Article
Biotechnology & Applied Microbiology
Lixian Huang, Bo Zhao, Qunxian Li, Jing Wu, Hui Jiang, Qingbin Li
Summary: Ephedrine has been proven to possess neuroprotective effects by activating the PI3K/AKT signaling pathway in a rat model of middle cerebral artery occlusion (MCAO), while also demonstrating anti-inflammatory and anti-oxidative stress effects.
Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Pradeepkumar Nambi, Yogeshkanna Sathyamoorthy, Kathiravan Kaliyappan, Rameshkumar Radhakrishnan
Summary: Ischemic reperfusion injury can lead to neural death and severe neurobehavioral deficits. Current interventions have not effectively targeted the multiple mechanisms involved in cerebral ischemia-induced damage. An integrative intervention is needed to overcome these harmful mechanisms.
Article
Biochemistry & Molecular Biology
Mikhail V. Onufriev, Yulia V. Moiseeva, Marina Y. Zhanina, Natalia A. Lazareva, Natalia V. Gulyaeva
Summary: A direct comparison between rat MCAO-KM and MCAO-LM models showed similar outcomes in terms of infarct volume, mortality rate, neurological deficit, and weight loss three days after MCAO induction, but significant differences were observed in corticosterone and interleukin-1 beta release as well as hippocampal accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Chanchan Li, Luyi Lin, Chengfeng Sun, Xiaozhu Hao, Lekang Yin, Xiaoxue Zhang, Jiaqi Tian, Zhengwei Yao, Xiaoyuan Feng, Yanmei Yang
Summary: This study aimed to investigate the changes in the impaired glymphatic system in the thalamus after ischemic stroke by pathology and MRI. The results showed that the glymphatic system was severely impaired at the 2nd week after stroke, and this could be observed by DCE-MRI. These findings contribute to a better understanding of the mechanism of brain injury after stroke and the clinical treatment of ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Sijie Li, Wenbo Zhao, Guiyou Liu, Changhong Ren, Ran Meng, Yuan Wang, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Chronic remote ischemic conditioning (RIC) appears to be well-tolerated and associated with a low annual risk of ischemic stroke and cardio-cerebrovascular events in patients with symptomatic internal carotid artery or middle cerebral artery occlusion with impaired hemodynamics.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuelin Zhao, Xiaohua Shi, Jiaoqi Wang, Jing Mang, Zhongxin Xu
Summary: The study found that betulinic acid can reduce cerebral injury by decreasing oxidative stress, as well as activate the SIRT1/FoxO1 pathway to suppress autophagy and improve cerebral injury.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mikhail V. V. Onufriev, Mikhail Y. Y. Stepanichev, Yulia V. V. Moiseeva, Marina Y. Y. Zhanina, Olga A. A. Nedogreeva, Pavel A. A. Kostryukov, Natalia A. A. Lazareva, Natalia V. V. Gulyaeva
Summary: This study showed that the use of different middle cerebral artery occlusion (MCAO) models in rats could result in distinct patterns of hormone and inflammatory cytokine accumulation. The MCAO-KM model, but not the MCAO-LM model, exhibited bilateral accumulation of corticosterone and IL1 beta in the hippocampus and frontal cortex. Furthermore, only the MCAO-LM rats demonstrated memory deficits in a passive avoidance test.
Article
Clinical Neurology
Andrea Naldi, Alessandra Di Liberto, Enrica Duc, Alessandro Rapellino, Giacomo Paolo Vaudano, Roberto Cavallo, Andrea Boghi
Summary: Bilateral simultaneous middle cerebral artery occlusion is a rare condition that requires rapid intervention for restoring brain perfusion. Perfusion-computed tomography is essential for selecting stroke patients for mechanical thrombectomy, but its role in guiding the optimal treatment strategy for concomitant multivessel cerebral occlusion has not been reported before. This case study highlights the importance of perfusion-computed tomography in both guiding endovascular procedures and planning the sequence of mechanical thrombectomies for bilateral middle cerebral artery occlusion.
NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo, John H. Zhang
Summary: Activation of TGR5 mitigates brain injury by inhibiting neuroinflammation after MCAO, potentially mediated by Pellino3 inhibition of caspase-8/NLRP3.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Shirley H. T. Truong, Benjamin Bonnici, Samoda Rupasinghe, Barbara K. Kemp-Harper, Chrishan S. Samuel, Brad R. S. Broughton
Summary: Brain inflammation and apoptosis contribute to neuronal damage and loss following ischaemic stroke, leading to cognitive and functional disability. H2-relaxin, a hormone with anti-inflammatory and anti-apoptotic effects, shows potential as a therapeutic for stroke. This study investigated the effects of post-stroke administration of H2-relaxin and found that it improved motor function and decreased apoptosis in a dose-dependent manner.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Neurosciences
Lang Zeng, Shengqi Hu, Lingcheng Zeng, Rudong Chen, Hua Li, Jiasheng Yu, Hongkuan Yang
Summary: Ischemic stroke is a common type of stroke that has a significant impact on human well-being and quality of life. To better understand the pathophysiology of ischemic stroke and develop new treatment strategies, controllable and consistent animal models are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used model for studying ischemic stroke. This review discusses different methods for constructing the MCAO model and compares their advantages and disadvantages, aiming to provide better approaches for studying ischemic stroke.
Review
Clinical Neurology
Jennifer D. Sokolowski, Sauson Soldozy, Khadijeh A. Sharifi, Pedro Norat, Kathryn N. Kearns, Lei Liu, Ashley M. Williams, Kaan Yagmurlu, Panagiotis Mastorakos, G. Wilson Miller, M. Yashar S. Kalani, Min S. Park, Ryan T. Kellogg, Petr Tvrdik
Summary: Stroke is a major burden, and despite advances in prevention and treatment, it still negatively affects patients, families, and healthcare professionals. Preclinical basic research, particularly using mouse models, can help to understand stroke pathology and discover effective interventions. This article reviews the middle cerebral artery occlusion technique and introduces various imaging approaches to enhance preclinical stroke evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Nobutaka Masuoka, Chitose Yoshimine, Marie Hori, Mieko Tanaka, Takashi Asada, Keiichi Abe, Tatsuhiro Hisatsune
Article
Neurosciences
Kung-Chun Kao, Tatsuhiro Hisatsune
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Keisuke Sakurai, Teppei Shintani, Naohiro Jomura, Takeshi Matsuda, Akira Sumiyoshi, Tatsuhiro Hisatsune
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Nobutaka Masuoka, Chenxu Lei, Haowei Li, Noriko Inamura, Shigenobu Shiotani, Nobuya Yanai, Kenichiro Sato, Keisuke Sakurai, Tatsuhiro Hisatsune
Summary: The study found that anserine can protect MCI patients from cognitive decline by suppressing MPO-mediated neuroinflammatory responses. The significant difference in MMSE change scores between the active and placebo arms highlights the protective effect of anserine on cognitive function in elderly individuals with MCI.
Article
Nutrition & Dietetics
Keisuke Sakurai, Chutong Shen, Yuri Ezaki, Noriko Inamura, Yoichi Fukushima, Nobutaka Masuoka, Tatsuhiro Hisatsune
Article
Nutrition & Dietetics
Keisuke Sakurai, Chutong Shen, Izumi Shiraishi, Noriko Inamura, Tatsuhiro Hisatsune
Summary: The study found a significant correlation between cognitive function in elderly individuals and daily consumption of fat, especially in monounsaturated fatty acids and oleic acid. This suggests that the intake of these fats may have a beneficial effect on cognitive decline in community-dwelling Japanese elderly individuals.
