Article
Neurosciences
Yiru Zhou, Ruihua Fan, Benson O. A. Botchway, Yong Zhang, Xuehong Liu
Summary: Traumatic brain injury (TBI) has high morbidity and mortality rates, impacting physical and mental health and causing significant burden to individuals and society. Current management strategies for TBI focus on controlling inflammation, with tumor necrotizing factor alpha (TNF-alpha) playing a crucial role in post-TBI neuroinflammation. Infliximab, a monoclonal anti-TNF-alpha antibody, is recognized for its ability to reduce inflammation in TBI.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Jianqin Xue, Yu Zhang, Junhua Zhang, Zhujun Zhu, Qi Lv, Jianhua Su
Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Leilei Mao, Limin Sun, Jingyi Sun, Baoliang Sun, Yanqin Gao, Hong Shi
Summary: The study demonstrates that EP treatment can improve sensorimotor function following TBI, reduce white matter injury, and modulate microglia polarization toward the anti-inflammatory M2 phenotype during the acute phase of TBI recovery, improving the release of inflammatory-related factors.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Ioannis Stratos, Ann-Kathrin Behrendt, Christian Anselm, Aldebarani Gonzalez, Thomas Mittlmeier, Brigitte Vollmar
Summary: The study found that TNF-alpha blockade may help promote recovery after muscle injury, positively impacting the repair of muscle tissue and reducing tissue degradation.
Review
Physiology
Rodrigo G. Mira, Matias Lira, Waldo Cerpa
Summary: Traumatic brain injury (TBI) is a heterogeneous disorder that causes brain damage due to external forces, leading to CNS damage under various mechanisms. Glial cells such as astrocytes, microglia, and oligodendrocytes play crucial roles in response to TBI, affecting neuronal damage and pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ping Zheng, Qingke Bai, Jiugeng Feng, Bing Zhao, Jian Duan, Lin Zhao, Ning Liu, Dabin Ren, Shufeng Zou, Wei Chen
Summary: The research showed that the transplantation of neonatal microglia or protease inhibitors-treated adult microglia significantly improved cognitive function and inhibited neuroinflammation in a rat model of traumatic brain injury.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Eric A. Sribnick, Timothy Warner, Mark W. Hall
Summary: The study suggests that combined injury can lead to adaptive immune suppression, particularly with a marked increase in apoptosis in the spleen, and potential bacterial colonization in the lungs. These findings contribute to a better understanding of post-injury immune system alterations.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Immunology
Pengju Wei, Ke Wang, Chen Luo, Yichen Huang, Dilidaer Misilimu, Huimei Wen, Peng Jin, Chuhua Li, Ye Gong, Yanqin Gao
Summary: The study demonstrates that cordycepin can protect neurological function by suppressing neutrophil infiltration, preserving blood-brain barrier integrity, and altering microglia/macrophage polarization after traumatic brain injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Tamas Kovacs-Oller, Renata Zempleni, Boglarka Balogh, Gergely Szarka, Balint Fazekas, Adam J. Tengolics, Krisztina Amrein, Endre Czeiter, Istvan Hernadi, Andras Buki, Bela Volgyi
Summary: Traumatic brain injury (TBI) is a major cause of sudden death after head trauma. The retina, as part of the brain, can also be affected by TBI, both in severe and mild-repetitive cases. Our study found that the level of inflammation and cell death in the retina differs between sTBI and rmTBI, indicating different response mechanisms. Therefore, the retina may serve as a model for studying head injuries and developing new diagnostic procedures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Kristina G. Witcher, Chelsea E. Bray, Titikorn Chunchai, Fangli Zhao, Shane M. O'Neil, Alan J. Gordillo, Warren A. Campbell, Daniel B. McKim, Xiaoyu Liu, Julia E. Dziabis, Ning Quan, Daniel S. Eiferman, Andy J. Fischer, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Saef Izzy, Alexander Brown-Whalen, Taha Yahya, Aliyah Sarro-Schwartz, Gina Jin, Joon Yong Chung, Sevda Lule, Liza M. Morsett, Ali Alquraini, Limin Wu, Suzanne E. Hickman, Michael J. Whalen, Joseph El Khoury
Summary: The study found that repetitive closed head injury (rCHI) did not accelerate tau pathology and did not worsen behavioral outcomes in adolescent mice. However, rCHI induced microgliosis in the cortex and hippocampus and astrocytosis in the corpus callosum of P301S mice by 40 days post-injury. There were no significant microgliosis or astrocytosis observed in age-matched WT mice or sham-injured P301S mice after rCHI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yunqian Guan, Ren Wang, Xiaobo Li, Haiqiang Zou, Wenxiu Yu, Zhaohui Liang, Lei Li, Ling Chen, Liping Zhou, Zhiguo Chen
Summary: The study found that astrocytes, not microglia, were the main source of TNF-alpha expression in the infarct area of rats after ischemia. MSC transplantation was shown to suppress TNF-alpha expression by astrocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouvina, Mollie Witzel, Jonathan P. Godbout
