Review
Environmental Sciences
Camila dos Reis Oliveira, Joedna Cavalcante Pereira, Andressa Barros Ibiapina, Italo Rossi Roseno Martins, Joao Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira, Felipe Cavalcanti Carneiro da Silva
Summary: Buthionine sulfoximine (BSO) is a synthetic amino acid that inhibits the production of a cellular antioxidant called reduced glutathione (GSH), which is present in tumor cells. By depleting GSH, BSO enhances the cytotoxicity of chemotherapy drugs in drug-resistant tumors. A systematic review and meta-analysis of preclinical studies found that BSO alone exhibits cytotoxic activity and is commonly used in combination with other antineoplastic strategies to improve treatment efficacy. This review provides important considerations for the use of BSO in cancer treatment and highlights its potential as an adjuvant therapy.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Article
Engineering, Environmental
Madhu Tiwari, Maria Kidwai, Prasanna Dutta, Shiv Narayan, Neelam Gautam, Khushboo Chawda, Pramod Arvind Shirke, Arun Kumar Mishra, Debasis Chakrabarty
Summary: Arsenic is a hazardous metalloid that hampers physiological activities in rice. In this study, the role of OsGSTU5 in arsenic tolerance was investigated. OsGSTU5 was found to enhance arsenic tolerance by regulating antioxidant activities and participating in arsenic chelation and transport processes.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Yang Gao, Yun Li, Hongmei Cao, Haixue Jia, Dianyu Wang, Chunhua Ren, Zhongyan Wang, Cuihong Yang, Jianfeng Liu
Summary: A self-assembled peptide derivative (NSBSO) based on BSO was developed to selectively deplete tumor GSH and inhibit its biosynthesis, leading to ferroptosis and pyroptosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Yuanyuan Li, Kun Liang, Lin Yuan, Jing Gao, Linquan Wei, Lijun Zhao
Summary: Antioxidant systems like Trx and Grx maintain oxidative stress balance. This study investigated the mechanisms of arsenic-induced liver injury and found that BSO exacerbated the toxicity of arsenic and affected the expression of the Trx and Grx systems. Trx had a longer-lasting impact and served as a backup antioxidant defense system in the liver.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Environmental Sciences
Ruben Bakker, Liyan Xie, Riet Vooijs, Dick Roelofs, Katja M. Hoedjes, Cornelis A. M. van Gestel
Summary: Neonicotinoid insecticides have negative effects on non-target soil invertebrates, but gene expression biomarkers could be used to measure exposure and toxicity. The expression of Glutathione S-Transferase 3 (GST3) has been proposed as a biomarker, but its reliability and its response to different neonicotinoids and metabolic inhibitors are unclear. In this study, springtails were exposed to neonicotinoids and a GST metabolic inhibitor, and the effects on fecundity and gene expression were measured. The results suggest that GST3 is not a reliable indicator of neonicotinoid exposure, and the toxicity of different neonicotinoids is mediated by probable GST enzymatic inhibition. Further research is needed to investigate biomarker reliability under different metabolic conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Yuxuan Xiong, Chen Xiao, Zifu Li, Xiangliang Yang
Summary: The combination of nanomedicine with GSH scavenging agents and therapeutic drugs has attracted significant interest in enhancing cancer treatment outcomes. Despite unsatisfactory results, this approach has shown promising results in a large number of rodent tumor models.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Nodoka Kudo, Rikuma Kouno, Yoshihiko Shibayama
Summary: This study found that the expression of solute carrier (SLC) family member SLC25A40 was up-regulated in doxorubicin-resistant K562/ADM cells, which affected cell proliferation and drug resistance to ADM.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Biotechnology & Applied Microbiology
Marta Kazimierska, Aleksandra Lesniewska, Anja Bakker, Arjan Diepstra, Marta Elzbieta Kasprzyk, Marta Podralska, Karolina Rassek, Joost Kluiver, Anke van den Berg, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk
Summary: This study found that GCLC plays an important role in Burkitt lymphoma, and inhibiting GCLC can decrease the viability of BL cells. Buthionine sulfoximine has a growth-inhibiting effect on BL cells and can enhance the cytotoxicity of doxorubicin and cyclophosphamide.
