Article
Biology
Abagael M. Lasseigne, Fabio A. Echeverry, Sundas Ijaz, Jennifer Carlisle Michel, E. Anne Martin, Audrey J. Marsh, Elisa Trujillo, Kurt C. Marsden, Alberto E. Pereda, Adam C. Miller
Summary: This study investigated the functional relationship between neuronal Connexins and ZO1, revealing that ZO1 is crucial for the localization of synaptic Connexins, while Connexins are not necessary for ZO1 localization. Disruption of this hierarchical ZO1/Connexin relationship abolishes electrical transmission and disrupts Mauthner cell-initiated escape responses.
Review
Endocrinology & Metabolism
Siyuan Shen, Chang Zhao, Chao Wu, Suyue Sun, Ziyan Li, Wei Yan, Zhenhua Shao
Summary: GPCRs, as the largest family of transmembrane proteins, regulate various physiological processes. However, their complicated signal transduction pathways and difficulties in drug development have presented challenges. By identifying new ligands that bind to allosteric sites, safer drugs for treating various diseases can be designed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee
Summary: This study reports the effective modulation of a GPCR for cancer treatment using small activating RNAs (saRNAs) for the first time. The saRNAs promote the expression of MAS1, a GPCR that counteracts cancer cell proliferation and migration. By enhancing MAS1 expression, these saRNAs suppress tumorigenesis and inhibit tumor progression in multiple cancer models. This research not only provides a new strategy for cancer therapy by targeting the renin-angiotensin system, but also offers a new avenue to modulate GPCR signaling through RNA activation.
Review
Biochemistry & Molecular Biology
Rachel Price, Nicola Biagio Mercuri, Ada Ledonne
Summary: PARs, a unique class of GPCRs, play crucial roles in regulating neurotransmission and synaptic plasticity, particularly through modulating glutamatergic and GABAergic transmission. In normal conditions, PARs are important regulators of synaptic efficacy and plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Li-Hua Zhao, Jingyu Lin, Su-Yu Ji, X. Edward Zhou, Chunyou Mao, Dan-Dan Shen, Xinheng He, Peng Xiao, Jinpeng Sun, Karsten Melcher, Yan Zhang, Xiao Yu, H. Eric Xu
Summary: This study presents the structures of CRF2R bound to UCN1 and coupled to G proteins G(11) and G(o), and compares them with the structure of CRF2R bound to G(s), uncovering the structural differences that determine the selective coupling of G protein subtypes by CRF2R.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Paola Muttathukunnel, Patrick Frei, Sarah Perry, Dion Dickman, Martin Mueller
Summary: Robust neural information transfer relies on the delicate molecular nano-architecture of chemical synapses. This study reveals the alignment of presynaptic nanorings with postsynaptic glutamate receptor rings and the formation of nanocolumn rings by presynaptic proteins and glutamate receptors. The impairment of glutamate receptors triggers the formation of transsynaptic nanocolumns on a minute timescale during homeostatic plasticity. This research uncovers the regulatory mechanism of synaptic nano-architecture and highlights its importance in stabilizing synaptic transmission.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Hyun-ju Lee, Tae-Ik Choi, Yong-Min Kim, Soonje Lee, Bing Han, In Seon Bak, Sun Ae Moon, Dae-Yeul Yu, Ki Soon Shin, Yunhee Kim Kwon, Cheil Moon, Jae Hwan Ryu, Hyang-Sook Hoe, Cheol-Hee Kim, Insop Shim
Summary: Recent studies have shown that Gng8 is mainly expressed in the MHb-IPN circuit of the mouse brain. Gng8KO mice exhibited deficiencies in learning and memory, as well as significantly reduced long-term potentiation in the hippocampus. Furthermore, levels of acetylcholine and choline acetyltransferase in the MHb and IPN of Gng8KO mice were significantly decreased, compared to WT mice.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Julia E. Manoim, Andrew M. Davidson, Shirley Weiss, Toshihide Hige, Moshe Parnas
Summary: In this study, the authors investigated a neuromodulatory mechanism in fruit flies that is essential for achieving stimulus specificity in learning. They found that cholinergic Kenyon cells, which represent olfactory signals, have axo-axonic connections mediated by the muscarinic type-B receptor. These connections suppress both odor-evoked calcium responses and dopamine-evoked cAMP signals in neighboring cells, contributing to effective and accurate memory formation.
Article
Biochemistry & Molecular Biology
Ildiko Piszar, Magor L. Lorincz
Summary: Serotonin plays an important role in regulating sensory inputs in the olfactory cortex by modulating synaptic transmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Fanhua Wang, Mingyao Liu, Ning Wang, Jian Luo
Summary: This review discusses the role of G-protein coupled receptors (GPCRs) in osteoarthritis (OA), including the pathophysiological processes involved, preclinical and clinical trial data, and the challenges in developing therapies targeting GPCRs for OA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Abby L. Olsen, Sabrina G. Clemens, Mel B. Feany
Summary: This study investigated the mechanism of smoking-SV2C interaction in a Drosophila model of PD, confirming a GxE interaction between nicotine and SV2, and suggesting the consideration of genetic variation in SV2C in future clinical trials on nicotine.
