Review
Neurosciences
Federica Genovese, Johannes Reisert, Vladimir J. Kefalov
Summary: The past decades have seen significant progress in understanding the function of photoreceptors and olfactory sensory neurons. This progress has been driven by the combination of physiological experimental tools and genetic manipulations, which have allowed researchers to identify molecular players in sensory neuron transduction cascades, explore how properties impact stimulus detection and disease effects on vision and smell.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Mitsumasa Koyanagi, Baoguo Shen, Takashi Nagata, Lanfang Sun, Seiji Wada, Satomi Kamimura, Eriko Kage-Nakadai, Akihisa Terakita
Summary: Optical control of GPCR signaling is a valuable approach for understanding and controlling GPCR-based physiologies. In this study, the performance of two bistable opsins, MosOpn3 and LamPP, in optical control in vivo was systematically investigated using Caenorhabditis elegans. The results demonstrated the advantages of MosOpn3 and LamPP in light-induced behavior and color-dependent control of behavior, respectively. Molecular engineering was also applied to enhance the usability of these opsins. These findings provide numerous strategies for optical control of GPCR-based physiologies and GPCR signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Hyungsup Kim, Hyesu Kim, Luan Thien Nguyen, Taewoong Ha, Sujin Lim, Kyungmin Kim, Soon Ho Kim, Kyungreem Han, Seung Jae Hyeon, Hoon Ryu, Yong Soo Park, Sang Hyun Kim, In-Beom Kim, Gyu-Sang Hong, Seung Eun Lee, Yunsook Choi, Lawrence B. Cohen, Uhtaek Oh
Summary: Animals rely on olfaction to determine the smells of foods, prey, or predators. The Anoctamin 9 channel in olfactory sensory neurons plays a crucial role in amplifying olfactory signals, impacting mammalian olfactory transduction.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Plant Sciences
Barkha Ravi, Christine H. Foyer, Girdhar K. Pandey
Summary: Reactive oxygen species (ROS) and calcium (Ca2+) signalling play important roles in plant growth, development, and defense. They function together with electric signals in directional cell-to-cell systemic signalling and even plant-to-plant communication. However, there is still limited understanding of the molecular mechanisms underlying the management of ROS and Ca2+ signals, as well as the synchronous and independent signaling in different cellular compartments. This review focuses on the proteins that may connect different pathways during abiotic stress responses, and highlights the crosstalk between ROS and Ca2+ pathways in cell signaling.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Francesca Aglialoro, Asena Abay, Nurcan Yagci, Minke A. E. Rab, Lars Kaestner, Richard van Wijk, Marieke von Lindern, Emile van den Akker
Summary: In this study, we found that PIEZO1 acts as a mechanosensor that, when transferred to orbital shaking, activates signaling cascades that are Ca2+-dependent, regulating various aspects of erythropoiesis. This suggests that there are direct physiological outcomes of mechanical stress on erythroblasts, as shown by the comparable activation of some Ca2+-dependent pathways induced by Yoda1 treatment and mechanical stress via orbital shaking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jun Xu, Nobuo Koizumi, Yusuke V. Morimoto, Ryo Ozuru, Toshiyuki Masuzawa, Shuichi Nakamura
Summary: Nucleotide second messengers play crucial roles in signal transduction in various organisms. A study has found that the swimming motility of the soil bacterium Leptospira kobayashii can be rapidly modulated by light stimulation. Through analysis of a loss-of-photoresponsivity mutant, a novel sensory gene was identified, and the light-dependent synthesis of cyclic adenosine monophosphate (cAMP) was elucidated. These findings reveal a new role for cAMP in controlling the flagella-dependent motility of Leptospira and highlight the global distribution of the newly discovered photoactivated cyclase among diverse microbial species.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yoona Jung, Jooseong Kim, Sukyoung Kim, Shin Hye Chung, Jinhong Wie
Summary: Bioceramics, such as calcium-phosphate-based materials, are used in medical and dental implants for bone tissue replacement or repair. The effect of bioceramic sintering on intracellular signaling pathways is still unknown. This study analyzed the impact of sintering on osteoblast cell signaling pathways using sintered and non-sintered hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP). The findings showed that sintering affects multiple signaling pathways, providing insights into bioceramic function and expanding their application scope in clinical settings.
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Ludmila Zylinska
Summary: The activity of specific populations of neurons in different brain areas plays a critical role in decision-making processes related to synaptic transmission, adaptations to external signals, and the maintenance of neural function. The endocannabinoid system (ECS) is identified as a vital control system in the central nervous system (CNS), allowing for rapid responses to synaptic processes and inducing long-term changes. Endocannabinoids are bioactive lipid mediators that act primarily through two receptors, CB1R and CB2R, which can regulate downstream Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Du Chen, Hankui Cheng, Siyan Liu, Umar Al-Sheikh, Yuedan Fan, Duo Duan, Wenjuan Zou, Linhui Zhu, Lijun Kang
Summary: The glial L-Type VGCC EGL-19 plays a crucial role in regulating calcium variations and behavioral outputs in C. elegans, and it also affects the morphologies of sensory neurons and glial cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Brendan Elsworth, Manoj T. Duraisingh
Summary: Babesia species are tick-borne parasites that infect mammalian red blood cells, causing severe diseases. They have complex life cycles involving multiple stages in both ticks and mammalian hosts, utilizing intricate signaling pathways for replication, egress, and invasion. Understanding the signaling pathways and environmental stimuli used by Babesia species during transmission is crucial for further biological and translational studies of these parasites.
