Article
Immunology
Andrew D. Gaudet, Laura K. Fonken, Monica T. Ayala, Steven F. Maier, Linda R. Watkins
Summary: Aging increases susceptibility to pain and death after SCI in mice, while deletion of miR-155 reduces pain symptoms and mortality. Aging mice exhibit heightened heat sensitivity and evoked pain symptoms, highlighting the importance of studying geriatric models of SCI.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biotechnology & Applied Microbiology
Volodymyr Krotov, Volodymyr Medvediev, Ibrahim Abdallah, Arseniy Bozhenko, Mykhailo Tatarchuk, Yevheniia Ishchenko, Leonid Pichkur, Serhii Savosko, Vitaliy Tsymbaliuk, Olga Kopach, Nana Voitenko
Summary: Motor disability is a common outcome of spinal cord injury (SCI), and the recovery of motor function depends on the severity of the injury. Pain is often comorbid with SCI, but its prediction remains poor. Our study found that in young rats with SCI, motor deficit can either improve or worsen over 4-5 weeks after injury, and all young rats showed changes in nociceptive sensitivity. The results suggest that motor dysfunction and pain syndromes following SCI can be predictable and can aid in long-term rehabilitation and recovery.
BIOENGINEERING-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Hanns Ulrich Zeilhofer, Karolina Werynska, Jacinthe Gingras, Gonzalo E. Yevenes
Summary: Restoring proper synaptic inhibition in the spinal cord, particularly through targeting the alpha 3 subtype of glycine receptors, may help reduce deleterious side effects and increase tolerability in chronic pain states. This review provides an update on the physiological properties and functions of alpha 3 subtype GlyRs and related drug discovery programs.
Article
Pharmacology & Pharmacy
Neha Munawar, Joelle Nader, Najat H. Khadadah, Ashraf Al Madhoun, Waleed Al-Ali, Linu A. Varghese, Willias Masocha, Fahd Al-Mulla, Milad S. Bitar
Summary: This study found that alpha-2A adrenoceptors (alpha 2-AR) in the nervous system of streptozotocin diabetic rats are upregulated, and the upregulation is associated with increased pain sensitivity. Chronic administration of the selective alpha 2-AR agonist guanfacine can downregulate the upregulation of alpha 2-AR and relieve hyperalgesia and allodynia in diabetic animals. These findings suggest that guanfacine may have potential as a potent analgesic for diabetic neuropathic pain.
Article
Chemistry, Medicinal
Zulkifal Malik, Muzaffar Abbas, Lina Tariq Al Kury, Fawad Ali Shah, Mahboob Alam, Arif-ullah Khan, Humaira Nadeem, Saad Alghamdi, Muhammad Umar Khayam Sahibzada, Shupeng Li
Summary: The study investigated the effects of thiazolidine derivatives 1b and 1d on inflammatory pain in mice. The compounds attenuated carrageenan-induced thermal hyperalgesia and mechanical allodynia, reduced IL-1 beta expression in the spinal cord, and were found to be safe with no motor coordination deficits.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Neha Munawar, Milad S. Bitar, Willias Masocha
Summary: This study investigates the role of serotoninergic nervous system in diabetic neuropathic pain (DNP) and suggests that treatment with 8-OH-DPAT, a selective 5-HT1AR agonist, could be effective in alleviating DNP symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Donya Ziafatdoost Abed, Reyhaneh Sadeghian, Saeed Mohammadi, Muhammad Akram
Summary: The essential oil of Thymus persicus showed strong antinociceptive and anti-neuropathic effects in Swiss mice, involving various signaling pathways and receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Alfonso Mata-Bermudez, Araceli Diaz-Ruiz, Masha Burelo, Betzabeth Anali Garcia-Martinez, Gustavo Jardon-Guadarrama, Francisco Calderon-Estrella, Andrea Rangel-Hernandez, Cuauhtemoc Perez-Gonzalez, Rios Camilo
Summary: The study evaluated the effect of dapsone on tactile allodynia and mechanical hyperalgesia in a spinal cord injury model in rats, and found that it can decrease nociceptive behaviors and oxidative stress. The anti-nociceptive effect of dapsone is regulated through the decrease of oxidative stress and the excitotoxicity associated with the activation of NMDA receptors.
