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Neurosciences
Marie-Elisabeth Lessmann, Cagdas Guducu, Bergoi Ibarlucea, Thomas Hummel
Summary: This study aimed to investigate whether HLA-associated peptides can elicit specific neuronal responses in human olfaction. Through testing the discrimination ability of peptides in the olfactory epithelium receptors and analyzing electrophysiological signals from participants, it was found that within this experimental setup, HLA-associated peptides do not produce specific olfactory activation in humans.
Article
Cardiac & Cardiovascular Systems
Rebecca A. Capel, Samuel J. Bose, Thomas P. Collins, Skanda Rajasundaram, Thamali Ayagama, Manuela Zaccolo, Rebecca-Ann Beatrice Burton, Derek A. Terrar
Summary: The study showed that the interaction between IP3 receptor pathways and Ca2+-stimulated adenylyl cyclases plays a crucial role in modulating cardiac function, particularly in the atria and sinoatrial node. Activation of IP3 receptors leads to increased Ca2+ transients through cAMP signaling, which is essential for initiation of atrial arrhythmias.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Abdullah AlMatrouk, Kayla Lemons, Tatsuya Ogura, Weihong Lin
Summary: This article discusses the impact of e-cigarettes on the olfactory system, including the effects of flavorants, nicotine, and harmful substances. The volatile odorants in e-liquids convey appealing flavors through the olfactory system. In addition, the aerosol produced by e-cigarettes contains toxicants and heavy metals that may directly affect the main olfactory epithelium.
COMPREHENSIVE PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rosemary C. Challis, Huikai Tian, Jue Wang, Jiwei He, Jianbo Jiang, Xuanmao Chen, Wenbin Yin, Timothy Connelly, Limei Ma, C. Ron Yu, Jennifer L. Pluznick, Daniel R. Storm, Liquan Huang, Kai Zhao, Minghong Ma
Article
Neurosciences
Xuanmao Chen, Hong Cao, Amit Saraf, Larry S. Zweifel, Daniel R. Storm
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Xuanmao Chen, Jie Luo, Yihua Leng, Yimei Yang, Larry S. Zweifel, Richard D. Palmiter, Daniel R. Storm
BIOLOGICAL PSYCHIATRY
(2016)
Article
Anesthesiology
Yun-Yan Xiang, Xuanmao Chen, Jingxin Li, Shuanglian Wang, Gil Faclier, John F. MacDonald, James C. Hogg, Beverley A. Orser, Wei-Yang Lu
Article
Multidisciplinary Sciences
Xuanmao Chen, Paul Whissell, Beverley A. Orser, John F. MacDonald
Article
Multidisciplinary Sciences
Jie Luo, Xuanmao Chen, Yung-Wei Pan, Song Lu, Zhengui Xia, Daniel R. Storm
Article
Pharmacology & Pharmacy
Ashley Sterpka, Xuanmao Chen
PHARMACOLOGICAL RESEARCH
(2018)
Article
Neurosciences
Yuxin Zhou, Liyan Qiu, Ashley Sterpka, Haiying Wang, Feixia Chu, Xuanmao Chen
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Liang Zhang, Xuanmao Chen, Carlos Sindreu, Song Lu, Daniel R. Storm, Larry S. Zweifel, Zhengui Xia
Article
Biochemistry & Molecular Biology
Yuxin Zhou, Liyan Qiu, Haiying Wang, Xuanmao Chen
Article
Neurosciences
Ashley Sterpka, Juan Yang, Matthew Strobel, Yuxin Zhou, Connor Pauplis, Xuanmao Chen
Article
Neurosciences
Juan Yang, Liyan Qiu, Matthew Strobel, Amanda Kabel, Xiang-Ming Zha, Xuanmao Chen
MOLECULAR NEUROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Ying-Jie Peng, Jayasri Nanduri, Ning Wang, Ganesh K. K. Kumar, Vytautas Bindokas, Bindu D. D. Paul, Xuanmao Chen, Aaron P. P. Fox, Thibaut Vignane, Milos R. R. Filipovic, Nanduri R. R. Prabhakar
Summary: This study shows that hydrogen sulfide (H2S) signaling plays a role in the activation of the carotid body during low oxygen conditions. The persulfidation of olfactory receptor 78 (Olfr78) by H2S is found to be essential for this activation. Mutations in Olfr78, adenylate cyclase 3 (Adcy3), or cyclic nucleotide-gated channel alpha 2 (Cnga2) impair the carotid body and glomus cell responses to H2S and hypoxia.
Article
Neurosciences
Sarah M. Wardlaw, Trongha X. Phan, Amit Saraf, Xuanmao Chen, Daniel R. Storm