Article
Anesthesiology
Donna L. Kennedy, Jan Vollert, Deborah Ridout, Caroline M. Alexander, Andrew S. C. Rice
Summary: The DFNS quantitative sensory testing method can effectively identify changes in sensory phenotype in patients with entrapment neuropathy, which are closely related to symptom changes after clinical interventions. In an entrapment neuropathy model, sensory phenotype is independent of disease severity and may reflect the underlying neuropathophysiology.
Article
Anesthesiology
Rui Li, Amy L. Holley, Tonya M. Palermo, Olivia Ohls, Robert R. Edwards, Jennifer A. Rabbitts
Summary: This study assessed the feasibility, reliability, and sources of variability of a brief QST protocol in youth with acute MSK pain. The results showed high completion rates and reliability of the protocol, and indicated that age and ethnicity had some influence on QST parameters.
Article
Anesthesiology
Julia Forstenpointner, Ruth Ruscheweyh, Nadine Attal, Ralf Baron, Didier Bouhassira, Elena K. Enax-Krumova, Nanna B. Finnerup, Rainer Freynhagen, Janne Gierthmuehlen, Per Hansson, Troels S. Jensen, Christoph Maier, Andrew S. C. Rice, Maerta Segerdahl, Thomas Toelle, Rolf-Detlef Treede, Jan Vollert
Summary: The study revealed that hypersensitivity symptoms, including hyperalgesia and allodynia, are present in patients with central and peripheral lesions of the somatosensory system, even if they do not report spontaneous pain. There was a difference in pain sensitivity between painful and painless neuropathic conditions, with hyperalgesia more common in painful mononeuropathy and hypoalgesia more pronounced in painful polyneuropathy.
Article
Medicine, General & Internal
Ashraf S. Gorgey, Refka E. Khalil, Malak Alrubaye, Ranjodh Gill, Jeannie Rivers, Lance L. Goetz, David X. Cifu, Teodoro Castillo, Deborah Caruso, Timothy D. Lavis, Edward J. Lesnefsky, Christopher C. Cardozo, Robert A. Adler
Summary: This study aims to investigate the effects of long pulse width stimulation (LPWS) and testosterone treatment (TT) on muscle size and metabolic health in individuals with spinal cord injury (SCI). Through various measurements and tests, the study hopes to determine if TT+LPWS can enhance protein synthesis, improve mitochondrial health, and ultimately lead to muscle growth and improved metabolic health.
Review
Clinical Neurology
Valentina Nicolardi, Isabella Fanizza, Giuseppe Accogli, Luigi Macchitella, Sara Scoditti, Antonio Trabacca
Summary: The sensory features of autism include hypo- or hyper-reactivity to pain, although previous studies on pain in autism have yielded conflicting results. This article discusses the current state of knowledge and methodological challenges regarding pain perception in autism, with a focus on studies that used standardized protocols such as Quantitative Sensory Testing (QST) to measure perception. The use of QST has challenged the assumption of hypo-sensitivity to pain in autism, which was based on parents' reports, as there is limited evidence supporting it. Both peripheral and central mechanisms have been found to be involved in the typical features of pain perception in autism. However, there is a scarcity of studies with controlled protocols, particularly in children. Collecting subjective and objective measures from autistic children presents complex ethical challenges that need to be addressed. Given the heterogeneity of neurodevelopmental features and intellectual disability in autism, novel or modified protocols are necessary for future research.
NEUROLOGICAL SCIENCES
(2023)
Article
Anesthesiology
Matthew J. Kmiecik, Frank F. Tu, Daniel J. Clauw, Kevin M. Hellman
Summary: Multimodal hypersensitivity (MMH), characterized by increased sensitivity across multiple sensory modalities, is associated with the development of chronic pain. This study examined a cohort of women and found that MMH was a significant predictor of pelvic pain, even after adjusting for baseline pain levels. These findings suggest that MMH may play a crucial role in the long-term risk and development of pelvic pain.
Review
Orthopedics
Mohamed Gomaa Sobeeh, Karima Abdelaty Hassan, Anabela Goncalves da Silva, Enas Fawzy Youssef, Nadia Abdelazim Fayaz, Maha Mostafa Mohammed
Summary: This review aimed to understand the sensory phenotype of complex regional pain syndrome (CRPS) and guide treatment strategies based on quantitative sensory testing (QST). The results showed that adults with CRPS experience significant loss of thermal, mechanical, and vibration sensations, as well as increased pain thresholds and ratings. Adolescents and children with CRPS have milder sensory abnormalities compared to adults. These findings are important for understanding the pain mechanisms of CRPS and guiding treatment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hye-Kyoung Kim, Mee-Eun Kim
Summary: Three heat and cold pain phenotypes were identified in patients with unilateral trigeminal nerve injury, with heat hypoalgesia being more common than heat hyperalgesia. Heat hypoalgesia was associated with subjective negative symptoms, while thermal hyperalgesia showed little relationship with negative and positive symptoms. The cold pain phenotypes differed between inferior alveolar nerve and lingual nerve injuries.
