Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yunsong Zhang, Yinying Shen, Li Zhao, Qian Zhao, Lili Zhao, Sheng Yi
Summary: Nerve injury-induced Schwann cell dedifferentiation promotes axon growth by creating a favorable microenvironment. Transcription factor BCL11A plays a crucial role in Schwann cell reprogramming during peripheral nerve regeneration. Silencing Bcl11a reduces Schwann cell viability, proliferation, migration rates, and debris clearance ability. Bcl11a deficiency leads to restricted axon elongation and myelin wrapping, resulting in failed recovery. Mechanistically, BCL11A regulates Schwann cell activity by binding to the Nr2f2 promoter and modulating Nr2f2 expression. In conclusion, BCL11A is essential for Schwann cell activation and peripheral nerve regeneration, making it a potential therapeutic target for peripheral nerve injury treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Estefania Contreras, Sara Bolivar, Nuria Nieto-Nicolau, Oscar Farinas, Patricia Lopez-Chicon, Xavier Navarro, Esther Udina
Summary: This study assessed the regenerative potential of decellularized nerve allografts compared to autografts for repairing nerve resections. The results showed that while decellularized allografts sustained regeneration in rats, regeneration was limited with decellularized xenografts.
CELL AND TISSUE RESEARCH
(2022)
Article
Neurosciences
Yunsong Zhang, Qian Zhao, Qianqian Chen, Lingchi Xu, Sheng Yi
Summary: Transcription factors play important roles in nerve regeneration after peripheral nerve injury, including regulating axon elongation and Schwann cell phenotype modulation. Understanding these transcription factors can help promote functional recovery of injured peripheral nerves.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Song Zhang, Ying Zhou, Hua Xian, Yifeng Shi, Yunxiao Liu, Zijian Li, Yingru Huang
Summary: Peripheral nerve injury often causes functional impairment or paralysis, and allograft has been proposed as a potential repair strategy. This study investigated the effect of endogenous neurotrophic factors (ENTFs) on nerve regeneration after the allograft of a cryopreserved sciatic nerve. The results showed that ENTFs were highly expressed in the sciatic nerves after pretreatment, and their expression continued in vitro after cryopreservation. The immune response was weak in the allograft group, promoting nerve regeneration. The 14-day Allo group had similar nerve regeneration and functional recovery compared to the fresh isograft group and better outcomes than the cryopreserved-fresh allograft and fresh allograft groups.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Max Y. Y. Jin, Tristan E. Weaver, Adam Farris, Mayank Gupta, Alaa Abd-Elsayed
Summary: While denervation can occur with aging, peripheral nerve injuries often result in loss of function and neuropathic pain. Neuromodulation has shown promise in enhancing peripheral nerve regeneration, but additional interventions are needed to control the direction of reinnervation. More human studies are required to validate findings from animal studies and optimize neuromodulation for functional restoration.
Article
Engineering, Biomedical
Yao Liu, Xiaonong Zhang, Chunsheng Xiao, Bin Liu
Summary: Peripheral nerve injury (PNI) is a complex disease that commonly affects young adults and has limited treatment options and poor clinical outcomes. Tissue-engineered hydrogels have shown promising results in promoting neural tissue regeneration and recovery of impaired neural function. This review discusses recent advances and various therapeutic strategies of hydrogels in peripheral nerve repair, as well as the prospects and challenges in their application for PNI treatment.
MATERIALS TODAY BIO
(2023)
Review
Biotechnology & Applied Microbiology
Ane Escobar, Rui Luis Reis, Joaquim Miguel Oliveira
Summary: Peripheral nerve injuries are a common cause of disabilities, and treatment with long nerve gap autografts is currently considered the best method. However, due to limited availability and potential issues at the donor site, research is focusing on developing regenerative strategies using artificial nerve guidance conduits (NGCs). These NGCs can be optimized through various methods to enhance nerve regeneration, and recent advancements in using different types of nanoparticles to introduce growth factors to NGCs are discussed in depth.
