ADAMTS proteoglycanases in the physiological and pathological central nervous system

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: Differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17

(2013) Tim G. Ashlin et al.   CYTOKINE

Direct nose to brain drug deliveryviaintegrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

(2013) Chandrakantsing Vijaysing Pardeshi et al.   Expert Opinion on Drug Delivery

Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix

(2013) Rowena C. Cua et al.   GLIA

ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse

(2013) Kadir Demircan et al.   NEUROSCIENCE LETTERS

Potential of Olfactory Ensheathing Cells from Different Sources for Spinal Cord Repair

(2013) Anne Mayeur et al.   PLoS One

ADAMTS5 Functions as an Anti-Angiogenic and Anti-Tumorigenic Protein Independent of Its Proteoglycanase Activity

(2012) Saran Kumar et al.   AMERICAN JOURNAL OF PATHOLOGY

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

(2012) Lorraine W. Lau et al.   ANNALS OF NEUROLOGY

ADAMTS-1 and ADAMTS-4 Levels Are Elevated in Thoracic Aortic Aneurysms and Dissections

(2012) Pingping Ren et al.   ANNALS OF THORACIC SURGERY

Delayed treatment with chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats

(2012) Sara Soleman et al.   BRAIN

Anti-angiogenic properties of ADAMTS-4 in vitro

(2012) Yi-Ping Hsu et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Novel Role of ADAMTS-5 Protein in Proteoglycan Turnover and Lipoprotein Retention in Atherosclerosis

(2012) Athanasios Didangelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WIN-34B, a new herbal medicine, inhibits the inflammatory response by inactivating IκB-α phosphorylation and mitogen activated protein kinase pathways in fibroblast-like synoviocytes

(2012) Jeong-Eun Huh et al.   JOURNAL OF ETHNOPHARMACOLOGY

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

(2012) Ryoji Tauchi et al.   Journal of Neuroinflammation

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Selective Decline of Synaptic Protein Levels in the Frontal Cortex of Female Mice Deficient in the Extracellular Metalloproteinase ADAMTS1

(2012) Matthew D. Howell et al.   PLoS One

Regulated Proteolytic Processing of Reelin through Interplay of Tissue Plasminogen Activator (tPA), ADAMTS-4, ADAMTS-5, and Their Modulators

(2012) Dimitrije Krstic et al.   PLoS One

Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats

(2012) J. J. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteoglycan degradation by the ADAMTS family of proteinases

(2011) Heather Stanton et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments

(2011) Masanori Sasaki et al.   EXPERIMENTAL NEUROLOGY

Chondroitinase treatment following spinal contusion injury increases migration of oligodendrocyte progenitor cells

(2011) Justin R. Siebert et al.   EXPERIMENTAL NEUROLOGY

Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2011) Yoshikuni MIMATA et al.   International Journal of Rheumatic Diseases

The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes

(2011) Justin R. Siebert et al.   JOURNAL OF NEUROCHEMISTRY

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

(2010) Ngee H. Lim et al.   BIOCHEMICAL JOURNAL

Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury

(2010) Elizabeth J. Bradbury et al.   BRAIN RESEARCH BULLETIN

Extracellular Protease ADAMTS9 Suppresses Esophageal and Nasopharyngeal Carcinoma Tumor Formation by Inhibiting Angiogenesis

(2010) P. H. Y. Lo et al.   CANCER RESEARCH

The role of ADAMTSs in arthritis

(2010) Edward A. Lin et al.   Protein & Cell

Combining Peripheral Nerve Grafts and Chondroitinase Promotes Functional Axonal Regeneration in the Chronically Injured Spinal Cord

(2009) V. J. Tom et al.   JOURNAL OF NEUROSCIENCE

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat

(2009) Martin J. Reid et al.   NEUROSCIENCE LETTERS

Brain Extracellular Matrix in Neurodegeneration

(2008) Dafna Bonneh-Barkay et al.   BRAIN PATHOLOGY

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques

(2007) Dick Wågsäter et al.   ATHEROSCLEROSIS

Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension

(2007) Michelle G. Hamel et al.   EXPERIMENTAL NEUROLOGY