JOURNAL OF APPLIED GENETICS
(2023)
Article
Nanoscience & Nanotechnology
Xiao Fu, Mingyang Li, Jiandong Ju, Haiwei Wu, Shanshan Jia, Shengfeng Li, Shengyun Huang, Miming Geng
Summary: Researchers designed a nano system that disrupts the redox balance to increase intracellular oxidative stress and improve the treatment of cisplatin-resistant cancer cells. This nano system can co-deliver L-buthionine sulfoximine and cisplatin prodrug, releasing free cisplatin for chemotherapy and depleting intracellular glutathione to disrupt the redox balance. Moreover, hyaluronic acid enhances the cell uptake and tumor accumulation of the nano system. In vivo studies showed that this nano system efficiently inhibits tumor growth without obvious side effects.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Rakesh Kumar Sharma, Manisha Singh, Khagendra Ghimeray, Pinky Juneja, Gagan Dev, Sridhar Pulavarthi, Sabbasani Rajasekhara Reddy, Ravi Shankar Akundi
Summary: The substituted imidazo[1,2-b]pyridazine compounds showed anti-proliferative, anti-migratory, and anti-inflammatory effects at higher doses, in addition to inhibiting AChE and bacterial lipopolysaccharide-mediated effects.
Article
Pharmacology & Pharmacy
Chengcheng Wang, Jiao Wang, Xue Pan, Shuang Yu, Meiqi Chen, Yan Gao, Zilin Song, Haiyang Hu, Xiuli Zhao, Dawei Chen, Fei Han, Mingxi Qiao
Summary: Ferroptosis is a potential strategy to overcome cancer chemotherapy resistance, but cancer cells can develop resistance to ferroptosis through antioxidative defense mechanisms. In this study, a BSO-loaded metal organic framework (BMH) was prepared to enhance oxidative damage and inhibit antioxidative defense. The results showed that BMH restored the susceptibility of cancer cells to ferroptosis under irradiation and exhibited superior anti-tumor performance in vivo.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ali Vaziri-Gohar, Jonathan J. Hue, Ata Abbas, Hallie J. Graor, Omid Hajihassani, Mehrdad Zarei, George Titomihelakis, John Feczko, Moeez Rathore, Sylwia Chelstowska, Alexander W. Loftus, Rui Wang, Mahsa Zarei, Maryam Goudarzi, Renliang Zhang, Belinda Willard, Li Zhang, Adam Kresak, Joseph E. Willis, Gi-Ming Wang, Curtis Tatsuoka, Joseph M. Salvino, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Jonathan R. Brody, Jordan M. Winter
Summary: The response to chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC) can be improved by hyperglycemia, which disrupts redox metabolism.
NATURE COMMUNICATIONS
(2023)
Article
Toxicology
Krishnan Silja, Natarajan Selvaganabathy, Thiyagarajan Kalaiselvi, Chinnasamy Thirunavukkarasu
Summary: This study investigated the restoration of glutathione (GSH) deficiency induced by an inhibitor of gamma-glutamyl cysteine synthetase (BSO) through the administration of GSH ester. It was found that mice fed a diet with cholesterol and sodium cholate developed fatty liver disease accompanied by reduced GSH levels. Additionally, the combination of BSO and fatty liver disease resulted in even lower GSH levels. Further analysis indicated that BSO plus fatty liver disease led to cholesterol accumulation, decreased antioxidant enzyme activity, increased reactive oxygen species (ROS) levels, elevated blood glucose, and abnormal plasma lipid profile. However, the administration of GSH ester prevented GSH depletion, increased antioxidant enzyme activity, reduced ROS levels, and restored plasma lipid concentration. Histopathological analysis also revealed that GSH ester administration ameliorated inflammation and hepatocyte ballooning. In conclusion, this study suggests that restoring GSH levels through GSH ester injection plays a crucial role in delaying the progression of fatty liver disease.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Materials Science, Biomaterials
Byunghee Hwang, Tae-Il Kim, Hyunjin Kim, Sungjin Jeon, Yongdoo Choi, Youngmi Kim
Summary: The PS-Q-NPs photosensitizer is highly stable in aqueous buffer solution and can be activated within the reductive intracellular environment of tumor cells, leading to enhanced fluorescence and therapeutic singlet oxygen generation. This suggests its potential application as an activatable photosensitizer for fluorescence imaging-guided photodynamic cancer therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biotechnology & Applied Microbiology
Yu Abalenikhina, P. D. Erokhina, P. Yu Mylnikov, A. Shchulkin, E. N. Yakusheva
Summary: The functioning and mechanism of P-glycoprotein regulation were studied under conditions of inhibition of glutathione synthesis. It was found that BSO directly inhibits Pgp activity, but also increases the amount and activity of Pgp through activation of the Nrf2 pathway.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2022)