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Oncology
Hisao Imai, Kyoichi Kaira, Kosuke Hashimoto, Hiroyuki Nitanda, Ryo Taguchi, Akitoshi Yanagihara, Tetsuya Umesaki, Ou Yamaguchi, Atsuto Mouri, Tomonori Kawasaki, Masanori Yasuda, Kunihiko Kobayashi, Hirozo Sakaguchi, Ichiei Kuji, Hiroshi Kagamu
Summary: The study revealed a close association between F-18-FDG accumulation and PD-L1/PD-L2 expression, which in turn correlated with glucose metabolism and hypoxia, potentially affecting the biological processes of thymic tumor cells.
Article
Immunology
Yiyan Songyang, Wen Li, Wenqiang Li, Ji Yang, TianBao Song
Summary: This study found that phloretin (PHL), an apple polyphenol, can prevent lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting glycolysis in macrophages, and its action depends on the inhibition of glucose transporter 1 (GLUT1).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shu-Man Pan, Yi-Fan Zhou, Na Zuo, Rui-Qing Jiao, Ling-Dong Kong, Ying Pan
Summary: Fluoxetine improves glucose uptake and glycolysis in astrocytes by restricting the GR-TXNIP-GLUT1 pathway, thereby alleviating corticosterone-induced depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiufang Qiu, Haixia Wu, Ting Xu, Shihan Xie, Ziqing You, Yixin Hu, Yinghong Zheng, Zewei Liang, Chaoxiong Huang, Li Yi, Li Li, Jing Liu, Zhaodong Fei, Chuanben Chen
Summary: This study aimed to reassess the clinical significance of standardized uptake values (SUVs) in nasopharyngeal carcinoma (NPC) on F-18-fluorodeoxyglucose (F-18-FDG) positron-emission tomography (PET). The results showed that high SUVs were associated with cancer recurrence, and the SUVmax-NTR ratio was identified as a potential prognostic factor.
Article
Biochemistry & Molecular Biology
Chukkris Heawchaiyaphum, Hironori Yoshiyama, Hisashi Iizasa, Ati Burassakarn, Zolzaya Tumurgan, Tipaya Ekalaksananan, Chamsai Pientong
Summary: This study revealed the oncogenic role of EBV in the progression of oral squamous cell carcinoma (OSCC) by inducing the Warburg effect and altering cancer stemness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Oncology
Jin Meng, Emmanuel Deshayes, Li Zhang, Wei Shi, Xiaomeng Zhang, Xingxing Chen, Xin Mei, Jinli Ma, Yizhou Jiang, Jiong Wu, Zhimin Shao, Xiaoli Yu, Zhaozhi Yang, Xiaomao Guo
Summary: The study identified a prognostic gene signature associated with glucose uptake in breast cancer patients after radiotherapy, using mRNA expression profiling on public datasets. Patients with a higher glucose uptake signature score had worse survival outcomes than those with a lower score. This suggests the potential prognostic value of glucose uptake signature in post-radiotherapy breast cancer patients.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Annan Zhang, Xiangxi Meng, Yuan Yao, Xin Zhou, Shuo Yan, Wang Fei, Nina Zhou, Yan Zhang, Hanjing Kong, Nan Li
Summary: This study investigates the application of F-18-FDG PET/MRI in predicting pleural invasion in lung cancer with a diameter of 3 cm or smaller, and the results show that it has high predictive value.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Anine Larsen Ottestad, Hakon Johansen, Tarje Onsoien Halvorsen, Hong Yan Dai, Sissel Gyrid Freim Wahl, Elisabeth Fritzke Emdal, Bjorn Henning Gronberg
Summary: This study investigated the association between circulating tumor DNA (ctDNA) levels and tumor metabolic activity in early-stage non-small cell lung cancer (NSCLC) patients. The results showed a positive correlation between ctDNA quantity and tumor metabolic parameters. Furthermore, ctDNA detection was found to be an independent negative prognostic factor.
