Article
Clinical Neurology
Farooq Kamal, Cassandra Morrison, Josefina Maranzano, Yashar Zeighami, Mahsa Dadar
Summary: This study aimed to investigate the association between the change in white matter hyperintensities (WMH) burden and conversion to dementia in individuals with mild cognitive impairment (MCI) who are either amyloid-positive (A & beta;+) or amyloid-negative (A & beta;-). The results showed that individuals with A & beta;+ had the highest increase in WMH burden and steepest accumulation over time compared to individuals with A & beta;-.
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Review
Surgery
Kosmas Paraskevas, Gianluca Faggioli, Stefano Ancetti, A. Ross Naylor
Summary: The study found that 94% of studies reported an association between ACS and one or more tests of cognitive impairment, but significant association does not necessarily imply a causal relationship. There is currently no clear evidence that ACS causes cognitive impairment through silent cortical infarction, but evidence suggests that patients with severe ACS and impaired CVR are more likely to experience cognitive impairment and further worsening cognition over time.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Neurosciences
Nauris Zdanovskis, Ardis Platkajis, Andrejs Kostiks, Olesja Grigorjeva, Guntis Karelis
Summary: Recent research has shown that the cerebellum is not only responsible for coordinating movement, but also plays a role in cognition. Analysis of cerebellar cortex and white matter volume revealed that participants with normal cognition tended to have higher volumes, but these differences were not statistically significant.
Article
Medicine, General & Internal
Angie A. Diaz Baquero, Maria Perea Bartolome, Jose Miguel Toribio-Guzman, Fernando Martinez-Abad, Esther Parra Vidales, Yolanda Bueno Aguado, Henriette G. van der Roest, Manuel A. Franco-Martin
Summary: This study aimed to identify the determinants that predicted adherence to a computerized cognitive training program in people with mild cognitive impairment and mild dementia. The results showed that good executive functioning, attention, working memory, and language abilities predicted higher adherence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Martina Vettore, Matteo De Marco, Claudia Pallucca, Matteo Bendini, Maurizio Gallucci, Annalena Venneri
Summary: The study found that the association between white-matter hyperintensities (WMHs) burden and strength of connectivity of resting-state functional networks differs between aMCI and naMCI patients, with significant interactions observed in the salience and left frontoparietal networks.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Mikko T. Huuskonen, Qinghai Liu, Krista Lamorie-Foote, Kristina Shkirkova, Michelle Connor, Arati Patel, Axel Montagne, Hans Baertsch, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, Berislav Zlokovic, William J. Mack
Summary: Exposure to air pollution nanoparticles exacerbates cerebrovascular pathology and demyelination, particularly in the presence of cerebral hypoperfusion, suggesting a potential link between air pollution and cognitive decline in elderly populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Alar Kaskikallio, Mira Karrasch, Juha Koikkalainen, Jyrki Lotjonen, Juha O. Rinne, Terhi Tuokkola, Riitta Parkkola, Petra Gronholm-Nyman
Summary: This study examined the relationship between WMH and verbal fluency in healthy elderly individuals and those with MCI/AD, finding associations between WMH in certain brain areas and impaired semantic fluency, particularly in right-handed participants. Elevated levels of WMH were not found to have cumulative effects on verbal fluency impairment in patients with MCI or AD, suggesting further research is needed in this area.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Surgery
Wei Zhou, Bahaa Succar, Devin P. Murphy, Yazan Ashouri, Ying-Hui Chou, Chiu-Hsieh Hsu, Steven Rapcsak, Theodore Trouard
Summary: This study demonstrated that carotid intervention could improve memory and executive function in patients with severe carotid occlusive disease. The cognitive benefits of carotid intervention were highlighted, especially in appropriately selected patients. Improvement was also observed in patients with preoperative stroke symptoms.
Article
Medicine, General & Internal
Meng Wang, Eric E. Smith, Nils Daniel Forkert, Thierry Chekouo, Zahinoor Ismail, Aravind Ganesh, Tolulope Sajobi
Summary: This study aims to develop a robust dementia risk score for individuals with MCI by assessing experts' beliefs and integrating expert knowledge with patient data using a Bayesian approach. By using SEE methodology and statistical modelling, the study will derive a dementia risk score that incorporates clinician expert knowledge for accurate risk stratification, prognosis and management of dementia.
Article
Clinical Neurology
Anisa Dhana, Charles DeCarli, Klodian Dhana, Pankaja Desai, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: By studying data from 701 older adults, we found that combining white matter hyperintensity (WMH) with neurofilament light chain (NfL) could provide additional information for cognition. Higher levels of WMH and NfL were associated with a faster rate of cognitive decline during the follow-up period, suggesting different underlying mechanisms affecting cognition.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Elveda Gozdas, Hannah Fingerhut, Hua Wu, Jennifer L. Bruno, Lauren Dacorro, Booil Jo, Ruth O'Hara, Allan L. Reiss, S. M. Hadi Hosseini
Summary: Healthy and pathological aging affect brain microstructure through complex processes. The study demonstrated that reduced MTV in association tracts is linked to older age in healthy aging, correlated with memory performance, and distinguishes aMCI from controls. Additionally, changes in gray matter tissue properties were also documented, showing a widespread decrease in R1 with age and decreased R1 in aMCI compared to controls.
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Surgery
Bahaa Succar, Ying-Hui Chou, Chiu-Hsieh Hsu, Steven Rapcsak, Theodore Trouard, Wei Zhou
Summary: This study aimed to evaluate postoperative cognitive changes in seniors older than 80 years undergoing carotid interventions. The findings showed that younger patients demonstrated cognitive improvements after the surgery, while no cognitive benefits were seen in male seniors older than 80 years.
Article
Immunology
Qian Liu, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Shanshan Song, Gulnaz Begum, Cullen B. Young, Lesley M. Foley, Fenghua Chen, T. Kevin Hitchens, Guodong Cao, Ansuman Chattopadhyay, Li He, Dandan Sun
Summary: Our study shows that NHE1 protein is involved in astrogliosis induced by CCH, and its blockade has potential for reducing astrogliosis, demyelination, and cognitive impairment.
JOURNAL OF NEUROINFLAMMATION
(2021)