Article
Behavioral Sciences
Samantha M. Smith, Elena L. Garcia, Caroline G. Davidson, John J. Thompson, Sarah D. Lovett, Nedi Ferekides, Quinten Federico, Argyle Bumanglag, Abbi R. Hernandez, Jose F. Abisambra, Sara N. Burke
Summary: Approximately 60-70 million people suffer from traumatic brain injury (TBI) each year. Animal models are essential for understanding mechanisms and testing treatments for TBI. This study examined the cognitive performance of rats with TBI using a touchscreen-based task and found that the task could be useful for evaluating novel interventions.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Engineering, Biomedical
Aria W. Tarudji, Connor C. Gee, Sarah M. Romereim, Anthony J. Convertine, Forrest M. Kievit
Summary: Utilizing antioxidant nanoparticles NP1, this study demonstrates a potential treatment strategy to reduce secondary spread of traumatic brain injury. The NP1 treatment protected mice from learning and memory deficits induced by injury, likely through reduction of oxidative stress and spread of neuroinflammation. These findings suggest that NP1-mediated reduction in post-traumatic oxidative stress correlates with protection of spatial memory and learning, offering an improved therapeutic approach for TBI.
Article
Biochemistry & Molecular Biology
Sydnee L. Spruiell Eldridge, Jonathan F. K. Teetsel, Ray A. Torres, Christina H. Ulrich, Vrutant V. Shah, Devanshi Singh, Melissa J. Zamora, Steven Zamora, Amy K. Sater
Summary: Traumatic Brain Injury (TBI) is a major cause of disability worldwide, and effective therapies are currently lacking. This study investigates the response to focal impact injury in Xenopus tadpoles and demonstrates similarities to cellular alterations observed in other animal models. The Xenopus tadpole offers a new scalable vertebrate model for TBI research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Terry Dean, Javid Ghaemmaghami, John Corso, Vittorio Gallo
Summary: Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide, with no targeted therapies available. The functions and mechanisms of NG2-glia, the largest population of regenerative cells in the mature cortex, are not well understood in the context of TBI. This study synthesizes results from multiple rodent models and proposes future avenues for exploring the role of NG2-glia in TBI, suggesting that targeting these cells may enhance local cellular recovery.
Article
Cell Biology
Anais Laine, Sebastien Brot, Afsaneh Gaillard
Summary: This study investigates the therapeutic effect of hyaluronic acid (HA) hydrogel on host tissue after cortical trauma. The results show that HA hydrogel promotes vascularization, reduces glial scar, and provides a favorable environment for the survival and maturation of newly generated neurons.
Article
Biology
Fritz I. Schneider, Sandro M. Krieg, Ute Lindauer, Michael Stoffel, Yu-Mi Ryang
Summary: This study aims to investigate the effects of argon gas on traumatic brain injury. The results showed that argon treatment at different concentrations did not significantly reduce the primary outcome parameter, brain contusion volume, and the secondary outcome parameter, brain edema. However, there was a significant decrease in intracranial pressure at 50% argon concentration and significant neurological improvement at 25% and 50% argon concentrations.
Review
Neurosciences
Olivia J. Kalimon, Patrick G. Sullivan
Summary: TBI is a complex disease with multifactorial injury cascades. Mitochondria play important roles in cellular energy generation, cell death regulation, and intracellular calcium modulation, making them susceptible to TBI.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Kristina G. Witcher, Chelsea E. Bray, Titikorn Chunchai, Fangli Zhao, Shane M. O'Neil, Alan J. Gordillo, Warren A. Campbell, Daniel B. McKim, Xiaoyu Liu, Julia E. Dziabis, Ning Quan, Daniel S. Eiferman, Andy J. Fischer, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Yu-Wen Hung, Guan-Ling Lu, Hwei-Hsien Chen, Hsiu-Hui Tung, Sheau-Ling Lee
Summary: Traumatic brain injury (TBI) can lead to long-term neurocognitive dysfunctions. In this study, the effects of DPP-4 inhibitors (gliptins) on hippocampal function and TBI cognitive sequelae were investigated. Sitagliptin and vildagliptin were found to attenuate the abnormal migration of immature neurons and prevent astrocyte reactivation after TBI, leading to improved cognitive behavior in a mouse model. These findings suggest that DPP-4 inhibitors may be a potential treatment for cognitive dysfunction following TBI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Holly T. Korthas, Bevan S. Main, Alex C. Harvey, Ruchelle G. Buenaventura, Evan Wicker, Patrick A. Forcelli, Mark P. Burns
Summary: Traumatic brain injury (TBI) is a significant risk factor for sleep and circadian rhythm impairments. Two different TBI models can disrupt the ability of brain cells to maintain circadian rhythms, but the injury groups can still maintain circadian behavior patterns. In terms of sleep, the severe brain injury model showed disrupted brain wave patterns during sleep.
