Review
Endocrinology & Metabolism
Xihua Lin, Hong Li
Summary: Obesity is a complex multifactorial disease with negative health effects, mainly caused by an energy imbalance. Treatment strategies should focus on biological mechanisms and reducing BMI.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Young-Sang Kim, Yao Yao, So-Won Lee, Nicola Veronese, Soo-Jin Ma, Yeon-Hee Park, Sang-Yhun Ju
Summary: This study analyzed panel data from Korean older adults and found that frailty was associated with a higher risk of falls. Social isolation and exhaustion were significantly associated with fall events, while weakness did not show a significant association. These findings suggest that interventions should focus on addressing social and psychological frailty in older adults.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Review
Medicine, General & Internal
Ying-Xin Xian, Jian-Ping Weng, Fen Xu
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide, closely associated with metabolic syndrome, obesity, and type 2 diabetes, with insulin resistance as the main pathophysiological mechanism. Recently, experts suggest renaming it as metabolic (dysfunction) associated fatty liver disease (MAFLD) to emphasize the important role of metabolic dysfunction.
CHINESE MEDICAL JOURNAL
(2021)
Article
Hematology
Antonella Tufano, Antonio Coppola, Maurizio Galderisi
Summary: Progress in cancer treatment has significantly improved patient survival, but cardiovascular complications may adversely affect prognosis. Cardiovascular oncology is an emerging field focusing on prevention, early detection, and management of cardiovascular disease in cancer patients.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Geriatrics & Gerontology
Yurun Cai, Suzanne G. Leveille, Ling Shi, Ping Chen, Tongjian You
Summary: The study found that chronic pain interference and pain distribution in older adults are associated with an increased risk of injurious falls, especially in women. Short-term moderate-to-severe pain also increases the risk of injurious falls in the subsequent month.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Anna M. Blokhuis, Johanna C. W. Deenen, Nicol C. Voermans, Baziel G. M. van Engelen, Wietske Kievit, Jan T. Groothuis
Summary: This study aimed at determining the socioeconomic burden of facioscapulohumeral muscular dystrophy (FSHD), finding that the total annual cost per patient is approximately €26,322, with direct medical costs being the largest component. Major cost-driving factors were formal home care and informal care, and decreased mobility levels were associated with higher direct costs of illness.
JOURNAL OF NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jessica Magid-Bernstein, Romuald Girard, Sean Polster, Abhinav Srinath, Sharbel Romanos, Issam A. Awad, Lauren H. Sansing
Summary: This review article provides an overview of the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of intracerebral hemorrhage (ICH). The incidence of hemorrhagic stroke has increased globally in the past 40 years, with changes in the cause over time due to improved hypertension management and increased use of anticoagulants. Preclinical and clinical trials have shed light on the underlying cause and mechanisms of injury from ICH, including the complex interaction between edema, inflammation, iron-induced injury, and oxidative stress. Although several trials have investigated the optimal medical and surgical management of ICH, there has been no clear improvement in survival and functional outcomes. Ongoing research into novel approaches for ICH management offers hope for reducing the devastating impact of this disease in the future.
CIRCULATION RESEARCH
(2022)
Article
Geriatrics & Gerontology
Andrea L. Rosso, Zachary A. Marcum, Xiaonan Zhu, Nicolaas Bohnen, Caterina Rosano
Summary: Anticholinergic medication use is associated with an increased risk of falls, while higher dopaminergic signaling may provide protection against this.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Joan Forns, J. Bradley Layton, Jennifer Bartsch, Mary Ellen Turner, Colleen Dempsey, Mary Anthony, Mary E. Ritchey, George Demos
Summary: The study evaluated the risk of falls and fractures in patients with Parkinson disease with psychosis (PDP) compared to those without psychosis at similar disease stages. The results showed that PDP patients had a slightly higher risk of falls and fractures, particularly in falls, compared to PD patients without psychosis.
Article
Geriatrics & Gerontology
Olivier Beauchet, Jacqueline Matskiv, Yves Rolland, Anne-Marie Schott, Gilles Allali
Summary: This study examines the association between ER2 risk levels and falls, their recurrence, and post-fall fractures in older community women. The results suggest that ER2 low and high risk levels are associated with incident fall outcomes.