Article
Neurosciences
Valerie Dietz, Katelyn Knox, Sherilynne Moore, Nolan Roberts, Karla Kassandra Corona, Jennifer N. Dulin
Summary: Spinal cord injury often leads to immediate and sustained neurological dysfunction, including neuropathic pain. This study found that the severity of the injury negatively correlated with the manifestation of mechanical hypersensitivity and suggests that the protection of dorsal horn neurons may be required for the development of neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Christopher L. Cioffi
Summary: The dysfunction of glycinergic neurotransmission in the spinal cord dorsal horn contributes to pathological pain, and enhancing this neurotransmission is proposed as a potential novel analgesic approach. Inhibitors of glycine transporters, especially GlyT1 and GlyT2, show promise as a new class of analgesics with broad efficacy in preclinical pain models. The development of GlyT inhibitors into safe and effective pain treatments presents key challenges but offers potential as a non-opioid analgesic with a differentiated mechanism of action.
Review
Cell Biology
Jing Chen, Norbert Weidner, Radhika Puttagunta
Summary: Physical activity-based rehabilitative interventions are important in treating neuropathic pain caused by spinal cord injury (SCI). Animal models have shown that these interventions can modulate inflammatory-related changes and induce structural and functional changes in the spinal cord circuitry. However, the cellular and molecular mechanisms behind this beneficial effect are not yet fully understood and further research is needed to develop individualized rehabilitative therapies.
Article
Behavioral Sciences
Guadalupe Garcia, Vladimir A. Martinez-Rojas, Janet Murbartian
Summary: TREK-1 channels play a crucial role in acute and persistent nociceptive hypersensitivity, with selective blockade or activation affecting pain behaviors. The activity of TREK-1 at peripheral and spinal sites can reduce neuronal excitability in a formalin-induced nociception model.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
A. Di Lionardo, G. Di Stefano, C. Leone, G. Di Pietro, E. Sgro, E. Malara, C. Cosentino, C. Mollica, A. J. Blockeel, O. Caspani, L. Garcia-Larrea, A. Mouraux, R. D. Treede, K. G. Phillips, M. Valeriani, Andrea Truini
Summary: This neurophysiological study demonstrated that capsaicin-induced central sensitization modulated N13 SEP amplitude, which was prevented by pregabalin, suggesting N13 SEP as a potential biomarker for changes in dorsal horn excitability during central sensitization.
SCIENTIFIC REPORTS
(2021)
Article
Anesthesiology
Courtney A. Bannerman, Katya Douchant, Julia P. Segal, Mitra Knezic, Alexandra E. Mack, Caitlin Lundell-Creagh, Jaqueline R. Silva, Scott Duggan, Prameet Sheth, Nader Ghasemlou
Summary: Chronic pain is a common complication of spinal cord injury. This study developed a mouse model of spinal cord injury and observed the pain phenotype and related pathology after injury. The study also investigated the changes in the gastrointestinal microbiome.