Article
Biochemical Research Methods
Connor C. Gee, Rylie Steffen, Forrest M. Kievit
Summary: This study improved and shortened the Barnes Maze protocol, resulting in a more accurate and reliable method for testing cognitive deficits in rodents. It provides a better tool for studying specific neurological disorders.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Cell Biology
Limin Wu, Joon Yong Chung, Tian Cao, Gina Jin, William J. Edmiston, Suzanne Hickman, Emily S. Levy, Jordyn A. Whalen, Eliza Sophie LaRovere Abrams, Alexei Degterev, Eng H. Lo, Lorenzo Tozzi, David L. Kaplan, Joseph El Khoury, Michael J. Whalen
Summary: Traumatic brain injury is a major cause of death and disability, and the role of RIPK3 in the pathogenesis and functional outcomes of TBI has been demonstrated. The activation of RIPK3 contributes to inflammation and affects postinjury motor and cognitive deficits, independent of necroptosis.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Maria Mazaharally, Sonja Stojanovski, Rebecca Trossman, Kamila Szulc-Lerch, M. Mallar Chakravarty, Brenda Colella, Joanna Glazer, Robin E. Green, Anne L. Wheeler
Summary: Progressive cortical volumetric loss is observed following moderate-severe traumatic brain injury (TBI), with thinner cortices and no significant changes in cortical surface area. The changes in CT and CSA exhibit widespread regional reductions and increases in TBI participants, suggesting differential neurodegenerative mechanisms at play. Additionally, the relationships between CT and CSA changes indicate complex bi-directional effects and highlight the importance of dissecting morphometric contributions to cortical volume change.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Shahmir Naseer, Laura Abelleira-Hervas, Dhwani Savani, Ross de Burgh, Robertas Aleksynas, Cornelius K. Donat, Nelofer Syed, Magdalena Sastre
Summary: There is compelling evidence that head injury is a significant environmental risk factor for Alzheimer's disease. This study found that traumatic brain injury (TBI) induces changes in miRNA expression, which in turn affects the expression of genes involved in neurodegeneration and AD pathology. These findings shed light on the mechanisms underlying the development of AD after TBI.
Article
Ergonomics
Gongxun Deng, Fang Wang, Chao Yu, Yong Peng, Hongzhen Xu, Zhixiang Li, Lin Hou, Zhen Wang
Summary: This paper investigates the dynamic response of the head-ground impact and traumatic brain injury (TBI) in subway collisions. It shows that the severity of passenger TBIs can be efficiently alleviated by the passenger body hitting the handrail before head-ground impact. The study also demonstrates that the risks of TBIs are sensitive to the handrail type in subway collisions, but not to the standing angle and friction coefficient. This research provides practical help for improving the interior crashworthiness performance of subways.
ACCIDENT ANALYSIS AND PREVENTION
(2022)
Article
Neurosciences
Suraj Sulhan, Kristopher A. Lyon, Lee A. Shapiro, Jason H. Huang
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Fengfei Wang, Shuang Zhou, Dan Qi, Shi-Hua Xiang, Eric T. Wong, Xuejing Wang, Ekokobe Fonkem, Tze-chen Hsieh, Jianhua Yang, Batool Kirmani, John B. Shabb, Joseph M. Wu, Min Wu, Jason H. Huang, Wei-Hsuan Yu, Erxi Wu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Editorial Material
Clinical Neurology
Jason H. Huang, Xiaoming Qi
Review
Clinical Neurology
Nitesh P. Patel, Timothy M. Robinson, Walter S. Lesley, David Garrett, Yuan Shan, Jason H. Huang
WORLD NEUROSURGERY
(2019)
Review
Medicine, General & Internal
Kristin A. Keith, Jason H. Huang
Article
Clinical Neurology
Jose M. Soto, Dongxia Feng, Huaiyu Sun, Yilu Zhang, Kristopher A. Lyon, Buqing Liang, Laura K. Reed, Jason H. Huang
Summary: The novel technique described in the article aims to preserve the vascular supply of scalp flap by modifying the incision site, potentially reducing wound complications and operative times. Hospital chart review of 7 cases showed successful preservation of superficial temporal and postauricular arteries, with rapid healing of the scalp flap and reduced complications.
