Article
Biochemistry & Molecular Biology
Karim Sahbani, Jiangping Pan, Mone Zaidi, Christopher P. Cardozo, William A. Bauman, Hesham A. Tawfeek
Summary: Abaloparatide, a modified parathyroid hormone related peptide, protects against spinal cord injury-induced bone loss by promoting bone formation, but does not prevent osteoporosis from occurring.
Article
Biochemistry & Molecular Biology
Pauline Michel-Flutot, Laurie Efthimiadi, Lynda Djerbal, Therese B. Deramaudt, Marcel Bonay, Stephane Vinit
Summary: This study evaluated the antioxidant response in phrenic motoneurons following C2 spinal cord lateral hemi-section in rats, and found that the AMPK-Nrf2 signaling pathway plays a significant role in the oxidative stress response after high SCI. Harnessing this pathway could improve the antioxidant response and help in improving diaphragm activity in patients with high SCI.
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biology
Pauline Michel-Flutot, Isley Jesus, Valentin Vanhee, Camille H. Bourcier, Laila Emam, Abderrahim Ouguerroudj, Kun-Ze Lee, Lyandysha Zholudeva, Michael A. Lane, Arnaud Mansart, Marcel Bonay, Stephane Vinit
Summary: High spinal cord injuries (SCIs) often result in permanent diaphragmatic paralysis. This study investigated the effects of repetitive transcranial magnetic stimulation (rTMS) as a potential noninvasive therapeutic tool for enhancing respiratory function and reducing post-traumatic inflammation in cervical spinal cord injuries. The results suggest that chronic high-frequency rTMS can improve respiratory dysfunction, promote neuronal plasticity, and reduce harmful post-traumatic inflammatory processes. This therapy could be combined with other interventions to enhance outcomes.
Article
Pediatrics
Nathan E. Cook, Grant L. Iverson, Bruce Maxwell, Ross Zafonte, Paul D. Berkner
Summary: The study found that adolescents with ADHD did not require longer recovery time to return to school and sports following a concussion compared to those without ADHD. Medication status and concussion history were also not associated with longer recovery times.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Nuria Gaja-Capdevila, Neus Hernandez, Daniel Zamanillo, Jose Miguel Vela, Manuel Merlos, Xavier Navarro, Mireia Herrando-Grabulosa
Summary: Research on the neuroprotective role of Sig-1R ligands in a mouse model of spinal root injury showed that they could reduce motor neuron loss by about 20% and modulate endoplasmic reticulum stress markers IRE1 alpha and XBP1, providing a promising target for the treatment of neural injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Andrew Q. Tan, Won Joon Sohn, Avantika Naidu, Randy D. Trumbower
Summary: Persons with incomplete spinal cord injuries often struggle to regain independent walking due to deficits in walking mechanics. Recent studies have shown that daily bouts of breathing low oxygen prior to locomotor training can lead to persistent improvement in overground walking speed and endurance. However, the effect on intralimb coordination remains untested.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siyu Wu, Concepcion Garcia-Rama, Lorenzo Romero-Ramirez, Johannes P. J. M. de Munter, Erik Ch Wolters, Boris W. Kramer, Jorg Mey
Summary: The study revealed that TUDCA did not have an additional effect in the treatment of spinal cord injury (SCI) and failed to improve treatment outcomes. Despite showing positive effects in promoting recovery of motor functions and improving autonomic bladder control, the benefits of TUDCA were only temporary.
Article
Biochemistry & Molecular Biology
Chih-Wei Zeng, Yasuhiro Kamei, Shuji Shigenobu, Jin-Chuan Sheu, Huai-Jen Tsai
Summary: The newly discovered SCI stress-responsive regenerating cells (SrRCs) play a crucial role in neuronal regeneration after spinal cord injury, forming a bridge across the lesion and connecting with neighboring undamaged motor neurons. Among different subtypes of SrRCs, rostral-SrRCs exhibit higher neuronal differentiation capability and increased expression of caveolin 1 (cav1), which is responsible for axonal regrowth and overall regenerative capability in neuronal regeneration post-SCI.
Article
Neurosciences
Ariadna Arbat-Plana, Sara Bolivar, Xavier Navarro, Esther Udina, Francisco J. Alvarez
Summary: Peripheral nerve injuries result in the retraction of Ia synapses from a-motoneurons, impairing functional recovery and correlating with injury severity and muscle reinnervation efficiency. This study analyzed VGluT1-labeled Ia synapses after nerve crush in 10-day-old rats and found a large loss of synapses similar to more severe injuries in adults. The mechanism of synapse loss in young animals may be associated with higher microglia synaptic pruning activity and results in greater losses after milder nerve injuries.
Article
Engineering, Biomedical
Kui Shen, Xiaowei Li, Guanning Huang, Zhongwen Yuan, Bin Xie, Tianfeng Chen, Lizhen He
Summary: This study developed a targeted nanozyme loaded with Rapamycin (Rapa) and hollow mesoporous Prussian blue (HMPB), which can scavenge free radicals and reduce inflammation to relieve secondary damage in spinal cord injury (SCI). The nanozyme exhibited ROS scavenging capacity and multienzyme-like activity, and effectively alleviated neuronal damage and promoted motor function recovery in SCI mice.
