Article
Biochemistry & Molecular Biology
Adelheid Weidinger, Nadja Milivojev, Arthur Hosmann, J. Catharina Duvigneau, Csaba Szabo, Gabor Toro, Laurin Rauter, Annette Vaglio-Garro, V. Garik Mkrtchyan, Lidia Trofimova, Rinat R. Sharipov, Alexander M. Surin, Irina A. Krasilnikova, Vsevolod G. Pinelis, Laszlo Tretter, Rudolf Moldzio, Hulya Bayir, Valerian E. Kagan, Victoria I. Bunikg, Andrey V. Kozlov
Summary: Brain injury leads to neuroinflammation, extracellular glutamate accumulation, and mitochondrial dysfunction, causing neuronal death. This study aimed to investigate the effects of these mechanisms on neuronal death. Patients with aneurysmal subarachnoid hemorrhage (SAH) were recruited from a neurosurgical intensive care unit, and in vitro experiments were performed using rat cortex homogenate, neuronal cultures, and cell lines. The results showed that elevated levels of extracellular glutamate and nitric oxide (NO) metabolites were associated with poor clinical outcome in SAH patients. Inhibition of the key enzyme OGDHC from the glutamate-dependent segment of the tricarboxylic acid cycle by NO led to extracellular glutamate accumulation and neuronal death. However, reactivation of OGDHC by its cofactor thiamine reduced extracellular glutamate levels and protected against glutamate toxicity.
Article
Environmental Sciences
Aqeel Ahmad, Waheed Ullah Khan, Anis Ali Shah, Nasim Ahmad Yasin, Shagufta Naz, Aamir Ali, Arifa Tahir, Aima Iram Batool
Summary: The study demonstrates that NO and Si together can alleviate the detrimental effects of As stress on plants, reducing As uptake. It is recommended to co-apply NO and Si in As-contaminated soils for improving plant growth and stress alleviation.
Article
Biochemistry & Molecular Biology
Vivian Doerr, Ryan N. Montalvo, Branden L. Nguyen, Franccesco P. Boeno, Michael D. Sunshine, Victoria E. Bindi, David D. Fuller, Ashley J. Smuder
Summary: DOX chemotherapy can lead to cardiorespiratory dysfunction, while HBO therapy may increase muscle antioxidant expression. However, HBO therapy is not sufficient to prevent DOX-induced cardiorespiratory dysfunction.
Review
Endocrinology & Metabolism
Xuyi Wu, Jiuhong You, Xinxin Chen, Mei Zhou, Hui Ma, Tianle Zhang, Cheng Huang
Summary: Ischemic stroke is a major cause of morbidity and mortality worldwide, and preventing it is crucial. Recent studies suggest that hyperbaric oxygen preconditioning may be an effective nonpharmacological method, but its underlying mechanisms are not fully understood. This study reviewed the pathophysiology of ischemic stroke and explored the potential mechanisms through which hyperbaric oxygen preconditioning provides protection.
METABOLIC BRAIN DISEASE
(2023)
Review
Plant Sciences
Rajesh Kumar Tewari, Nele Horemans, Masami Watanabe
Summary: Nitric oxide (NO) is now recognized as an essential regulatory molecule in plants, playing a key role in iron (Fe) homeostasis and alleviating oxidative stress. Further investigations are needed to explore the interaction of NO with intracellular target molecules to enhance internal Fe availability in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Zebus Sehar, Iqbal R. Mir, Sheen Khan, Asim Masood, Nafees A. Khan
Summary: The study investigated the effects of exogenous NO and proline on the protection of wheat plants from heat stress. Heat-stressed plants showed increased oxidative stress and proline accumulation, as well as elevated levels of ethylene and NO generation. The application of SNP and proline improved photosynthesis and reduced oxidative stress in heat-stressed plants by enhancing the antioxidant defense system.