Article
Anesthesiology
Frank F. Tu, Kevin M. Hellman, Genevieve E. Roth, Katlyn E. Dillane, Lynn S. Walker
Summary: This study evaluated the validity and reliability of a noninvasive bladder pain test in healthy premenarchal females and found that adolescents had similar bladder pain compared to young adult females, with higher pain at first sensation to void and lower maximum tolerance volume. Anxiety, depression, somatic symptoms, and pain catastrophizing predicted provoked bladder pain. Bladder pain was inversely correlated with pressure pain thresholds and positively correlated with frequency of abdominal pain symptoms.
Article
Neurosciences
Andrew Wold, Lisa Radman, Kerstin Norman, Hakan Olausson, Magnus Thordstein
Summary: This study used clinical neurophysiological techniques to assess neurosensory function in patients after workplace electrical accidents and correlated test results with symptoms. The results showed that a majority of patients had neurosensory impairments, with a weak correlation between test results and self-reported symptoms.
Review
Neurosciences
S. A. Holmes, A. Kim, D. Borsook
Summary: The human motor system has the capacity to act as an internal form of analgesia through either indirect or direct activation of the motor axis. Current research focuses on evaluating the effects of motor activation on acute and chronic pain, providing a basis for reducing pain symptom loads for patients. Future research directions in this area are also proposed.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Sheera F. Lerman, Chung Jung Mun, Carly A. Hunt, Shriya Kunatharaju, Luis F. Buenaver, Patrick H. Finan, Claudia M. Campbell, Jane Phillips, Julio Fernandez-Mendoza, Jennifer A. Haythornthwaite, Michael T. Smith
Summary: This study is the first to characterize the ISSD phenotype in a chronic pain sample and expand the scope of its negative health outcomes to chronic pain. ISSD may be an important chronic pain phenotype associated with a more severe clinical and laboratory pain profile, and future studies should focus on implications for treatment response and disease trajectory.
Article
Environmental Sciences
Alona Emodi-Perlman, Deia Altarescu, Pessia Frideman-Rubin, Ilana Eli
Summary: The study found that qualitative sensory testing can predict postoperative dental pain following restorative dental procedures. Participants' reaction to intra-oral cold stimulation can serve as a potential tool for predicting postoperative pain.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Rheumatology
Anne-Priscille Trouvin, Nadine Attal, Serge Perrot
Summary: The persistence of pain in inflammatory rheumatic diseases suggests the involvement of central sensitization, but the inconsistent results of other sensory tests prevent confirmation of this hypothesis.
Article
Clinical Neurology
P. V. S. Souza, W. B. V. R. Pinto, A. Ricarte, B. M. L. Badia, D. D. Seneor, D. T. Teixeira, L. Caetano, E. A. Goncalves, M. A. T. Chieia, I. B. Farias, E. Bertini, A. S. B. Oliveira
Summary: This study identified a cohort of 20 patients with SMA type 4 in a Brazilian cohort of 227 SMA patients. The most common clinical symptom was limb-girdle muscle weakness, with absent tendon reflexes in 90% of patients and fasciculations in 45% of patients. The majority of patients (80%) had the homozygous deletion of exon 7 in the SMN1 gene, with 60% of them showing four copies of the SMN2 gene.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Letter
Medicine, General & Internal
Stefano Tamburin, Elisa Mantovani, Fabio Lugoboni
INTERNAL AND EMERGENCY MEDICINE
(2021)
Letter
Medicine, General & Internal