WORLD NEUROSURGERY
(2021)
Letter
Clinical Neurology
Dongxia Feng, Jason H. Huang
WORLD NEUROSURGERY
(2021)
Review
Neurosciences
Jie Dong, Tingwei Xiao, Qiuyue Xu, Fei Liang, Simeng Gu, Fushun Wang, Jason H. Huang
Summary: This study provides a review of the development of personality theories and emotional dimensional theory, exploring the relationship between them and the neural mechanisms involved. The results suggest a correlation between personality traits and emotions, both of which are influenced by monoamine neurotransmitters.
Review
Chemistry, Medicinal
Yao Jiang, Di Zou, Yumeng Li, Simeng Gu, Jie Dong, Xianjun Ma, Shijun Xu, Fushun Wang, Jason H. Huang
Summary: This study reviews the advancements in monoamine neurotransmitters in the field of Major Depressive Disorder (MDD) and their impact on new pathways such as inflammation, oxidative stress, neurotrophins, and neurogenesis. The monoamine hypothesis is extended to basic emotions, with dopamine, norepinephrine, and serotonin playing different roles. The paper also briefly discusses the potential of monoamine neurotransmitters as a therapeutic approach for MDD, along with their limited clinical efficacy, side effects, and delayed onset of action.
Article
Genetics & Heredity
Dan Qi, Yiqun Geng, Jacob Cardenas, Jinghua Gu, S. Stephen Yi, Jason H. H. Huang, Ekokobe Fonkem, Erxi Wu
Summary: Peripheral blood is being explored as a noninvasive alternative to tissue biopsy for developing biomarkers for glioblastoma (GBM), but the lack of a robust detection approach has hindered the identification of widely utilized blood-based biomarkers in clinical settings. This study introduces WBGR, a globin reduction technique for RNA sequencing of whole blood, and demonstrates its ability to detect GBM-associated transcriptomic changes. Through transcriptomic analysis of tumor tissues, a 10-gene panel (GBM-Dx panel) consisting of mRNA, long noncoding RNA, and microRNA was identified as a potential tool for early detection and clinical management of GBM. The integrated approach of WBGR offers comprehensive analytic capacity for blood-based marker identification.
NPJ GENOMIC MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Simeng Gu, Yumeng Li, Yao Jiang, Jason H. Huang, Fushun Wang
Summary: This paper reviews the role of trauma-induced glymphatic system impairment and ROS-mediated inflammation in Major Depressive Disorder (MDD).
Review
Biochemistry & Molecular Biology
Matthew Su, Damir Nizamutdinov, Hanli Liu, Jason H. H. Huang
Summary: Alzheimer's disease is a neurodegenerative disease and the leading cause of dementia worldwide, characterized by progressive memory and intellectual decline. There is currently no known cure or treatment to stop its irreversible progression. Photobiomodulation using light in the red to near-infrared spectrum has shown promise in improving brain function. This review discusses recent advancements and mechanisms in Alzheimer's disease pathogenesis, as well as the potential therapeutic benefits of transcranial near-infrared light treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anthony V. Nguyen, Jose M. Soto, Sarah-Marie Gonzalez, Jennifer Murillo, Eric R. Trumble, Frank Y. Shan, Jason H. Huang
Summary: The 2021 World Health Organization Classification of Tumors of the Central Nervous System introduced the H3.3-G34R/V mutant glioma alongside the already recognized H3-K27M altered glioma, reflecting advances in understanding the roles of oncohistones in gliomagenesis. However, the prognosis remains poor for patients with these disease entities and the H3.3-G34R/V mutant gliomas are particularly understudied. Further research is needed to explore the molecular mechanisms underlying gliomagenesis and develop effective diagnosis, treatment, and future therapeutics.
Article
Surgery
Samantha Dayawansa, David Garrett, Marcus Wong, Jason H. Huang
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2019)
Article
Endocrinology & Metabolism
Qiuqian Wu, Chun Mathers, Ernest W. Wang, Sen Sheng, David Wenkert, Jason H. Huang