Article
Chemistry, Analytical
Mei-Jia Hou, Zhi-Qing Wang, Jun-Tao Chen, Zhi-Ke Tan, Guo-Jiang Mao, Junjie Fei, Chun-Yan Li
Summary: This study developed a fluorescent nanoprobe for sequential detection of ATP and ONOO-, showing potential for accurate cancer diagnosis by distinguishing cancer cells from normal cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ming-Jie Hou, Pan Wang, Bao Ting Zhu
Summary: In this study, it was found that protein disulfide isomerase (PDI)-mediated neuronal nitric oxide synthase (nNOS) activation plays a critical role in chemically-induced ferroptosis, which is characterized by the accumulation of nitric oxide (NO), reactive oxygen species (ROS), and lipid-ROS. Inhibition or knockdown of PDI can effectively prevent ferroptotic cell death.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Environmental Sciences
Pragyan Dash, C. Siva, Ritesh Shantilal Tandel, Raja Aadil Hussain Bhat, Pankaj Gargotra, Narinder Kumar Chadha, Pramod Kumar Pandey
Summary: The effects of long-term acclimation temperature on biomarkers of oxidative stress, metabolic stress, expression of heat shock proteins (Hsps), and warm-temperature acclimation related 65-kDa protein (Wap65) were studied in the chocolate mahseer. Acclimation to 31°C increased the expression of certain antioxidant genes and enzyme activities while downregulating the expression of superoxide dismutase 1 (SOD1). Fish acclimated to 15°C showed elevated transcript levels of all antioxidant genes. The expression of Hsp47 and Hsp70 varied with different acclimation temperatures. Wap65-1 transcription did not show significant variation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chan Lee, Jung-Hee Jang, Gyu Hwan Park
Summary: Stress can disrupt body balance, but controllable stress and the ability to overcome stress can enhance resilience against more intense stress. This study found that corticosterone (CORT), a stress hormone, protects against hydrogen peroxide-induced neuronal cell death by regulating apoptotic markers and promoting antioxidant enzyme activity. These findings suggest that low concentration of CORT plays a crucial role in enhancing intracellular self-defense and promoting neuronal cell survival.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Cell Biology
Gala Freixer, Khaoula Zekri-Nechar, Jose J. Zamorano-Leon, Carlos Hugo-Martinez, Nora Butta, Elena Monzon, Maria-Jose Recio, Manel Giner, Antonio Lopez-Farre
Summary: Exposure of megakaryocytes to low ASA concentration leads to higher apoptotic sensitivity in the newly generated platelet-like particles under stimulating conditions, possibly due to differences in mitochondrial functionality and NO formation.
Article
Biochemistry & Molecular Biology
Hyo-Gu Kang, Sanghoon Lee, Pil-Soo Jeong, Min Ju Kim, Soo-Hyun Park, Ye Eun Joo, Sung Hyun Park, Bong-Seok Song, Sun-Uk Kim, Min Kyu Kim, Bo-Woong Sim
Summary: The study found that supplementation of 0.1 μM lycopene enhanced embryonic development in pigs by regulating oxidative stress and mitochondria-dependent apoptosis.
Article
Sport Sciences
Rachel Tan, Matthew Black, Joseph Home, Jamie Blackwell, Ida Clark, Lee Wylie, Anni Vanhatalo, Andrew M. M. Jones
Summary: The purpose of this study was to investigate the effects of concurrent and independent administration of dietary nitrate and N-acetylcysteine on physiological responses during prolonged exercise and subsequent high-intensity exercise tolerance. The results showed that plasma levels of nitrate and nitrite were significantly increased in the group that ingested beetroot juice and N-acetylcysteine, and plasma cysteine levels were increased in the group that ingested N-acetylcysteine. Muscle excitability during prolonged cycling was better preserved in the group that ingested N-acetylcysteine compared to the other groups. However, there was no effect of supplementation on subsequent exercise tolerance.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Michal Kluknavsky, Andrea Micurova, Martina Cebova, Ezgi Saman, Sona Cacanyiova, Iveta Bernatova
Summary: MLN-4760 did not worsen pre-existing hypertension and behavioral hyperactivity/anxiety in SHRs. However, MLN-4760-induced oxidative damage in the brainstem was associated with activation of NO- and H2S-mediated compensatory mechanisms and increased expression of antioxidant, NO and H2S-producing enzymes, which correlated positively with elevated Nfe2l2 expression.