Article
Multidisciplinary Sciences
Keisuke Sakurai, Haowei Li, Noriko Inamura, Nobutaka Masuoka, Tatsuhiro Hisatsune
SCIENTIFIC REPORTS
(2020)
Article
Engineering, Electrical & Electronic
Tobias Tymosch, Manuel Fischer, Vasken Ketchedjian, Yutaka Terao, Hiroyuki Ohsaki
Summary: This article evaluates a novel design approach for a 3 MW partially superconducting synchronous machine for electric aircraft propulsion, which uses an electromagnetic Halbach array to reduce back yoke weight and increase overall power density. The Halbach array achieves better magnetic field intensity characteristics compared to traditional superconducting field winding designs, with potential reductions in yoke thickness and weight.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2021)
Article
Neurosciences
Daisuke Koketsu, Satomi Chiken, Tatsuhiro Hisatsune, Shigehiro Miyachi, Atsushi Nambu
Summary: This study used a photodynamic technique to selectively eliminate the cortico-subthalamo projection in male mice, and found that after elimination, cortically evoked early excitation in the substantia nigra pars reticulata was diminished, while the cortically evoked inhibition and late excitation delivered through the direct and indirect pathways remained unchanged. In addition, locomotor activity was significantly increased after bilateral cortico-subthalamo elimination.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Kezhen Qian, Yutaka Terao, Hiroyuki Ohsaki
Summary: A versatile 3D electromagnetic and thermal field coupled FEM analysis tool was developed for REBCO coils in this research, and its capability in studying the transient electromagnetic and thermal behaviors was verified through two case studies. The first case study focused on the transient behaviors of SFCL REBCO coils under overcurrent, while the second case study explored the influence of external energy input on the quench of magnet REBCO coils. Additionally, the limitations and improvements of the quench detection scheme based on voltage detection were discussed.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2021)
Article
Engineering, Electrical & Electronic
Y. Terao, Y. Iwata, Y. Takagi, S. Fuchino, H. Ohsaki
Summary: This paper presents a new AC loss measurement system for MgB2 superconducting coils under a rotating magnetic field. The system measures the AC loss by measuring the difference in mechanical input. Experimental results show that this method is effective and accurate.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2022)
Article
Nutrition & Dietetics
Keisuke Sakurai, Takayuki Toshimitsu, Erika Okada, Saya Anzai, Izumi Shiraishi, Noriko Inamura, Satoru Kobayashi, Toshihiro Sashihara, Tatsuhiro Hisatsune
Summary: This study found that ingestion of Lactiplantibacillus plantarum OLL2712 had protective effects against memory function decline in older adults. Significant improvements in composite memory and visual memory scores were observed in the active group. Additionally, the active group showed a lower abundance ratio of bacteria genera related to inflammation.
Article
Nutrition & Dietetics
Keisuke Sakurai, Erika Okada, Saya Anzai, Risako Tamura, Izumi Shiraishi, Noriko Inamura, Satoru Kobayashi, Mikako Sato, Takashi Matsumoto, Kazuyuki Kudo, Yukihiro Sugawara, Tatsuhiro Hisatsune
Summary: In this study, the dietary patterns of elderly Japanese individuals were classified using cluster analysis, and a high-carbohydrate (HC) dietary pattern and a protein-balanced (PB) dietary pattern were identified. Cognitive function was significantly higher in the PB group than in the HC group. A classification model was created to predict cognitive reservation in community-dwelling older adults based on these dietary patterns.
Article
Engineering, Electrical & Electronic
Yutaka Terao, Haruka Nakamura, Satsuki Okumura, Shuichiro Fuchino, Hiroyuki Ohsaki
Summary: In this paper, the authors measured AC losses of an MgB2 superconducting coil at 20 K by applying a rotating magnetic field and induced alternating current. The AC loss of the coil and the ohmic loss at the load were measured and estimated using torque meter and current probe, respectively. The results showed good agreement between the measured and calculated AC losses at 80 Hz, with values of 7.23 W/cm(3) and 7.17 W/cm(3), respectively. Measurement and analysis results were consistent in the 40-80 Hz range.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2023)
Article
Engineering, Electrical & Electronic
Brian Marchionini, Steve Eckroad, Laura Serri, Giuliano Angeli, Hiroyuki Ohsaki, Donald Mosteller, Luciano Martini
Summary: The International Energy Agency's High Temperature Superconductivity Technology Collaboration Program (IEA HTS TCP) analyzed the readiness levels of HTS applications in the energy delivery sector. A Readiness Map was created to illustrate the technology readiness over time. Assessing these levels is important for the transition to safer, more efficient and cleaner power supply. The experts categorized the applications into low, medium and high readiness levels instead of specific TRL numbers.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2023)