Article
Psychiatry
Ivan Milenkovic, Lucie Bartova, Konstantinos Papageorgiou, Siegfried Kasper, Tatjana Traub-Weidinger, Dietmar Winkler
Summary: Diagnosing parkinsonian syndromes in patients with severe depression can be challenging due to overlapping clinical phenomena. [I-123]FP-CIT-SPECT is a useful method for detecting degenerative parkinsonian disorders but drugs may influence the results. Consultation with a movement disorder specialist prior to dopamine transporter imaging is recommended.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Hiroshi Mitoma, Hitoshi Aizawa
Summary: The results of this study showed that I-123-FP-CIT-SPECT findings were significantly associated with motor severity and gait severity in drug-naive patients with Parkinson's disease (PD), particularly the mean specific binding ratios of the striatum and anterior putamen.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Yuan Chen, Marlies C. Goorden, Freek J. Beekman
Summary: The study investigated the feasibility of CNN methods for axially focused I-123-FP-CIT scans, showing that CNN-AC can significantly improve the quantitative accuracy of localized regions.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Biology
Maria Silvia De Feo, Viviana Frantellizzi, Nicoletta Locuratolo, Arianna Di Rocco, Alessio Farcomeni, Caterina Pauletti, Andrea Marongiu, Julia Lazri, Susanna Nuvoli, Francesco Fattapposta, Giuseppe De Vincentis, Angela Spanu
Summary: This multicenter retrospective study aimed to assess the diagnostic accuracy of 123I-FP-CIT (DAT-SPECT), 123I-MIBG (mIBG-scintigraphy), or a combination of both exams in de novo Parkinson's disease patients. The results showed that mIBG-scintigraphy has higher diagnostic accuracy in de novo Parkinson's disease patients compared to DAT-SPECT. Therefore, the combined use of both exams does not appear to be mandatory in the early phase of Parkinson's disease.
Review
Clinical Neurology
Balestrino Roberta, Barone Paolo, Filippi Massimo, Erro Roberto
Summary: Although the diagnosis of Parkinson's disease relies on clinical presentation, the use of imaging techniques, particularly DAT imaging, can aid in differential diagnosis. Structural lesions and certain medications may alter the results of DAT imaging, and unexpected findings such as SWEDD or SWIDD should be considered.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Claudia Del Gamba, Antonino Bruno, Daniela Frosini, Duccio Volterrani, Gianmichele Migaleddu, Nicola Benedetto, Paolo Perrini, Claudio Pacchetti, Mirco Cosottini, Ubaldo Bonuccelli, Roberto Ceravolo
Summary: iNPH is a debated condition with controversial pathogenesis and diagnostic criteria. Parkinsonian signs are frequently reported, which may or may not be related to an underlying neurodegenerative parkinsonism, and distinguishing between the two is crucial for predicting long-term response to cerebrospinal fluid drainage.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuliya Piatkova, Pierre Payoux, Caroline Boursier, Manon Bordonne, Veronique Roch, Pierre-Yves Marie, Gabriela Hossu, Laetitia Imbert, Antoine Verger
Summary: This study compared I-123-FP-CIT SPECT imaging obtained from a 360 degrees CZT camera with different focus configurations to that from a conventional Anger camera. The results showed that the 360 degrees CZT camera provided higher image quality, shorter acquisition times, and fewer discordant cases compared to the conventional camera, possibly due to its higher spatial resolution.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthime Flaus, Remi Philippe, Stephane Thobois, Marc Janier, Christian Scheiber
Summary: This study aimed to demonstrate the equivalence between the specific binding ratios (SBR) of visually normal I-123-FP-CIT SPECT scans from patients and those from healthy volunteers or patients without dopaminergic degeneration, for use as a reference database. A statistical model was constructed, which showed significant correlations between SBR values and age and gender, as well as an interaction between SBR and age-gender. The proposed post-reconstruction harmonization method can facilitate the use of semi-quantitative analysis.
Article
Geriatrics & Gerontology
Toji Miyagawa, Scott A. Przybelski, Daniela Maltais, Hoon-Ki Min, Lennon Jordan, Timothy G. Lesnick, Qin Chen, Jonathan Graff-Radford, David Jones, Rodolfo Savica, David Knopman, Ronald Petersen, Walter K. Kremers, Leah K. Forsberg, Julie A. Fields, Tanis J. Ferman, Laura Allen, Joseph Parisi, R. Ross Reichard, Melissa Murray, Dennis Dickson, Bradley F. Boeve, Kejal Kantarci, Val J. Lowe
Summary: Multimodal imaging with I-123-FP-CIT SPECT helps differentiate DLBs and ADem, providing additional diagnostic value and detecting complex pathology in patients with DLBs and ADem.