Article
Plant Sciences
Farwa Basit, Zaid Ulhassan, Qingshan Mou, Muhammad Mudassar Nazir, Jin Hu, Weimin Hu, Wenjian Song, Mohamed Salah Sheteiwy, Weijun Zhou, Javaid Akhter Bhat, Kaouthar Jeddi, Kamel Hessini, Yajing Guan
Summary: This study investigates the protective efficacy of seed priming with nitric oxide (NO) and/or spermine (Spm) in minimizing the toxic effects of chromium (Cr) in rice plants. The results show that the combined application of NO and Spm can effectively reverse the toxic effects of Cr by reducing its accumulation, maintaining nutrient balance, improving plant growth, and enhancing antioxidative enzyme activities. The co-exposure of NO and Spm is more effective in mitigating Cr-induced toxicity compared to individual treatments. Therefore, NO and Spm can be utilized to enhance rice tolerance under Cr stress conditions.
FUNCTIONAL PLANT BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Zhenhua Zhou, Ningbo Xu, Nathanael Matei, Devin W. McBride, Yan Ding, Hui Liang, Jiping Tang, John H. Zhang
Summary: The study demonstrated that intranasal administration of sodium butyrate reduced infarct volume and improved neurological function after middle cerebral artery occlusion (MCAO) in rats. The mechanism involved the activation of the PI3K/Akt pathway via GPR41/G beta gamma, leading to attenuation of neuronal apoptosis.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Lei Huang, Cameron Lenahan, Warren Boling, Jiping Tang, John H. Zhang
Summary: Stroke is a major global health concern with limited effective treatments. Molecular hydrogen, as a novel medical gas, shows therapeutic potential for neurological diseases, including stroke. Studies have demonstrated neuroprotective effects of molecular hydrogen therapy in stroke patients and models, providing new insights for stroke treatment.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Endocrinology & Metabolism
Richard Camara, Nathanael Matei, John H. Zhang
Summary: Although many patients are not eligible for reperfusion within 24 hours according to current guidelines, case studies show favorable outcomes for delayed recanalization beyond 24 hours after symptom onset. Modern imaging techniques aid in identifying penumbra and improving understanding of reperfusion risks and complications. There is an urgent need to further comprehend the pathophysiologic mechanisms and optimal conditions for delayed recanalization after 24 hours of ischemia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, General & Internal
Yachen Si, Lulu Liu, Jin Cheng, Tingting Zhao, Qi Zhou, Jianpeng Yu, Wei Chen, Jiarong Ding, Xuejun Sun, Hongtao Lu, Zhiyong Guo
Summary: The study demonstrated that hydrogen-rich water can improve crystal deposition, tubular injury, fibrosis, and ROS production in mouse kidneys induced by oxalate diet, and reduce renal injury, inflammation, and oxidative stress indexes. A total of 3,566 differential genes were screened by RNA-seq, and the PI3K/AKT, NF-kappa B, and TGF-beta pathways were identified as key targets for further investigation.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yuanyuan Gao, Yong Guo, Zackary D. Travis, Jiping Tang, Wen-Xiong Chen, John H. Zhang
Summary: The activation of MC1R with BMS-470539 attenuates oxidative stress and neuronal apoptosis in a neonatal HI rat model, improving neurological deficits. This effect is partially mediated by the MC1R/cAMP/PKA/Nurr1 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Nanoscience & Nanotechnology
Caiyou Zeng, Xuejun Sun, Bojin Qi, Yipeng Wang, Haibo Wang, Zhejun Tan, Yong Peng, Baoqiang Cong
Summary: This study demonstrates a novel strategy to enhance the strength and ductility of AA2219 Al-6.3Cu alloy arc-welded joints by introducing TiC particles and using a distinctive ultrasonic frequency double-pulsed arc. The fabricated TiCp/Al6.3Cu joint shows a fine-grained structure and a hierarchical alpha-Al grain structure embedded with dense nano-precipitation. The joint exhibits an unprecedented joint coefficient and excellent mechanical performance.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Cell Biology