Article
Orthopedics
Leo H. Wang, Dennis W. W. Shaw, Anna Faino, Christopher B. Budech, Leann M. Lewis, Jeffrey Statland, Katy Eichinger, Stephen J. Tapscott, Rabi N. Tawil, Seth D. Friedman
Summary: This study found that muscles with intermediate baseline fat fraction were more likely to progress in FSHD patients. Functional outcome measures were correlated with overall MRI disease burden but did not show significant changes in the short term. Quantitative strength measurement of the TA revealed a steep loss of strength when the muscle had more than 20% fatty infiltration.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Nicholas C. Harvey, Eric Orwoll, Timothy Kwok, Magnus K. Karlsson, Bjorn E. Rosengren, Eva Ribom, Jane A. Cauley, Peggy M. Cawthon, Kristine Ensrud, Enwu Liu, Alfonso J. Cruz-Jentoft, Roger A. Fielding, Cyrus Cooper, John A. Kanis, Mattias Lorentzon, Claes Ohlsson, Dan Mellstrom, Helena Johansson, Eugene McCloskey
Summary: Adjustment for femoral neck bone mineral density (fnBMD) reduces the predictive value for fracture of sarcopenia definitions based on appendicular lean mass (ALM), but inclusion of physical performance measures strengthens it. Severe sarcopenia definitions incorporating chair stand time, gait speed, and grip strength demonstrate the highest predictability for fracture, even at low prevalence levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Kazunari Ninomiya, Naonobu Takahira, Takashi Ikeda, Koji Suzuki, Ryoji Sato, Kazuo Hirakawa
Summary: This study evaluated the prevalence of locomotive syndrome (LS) in patients more than 10 years after total hip arthroplasty (THA) and found that LS is associated not only with motor diseases but also with cardiometabolic diseases.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Article
Clinical Neurology
Beata Lindholm, Christina Brogardh, Per Odin, Peter Hagell
Summary: The study identified predictors for falls/near falls in Parkinson’s disease, including history of falls, abnormal tandem gait, and lower MMSE scores. These factors not only affect the fall risk in the short term but also in the long term among patients with PD.
JOURNAL OF NEUROLOGY
(2021)
Review
Pharmacology & Pharmacy
Xin Jin, Tingting Qiu, Li Li, Rilei Yu, Xiguang Chen, Changgui Li, Christopher G. Proud, Tao Jiang
Summary: The occurrence of obesity has increased worldwide and contributes to the development of various diseases. Excess energy intake leads to adipocyte hypertrophy, hyperplasia, and visceral fat formation, resulting in cardiovascular and liver diseases. Adipose tissue can secrete adipokines and cytokines, causing insulin resistance and hyperglycemia, exacerbating obesity-related diseases. Although progress has been made in obesity treatment, the progression and pathogenesis of obesity-induced diseases are still unclear. Understanding their links is essential for better management and treatment.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Clinical Neurology
Karlijn Bouman, Anne T. M. Dittrich, Jan T. Groothuis, Baziel G. M. van Engelen, Mirian C. H. Janssen, Nicol C. Voermans, Jos M. T. Draaisma, Corrie E. Erasmus
Summary: This scoping review summarizes the evidence on bone quality in congenital myopathies and provides recommendations for bone quality management, including bone mineral density assessment, vitamin D and calcium supplementation, and referral to internal medicine or pediatrics for consideration of additional therapies to prevent complications of low bone mineral density.
JOURNAL OF NEUROMUSCULAR DISEASES
(2023)
Review
Clinical Neurology
Bastiaan R. Bloem, Erik Post, Deborah A. Hall
Summary: The Rune Labs Kinematics System, a smartwatch-based monitoring system, has been cleared by the FDA to remotely track motor impairments in Parkinson's disease. While this new digital approach shows promise, further validation studies are needed to determine its clinical significance and use in research.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Renske M. J. Janssen, Renee Lustenhouwer, Edith H. C. Cup, Nens van Alfen, Jos Ijspeert, Rick C. Helmich, Ian G. M. Cameron, Alexander C. H. Geurts, Baziel G. M. van Engelen, Maud J. L. Graff, Jan T. Groothuis
Summary: This study compared the effects of multidisciplinary rehabilitation with usual care on the functional capability of the shoulder, arm, and hand in patients with neuralgic amyotrophy. The results showed that multidisciplinary rehabilitation was more effective in improving shoulder functional capability and reducing pain and fatigue.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Geriatrics & Gerontology
Lily Man Lee Chan, Oliver Yongyang Yan, Jay Jung Jae Lee, Wendy Wing Tak Lam, Chia-Chin Lin, Man Auyeung, Bastiaan R. Bloem, Jojo Yan Yan Kwok
Summary: Palliative care is associated with lower symptom burden and higher caregiver and patient satisfaction in patients with progressive neurologic diseases. However, the associations are not significant after excluding studies with high risk of bias. The effects of palliative care on caregiver burden and patient quality of life are inconclusive.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Clinical Neurology
Jildou N. Dijkstra, Eline Boon, Nick Kruijt, Esther Brusse, Sithara Ramdas, Heinz Jungbluth, Baziel G. M. van Engelen, Jon Walters, Nicol C. Voermans
Summary: Muscle cramps are painful, involuntary contractions that are typically a normal part of human physiology. They can be caused by various acquired or inherited factors, but rarely by progressive systemic or neuromuscular diseases. General practitioners and neurologists often encounter patients with muscle cramps and less frequently those with contractures. Clinicians need to determine whether it is a muscle cramp, contracture, or mimic, as well as the cause and appropriate diagnostic and treatment strategies.
PRACTICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Pierre-Emmanuel Sugier, Elise A. Lucotte, Cloe Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq-Daian, Anne Boland-Auge, Robert Olaso, Jean-francois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guenel, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Roedstroem, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Therese Truong, Alexis Elbaz
Summary: By using genome-wide association studies, this study found that Parkinson's disease (PD) is genetically correlated with melanoma and prostate cancer, while it is inversely correlated with ovarian cancer. These findings suggest that pleiotropic genes contribute to the association between PD and specific cancers.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Joery P. Molenaar, Esmee van Kleef, Elianne van Zandvoort, Nens van Alfen, Baziel G. van Engelen, Nicol C. Voermans, Jonne Doorduin
Summary: Assessing muscle relaxation using TMS can serve as a diagnostic tool and outcome measure in clinical trials for specific myopathies, and differentiate symptomatic controls from myopathy patients.
NEUROMUSCULAR DISORDERS
(2023)
Article
Clinical Neurology
Joost Kools, Willem Aerts, Erik H. Niks, Karlien Mul, Lisa Pagan, Jake S. F. Maurits, Renee Thewissen, Baziel G. van Engelen, Nicol C. Voermans
Summary: This study assessed the burden and pain level of muscle biopsies in FSHD patients and found that they are significant in research settings, with BN-biopsies being less painful compared to MRI-biopsies.
NEUROMUSCULAR DISORDERS
(2023)
Review
Clinical Neurology
Jesco Streumer, Ashok K. Selvaraj, Erkan Kurt, Bastiaan R. Bloem, Rianne A. J. Esselink, Ronald H. M. A. Bartels, Dejan Georgiev, R. Saman Vinke
Summary: Axial disability, including gait disturbances, is common in Parkinson's disease (PD), especially in advanced stages. Epidural spinal cord stimulation (SCS) has been investigated as a treatment option for gait disorders in PD. This review examines the literature on SCS in PD and evaluates its efficacy, optimal stimulation parameters, optimal electrode locations, possible effects of concurrent deep brain stimulation, and possible working mechanisms on gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Irene Gottgens, Linda Modderkolk, Corine Jansen, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Sabine Oertelt-Prigione
Summary: This study explores the salience of gender-related aspects in the illness experiences and care provision preferences of people with Parkinson's disease (PD). Most participants did not consider gender-related aspects salient towards their illness experiences, but some described stereotypical views related to visibility of PD, emotional experiences, help seeking, role patterns, and physical appearance. While most participants did not express specific gender-related preferences for their healthcare providers, those that did preferred women as healthcare providers, citing attributed feminine traits relevant in physical examinations of people with PD.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Geriatrics & Gerontology
Sanne C. C. Vincenten, Karlien Mul, Daniel van As, Julia J. Jansen, Linda Heskamp, Arend Heerschap, Baziel G. M. van Engelen, Nicol C. Voermans
Summary: This study found significant changes in both MRI imaging and clinical outcome measures in a large longitudinal prospective cohort of FSHD patients. There was a significant correlation between changes in MRI-CoS and changes in clinical outcome measures. The study also identified subgroups of patients that are most prone to radiological disease progression. These findings further establish quantitative MRI parameters as prognostic biomarkers in FSHD and as efficacy biomarkers in upcoming clinical trials.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Cell Biology
Clothilde Claus, Moriya Slavin, Eugenie Ansseau, Celine Lancelot, Karimatou Bah, Saskia Lassche, Manon Fievet, Anna Greco, Sara Tomaiuolo, Alexandra Tassin, Virginie Dudome, Benno Kusters, Anne-Emilie Decleves, Dalila Laoudj-Chenivesse, Baziel G. M. van Engelen, Denis Nonclercq, Alexandra Belayew, Nir Kalisman, Frederique Coppee
Summary: The presence and interaction between DUX4c and DUX4 proteins in FSHD muscle cells suggest their involvement in muscle regeneration and pathology. The interaction of DUX4c with specific protein partners and markers indicates its physiological role in muscle repair. Therapeutic strategies targeting DUX4 should consider the potential interference with DUX4c functions.
Editorial Material
Clinical Neurology
Jules M. Janssen Daalen, Thomas H. Oosterhof, Bastiaan R. Bloem, Sirwan K. L. Darweesh
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Ronne Pater, Joana Garmendia, Benjamin Gallais, Christopher Graham, Nicoline Voet
Summary: This workshop aimed to develop recommendations for psychological interventions to support people living with slowly progressive neuromuscular disorders (NMD). The group recommends that psychological interventions should be embedded in the routine clinical care offered to people living with NMD based on evidence from randomised controlled trials, carefully conducted observational studies, and the coherence of these data with the experience of those living with NMD. The workshop included clinicians, researchers, people living with NMD and their relatives, who discussed key psychological challenges presented by NMD and ways to adapt therapies for cognitive impairments or neurodevelopmental differences that occur in some NMD.
NEUROMUSCULAR DISORDERS
(2023)
Editorial Material
Neurosciences
Federica Albanese, Bastiaan R. Bloem, Lorraine V. Kalia
Summary: Metascience emphasizes the importance of replication, reproducibility, and rigor in research, particularly in studying major diseases like Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2023)