Article
Multidisciplinary Sciences
Yulia Dembitskaya, Charlotte Piette, Sylvie Perez, Hugues Berry, Pierre J. Magistretti, Laurent Venance
Summary: The study shows that glucose and lactate play different roles in memory engram and neural computation. Lactate is important for high-stimulation load activity patterns and high attentional load in cognitive tasks, while glucose is sufficient for less demanding neural computation and learning tasks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Ivan Ballasch, Esther Garcia-Garcia, Cristina Vila, Anna Perez-Gonzalez, Anna Sancho-Balsells, Jessica Fernandez, David Soto, Mar Puigdellivol, Xavier Gasull, Jordi Alberch, Manuel J. Rodriguez, Josep M. Canals, Albert Giralt
Summary: In the last two decades, microglia have been recognized as important contributors to neurological disorders, not only through their immunological functions, but also through their ability to modulate synaptic and neural activity. The Ikzf1 gene, which plays crucial roles in regulating the function of circulating monocytes and lymphocytes, was found to be specifically expressed in adult microglia in the brain. Studies using Ikzf1 deficient mice revealed spatial learning deficits, impaired hippocampal function, and altered microglial morphology, suggesting that Ikzf1 is involved in microglial state and function. Furthermore, altered levels of Ikzf1 were observed in neurological disorder models and Alzheimer's disease patients, indicating its potential role in disease pathology.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Timothy Tadros, Maxim Bazhenov
Summary: Relational memory is critical for mammalian reasoning. Sleep plays a crucial role in offline processing and improving the ability to make indirect associations.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Ping Liao, Qing-Yun Wu, Sen Li, Kai-Bin Hu, Hui-Lin Liu, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wang
Summary: Abscisic acid (ABA) is a hormone found in plants and animals that regulates blood glucose and inflammation. It has therapeutic effects on obesity, diabetes, atherosclerosis, and inflammatory diseases. Studies have shown that ABA can cross the blood-brain barrier and improve learning, memory, and cognitive ability in the central nervous system. Additionally, it plays a crucial role in improving Alzheimer's disease, depression, and anxiety.
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Yifeng Rang, Huan Liu, Chunhong Liu
Summary: This review summarizes the mechanisms underlying Nonylphenol (NP)-induced learning and memory impairment and proposes possible therapeutic methods. Through behavior tests and other studies, oxidative stress, neurotransmitter disorder, synaptic plasticity impairment, and neuron injury are identified as key factors contributing to learning and memory deficits. In addition, chronic inflammation and increased gut permeability are also suggested to be associated with NP-induced learning and memory impairment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Neurosciences
Xingzhi He, Jiarui Li, Guangjun Zhou, Jing Yang, Sam McKenzie, Yanjun Li, Wenwen Li, Jun Yu, Yang Wang, Jing Qu, Zhiying Wu, Hailan Hu, Shumin Duan, Huan Ma
Summary: This study shows a positive correlation between hippocampal oscillatory strength and excitatory monosynaptic drive onto inhibitory neurons in freely behaving mice. By manipulating experience-dependent E -> I synaptic input/plasticity, the researchers were able to demonstrate its role in memory function. Deleting a specific protein affected long-term memory and brain wave rhythms.
Article
Neurosciences
Nastaran Golitabari, Forouzan Mohammadian, Ali-Akbar Salari, Mohammad Amani
Summary: This study found that early life exposure to PCP can negatively affect the synaptic function of CA1 neurons in the hippocampus of adult rats, including inhibiting long-term potentiation and depression, and causing significant changes in complex response profiles.
Article
Physics, Fluids & Plasmas
Wenxuan Zou, Chan Li, Haiping Huang
Summary: In this study, the authors propose a spike and slab distribution to model the individual connections in recurrent neural networks for temporal credit assignment. They derive a mean-field algorithm to train the network and apply the method to classification and multisensory integration tasks. The study uncovers important connections in the network and reveals different types of neural selectivity.
Article
Biology
Dhruva Raman, Timothy O'Leary
Summary: Synaptic connections in many brain circuits exhibit substantial turnover and remodeling over hours to days, even in the absence of learning or known plasticity signals. Compensatory plasticity should be at most equal in magnitude to fluctuations, and often less, regardless of plasticity mechanisms and circuit architectures. This high proportion of learning-independent synaptic change is consistent with plasticity mechanisms that accurately compute error gradients.