Summary: The neurobiological mechanisms underlying worsened functional outcomes after traumatic brain injury (TBI) in the elderly remain unclear. This study found that aged mice showed more severe cognitive impairment, gliosis, and neuroinflammation after TBI compared to adult mice. Age was associated with enhanced expression of cytokine/chemokine, complement, innate immune, and interferon-associated inflammatory genes in the cortex. Type I interferon (IFN) signaling was significantly enhanced in the aged brain after TBI. Overall, TBI promoted amplified IFN signaling in aged mice, resulting in extended inflammation and gliosis.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Karen Krukowski, Amber Nolan, McKenna Becker, Katherine Picard, Nathalie Vernoux, Elma S. Frias, Xi Feng, Marie-Eve Tremblay, Susanna Rosi
Summary: The study revealed that one week after brain injury, microglia exhibit increased phagocytic activity, synaptic engulfment, and neuronal contact, which may contribute to cognitive deficits. By utilizing state-of-the-art techniques, novel microglia-mediated mechanisms that impact neuronal function after TBI were uncovered.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Marine Tessier, Marta Saez Garcia, Emmanuelle Goubert, Edith Blasco, Amandine Consumi, Benoit Dehapiot, Li Tian, Florence Molinari, Jerome Laurin, Francois Guillemot, Christian A. Huebner, Christophe Pellegrino, Claudio Rivera
Summary: The study reveals a novel mechanism of action for the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide in neurological disorders. It shows that bumetanide accelerates microglial activation dynamics, resulting in an increase in parvalbumin interneuron survival through increased microglial BDNF expression and contact with interneurons.
Review
Toxicology
Rong-Jane Chen, Yu-Hsuan Lee, Tzu-Hao Chen, Yu-Ying Chen, Ya-Ling Yeh, Ching-Ping Chang, Chien-Cheng Huang, How-Ran Guo, Ying-Jan Wang
Summary: Carbon monoxide, known as a silent killer, can reduce oxygen carrying capacity in the body by binding to hemoglobin. While toxic at high concentrations, CO has cyto- and tissue-protective effects at low concentrations, modulating inflammatory responses through regulation of cytokine production. Understanding the interplay between mitochondria, autophagy, exosomes, and the inflammasome is crucial for understanding the health effects of CO and potential treatment strategies for inflammation-related diseases.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Pei-Hsuan Lin, Kuan-Hua Huang, Yu-Feng Tian, Cheng-Hsien Lin, Chien-Ming Chao, Ling-Yu Tang, Kun-Lin Hsieh, Ching-Ping Chang
Summary: This study examined the effects of exertional heat stroke (EHS) on fertility, erectile function, and testicular morphology in male rats. The results showed that EHS caused testicular temperature disruption, damage to testicular tissues, and erectile dysfunction in the rats.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Shu-Chun Kuo, Chung-Ching Chio, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
Summary: In vivo and in vitro studies showed that A beta(1-42) oligomer affects retinal morphology and cell viability, leading to dysmorphological changes and decreased expression of tight junction proteins. Conditioned medium from mesenchymal stem cells protected against A beta-induced retinal pathology by influencing various signaling pathways and protein expressions. Secretomes from MSC-CM might have potential therapeutic implications in age-related macular degeneration.
Correction
Neurosciences
Yu-Lin Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Yu-Ling Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
Summary: This study aims to investigate the beneficial effects of exercise rehabilitation and/or astragaloside in counteracting amyloid-beta pathology. The results showed that exercise rehabilitation and/or astragaloside reversed the neurobehavioral disorders and neuropathology caused by amyloid-beta. The application of BDNF and/or astragaloside also reversed the cytotoxicity and mitochondrial distress induced by amyloid-beta in cortical neurons. The combined therapy of exercise rehabilitation (or BDNF) and astragaloside showed superior therapeutic effects compared to individual treatments. The results indicate that exercise rehabilitation (or BDNF) and astragaloside attenuate amyloid-beta pathology by reversing BDNF/TrkB signaling deficits and mitochondrial dysfunction, and their combination potentiates each other's therapeutic effects. Astragaloside can be an alternative therapy to replace exercise rehabilitation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Materials Science, Coatings & Films
W. T. Lin, Z. W. Lin, T. Y. Kuo, C. S. Chien, J. W. Huang, Y. L. Chung, C. P. Chang, M. Z. Ibrahim, H. T. Lee
Summary: The addition of CNTs improves the indentation fracture toughness of Ta2O5 coatings deposited by atmospheric plasma spraying, without degrading their surface morphology and roughness. However, higher CNT content increases the coating porosity and reduces the microhardness.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Chi-Chun Chen, Yu-Lin Wang, Ching-Ping Chang
Summary: This study developed an optimised rehabilitation training system for rats with various stroke severities and used a modified ladder-climbing method for training. The results showed that this method was effective in promoting recovery for subjects with different stroke severities.
