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Multidisciplinary Sciences
Yuya Sakimoto, Ako Shintani, Daiki Yoshiura, Makoto Goshima, Hiroyuki Kida, Dai Mitsushima
Summary: This study reports the postnatal development of hippocampal function and the impact of an inhibitory avoidance task on synaptic plasticity in rats. The results show an improvement in learning performance from juvenile to adulthood and different effects of training on synaptic amplitudes at different time points.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Donovan M. Ashby, Stan B. Floresco, Anthony G. Phillips, Alexander McGirr, Jeremy K. Seamans, Yu Tian Wang
Summary: Hippocampal LTD plays a critical role in the acute formation and maintenance of place fields, regulating the dynamics and stability of novel spatial information in adult rats.
NATURE COMMUNICATIONS
(2021)
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Clinical Neurology
Marta Montero-Crespo, Marta Dominguez-Alvaro, Lidia Alonso-Nanclares, Javier DeFelipe, Lidia Blazquez-Llorca
Summary: Alzheimer's disease is a common form of dementia characterized by cognitive impairment, with extracellular protein deposits and abnormal protein accumulation in neurons. Synaptic alterations were found in different stages of the disease, with more severe changes observed in late-stage cases.
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Cell Biology
Mark Rigby, Federico W. Grillo, Benjamin Compans, Guilherme Neves, Julia Gallinaro, Sophie Nashashibi, Sally Horton, Pedro M. Pereira Machado, Maria Alejandra Carbajal, Gema Vizcay-Barrena, Florian Levet, Jean-Baptiste Sibarita, Angus Kirkland, Roland A. Fleck, Claudia Clopath, Juan Burrone
Summary: Using scanning electron microscopy, researchers found that excitatory synapses in the hippocampus CA1 region do not fully adhere to the traditional definition. Over half of the excitatory synapses are multi-synaptic boutons, where a single presynaptic bouton can connect to multiple postsynaptic spines on different dendrites. The proportion of multi-synaptic boutons changes during development and with distance from the cell body. These structures exhibit less variability in synaptic properties compared to single synaptic boutons, promoting synchronous activity.
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Clinical Neurology
Marta Montero-Crespo, Marta Dominguez-Alvaro, Lidia Alonso-Nanclares, Javier DeFelipe, Lidia Blazquez-Llorca
Summary: Alzheimer's disease is a common form of dementia characterized by persistent and progressive impairment of cognitive functions. Early-stage cases show normal synaptic morphology, but late-stage cases experience decreased synaptic density and morphological alterations.
Article
Multidisciplinary Sciences
Patrycja Brzdak, Katarzyna Lebida, Marcin Wyroslak, Jerzy W. Mozrzymas
Summary: GABAergic transmission onto pyramidal neurons shows different forms of plasticity, and plasticity at inhibitory interneurons remains largely unknown. This study investigated the impact of integrins on the long-term plasticity of GABAergic synapses on specific inhibitory interneurons. The results revealed interneuron-specific plasticity and differences in the underlying integrin-dependent mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Solenn Percelay, Jean-Marie Billard, Thomas Freret, Annie Andrieux, Michel Boulouard, Valentine Bouet
Summary: The study revealed dysregulations of functional properties and plasticity in hippocampal networks of 3-hit mice, potentially contributing to the pathophysiology of schizophrenia. Additionally, differences between males and females were observed, supporting the sexual dimorphism seen in the disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pietro Micheli, Rui Ribeiro, Alejandro Giorgetti
Summary: The study presents a compartmentalized kinetic model for CA3-CA1 synaptic transmission to predict the functional impact of disease-associated variants of NMDA receptors in severe cognitive impairment. The results show consistency with experimental data, demonstrating the predictive power of this multiscale viewpoint.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Neurosciences
Isabel Espadas, Oscar Ortiz, Patricia Garcia-Sanz, Adrian Sanz-Magro, Samuel Alberquilla, Oscar Solis, Jose Maria Delgado-Garcia, Agnes Gruart, Rosario Moratalla
Summary: The genetic inactivation of D2R impairs spatial memory, associative learning, and classical conditioning of eyelid responses, as well as reduces activity-dependent synaptic plasticity in the hippocampal CA1-CA3 synapse. These findings demonstrate the key role of D2R in regulating hippocampal plasticity changes and affecting the acquisition and consolidation of spatial and associative forms of memory.