Article
Neurosciences
Fang-Fei Tao, Zi-Yu Wang, Ying Wang, Qian-Ru Lv, Peng-Peng Cai, Hai-Wen Min, Jian-Wei Ge, Chun-Yu Yin, Rui Cheng
Summary: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), but the effect of hippocampal cyclin-dependent kinase 5 (CDK5) on BPD-associated neurodevelopment deficits is not fully understood. Inhibition of CDK5 overactivation can improve cognitive deficits, neuronal apoptosis, and synaptic plasticity disorders in BPD mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Shunqin Fan, Xijun Wang, Ning Gao, Songli Wei
Summary: In a rat model, electroacupuncture pretreatment was found to improve learning and memory deficits induced by recurrent propofol exposure. It also enhanced hippocampal synaptic plasticity, activated the pCREB/BDNF pathway, and inhibited neuronal apoptosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Forouzan Mohammadian, Nastaran Golitabari, Ali Abedi, Hakimeh Saadati, Hamid Sheikhkanloui Milan, Ali-Akbar Salari, Mohammad Amani
Summary: Gamma-aminobutyric acid (GABA) plays an important role in balancing excitatory and inhibitory networks in the brain. The disruption of GABA's depolarizing action during early life can lead to neurodevelopmental disorders. This study shows that postnatal exposure to bicuculline, a GABA(A) receptor antagonist, impairs short- and long-term synaptic plasticity in hippocampal CA1 neurons, resulting in disturbances in spatial memory.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Wanqiu Niu, Yanhong Duan, Yu Kang, Xiaohua Cao, Qingsheng Xue
Summary: This study investigated the effect of propofol on fear memory extinction and synaptic plasticity in a PTSD mice model. The results showed that propofol can accelerate fear memory extinction and restore impaired synaptic plasticity in the hippocampus of PTSD mice.
Review
Neurosciences
Yanis Inglebert, Dominique Debanne
Summary: The importance of considering physiological levels of extracellular calcium concentration in studying functional plasticity is discussed in this study.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Deborah J. Watson, Linnaea Ostroff, Guan Cao, Patrick H. Parker, Heather Smith, Kristen M. Harris
Article
Cell Biology
Craig H. Bailey, Eric R. Kandel, Kristen M. Harris
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2015)
Article
Biology
Thomas M. Bartol, Cailey Bromer, Justin Kinney, Michael A. Chirillo, Jennifer N. Bourne, Kristen M. Harris, Terrence J. Sejnowski
Article
Multidisciplinary Sciences
Kristen M. Harris, Josef Spacek, Maria Elizabeth Bell, Patrick H. Parker, Laurence F. Lindsey, Alexander D. Baden, Joshua T. Vogelstein, Randal Burns
Article
Biology
Heather L. Smith, Jennifer N. Bourne, Guan Cao, Michael A. Chirillo, Linnaea E. Ostroff, Deborah J. Watson, Kristen M. Harris
Article
Neurosciences
Justin P. Kinney, Josef Spacek, Thomas M. Bartol, Chandrajit L. Bajaj, Kristen M. Harris, Terrence J. Sejnowski
JOURNAL OF COMPARATIVE NEUROLOGY
(2013)
Article
Neurosciences
Jennifer N. Bourne, Michael A. Chirillo, Kristen M. Harris
JOURNAL OF COMPARATIVE NEUROLOGY
(2013)
Article
Neurosciences
Maria Elizabeth Bell, Jennifer N. Bourne, Michael A. Chirillo, John M. Mendenhall, Masaaki Kuwajima, Kristen M. Harris
JOURNAL OF COMPARATIVE NEUROLOGY
(2014)
Article
Neurosciences
Guan Cao, Kristen M. Harris
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Article
Computer Science, Interdisciplinary Applications
John Edwards, Eric Daniel, Justin Kinney, Tom Bartol, Terrence Sejnowski, Daniel Johnston, Kristen Harris, Chandrajit Bajaj
Article
Biology
Yelena D. Kulik, Deborah J. Watson, Guan Cao, Masaaki Kuwajima, Kristen M. Harris
Article
Neurosciences
Elizabeth Litvina, Amy Adams, Alison Barth, Marcel Bruchez, James Carson, Jason E. Chung, Kristin B. Dupre, Loren M. Frank, Kathleen M. Gates, Kristen M. Harris, Hannah Joo, Jeff William Lichtman, Khara M. Ramos, Terrence Sejnowski, James S. Trimmer, Samantha White, Walter Koroshetz
JOURNAL OF NEUROSCIENCE
(2019)
Editorial Material
Neurosciences
Kristen M. Harris
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Olga I. Ostrovskaya, Guan Cao, Cagla Eroglu, Kristen M. Harris
Article
Multidisciplinary Sciences
Jae Hoon Jung, Lyndsey M. Kirk, Jennifer N. Bourne, Kristen M. Harris
Summary: Long-term potentiation is a cellular mechanism of learning and memory characterized by changes in vesicle density and structure of vesicle tethering filaments, resulting in an increase in release probability following LTP.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)