Article
Oncology
Oystein Hoydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen, Birger Henning Endreseth
Summary: This study evaluates the treatment, postoperative complications, and survival in older patients treated for rectal cancer. It found that older patients were less likely to undergo a major resection with curative intent and experienced more severe complications after surgery. However, if older patients received a major resection with curative intent, their long-term survival rate was comparable to that of younger patients.
Article
Oncology
Panu Aaltonen, Olli Carpen, Harri Mustonen, Pauli Puolakkainen, Caj Haglund, Katriina Peltola, Hanna Seppanen
Summary: This study analysed the impact of treatment modality changes on the survival of pancreatic cancer patients in Finland. The results showed that median survival improved in radical surgery patients, while slightly improved in the no-surgery group. The proportion of radical surgery patients receiving preoperative oncological treatment increased, which may contribute to the improved prognosis of pancreatic cancer patients.
Review
Nanoscience & Nanotechnology
Mesfin Dessale, Getachew Mengistu, Hylemariam Mihiretie Mengist
Summary: Cancer is the most devastating disease worldwide, and current conventional diagnostic and therapeutic methods are not efficient. Nanotechnology holds promise for quick, safe, cost-effective, and efficient cancer diagnosis and treatment, providing simultaneous diagnosis and therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Surgery
Theresa Relation, Yaming Li, James L. Fisher, Allan Tsung, Bridget Oppong, Mariam F. Eskander, Samilia Obeng-Gyasi
Summary: The study found that disease-specific mortality among inflammatory breast cancer patients is primarily associated with tumor biology and patient characteristics rather than treatment disparities or neighborhood socioeconomic status.
Article
Ecology
Marcela Braga Mansur, Nandita M. desouza, Rachael Natrajan, Lisa M. Abegglen, Joshua D. Schiffman, Mel Greaves
Summary: The emergence of drug-resistant cells, most of which have a mutated TP53 gene, prevents curative treatment in most advanced and common metastatic cancers of adults. Yet, a few, rarer malignancies, all of which are TP53 wild type, have high cure rates. This Perspective discusses common features of curable cancers to gain insights into the evolutionary and developmental determinants of drug resistance.
NATURE ECOLOGY & EVOLUTION
(2023)
Article
Oncology
Abdallah Al-Ani, Justin Z. Amarin, Leen Al-Huneidy, Maysa Al-Hussaini
Summary: This study investigated the consistent trends of female survival advantage in cancer among Jordanian patients across different age groups and nonsex specific cancer types. The results showed that females exhibited better overall survival in the adolescent and young adult (AYA) and older adults' groups. Further studies are needed to examine the underlying factors causing this discrepancy and develop sex-specific interventions.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan Taprogge, Carla Abreu, Siraj Yusuf, Gemma Ainsworth, Rachel H. Phillip, Jonathan I. Gear, Rebecca Gregory, Francesca Leek, Iain Murray, Amy B. Coulson, Sarah R. Brown, Yong Du, Kate Newbold, Jonathan Wadsley, Glenn D. Flux
Summary: Radioactive iodine is a successful treatment for differentiated thyroid cancer, but some patients become refractory to it. Selumetinib, by modulating the expression of sodium iodide symporter, shows potential in treating RAI-refractory DTC. Personalized treatment planning based on absorbed doses and enhanced iodine uptake may improve outcomes.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nickolas Stabellini, Apoorva Krishna Chandar, Amitabh Chak, Amie J. Barda, Mantas Dmukauskas, Kristin Waite, Jill S. Barnholtz-Sloan
Summary: Esophageal cancer is the seventh most common type of cancer worldwide and the sixth leading cause of cancer-related death. The incidence of esophageal cancer is higher in males, but there is limited data on prognosis and survival. This study aimed to analyze the differences between sexes and other factors in patients with primary esophageal cancer. The analysis of data from 2005 to 2020 showed differences between males and females in age at diagnosis, histology, smoking status, and prescriptions of NSAIDs. However, there was no significant difference in survival between males and females.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Evelien J. M. de Jong, Sandra M. E. Geurts, Lydia G. van der Geest, Marc G. Besselink, Stefan A. W. Bouwense, Jeroen Buijsen, Cornelis H. C. Dejong, Lara R. Heij, Bas Groot Koerkamp, Ignace H. J. T. de Hingh, Chantal Hoge, Geert Kazemier, Hanneke W. M. van Laarhoven, Vincent E. de Meijer, Nadia Haj Mohammad, Marin Strijker, Karin C. A. A. Timmermans, Liselot B. J. Valkenburg-van Iersel, Johanna W. Wilmink, Vivianne C. G. Tjan-Heijnen, Judith de Vos-Geelen
Summary: Incidence and overall survival of ampullary cancer in the Netherlands increased from 1989 to 2016, likely due to increased resection rates and use of adjuvant therapy observed during the study period.