Article
Immunology
Jiawei Xu, Jinkun Wen, Lanya Fu, Liqiang Liao, Ying Zou, Jiaqi Zhang, Junyao Deng, Haowen Zhang, Jingmin Liu, Xianghai Wang, Daming Zuo, Jiasong Guo
Summary: The depletion of RhoA in macrophages has a negative impact on Wallerian degeneration and nerve regeneration, mainly due to impaired migration and phagocytosis of macrophages resulting from disrupted RhoA/ROCK/MLCK pathway. Since previous research has shown that RhoA inhibition in neurons promotes axonal regeneration, the study highlights the importance of considering cellular specificity of RhoA-targeted drugs in future applications for treating peripheral nerve injuries.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Neurosciences
Kathryn L. Wofford, Robert B. Shultz, Justin C. Burrell, D. Kacy Cullen
Summary: Peripheral nerve injuries disrupt cellular communication between the central nervous system and somatic distal end targets, leading to limited muscle reinnervation and functional recovery. Macrophages play a critical role in the regeneration of the injured peripheral nervous system, and implementing macrophage-based immunomodulatory therapies is promising for nerve injuries in various clinical presentations.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Engineering, Biomedical
Can Liu, Lei Fan, Zhenming Tian, Huiquan Wen, Lei Zhou, Pengfei Guan, Yian Luo, Chuncheung Chan, Guoxin Tan, Chengyun Ning, Limin Rong, Bin Liu
Summary: Conductive scaffolds have shown therapeutic effects for patients with peripheral nerve injuries. The development of biocompatible electroconductive hydrogels has been proposed in this study, which can promote nerve repair and functional recovery.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Teng Ma, Yiming Hao, Shengyou Li, Bing Xia, Xue Gao, Yi Zheng, Liangwei Mei, Yitao Wei, Changbin Yang, Lei Lu, Zhuojing Luo, Jinghui Huang
Summary: In this study, a sequential oxygen supply system was developed using core-shell fibers to repair peripheral nerve defects. The system showed significant improvements in cell protection, angiogenesis, and nerve regeneration. The sequential oxygen supply conduits acted as oxygen suppliers for cells and resulted in similar functional outcomes as autografts.
Article
Biochemistry & Molecular Biology
Arthur W. English, Ken Berglund, Dario Carrasco, Katharina Goebel, Robert E. Gross, Robin Isaacson, Olivia C. Mistretta, Carly Wynans
Summary: Functional recovery after peripheral nerve injury is challenging due to slow and incomplete axon regeneration. Bioluminescent optogenetics, utilizing fusion proteins of luciferase and light-sensing ion channels, shows promise in enhancing axon regeneration by increasing neuronal excitability. Experimental studies in transgenic mice and viral vector-transduced mice demonstrate enhanced motor axon regeneration and successful muscle reinnervation after treatment with bioluminescent optogenetics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Estefania Contreras, Sara Traserra, Sara Bolivar, Joaquim Fores, Eduard Jose-Cunilleras, Ignacio Delgado-Martinez, Felix Garcia, Esther Udina, Xavier Navarro
Summary: This study used sheep as a model to investigate the repair of long-gap peripheral nerve injuries through autograft transplantation. Functional evaluation, electromyographic and ultrasound tests were performed. The results suggest that sheep nerve repair is a useful model for studying such injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Zhiqian Ye, Junbin Wei, Chaoning Zhan, Jin Hou