Article
Radiology, Nuclear Medicine & Medical Imaging
Achraf Bahloul, Caroline Boursier, Helene Jeulin, Laetitia Imbert, Damien Mandry, Gilles Karcher, Pierre-Yves Marie, Antoine Verger
Summary: Our study aimed to identify specific (18)F-FDG-PET signs of COVID-19 in patients suspected of lung infection during the COVID-19 outbreak. Among our sample of 22 patients with CT evidence of lung infection, those with confirmed COVID-19 had lower SUVmax values on PET imaging compared to those without COVID-19, suggesting a more limited uptake in COVID-19 related abnormalities.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Kotaro Shimura, Seiji Mabuchi, Naoko Komura, Eriko Yokoi, Katsumi Kozasa, Tomoyuki Sasano, Mahiru Kawano, Yuri Matsumoto, Tadashi Watabe, Michiko Kodama, Kae Hashimoto, Kenjiro Sawada, Jun Hatazawa, Tadashi Kimura
Summary: Increased bone marrow FDG-uptake, represented by BAR, is associated with poor prognosis in patients with gynecological cancer. The mechanism involves tumor-derived G-CSF leading to increased BM FDG-uptake and immune suppression by G-CSF-induced MDSCs, contributing to the poor prognosis of this cancer type.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ke Li, Xing Ji, Rebecca Seeley, Wen-Chih Lee, Yu Shi, Fangfang Song, Xueyang Liao, Chao Song, Xiaobin Huang, Danielle Rux, Ju Cao, Xiaoji Luo, Steven M. Anderson, Wei Huang, Fanxin Long
Summary: This study found that the expression of glucose transporter Glut1 is reduced in articular cartilage in osteoarthritis (OA). Inducible deletion or forced expression of Glut1 can accelerate or protect against cartilage destruction, respectively. Moreover, in diabetic mice, both Glut1 expression and glycolysis rate are diminished in articular cartilage, resulting in more severe cartilage destruction.
Article
Oncology
Ming Chen, Kaili Cen, Yinjing Song, Xiaochen Zhang, Yih-Cherng Liou, Pu Liu, Jinyan Huang, Jian Ruan, Jia He, Wanyi Ye, Tianyue Wang, Xing Huang, Jiaqi Yang, Yunlu Jia, Xue Liang, Peng Shen, Qingqing Wang, Tingbo Liang
Summary: NUSAP1 plays a role in promoting metastasis and glycolysis in PDAC by regulating LDHA expression. This regulation mechanism forms a NUSAP1-LDHA-glycolysis-lactate positive feedback loop, explaining the metastasis and glycolytic metabolic potential in PDAC.
Article
Medicine, Research & Experimental
Kun Zhang, Tao Zhang, Yuhan Yang, Wenling Tu, Hongbin Huang, Yujun Wang, Yuzhuo Chen, Kejian Pan, Zhuojia Chen
Summary: The study reveals that the METTL3/LDHA axis-induced glucose metabolism could be a potential therapeutic target to overcome 5-FU resistance in CRC cells.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Juan Jose Rosales Castillo, Laura Garcia, Juan Fernando Bastidas, Angela Bronte, Maria Jose Garcia-Velloso
Summary: A 75-year-old man presented with dyspnea for more than 2 months, with low platelet count and severe pulmonary hypertension detected. Further evaluation including FDG PET/CT supported the diagnosis of pulmonary embolism, although surgical intervention revealed a pulmonary artery sarcoma.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chang Su, Dongjian Zhang, Na Bao, Aiyan Ji, Yuanbo Feng, Li Chen, Yicheng Ni, Jian Zhang, Zhiqi Yin
MOLECULAR IMAGING AND BIOLOGY
(2018)
Article
Medicine, Research & Experimental
Jiajia Liang, Ziping Sun, Dongjian Zhang, Qiaomei Jin, Lingqiao Cai, Lin Ma, Wei Liu, Yicheng Ni, Jian Zhang, Zhiqi Yin