IET CIRCUITS DEVICES & SYSTEMS
(2022)
Article
Public, Environmental & Occupational Health
Chien-Cheng Huang, Tzu-Hao Chen, Chung -Han Ho, Yi-Chen Chen, Rong-Jane Chen, Ying-Jan Wang, Chien -Chin Hsu, Hung -Jung Lin, Jhi-Joung Wang, Ching -Ping Chang, How-Ran Guo
Summary: This study investigated the effects of CO poisoning on the development of diabetes and on existing diabetes through epidemiologic analyses and animal experiments. The results showed that CO poisoning increased the risks of diabetes and hyperglycemic crisis, which may be attributable to damages in the pancreas and hypothalamus.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Chemistry, Physical
Kuan-Ting Chen, Jun-Wei Huang, Wei-Ting Lin, Tsung-Yuan Kuo, Chi-Sheng Chien, Ching-Ping Chang, Yung-Ding Lin
Summary: The micro-arc oxidation (MAO) process was used to prepare hydroxyapatite-containing flower-like structure coatings on commercially pure titanium substrates. The morphology of the coatings depended on the applied voltage, with 330 V resulting in a flower-like/plate-like structure, and 390 V and 450 V resulting in a flower-like structure and a porous morphology respectively. The applied current and duration time affected the coating formation speed and petal size of the flower-like structures. The coatings with flower-like/plate-like or flower-like structures exhibited higher roughness, increased hydrophilicity, and superior bioactivity and biocompatibility. The 390 V coating had the optimal biomedical performance due to its flower-like structure and high HA/DCPD ratio.
Article
Biology
Kuan-Hua Huang, Ching-Ping Chang, Lan-Hsiang Chien, Chien-Feng Li, Ling-Yu Tang, Yu-Yi Chan, Ting-Feng Wu
Summary: This study aimed to investigate the inhibitory molecular process of pomegranate peel on urinary bladder urothelial carcinoma using a proteomics strategy. The results revealed that pomegranate peel extract can regulate various proteins involved in cell apoptosis, cell proliferation, and signaling pathways, thus inhibiting the growth and spread of cancer cells. These findings suggest that pomegranate might serve as a potential chemopreventive resource for UBUC carcinogenesis.
Article
Medicine, Research & Experimental
Chien-Ming Chao, Lin-Yu Wang, Chien-Cheng Huang, Wei-Ting Chang, Ling-Yu Tang, Mao-Tsun Lin, Chang Ching-Ping
Summary: Using a survival male rat model of acute exertional heat stroke (EHS), this study investigated the effects of EHS on myocardium structure and function. It was found that EHS caused skeletal muscle and myocardial damage, with myocardial damage lasting for at least 14 days post-EHS. This study is significant as it provides key findings on the pathophysiology and risk factors of EHS, as well as highlighting the need for further research.
Article
Neurosciences
Tian-Hoe Tan, Shih-Wen Li, Chih-Wei Chang, Yuan-Chih Chen, Yu-Hsuan Liu, Jui-Ti Ma, Ching-Ping Chang, Pao-Chi Liao
Summary: In this study, hair was found to undergo metabolic changes in rats induced with beta-amyloid, which were associated with cognitive impairments. Furthermore, these changes observed in the hair of beta-amyloid-induced rats showed a similar trend to the metabolites found in the cerebrospinal fluid of Alzheimer's disease patients. Therefore, hair can be a valuable biospecimen for assessing endogenous metabolic disturbances and identifying biomarkers of Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chien-Liang Liu, Hung-Wen Tsai, Shu-Ling Peng, Ching-Ping Chang, Yu-Hao Chang, Huei-Sheng Huang
Summary: Urine-based cytology is commonly used for clinical diagnosis of urothelial carcinoma (UC), but its sensitivity is limited for low-grade UC detection. This study found that CDCP1 expression was significantly higher in UC patients, especially those with low-grade UC, compared to normal individuals. CDCP1 expression in urinary UC cells was also detected using immunocytochemistry. The overexpression and knockdown of CDCP1 in UC cells influenced migration ability, suggesting its potential role in the malignant progression of UC.
Article
Cell Biology
Tzong-Bor Sun, Kuo-Feng Huang, Ko-Chi Niu, Cheng-Hsien Lin, Wen-Pin Liu, Chao-Hung Yeh, Shu-Chun Kuo, Ching-Ping Chang
Summary: Hyperbaric oxygen preconditioning can reverse oxygen-glucose deprivation-induced retinal pigment epithelial cell injury by activating PPAR-a signaling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Meeting Abstract
Urology & Nephrology
Kun-Lin Hsieh, Ching-Ping Chang, Kuan-Hua Huang, Allen W. Chiu
INTERNATIONAL JOURNAL OF UROLOGY
(2022)