article discusses two main regulatory mechanisms of H2S on redox homeostasis: one is the impact on cellular effects through protein persulfidation, and the other is the influence on major redox nodes through remodeling the redox metabolome. These regulatory mechanisms help protect the thiol proteome from oxidative damage.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Electrochemistry
Zhihua Wang, Yingying You, Yingying Cai, Junze Ni, Yilin Liu, Hanping Zhang
Summary: This study proposes a concept of cluster-type lithium polysulfides regulator to address the performance and capacity decay issues in lithium-sulfur batteries. By introducing dipyridyl disulfide, the formation of macromolecular lithium pyridine-2-thiolate clusters restricts the polysulfides to the cathode side and enhances the redox activity of lithium polysulfides. The regulated Li-S battery exhibits a high capacity at a high C rate.
ELECTROCHIMICA ACTA
(2023)
Article
Engineering, Chemical
Xiaoxiao Wang, Nanping Deng, Jingge Ju, Gang Wang, Liying Wei, Hongjing Gao, Bowen Cheng, Weimin Kang
Summary: Lithium-sulfur batteries are promising energy storage candidates due to their high energy density and low cost, but challenges such as low electrical conductivity of sulfur and LiPS shuttle effect lead to capacity fade. This study introduces a modification strategy by coating MoP-MoS2 and PCNFs on the separator, significantly improving battery performance and showing great potential for practical application.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Review
Nutrition & Dietetics
Huifeng Jin, Haojie Cheng, Wei Chen, Xiaoming Sheng, Mark A. Levy, Mark J. Brown, Junqiang Tian
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2018)
Article
Oncology
Junqiang Tian, Donna M. Peehl, Susan J. Knox
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2010)
Article
Oncology
Junqiang Tian, Donna M. Peehl, Wengwei Zheng, Susan J. Knox
Article
Oncology
Shoucheng Ning, Junqiang Tian, Deborah J. Marshall, Susan J. Knox
Article
Oncology
Junqiang Tian, Hongjuan Zhao, Rosalie Nolley, Stephen W. Reese, Sarah R. Young, Xuejun Li, Donna M. Peehl, Susan J. Knox
CLINICAL CANCER RESEARCH
(2012)
Article
Oncology
Junqiang Tian, Shouchen Ning, Susan J. Knox
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2010)
Article
Oncology
Junqiang Tian, Hiroshi Doi, Matthias Saar, Jennifer Santos, Xuejun Li, Donna M. Peehl, Susan J. Knox
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2013)
Article
Urology & Nephrology
Taija M. af Hallstrom, Hongjuan Zhao, Junqiang Tian, Ville Rantanen, Stephen W. Reese, Rosalie Nolley, Marikki Laiho, Donna M. Peehl
JOURNAL OF UROLOGY
(2014)
Article
Cell Biology
Yi Huang, Yan Chen, Amanda Marie Shaw, Howard Goldfine, Junqiang Tian, Jiyang Cai
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Integrative & Complementary Medicine
Junrong Wu, Haojie Cheng, Jianpin Shi, Weidong Yin, Jun Wang, Xuanqiao Ou, Jin Li Chen, Ira Bernstein, Mark Levy, Rolando Maddela, Robert Sinnott, Junqiang Tian
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2020)
Article
Integrative & Complementary Medicine
Mark Levy, Wu Jun-rong, Shi Jian-pin, Cheng Hao-jie, Qu Xuan-qiao, Ira Bernstein, Robert Sinnott, Tian Jun-qiang
Summary: The study developed a preliminary diagnostic risk score for protective qi deficiency (PQD) using a multivariate logistic model, and showed that beta-glucan had a positive impact on improving PQD. The research indicated the feasibility of utilizing therapies from mainstream biomedicine to enhance treatment guided by traditional Chinese medicine principles.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Jun-rong Wu, Hao-jie Cheng, Jian-pin Shi, Wei-dong Yin, Jun Wang, Xuan-qiao Ou, Jin-li Chen, Ira Bernstein, Mark Levy, Rolando Maddela, Robert Sinnott, Jun-qiang Tian
Summary: The study demonstrated that beta-glucan can improve the protective qi status of PQD individuals, enhancing the body's defense against external harmful influences. Additionally, beta-glucan also improves symptoms of upper respiratory tract infections, levels of saliva secretory IgA, and physical and mental health status.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Letter
Pharmacology & Pharmacy
Junqiang J. Tian, Mark Levy, Robert Sinnott
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Junqiang J. Tian, Mark Levy, Xuekai Zhang, Robert Sinnott, Rolando Maddela
Summary: Homeostasis is a steady state of physiological parameters that vary within a certain range and are maintained by negative feedback mechanisms. This concept applies to both whole-body and cellular levels, and is crucial for adaptation to stress. However, chronic stress can lead to collateral damages.
PHARMACOLOGICAL RESEARCH
(2022)