Article
Biochemistry & Molecular Biology
Karen Simonyan, Lilit Avetisyan, Armine Isoyan, Vergine Chavushyan
Summary: This study assessed the short-term plasticity of lumbar spinal cord motoneurons in conditions of spinal cord injury and diabetes. The findings suggest that under traumatic and/or metabolic pathology, synaptic inputs exhibit opposing plasticity for homeostatic control of neurotransmission. These results are important for understanding the impact of spinal cord injury and diabetes on motor impairment.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Eng Kuan Moo, Mohammadhossein Ebrahimi, Scott C. Sibole, Petri Tanska, Rami K. Korhonen
Summary: The function of articular cartilage relies on the balance between the PG matrix and collagen fibrous network. Degradation of PGs and collagen can lead to joint diseases such as osteoarthritis. This study uses Finite Element models to analyze the degradation of PGs and collagen, and suggests that the disorganization of collagen structure is the main cause of early collagenous degradation in osteoarthritic cartilage.
ACTA BIOMATERIALIA
(2022)
Article
Neurosciences
D. Leonardo Garcia-Ramirez, Ngoc T. Ha, Steve Bibu, Nicholas J. Stachowski, Kimberly J. Dougherty
Summary: The impact of spinal cord injury on Shox2 interneurons mainly manifests as changes in sensory afferent input pathways and modulation of Shox2 interneurons by 5-HT, enhancing excitatory responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Masahito Takiguchi, Takashi Akaike, Kaoru Shindo, Risa Sakuyama, Ran Koganemaru, Kengo Funakoshi
Summary: The study observed changes in the expression of PNN surrounding the motoneurons after complete spinal transection in neonatal and juvenile rats. The results suggest that decreased expression of CS-C in neonatal rats may facilitate recovery, whereas decreased expression of CS-A in juvenile rats may be associated with poor recovery.
NEUROSCIENCE LETTERS
(2022)
Article
Physiology
Wenbin Yang, Ryan E. Yaggie, Mingchen C. Jiang, Charles N. Rudick, Joseph Done, Charles J. Heckman, John M. Rosen, Anthony J. Schaeffer, David J. Klumpp
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2018)
Article
Cell & Tissue Engineering
Michael J. Ziller, Juan A. Ortega, Katharina A. Quinlan, David P. Santos, Hongcang Gu, Eric J. Martin, Christina Galonska, Ramona Pop, Susanne Maidl, Alba Di Pardo, Mei Huang, Herbert Y. Meltzer, Andreas Gnirke, C. J. Heckman, Alexander Meissner, Evangelos Kiskinis
Article
Neurosciences
Jacob G. McPherson, Laura M. McPherson, Christopher K. Thompson, Michael D. Ellis, Charles J. Heckman, Julius P. A. Dewald
FRONTIERS IN HUMAN NEUROSCIENCE
(2018)
Article
Neurosciences
Christopher K. Thompson, Francesco Negro, Michael D. Johnson, Matthew R. Holmes, Laura Miller McPherson, Randall K. Powers, Dario Farina, Charles J. Heckman
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Neurosciences
Jacob G. McPherson, Albert Chen, Michael D. Ellis, Jun Yao, C. J. Heckman, Julius P. A. Dewald
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Biology
Maria de Lourdes Martinez-Silva, Rebecca D. Imhoff-Manuel, Aarti Sharma, C. J. Heckman, Neil A. Shneider, Francesco Roselli, Daniel Zytnicki, Marin Manuel
Article
Clinical Neurology
Jacob G. McPherson, Michael D. Ellis, R. Norman Harden, Carolina Carmona, Justin M. Drogos, Charles J. Heckman, Julius P. A. Dewald
FRONTIERS IN NEUROLOGY
(2018)
Article
Neurosciences
Ana M. Lucas-Osma, Yaqing Li, Katie Murray, Shihao Lin, Sophie Black, Marilee J. Stephens, Andrew H. Ahn, C. J. Heckman, Keith K. Fenrich, Karim Fouad, David J. Bennett
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Article
Neurosciences
Shihao Lin, Yaqing Li, Ana M. Lucas-Osma, Krishnapriya Hari, Marilee J. Stephens, Rahul Singla, C. J. Heckman, Ying Zhang, Karim Fouad, Keith K. Fenrich, David J. Bennett
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Review
Physiology
Marin Manuel, Matthieu Chardon, Vicki Tysseling, C. J. Heckman
Review
Physiology
Christopher K. Thompson, Michael D. Johnson, Francesco Negro, Laura Miller Mcpherson, Dario Farina, Charles J. Heckman
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Neurosciences
K. A. Quinlan, E. J. Reedich, W. D. Arnold, A. C. Puritz, C. F. Cavarsan, C. J. Heckman, C. J. DiDonato
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Editorial Material
Neurosciences
Edward H. Kim, Altamash S. Hassan, Charles J. Heckman
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Letter
Neurosciences
Jacob Graves McPherson, Albert Chen, Michael D. Ellis, Jun Yao, C. J. Heckman, Julius P. A. Dewald
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Review
Physiology
Marc D. Binder, Randall K. Powers, C. J. Heckman