A Biological Perspective of CSF Lipids as Surrogate Markers for Cognitive Status in HIV

Decreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity

(2014) Mehrdad Alirezaei et al.   Autophagy

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy

(2013) Aylin Yilmaz et al.   Journal of Neuroinflammation

Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

(2013) LiZe Gu et al.   Journal of Neuroinflammation

The New Small-Molecule Mixed-Lineage Kinase 3 Inhibitor URMC-099 Is Neuroprotective and Anti-Inflammatory in Models of Human Immunodeficiency Virus-Associated Neurocognitive Disorders

(2013) D. F. Marker et al.   JOURNAL OF NEUROSCIENCE

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production

(2013) Xuesong Chen et al.   NEUROBIOLOGY OF AGING

A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects

(2013) V. V. R. Bandaru et al.   NEUROLOGY

Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

(2012) Ruben van Doorn et al.   ACTA NEUROPATHOLOGICA

Ceramide function in the brain: when a slight tilt is enough

(2012) Chiara Mencarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection

(2012) Anupa Kamat et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

(2012) Terina N Martinez et al.   Molecular Neurodegeneration

Sphingolipids: Critical players in Alzheimer’s disease

(2012) Gerhild van Echten-Deckert et al.   PROGRESS IN LIPID RESEARCH

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Aberrant Upregulation of Astroglial Ceramide Potentiates Oligodendrocyte Injury

(2011) SunJa Kim et al.   BRAIN PATHOLOGY

Ceramides as modulators of cellular and whole-body metabolism

(2011) Benjamin T. Bikman et al.   JOURNAL OF CLINICAL INVESTIGATION

SIV/Macaque Model of HIV Infection in Cocaine Users: Minimal Effects of Cocaine on Behavior, Virus Replication, and CNS Inflammation

(2011) Michael Weed et al.   Journal of Neuroimmune Pharmacology

The Human Immunodeficiency Virus Coat Protein gp120 Promotes Forward Trafficking and Surface Clustering of NMDA Receptors in Membrane Microdomains

(2011) H. Xu et al.   JOURNAL OF NEUROSCIENCE

Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes

(2011) Ronald A Cohen et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 Coinfection and Morphine Coexposure Severely Dysregulate Hepatitis C Virus-Induced Hepatic Proinflammatory Cytokine Release and Free Radical Production: Increased Pathogenesis Coincides with Uncoordinated Host Defenses

(2011) N. El-Hage et al.   JOURNAL OF VIROLOGY

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease

(2011) Yong Joo Lee et al.   PLoS One

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

(2011) Danni Cheng et al.   PLoS One

Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss

(2010) Michelle M. Mielke et al.   Alzheimers & Dementia

PrPC, the Cellular Isoform of the Human Prion Protein, Is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation

(2010) Toni K. Roberts et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits

(2010) Y. Sun et al.   HUMAN MOLECULAR GENETICS

HIV Infection and Aging Independently Affect Brain Function as Measured by Functional Magnetic Resonance Imaging

(2010) Beau M. Ances et al.   JOURNAL OF INFECTIOUS DISEASES

Pathophysiology of neuropathic lysosomal storage disorders

(2010) Cinzia Maria Bellettato et al.   JOURNAL OF INHERITED METABOLIC DISEASE

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Sphingolipids in Neurodegeneration

(2010) Norman J. Haughey   NEUROMOLECULAR MEDICINE

Increased Monocyte Turnover from Bone Marrow Correlates with Severity of SIV Encephalitis and CD163 Levels in Plasma

(2010) Tricia H. Burdo et al.   PLoS Pathogens

Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection

(2010) Lars Hagberg et al.   AIDS Research and Therapy

Persistent Hijacking of Brain Proteasomes in HIV-Associated Dementia

(2009) Trung P. Nguyen et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingolipids in inflammation: pathological implications and potential therapeutic targets

(2009) Graeme F. Nixon   BRITISH JOURNAL OF PHARMACOLOGY

Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

(2009) David Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

(2009) Cristian L. Achim et al.   Journal of Neuroimmune Pharmacology

Increased frequency of α-synuclein in the substantia nigra in human immunodeficiency virus infection

(2009) Negar Khanlou et al.   JOURNAL OF NEUROVIROLOGY

White matter tract injury and cognitive impairment in human immunodeficiency virus–infected individuals

(2009) Assawin Gongvatana et al.   JOURNAL OF NEUROVIROLOGY

Evidence for ongoing brain injury in human immunodeficiency virus–positive patients treated with antiretroviral therapy

(2009) VA Cardenas et al.   JOURNAL OF NEUROVIROLOGY

Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death

(2009) Arundhati Jana et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Ceramide-enriched membrane domains—Structure and function

(2008) Yang Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

(2008) David Wheeler et al.   BRAIN

Cyclooxygenase-1 and -2 in the Different Stages of Alzheimers Disease Pathology

(2008) J. Hoozemans et al.   CURRENT PHARMACEUTICAL DESIGN

Neurodegeneration and Ageing in the HAART Era

(2008) Bruce J. Brew et al.   Journal of Neuroimmune Pharmacology

Greater Than Age-Related Changes in Brain Diffusion of HIV Patients After 1 Year

(2008) Linda Chang et al.   Journal of Neuroimmune Pharmacology

Aging exacerbates extrapyramidal motor signs in the era of highly active antiretroviral therapy

(2008) Victor Valcour et al.   JOURNAL OF NEUROVIROLOGY

Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study

(2008) Aaron McMurtray et al.   Journal of Stroke & Cerebrovascular Diseases

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration

(2008) Mehrdad Alirezaei et al.   PLoS One

Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones

(2007) N Tsakiri et al.   BRITISH JOURNAL OF PHARMACOLOGY

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

(2007) Veera Venkata Ratnam Bandaru et al.   NEUROBIOLOGY OF AGING