MOLECULAR PHARMACEUTICS
(2018)
Article
Chemistry, Multidisciplinary
Lin Ma, Lingqiao Cai, Qiaomei Jin, Jiajia Liang, Dongjian Zhang, Wei Liu, Yicheng Ni, Zhiqi Yin, Jian Zhang, Ke Pan
CHINESE CHEMICAL LETTERS
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Linpeng Yao, Xing Xue, Peipei Yu, Yicheng Ni, Feng Chen
CONTRAST MEDIA & MOLECULAR IMAGING
(2018)
Article
Pharmacology & Pharmacy
Bianca Hemmeryckx, Yuanbo Feng, Liesbeth Frederix, Marleen Lox, Sander Trenson, Rob Vreeken, Hua Rong Lu, David Gallacher, Yicheng Ni, H. Roger Lijnen
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Review
Pharmacology & Pharmacy
Dongjian Zhang, Meng Gao, Qiaomei Jin, Yicheng Ni, Jian Zhang
ACTA PHARMACEUTICA SINICA B
(2019)
Review
Oncology
Shuncong Wang, Yewei Liu, Yuanbo Feng, Jian Zhang, Johan Swinnen, Yue Li, Yicheng Ni
Review
Pharmacology & Pharmacy
Dongjian Zhang, Cuihua Jiang, Yuanbo Feng, Yicheng Ni, Jian Zhang
JOURNAL OF DRUG TARGETING
(2020)
Review
Medicine, General & Internal
Yewei Liu, Shuncong Wang, Xiaohui Zhao, Yuanbo Feng, Guy Bormans, Johan Swinnen, Raymond Oyen, Gang Huang, Yicheng Ni, Yue Li
Review
Pharmacology & Pharmacy
Zhang Dongjian, Jin Qiaomei, Ni Yicheng, Zhang Jian
JOURNAL OF DRUG TARGETING
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Shuncong Wang, Yicheng Ni
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Cell Biology
Lei Chen, Shuncong Wang, Yuanbo Feng, Jinyong Zhang, Yuqing Du, Jiang Zhang, Chantal Van Ongeval, Yicheng Ni, Yue Li
Summary: This review systematically introduces the applications of the chick embryo chorioallantoic membrane (CAM) in biomedicine and bioengineering fields, particularly in vascular study, cancer research, drug screening and development. The article discusses the structural evolution, functions, vascular features, and cell regulatory factors of CAM, as well as its major applications in assays for pharmacokinetics, drug efficacy testing, and toxicology screening. Additionally, it highlights potential uses of CAM for preclinical studies on vascular-targeted therapy and modern imaging technologies for real-time visualization and monitoring of changes in CAM vasculature.
Correction
Radiology, Nuclear Medicine & Medical Imaging
Linpeng Yao, Xing Xue, Peipei Yu, Yicheng Ni, Feng Chen
CONTRAST MEDIA & MOLECULAR IMAGING
(2021)
Article
Oncology
Shuncong Wang, Lei Chen, Yuanbo Feng, Johan Swinnen, Charles Jonscher, Chantal Van Ongeval, Yicheng Ni
Summary: This study examines the prevalence and prognosis of synchronous lung metastasis (sLM) among cancer patients based on the SEER database. The findings reveal disparities in sLM by primary cancer type and clinicodemographic factors, highlighting the need for risk assessment and prognosis classification tools in clinical management.
Article
Oncology
Shuncong Wang, Yuanbo Feng, Lei Chen, Jie Yu, Yue Li, Yicheng Ni
Summary: The role of the blood-brain barrier in intracranial cancer treatment with vascular-disrupting agents is not clear. This study used a craniofacial metastasis model to compare the vascular shutdown between intracranial and extracranial tumors using in vivo MRI imaging, postmortem NanoCT, and pathology analyses. The results showed that intracranial tumors had weaker vascular shutdown compared to extracranial tumors. In vivo multiparametric MRI may predict the efficacy of vascular-disrupting agents on craniofacial tumors.