Summary: Peripheral nerve injury is a common concern in trauma patients, and the outcome of repair surgeries can be unsatisfactory. Transforming growth factor-beta (TGF-beta), a multifunctional cytokine, plays a crucial role in peripheral nerve regeneration by enhancing nerve regrowth capacity. The potential of TGF-beta in promoting nerve regeneration is promising, providing new cues for better treatment of peripheral nerve injuries.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Willem D. Rinkel, M. Hosein Aziz, Meike J. M. Van Deelen, Sten P. Willemsen, Manuel Castro Cabezas, Johan W. Van Neck, J. Henk Coert
Article
Surgery
Willem D. Rinkel, Manuel Castro Cabezas, Jonathan H. Setyo, Johan W. Van Neck, J. Henk Coert
PLASTIC AND RECONSTRUCTIVE SURGERY
(2017)
Review
Multidisciplinary Sciences
Tamara Hoppenbrouwers, Anouchska S. A. Autar, Andi R. Sultan, Tsion E. Abraham, Wiggert A. van Cappellen, Adriaan B. Houtsmuller, Willem J. B. van Wamel, Heleen M. M. van Beusekom, Johan W. van Neck, Moniek P. M. de Maat
Article
Multidisciplinary Sciences
Johan W. van Neck, Bastiaan Tuk, Esther M. G. Fijneman, Jonathan J. Redeker, Edwin M. Talahatu, Miao Tong
Article
Hematology
Tamara Hoppenbrouwers, Bastiaan Tuk, Esther M. G. Fijneman, Moniek P. M. de Maat, Johan W. van Neck
THROMBOSIS RESEARCH
(2017)
Article
Clinical Neurology
Anne Bolleboom, Godard C. W. de Ruiter, J. Henk Coert, Bastiaan Tuk, Jan C. Holstege, Johan W. van Neck
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
Willem D. Rinkel, Dimitris Rizopoulos, M. Hosein Aziz, Johan W. Van Neck, Manuel Castro Cabezas, J. Henk Coert
Article
Immunology
Tamara Hoppenbrouwers, Andi R. Sultan, Tsion E. Abraham, Nicole A. Lemmens-den Toom, Silvie Hansenova Manaskova, Wiggert A. van Cappellen, Adriaan B. Houtsmuller, Willem J. B. van Wamel, Moniek P. M. de Maat, Johan W. van Neck
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Surgery
Willem D. Rinkel, Manuel Castro Cabezas, Johan W. van Neck, Erwin Birnie, Steven E. R. Hovius, J. Henk Coert
PLASTIC AND RECONSTRUCTIVE SURGERY
(2018)
Article
Immunology
Andi R. Sultan, Tamara Hoppenbrouwers, Nicole A. Lemmens-den Toom, Susan Snijders, Johan W. van Neck, Annelies Verbon, Moniek P. M. de Maat, Willem J. B. van Wamel
INFECTION AND IMMUNITY
(2019)
Article
Orthopedics
M. S. Saltzherr, G. S. R. Muradin, I. K. Haugen, R. W. Selles, J. W. van Neck, J. H. Coert, J. M. W. Hazes, J. J. Luime
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Dermatology
Maryam Mohammad Zadeh, Hester Lingsma, Johan W. van Neck, Dalibor Vasilic, Anne-Margreet van Dishoeck
INTERNATIONAL WOUND JOURNAL
(2019)
Article
Endocrinology & Metabolism
Willem D. Rinkel, Shelly van Nieuwkasteele, Manuel Castro Cabezas, Johan W. van Neck, Erwin Birnie, J. Henk Coert
DIABETES RESEARCH AND CLINICAL PRACTICE
(2019)
Article
Engineering, Biomedical
Shuang Zhang, Bastiaan Tuk, Jeroen Van de Peppel, Gert-Jan Kremers, Marijke Koedam, Georg R. Pesch, Zaid Rahman, Remco M. Hoogenboezem, Eric M. J. Bindels, Johan W. Van Neck, Pouyan E. Boukany, Johannes P. T. M. Van Leeuwen, Bram C. J. Van der Eerden
Summary: A functional vascular system is crucial for bone repair, and disrupted angiogenesis can lead to non-union. Paracrine factors released by human bone marrow derived mesenchymal stromal cells (BM-SCs) have angiogenic effects on endothelial cells. This study used microfluidic designs to investigate angiogenesis and found that BMSC conditioned medium (CM) significantly promoted endothelial cell proliferation, chemotactic and mechanotactic migration. Transcriptional analysis of endothelial cells revealed unique gene expression related to tricarboxylic acid cycle and energy metabolism when exposed to both BMSC-CM and shear stress. This study highlights the importance of considering in vivo-like microenvironments when studying vessel repair during fracture healing.
ACTA BIOMATERIALIA
(2022)
Article
Rheumatology
Michael S. Saltzherr, J. Henk Coert, Ruud W. Selles, Johan W. van Neck, Jean-Bart Jaquet, Gerjo J. V. M. van Osch, Edwin H. G. Oei, Jolanda J. Luime, Galied S. R. Muradin
ARTHRITIS RESEARCH & THERAPY
(2017)