Article
Multidisciplinary Sciences
Anurag Singh, Shruthi Sateesh, Owen D. Jones, Wickliffe C. Abraham
Summary: The study revealed a pathway specificity for the heterodendritic metaplasticity in CA1, where Schaffer collateral/commissural synapses in the stratum radiatum were particularly sensitive to the inhibitory effects of high-frequency priming stimulation mediated by tumor necrosis factor (TNF). The metaplasticity effects were absent in TNFR1 knock-out mice, indicating a dependence on TNF regulation. This suggests an important control of information processing in this pathway, along with potential implications for neuroinflammation sensitivity under disease conditions.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Adam Ponzi, Salvador Dura-Bernal, Michele Migliore
Summary: Oscillations are a common feature of brain operations and are found across different animal species. These oscillations appear in discrete frequencies and are coupled, with the phase of one oscillation modulating the amplitude of another. However, the biophysical origin and reasons for the ubiquity of these oscillations remain unclear. Using a data-driven computational model, researchers demonstrate how a basic microcircuit can generate phase-amplitude coupled oscillations, suggesting a general underlying mechanism.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Fatemeh Khani, Ali Pourmotabbed, Mozhgan Veisi, Narges Hosseinmardi, Yaghoub Fathollahi, Hossein Azizi
Summary: Adolescence is a critical period for neurodevelopmental processes, and opioid exposure during this stage can have lasting effects on cognitive abilities. This study found that adolescent morphine exposure led to decreased weight gain, impaired avoidance memory, and disrupted synaptic plasticity in the ventral hippocampal CA1 region. These findings suggest that adolescent morphine exposure can have long-term effects on memory function and synaptic activity.
Article
Cell Biology
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C. Hays, Patrick R. Hof, W. Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer Luebke, Tsuneya Ikezu
Summary: The study shows that in early stages of Alzheimer's disease, Wfs1(+) neurons in the ECII region are associated with abnormally phosphorylated tau, leading to the spread of tau and potential functional abnormalities in CA1 pyramidal neurons.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hyeon Jeong Seo, Jung Eun Park, Seong-Min Choi, Taekyoung Kim, Soo Hyun Cho, Kyung-Hwa Lee, Woo Keun Song, Juhyun Song, Han-Seong Jeong, Dong Hyun Kim, Byeong C. Kim
Summary: The study found that impaired neuronal networks in 5xFAD mice are associated with aberrant NRG1-ErbB signaling, leading to hippocampal dysfunction and impaired LTP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Kei Suga, Ayako Saito, Tatsuya Mishima, Kimio Akagawa
NEUROSCIENCE LETTERS
(2015)
Article
Neurosciences
Tomonori Fujiwara, Takefumi Kofuji, Tatsuya Mishima, Kimio Akagawa
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Masaaki Iwano, Evan S. Hill, Akio Mori, Tatsuya Mishima, Tsuneko Mishima, Kei Ito, Ryohei Kanzaki
JOURNAL OF COMPARATIVE NEUROLOGY
(2010)
Article
Biochemistry & Molecular Biology
Takefumi Kofuji, Tomonori Fujiwara, Masumi Sanada, Tatsuya Mishima, Kimio Akagawa
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Kensuke Tanaka, Takehiko Iijima, Tatsuya Mishima, Kei Suga, Kimio Akagawa, Yasuhide Iwao
NEUROCHEMICAL RESEARCH
(2009)
Article
Neurosciences
Takehiko Iijima, Kensuke Tanaka, Sachie Matsubara, Hayato Kawakami, Tatsuya Mishima, Kei Suga, Kimio Akagawa, Yasuhide Mao
NEUROSCIENCE LETTERS
(2008)
Article
Neurosciences
Harumasa Nakazawa, Akiko Nishimura, Kei Suga, Tatsuya Mishima, Tomoko Yorozu, Takehiko Iijima
NEUROSCIENCE LETTERS
(2013)
Article
Multidisciplinary Sciences
Tatsuya Mishima, Tomonori Fujiwara, Masumi Sanada, Takefumi Kofuji, Masami Kanai-Azuma, Kimio Akagawa
Article
Biochemistry & Molecular Biology
Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Ayako Saito, Yasuo Terao, Kimio Akagawa
Summary: Mutations in the STX1B gene affect GABA release and reuptake, increasing neural circuit excitability during hyperthermia.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Kei Suga, Ayako Saito, Tatsuya Mishima, Kimio Akagawa
Article
Neurosciences
Takehiko Iijima, Tatsuya Mishima, Kimio Akayawa, Yasuhide Huaa
Article
Neurosciences
Tomonori Fujiwara, Tatsuya Mishima, Takefumi Kofuji, Tomoki Chiba, Keiji Tanaka, Akitsugu Yamamoto, Kimio Akagawa
JOURNAL OF NEUROSCIENCE
(2006)
Article
Neurosciences
T Iijima, T Mishima, K Akagawa, Y Iwao
Article
Biochemistry & Molecular Biology
T Iijima, T Mishima, M Tohyama, K Akagawa, Y Iwao
NEUROCHEMISTRY INTERNATIONAL
(2003)