Article
Multidisciplinary Sciences
Francisco Botelho, Rui Lopes, Francisco Pina, Carlos Silva, Luis Pacheco-Figueiredo, Nuno Lunet
Summary: This study describes the time trends and case volume per hospital of prostate cancer treatments in Portugal. The number of radical prostatectomy and brachytherapy treatments increased over time, but there is still ample room for concentration of treatments to improve case volume in hospitals.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Amy E. Pomeroy, Emmett V. Schmidt, Peter K. Sorger, Adam C. Palmer
Summary: Combination chemotherapy can cure certain leukemias and lymphomas, but most solid cancers are only curable at early stages. Understanding the mechanistic principles underlying curative treatments is valuable for improving future combination therapies.
Review
Biochemistry & Molecular Biology
Mai Lin, Ryan P. Coll, Allison S. Cohen, Dimitra K. Georgiou, Henry Charles Manning
Summary: Molecular imaging is a visual method used to study biological processes at the cellular or molecular level in living organisms. PET, among all imaging modalities, has significant advantages in sensitivity and quantification of imaging after corrections. PET, with the ability to label various biological molecules, has been widely used in molecular imaging. This article provides an overview of the recent advances in PET radiopharmaceuticals and their clinical applications in oncology.
Review
Chemistry, Multidisciplinary
So Yeon Ahn, Jin Liu, Srivithya Vellampatti, Yuzhou Wu, Soong Ho Um
Summary: As a new material, DNA is increasingly utilized in electronic and catalytic applications due to its unique characteristics. Challenges and opportunities in the biomedical application of DNA are being demonstrated, with new platforms enhancing diagnostic ability and therapeutic efficacy. There is confidence in DNA playing a significant role in next-generation clinical technology and multifaceted applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Divya S. Parimi, Yamini Gupta, Sreekar Marpu, Chandra S. Bhatt, Tharun K. Bollu, Anil K. Suresh
Summary: Cancer therapy has seen advancements with the use of nanovectors, particularly superparamagnetic iron oxide nanoparticles (SPION). SPIONs possess high reactivity, superior contrast, and magnetic and photo-inducibility properties, making them significant in cancer treatment. This article summarizes the progress of nanomagnets in cancer therapy, focusing on sustainable biomimetic approaches.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Oncology
Nour K. Younis, Rami Roumieh, Emmanuel P. Bassil, Joseph A. Ghoubaira, Firas Kobeissy, Ali H. Eid
Summary: This article introduces the role and potential of nanoparticles in diagnosing and treating colorectal cancer. Nanomedicine, as a new treatment modality, has the ability to overcome the limitations of traditional treatments and has been widely studied in clinical research. The article describes the therapeutic effects of several types of nanoparticles and their significance in targeted drug delivery, while also emphasizing the importance of nanomedicine in managing colorectal cancer and other diseases.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dongjian Zhang, Cuihua Jiang, Yuanbo Feng, Yicheng Ni, Jian Zhang
JOURNAL OF DRUG TARGETING
(2020)
Review
Medicine, General & Internal
Yewei Liu, Shuncong Wang, Xiaohui Zhao, Yuanbo Feng, Guy Bormans, Johan Swinnen, Raymond Oyen, Gang Huang, Yicheng Ni, Yue Li
Review
Pharmacology & Pharmacy
Zhang Dongjian, Jin Qiaomei, Ni Yicheng, Zhang Jian
JOURNAL OF DRUG TARGETING
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Shuncong Wang, Yicheng Ni
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Cell Biology
Lei Chen, Shuncong Wang, Yuanbo Feng, Jinyong Zhang, Yuqing Du, Jiang Zhang, Chantal Van Ongeval, Yicheng Ni, Yue Li
Summary: This review systematically introduces the applications of the chick embryo chorioallantoic membrane (CAM) in biomedicine and bioengineering fields, particularly in vascular study, cancer research, drug screening and development. The article discusses the structural evolution, functions, vascular features, and cell regulatory factors of CAM, as well as its major applications in assays for pharmacokinetics, drug efficacy testing, and toxicology screening. Additionally, it highlights potential uses of CAM for preclinical studies on vascular-targeted therapy and modern imaging technologies for real-time visualization and monitoring of changes in CAM vasculature.
Correction
Radiology, Nuclear Medicine & Medical Imaging
Linpeng Yao, Xing Xue, Peipei Yu, Yicheng Ni, Feng Chen
CONTRAST MEDIA & MOLECULAR IMAGING
(2021)
Article
Oncology
Shuncong Wang, Lei Chen, Yuanbo Feng, Johan Swinnen, Charles Jonscher, Chantal Van Ongeval, Yicheng Ni
Summary: This study examines the prevalence and prognosis of synchronous lung metastasis (sLM) among cancer patients based on the SEER database. The findings reveal disparities in sLM by primary cancer type and clinicodemographic factors, highlighting the need for risk assessment and prognosis classification tools in clinical management.
Article
Oncology
Shuncong Wang, Yuanbo Feng, Lei Chen, Jie Yu, Yue Li, Yicheng Ni
Summary: The role of the blood-brain barrier in intracranial cancer treatment with vascular-disrupting agents is not clear. This study used a craniofacial metastasis model to compare the vascular shutdown between intracranial and extracranial tumors using in vivo MRI imaging, postmortem NanoCT, and pathology analyses. The results showed that intracranial tumors had weaker vascular shutdown compared to extracranial tumors. In vivo multiparametric MRI may predict the efficacy of vascular-disrupting agents on craniofacial tumors.