Xuan Shi, Lina Zhu, Sheng Wang, Wanli Zhu, Quanfu Li, Juan Wei, Di Feng, Meiyun Liu, Yuanli Chen, Xuejun Sun, Hongtao Lu, Xin Lv
Summary: This study explored the protective effects of magnesium hydride (MgH2) on two types of ARDS models and its underlying mechanism in a lipopolysaccharide (LPS)-induced ARDS model of the A549 cell line. Results showed that MgH2 exerted anti-inflammatory, antioxidant, anti-apoptotic, and barrier-protective effects by regulating molecular signaling pathways. The in vivo study also demonstrated that MgH2-treated mice had a better survival rate and less pathological damage.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Xiaoya Li, Xueqi Ma, Xintong Chen, Tingfang Wang, Qing Liu, Yongfang Wang, Zhezhe Li, Juan Hofer, Fangbing Li, Liang Xiao, Xuejun Sun, Jinggang Mo
Summary: This study analyzed the molecular composition of the medusa and polyp of Aurelia coerulea and compared its toxicity with another scyphozoan jellyfish, Stomolophus meleagris. The results showed that A. coerulea medusae and polyps have similar molecular compositions, but their gene expressions are significantly different. A. coerulea medusa displayed weaker toxicity compared to S. meleagris medusa, and the variation in toxin expressions may be an important factor contributing to the difference in toxicity.
Article
Cell Biology
Jinwei Pang, Nathanael Matei, Jianhua Peng, Wen Zheng, Jing Yu, Xu Luo, Richard Camara, Ligang Chen, Jiping Tang, John H. Zhang, Yong Jiang
Summary: Delayed recanalization at day 3 postinfarct can significantly improve neurological outcomes after ischemic stroke. Macrophages play a critical role in this process by promoting angiogenesis and reducing neurodegeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Engineering, Manufacturing
Xuejun Sun, Bojin Qi, Zihao Jiang, Caiyou Zeng, Baoqiang Cong
Summary: In this study, different current modes were used to butt-weld 1460 Al-Li alloy plates. The effects of these current modes on the weld microstructure and mechanical properties were compared. The results showed that modulating pulsed current can refine the grains in the weld zone and fusion zone, and significantly increase the quantity and width of a fine strip-like equiaxed grain zone. Both P-VPTIG and DP-VPTIG processes effectively enhanced the strength and elongation of the joints.
JOURNAL OF MANUFACTURING PROCESSES
(2022)
Article
Economics
Jingpei Ma, Xuejun Sun
Summary: The development of green technology allows manufacturers in traditional industries to reduce carbon emissions, but the adoption of this technology varies among manufacturers. By implementing an effective green technology licensing strategy, highly efficient manufacturers can share their technology with less efficient manufacturers. The government has introduced subsidies to promote the use of green technology among manufacturers. However, the effectiveness of these subsidies, especially in the face of intense market competition, is still uncertain. This study develops a game theory model to analyze the optimal subsidy policy for the government.
MANAGERIAL AND DECISION ECONOMICS
(2023)
Editorial Material
Medicine, Research & Experimental
Xuejun Sun, Shigeo Ohta, John H. Zhang
MEDICAL GAS RESEARCH
(2023)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Engineering, Biomedical
Jing Ma, Suhe Dong, Hongtao Lu, Zhongmin Chen, Huijie Yu, Xuejun Sun, Renjun Peng, Wei Li, Sinian Wang, Qisheng Jiang, Fengsheng Li, Li Ma
Summary: This study revealed the protective effect of MgH2, a hydrogen storage nanomaterial, on radiation-induced male fertility impairment. MgH2 improved testicular structure, sperm quality, genetic effect, spermatogenesis, and hormone secretion. It also eliminated free radicals, suppressed ROS production, alleviated oxidative stress, and inhibited apoptosis and inflammation induced by radiation.
BIOMATERIALS RESEARCH
(2022)