Stefano Tamburin, Elisa Mantovani, Ernesto De Bernardis, Donato Zipeto, Fabio Lugoboni, Costanza Agostoni, Costanza Agostoni, Roberta Almasio, Paola Avveduti, Ornella Baisini, Martina Ballerio, Alessandro Barbero, Marina Bellinato, Carlo Benevento, Loretta Bin, Veronica Bonizzi, Gianmario Borroni, Angelo Bove, Rita Broccardo, Sandra Bruschi, Roberta Brusini, Manuela Cairati, Liborio Martino Cammarata, Andrea Canale, Donatella Cantiero, Tania Capovilla, Maria Cristina Chiroli, Mauro Cibin, Raffaella Collesei, Daniela Colombo, Tiziana Cuomo, Annalisa D'Angelo, Susanna Dedola, Marco Degli Esposti, Giovanni De Micco, Vincenzo De Stefano, Filomena Di Cosmo, Tiziana Di Dio, Carmela Maria Di Fazio, Claudia Dona, Lorenza Fabiano, Mariacristina Fanton, Fulvio Fantozzi, Egle Maria Fergonzi, Elena Finotti, Francesca Fiore, Donatella Fiorentini, Nadia Fontana, Laura Franceschini, Luciana Furini, Paola Galletta, Francesco Gallo, Marianna Gardiolo, Roberta Gaspari, Nicola Gentile, Daniela Gervino, Novella Ghezzo, Cinzia Ghidoni, Maura Giubertoni, Paola Giussani, Filippo Gori, Francesca Groppa, Cinzia Grosina, Maria Raffaella Guzzetti, Paolo Jarre, Giovanna Maria Latino, Gianluca Lerro, Salvatore Lobello, Gloria Lobrano, Ilaria Valerida Lotti, Michael Malago, Marcello Mazzo, Stefano Mellini, Cristina Meneguzzi, Rocco Mercuri, Sabrina Migliozzi, Elena Molinaroli, Antonio Mosti, Daniela Mussi, Alessandra Novelli, Anna Padovani, Carmela Palmigiano, Elio Panelli, Alessandro Pani, Serena Passaretti, Valentina Pavani, Maria Pecoraro, Ivo Peroglia, Marina Pitasi, Roberto Poli, Edoardo Polidori, Anna Laura Porcu, Davide Possetto, Antonio Prete, Serenella Quaresima, Paola Rapuzzi, Rosa Recchia, Fabio Reina, Marco Riglietta, Elisabetta Rizzo, Fabio Rugani, Maria Adele Salvadori, Stefania Samaia, Samantha Sanchini, Paolo Sandrone, Francesca Sassella, Antonia Scala, Michele Scarzella, Bruno Sciutteri, Ivana Sclaverano, Massimo Sorce, Elvira Speranza, Maria Caterina Staccioli, Laura Suardi, Fiorella Talassi, Anna Talluto, Biagio Tinghino, Sonia Tiso, Tania Tosi, Antonella Tusa, Maria Sabrina Ungari, Riccardo Valenti, Lucia Vecchi, Alessandro Vegliach, Rita Vercellone, Flavio Verdelli, Serena Vicario, Francesca Vignola, Cinzia Zambon, Angela Zannini, Ilenia Zanoni, Valeria Zavan, Cristina Zerbini
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Clinical Neurology
Angela Federico, Elisa Mantovani, Rebecca Casari, Anna Bertoldi, Fabio Lugoboni, Stefano Tamburin
Summary: High-dose use of benzodiazepines (BZDs) and Z-drugs is associated with adult attention deficit/hyperactivity disorder (ADHD) and multidomain cognitive deficits, impacting quality of life (QoL). Adult ADHD and cognitive dysfunction have a complex interplay, worsening QoL in high-dose BZD/Z-drug users. More research is needed to explore if pharmacological treatment can improve cognitive dysfunction and QoL in this population.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Letter
Clinical Neurology
Alice Martini, Elisa Mantovani, Stefano Tamburin
Summary: The recent paper by Kobylecki et al. discusses the association between impulse control behaviors and pain in Parkinson's disease, suggesting a shared mesolimbic dysfunction. The authors propose the dorsolateral prefrontal cortex as a therapeutic target for this pain-predominant symptom subtype.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Stefano Tamburin, Denise Dal Lago, Federica Armani, Marco Turatti, Riccardo Sacca, Simone Campagnari, Cristiano Chiamulera
Summary: The study aims to investigate the effects of a VR smoking cue-reactivity paradigm on smoking craving, feasibility of EEG recording, and induction of craving levels associated to EEG desynchronization. The results showed that smoking cue VR increased smoking craving in smokers, but not in non-smokers, and that EEG alpha band power in posterior leads was significantly increased by the smoking context scenario in smokers, indicating a potential neurophysiological marker of smoking cue-reactivity.
PSYCHOPHARMACOLOGY
(2021)
Review
Food Science & Technology
Alessandro Picelli, Mirko Filippetti, Giorgio Sandrini, Cristina Tassorelli, Roberto De Icco, Nicola Smania, Stefano Tamburin
Summary: This systematic review provides a comprehensive overview of the current literature on the protocols of electrical stimulation to enhance the effect of BoNT-A injection in treating spasticity. Data on patient characteristics, electrical stimulation protocols, and outcome measures were collected and critically discussed based on the neurobiology of BoNT-A uptake.