Article
Virology
Songbin Wu, Shaomin Yang, Rongzhen Li, Xiyuan Ba, Changyu Jiang, Donglin Xiong, Lizu Xiao, Wuping Sun
Summary: Herpetic-related neuralgia (HN) caused by varicella-zoster virus (VZV) infection is a common neuropathic pain. The molecular mechanisms and therapeutic targets of HN are still unclear. This study used an HSV-1 infection-induced HN mouse model to identify differentially expressed genes (DEGs) and explored the signaling pathways and expression patterns of these DEGs. The results showed that HSV-1 infection led to allodynia and hyperalgesia in mice, upregulation of certain genes in DRG and spinal cord, activation of astrocytes and microglia, and dysregulation of immune response and cytokine-cytokine receptor interaction. Blocking CCR5 exhibited analgesic effects and suppressed the upregulation of inflammatory cytokines. CCR5 could be a potential therapeutic target for HSV-1 infection-induced HN.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Neurosciences
Di Wu, Michelle C. Klaw, Nikolai Kholodilov, Robert E. Burke, Megan R. Detloff, Marie-Pascale Cote, Veronica J. Tom
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2016)
Article
Physiology
Jayakrishnan Nair, Tatiana Bezdudnaya, Lyandysha V. Zholudeva, Megan R. Detloff, Paul J. Reier, Michael A. Lane, David D. Fuller
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2017)
Article
Neurosciences
Megan Ryan Detloff, Lesley C. Fisher, Violetta McGaughy, Erin E. Longbrake, Phillip G. Popovich, D. Michele Basso
EXPERIMENTAL NEUROLOGY
(2008)
Article
Neurosciences
Megan Ryan Detloff, Leslie M. Clark, Karen J. Hutchinson, Anne D. Kloos, Lesley C. Fisher, D. Michele Basso
EXPERIMENTAL NEUROLOGY
(2010)
Article
Neurosciences
Gang Liu, Megan Ryan Detloff, Kassi N. Miller, Lauren Santi, John D. Houle
EXPERIMENTAL NEUROLOGY
(2012)
Article
Neurosciences
Megan Ryan Detloff, Evan J. Smith, Daniel Quiros Molina, Patrick D. Ganzer, John D. Houle
EXPERIMENTAL NEUROLOGY
(2014)
Article
Critical Care Medicine
Soha J. Chhaya, Daniel Quiros-Molina, Alessandra D. Tamashiro-Orrego, John D. Houle, Megan Ryan Detloff
JOURNAL OF NEUROTRAUMA
(2019)
Article
Physiology
Marie-Pascale Cote, Megan R. Detloff, Rodel E. Wade, Michel A. Lemayand, John D. Houle
FRONTIERS IN PHYSIOLOGY
(2012)
Article
Multidisciplinary Sciences
Megan Ryan Detloff, Lesley C. Fisher, Rochelle J. Deibert, D. Michele Basso
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2012)
Review
Biology
John R. Walker, Megan Ryan Detloff
Summary: This review discusses the impact of spinal cord injury on neural plasticity and emphasizes the importance of rehabilitation in restoring function, particularly in cases of cervical spinal cord injury affecting upper limb control. Neuroplasticity is a mechanism by which the central nervous system adapts to disruptions, and can be harnessed through rehabilitation and neuromodulation to improve outcomes.
Article
Neurosciences
Emily J. Reedich, Landon T. Genry, Meredith A. Singer, Clarissa Fantin Cavarsan, Elvia Mena Avila, Daphne M. Boudreau, Michael C. Brennan, Alyssa M. Garrett, Lisa Dowaliby, Megan R. Detloff, Katharina A. Quinlan
Summary: Spastic cerebral palsy (CP) is a movement disorder characterized by hypertonia and hyperreflexia. The most common comorbidity is pain. This study investigated the relationship between prenatal hypoxia-ischemia (HI) injury, which can cause CP, and changes in spinal nociceptive circuitry. The findings suggest that HI impacts spinal sensory pathways and enhances mechanical and thermal nociception in CP, even in the absence of motor deficits.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Rehabilitation
Laura Krisa, Madeline Runyen, Megan Ryan Detloff
TOPICS IN SPINAL CORD INJURY REHABILITATION
(2018)
Article
Clinical Neurology
Megan Ryan Detloff, Daniel Quiros-Molina, Amy S. Javia, Lekhaj Daggubati, Anthony D. Nehlsen, Ali Naqvi, Vinu Ninan, Kirsten N. Vannix, Mary-Katharine McMullen, Sheena Amin, Patrick D. Ganzer, John D. Houle
NEUROREHABILITATION AND NEURAL REPAIR
(2016)
Article
Neurosciences
AD Kloos, LC Fisher, MR Detloff, DL Hassenzahl, DM Basso
EXPERIMENTAL NEUROLOGY
(2005)