MOLECULAR MICROBIOLOGY
(2021)
Article
Plant Sciences
Kyle Symonds, Howard Teresinski, Bryan Hau, David Chiasson, Kirsten Benidickson, William Plaxton, Wayne A. Snedden
Summary: Calmodulin-like proteins (CMLs) are the largest family of calcium-binding proteins in plants. The study found that CML13 and CML14 play important roles in plant development, regulating development and morphological features through interactions with other proteins. Inhibition of CML13 or CML14 transcript levels leads to abnormal plant development, including difficulties in germination, chlorosis, and leaf senescence.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Moriah Gildart Turcotte, Hrishikesh Thakur, Michael S. Kapiloff, Kimberly L. Dodge-Kafka
Summary: Pathological cardiac myocyte hypertrophy, which is a condition characterized by the enlargement of heart cells, is regulated by the pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin. This study reveals that the scaffold protein muscle A-Kinase Anchoring Protein beta (mAKAP beta/AKAP6 beta) organizes perinuclear signalosomes, which are responsible for localized calcium transients and the subsequent activation of calcineurin-dependent NFATc nuclear localization, leading to myocyte hypertrophy upon beta-adrenergic receptor activation. These findings demonstrate the existence of a functionally independent calcium signaling compartment in cardiac myocytes that regulates hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemical Research Methods
S. Wenceslao Evans, Dong-Qing Shi, Mariya Chavarha, Mark H. Plitt, Jiannis Taxidis, Blake Madruga, Jiang Lan Fan, Fuu-Jiun Hwang, Siri C. van Keulen, Carl-Mikael Suomivuori, Michelle M. Pang, Sharon Su, Sungmoo Lee, Yukun A. Hao, Guofeng Zhang, Dongyun Jiang, Lagnajeet Pradhan, Richard H. Roth, Yu Liu, Conor C. Dorian, Austin L. Reese, Adrian Negrean, Attila Losonczy, Christopher D. Makinson, Sui Wang, Thomas R. Clandinin, Ron O. Dror, Jun B. Ding, Na Ji, Peyman Golshani, Lisa M. Giocomo, Guo-Qiang Bi, Michael Z. Lin
Summary: By inverting the fluorescence-voltage relationship, the photostability of ASAP family genetically encoded voltage indicators (GEVIs) has been enhanced. Two improved GEVIs, ASAP4b and ASAP4e, enable single-trial detection and recording in standard one- and two-photon microscopes with better temporal resolution. They can simultaneously detect voltage and calcium signals and extend the duration of voltage recordings.
Article
Plant Sciences
Xiaotong Shi, Jinyu Bao, Xu Lu, Lei Ma, Yi Zhao, Shimin Lan, Jie Cao, Shaoying Ma, Sheng Li
Summary: Ca2+ is an essential metal ion for plant growth and development, playing important roles in plant signal transduction and metabolic processes. This review summarizes the mechanisms of Ca2+ response to stress signals, the regulation of ion transport, the interaction with phytohormones, and the role of calcium-dependent proteins in stress response.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Xiaopeng Li, Jingjie Zhang, Hongyong Shi, Bo Li, Jia Li
Summary: Receptor-like kinases (RLKs) are a group of plant-specific transmembrane proteins that can convert extracellular signals into intracellular responses by altering gene expression profiles. Recent studies have found that many RLKs can physically interact with membrane-localized transport proteins, allowing for rapid responses in specific tissues or cells.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Otorhinolaryngology
Kengo Tamari, Hiroko Takeuchi, Masayoshi Kobayashi, Takashi Kurahashi, Tetsuro Yamamoto
AURIS NASUS LARYNX
(2013)
Article
Physiology
Hiroko Takeuchi, Hirohiko Ishida, Satoshi Hikichi, Takashi Kurahashi
JOURNAL OF GENERAL PHYSIOLOGY
(2009)
Article
Physiology
Yukako Kishino, Hiroyuki Kato, Takashi Kurahashi, Hiroko Takeuchi
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2011)
Article
Multidisciplinary Sciences
Hiroko Takeuchi, Hiroyuki Kato, Takashi Kurahashi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Zoology
Kyohei Matsumura, Masahiro Matsumoto, Takashi Kurahashi, Hiroko Takeuchi
ZOOLOGICAL SCIENCE
(2012)
Article
Physiology
Hiroko Takeuchi, Takashi Kurahashi
JOURNAL OF GENERAL PHYSIOLOGY
(2018)
Article
Neurosciences
H Takeuchi, T Kurahashi
JOURNAL OF NEUROSCIENCE
(2005)
Article
Biochemistry & Molecular Biology
T Furuta, H Takeuchi, M Isozaki, Y Takahashi, M Kanehara, M Sugimoto, T Watanabe, K Noguchi, TM Dore, T Kurahashi, M Iwamura, RY Tsien
Article
Physiology
H Takeuchi, Y Imanaka, J Hirono, T Kurahashi
JOURNAL OF GENERAL PHYSIOLOGY
(2003)
Article
Neurosciences
H Takeuchi, T Kurahashi
JOURNAL OF PHYSIOLOGY-LONDON
(2002)
Article
Food Science & Technology
Hiroko Takeuchi, Takashi Kurahashi
NPJ SCIENCE OF FOOD
(2019)
Article
Physiology
H Takeuchi, T Kurahashi
JOURNAL OF GENERAL PHYSIOLOGY
(2003)