Review
Oncology
Stefano Tamburin, Susanna B. Park, Angelo Schenone, Elisa Mantovani, Mehrnaz Hamedani, Paola Alberti, Vesile Yildiz-Kabak, Ian R. Kleckner, Noah Kolb, Miryam Mazzucchelli, Brendan L. McNeish, Andreas A. Argyriou, Guido Cavaletti, Ahmet Hoke
Summary: Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are limited. This study systematically reviewed non-pharmacological interventions for CIPN and provided evidence-based recommendations. However, due to methodological issues in the included studies, the reviewed evidence should be considered as preliminary.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Neurosciences
Damiana Scuteri, Marianna Contrada, Teresa Loria, Paolo Tonin, Giorgio Sandrini, Stefano Tamburin, Pierluigi Nicotera, Giacinto Bagetta, Maria Tiziana Corasaniti
Summary: This study aims to assess the effectiveness of analgesia therapy for agitation in Alzheimer's disease patients and the effect of painkillers on pain relief and reduction of agitation.
Editorial Material
Clinical Neurology
Elisa Mantovani, Stefano Tamburin
Summary: Chemosensory dysfunction, including olfaction and taste, is common in various diseases and the elderly population. It significantly impacts patients' quality of life, yet there is no established treatment for taste disorders. A recent study suggests that pramipexole, a D2/D3 agonist, may be a potential therapeutic target for taste dysfunction, warranting further clinical trials.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Alessandro Dinoto, Elisa Mantovani, Sergio Ferrari, Sara Mariotto, Stefano Tamburin
Summary: This study aimed to phenotype cerebellar immune-related adverse events (iRAEs). The findings revealed that cerebellar iRAEs are usually multifocal and most associated with exposure to PD-1 inhibitors. The most common associated tumors among the patients were lung cancer, melanoma, and Merkel cell carcinoma. Abnormalities were observed in magnetic resonance imaging and inflammatory cerebrospinal fluid findings.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Elisa Mantovani, Florenc Demrozi, Daniel L. Hertz, Cristian Turetta, Omar Ferro, Andreas A. Argyriou, Graziano Pravadelli, Stefano Tamburin
Summary: This study systematically reviewed data on the use of wearables, sensors, and smart devices for detecting and monitoring symptoms of CIPN. The results are promising and provide preliminary evidence for the early detection and monitoring of CIPN. However, there are several issues and knowledge gaps that need to be addressed, and the authors propose a framework for future studies.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2022)
Article
Food Science & Technology
Mirko Filippetti, Alessandro Picelli, Rita Di Censo, Sabrina Vantin, Pietro Nicola Randazzo, Giorgio Sandrini, Cristina Tassorelli, Roberto De Icco, Nicola Smania, Stefano Tamburin
Summary: This study retrospectively analyzed the use of incobotulinumtoxinA injection in children with idiopathic toe walking (ITW). The results showed that the treatment improved ankle dorsiflexion and had a longer-than-expected effect of up to 6 months in some children. No adverse effects were reported. These findings provide a basis for future randomized controlled trials and studies examining the combination of BoNT-A with other non-invasive approaches and exercise programs in ITW children.
Article
Neurosciences
Valentina Varalta, Elisa Evangelista, Anna Righetti, Giovanni Morone, Stefano Tamburin, Alessandro Picelli, Cristina Fonte, Michele Tinazzi, Ilaria Antonella Di Vico, Andreas Waldner, Mirko Filippetti, Nicola Smania
Summary: This study investigated the effect of upper limb vibratory stimulation training on cognitive functioning in individuals with Parkinson's disease. The results showed significant improvements in cognitive status, attention, and motor functioning after rehabilitation, suggesting an impact of upper limb motor rehabilitation on cognition in Parkinson's disease.
Article
Clinical Neurology
Salvatore Sardo, Giustino Varrassi, Mario Scartozzi, Maria Caterina Pace, Vittorio Schweiger, Stefano Tamburin, Mario Musu, Gabriele Finco
Summary: This study suggests that implementing a DOOR framework for CIPN using healthcare professionals is more difficult than expected, given the significant disagreement in ranking outcomes among respondents. The survey also revealed that many prescribed drugs for CIPN have not been clinically proven to be effective.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Clinical Neurology
Chiara Barbi, Francesca Benedetta Pizzini, Stefano Tamburin, Alice Martini, Anna Pedrinolla, Fabio Giuseppe Laginestra, Gaia Giuriato, Camilla Martignon, Federico Schena, Massimo Venturelli
Summary: Fatigue is a disabling symptom of multiple sclerosis (MS) that significantly affects patients' quality of life. This review suggests that there may be structural and functional abnormalities in the brain, particularly in the thalamus and sensorimotor network, that are associated with fatigue symptoms in MS patients.
NEUROLOGY INTERNATIONAL
(2022)