MOVEMENT DISORDERS
(2023)
Article
Chemistry, Multidisciplinary
Stefanie Kampen, Duc Duy Vo, Xiaoqun Zhang, Nicolas Panel, Yunting Yang, Mariama Jaiteh, Pierre Matricon, Per Svenningsson, Jose Brea, Maria Isabel Loza, Jan Kihlberg, Jens Carlsson
Summary: This study presents a structure-based strategy to design compounds with dual-target properties, which can both antagonize the A(2A) adenosine receptor and activate the D-2 dopamine receptor, showing promising potential as anti-parkinson drugs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Neurosciences
Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W. B. Goetz, Susanne Ditlevsen, Alexander M. Walter
Summary: Synaptic transmission relies on the release of neurotransmitter from synaptic vesicles and its detection by postsynaptic receptors. There are two principal modes of transmission: action-potential evoked and spontaneous transmission. This study investigates the functional interdependence of these modes at individual synaptic contacts in Drosophila larval neuromuscular junctions. The results show that spontaneous activity can predict the responsiveness of synapses to action-potential stimulation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Emily Church, Edaeni Hamid, Zack Zurawski, Mariana Potcoava, Eden Flores-Barrera, Adriana Caballero, Kuei Y. Tseng, Simon Alford
Summary: Presynaptic inhibition plays a crucial role in presynaptic terminals, with GABAB receptors inhibiting Ca2+ entry and 5-HT1B receptors targeting SNARE complexes. The colocalization of these receptors provides synaptic integration and allows for complex presynaptic integration.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Eric Jacobi, Jakob von Engelhardt
Summary: AMPAR auxiliary subunits play a pivotal role in modulating AMPAR function, influencing synaptic strength, temporal precision, and integrative properties, as well as participating in synaptic plasticity.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Stephane Dissel, Veena Angadi, Leonie Kirszenblat, Yasuko Suzuki, Jeff Donlea, Markus Klose, Zachary Koch, Denis English, Raphaelle Winsky-Sommerer, Bruno van Swinderen, Paul J. Shaw
Article
Neurosciences
Markus Klose, Laura B. Duvall, Weihua Li, Xitong Liang, Chi Ren, Joe Henry Steinbach, Paul H. Taghert
Article
Neurosciences
Andrew P. Hegle, C. Andrew Frank, Anthony Berndt, Markus Klose, Douglas W. Allan, Eric A. Accili
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Cell Biology
Jesus Romero-Pozuelo, Jeffrey S. Dason, Alicia Mansilla, Soledad Banos-Mateos, Jose L. Sardina, Antonio Chaves-Sanjuan, Jaime Jurado-Gomez, Elena Santana, Harold L. Atwood, Angel Hernandez-Hernandez, Maria Jose Sanchez-Barrena, Alberto Ferrus
JOURNAL OF CELL SCIENCE
(2014)
Article
Biology
Maja Milakovic, Kiel G. Ormerod, Markus K. Klose, A. Joffre Mercier
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Article
Genetics & Heredity
Kristyn C. Cantarutti, Jason Burgess, Julie A. Brill, Jeffrey S. Dason
JOURNAL OF NEUROGENETICS
(2018)
Article
Neurosciences
Jeffrey S. Dason, Alex J. Smith, Leo Marin, Milton P. Charlton
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Neurosciences
Jeffrey S. Dason, Jesus Romero-Pozuelo, Harold L. Atwood, Alberto Ferrus
MOLECULAR NEUROBIOLOGY
(2012)
Article
Cell Biology
Jeffrey S. Dason, Aaron M. Allen, Oscar E. Vasquez, Marla B. Sokolowski
JOURNAL OF CELL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Jeffrey S. Dason, Amanda Cheung, Ina Anreiter, Vanessa A. Montemurri, Aaron M. Allen, Marla B. Sokolowski
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Genetics & Heredity
Jeffrey S. Dason, Marla B. Sokolowski
Summary: The cGMP-dependent protein kinase PKG encoded by the Drosophila foraging gene regulates synaptic structure and neurotransmission through independent mechanisms. Glial for restricts nerve terminal growth, and presynaptic for inhibits synaptic vesicle exocytosis while facilitating endocytosis. Knockdown of for in presynaptic neurons impairs SV endocytosis, while knockdown of glial for enhances nerve terminal growth and neurotransmitter release.
JOURNAL OF NEUROGENETICS
(2021)
Article
Multidisciplinary Sciences
Markus K. Klose, Marcel P. Bruchez, David L. Deitcher, Edwin S. Levitan
Summary: Neuropeptide release in Drosophila clock neurons shows a diurnal rhythm, with different mechanisms for release at the soma and terminals, which control specific features of clock neuron-dependent behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Genetics & Heredity
Ina Anreiter, Jeffrey S. Dason
JOURNAL OF NEUROGENETICS
(2021)
Editorial Material
Genetics & Heredity
Jeffrey S. Dason, Ina Anreiter, Chun-Fang Wu
JOURNAL OF NEUROGENETICS
(2021)
Article
Biochemistry & Molecular Biology
Markus K. Klose, Paul J. Shaw
Summary: Recent studies have shown that high sleep pressure can quickly reprogram large ventrolateral clock neurons to express specific receptors, leading to increased waking and early mating success. This receptor respecification mechanism involves dopamine receptors and activation of transcriptional regulator proteins.