NEUROBIOLOGY OF AGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elon Wallert, Erwann Letort, Friso van der Zant, Ania Winogrodzka, Henk Berendse, Martijn Beudel, Rob de Bie, Jan Booij, Pieter Raijmakers, Elsmarieke van de Giessen
Summary: This study compared the results of FDOPA-PET and DAT-SPECT in patients with parkinsonian syndromes and found that DAT-SPECT was more often abnormal than FDOPA-PET in early disease stages, indicating a greater loss of DAT binding in CUPS patients.
Article
Neurosciences
Cecilia Boccalini, Giulia Carli, Andrea Pilotto, Alessandro Padovani, Daniela Perani
Summary: This study investigated the impact of gender differences on clinical features, dopaminergic dysfunction, and connectivity in patients with Parkinson's disease across different clinical subtypes. Results showed that males and females with idiopathic PD exhibit distinct vulnerabilities and disease expressions, particularly in cognitive function, anxiety symptoms, and dopaminergic binding patterns in different brain regions.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Geriatrics & Gerontology
Niels Hansen, Claudia Lange, Charles Timaeus, Jens Wiltfang, Caroline Bouter
Summary: The study found that 55% of patients with positive 123I-FP-CIT SPECT and probable DLB exhibited psychiatric features, and there was a significant increase in the number of probable DLB patients with psychiatric symptoms after undergoing 123I-FP-CIT SPECT over a 6-year period. Additionally, there were no phenotypical differences between DLB patients with positive and negative 123I-FP-CIT SPECT.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Elena Contaldi, Luca Magistrelli, Alessia Furgiuele, Silvia Gallo, Cristoforo Comi
Summary: Dysregulation of CD4 + T cell compartment occurs in Parkinson's Disease (PD), but its relationship with dopamine transporter (DAT) SPECT denervation patterns is unknown.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Jonathan R. Isaacson, Salima Brillman, Nisha Chhabria, Stuart H. Isaacson
Summary: DaTscan imaging proves to be valuable in determining the presence of NSDD in various clinical scenarios. It significantly impacts both altering or confirming clinical diagnosis and guiding treatment adjustments.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Clinical Neurology
Florian Holtbernd, N. Jon Shah
Summary: Functional imaging studies consistently show altered functional connectivity in the cerebellum and cerebello-thalamico-cortical circuitry. Structural imaging studies are less consistent, with no clear evidence for cerebellar neurodegeneration, but diffusion tensor imaging robustly points toward microstructural cerebellar changes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Cornelis Blauwendraat, Karl Heilbron, Costanza L. Vallerga, Sara Bandres-Ciga, Rainer von Coelln, Lasse Pihlstrom, Javier Simon-Sanchez, Claudia Schulte, Manu Sharma, Lynne Krohn, Ari Siitonen, Hirotaka Iwaki, Hampton Leonard, Alastair J. Noyce, Manuela Tan, J. Raphael Gibbs, Dena G. Hernandez, Sonja W. Scholz, Joseph Jankovic, Lisa M. Shulman, Suzanne Lesage, Jean-Christophe Corvol, Alexis Brice, Jacobus J. van Hilten, Johan Marinus, Johanna Eerola-Rautio, Pentti Tienari, Kari Majamaa, Mathias Toft, Donald G. Grosset, Thomas Gasser, Peter Heutink, Joshua M. Shulman, Nicolas Wood, John Hardy, Huw R. Morris, David A. Hinds, Jacob Gratten, Peter M. Visscher, Ziv Gan-Or, Mike A. Nalls, Andrew B. Singleton
MOVEMENT DISORDERS
(2019)
Article
Clinical Neurology
Naveed Malek, Sofia Kanavou, Michael A. Lawton, Vanessa Pitz, Katherine A. Grosset, Nin Bajaj, Roger A. Barker, Yoav Ben-Shlomo, David J. Burn, Tom Foltynie, John Hardy, Nigel M. Williams, Nicholas Wood, Huw R. Morris, Donald G. Grosset
PARKINSONISM & RELATED DISORDERS
(2019)
Editorial Material
Clinical Neurology
Eva-Juliane Vollstedt, Meike Kasten, Christine Klein
ANNALS OF NEUROLOGY
(2019)
Review
Clinical Neurology
Robert A. Hauser, Jonathan M. Meyer, Stewart A. Factor, Cynthia L. Comella, Caroline M. Tanner, Rose Mary Xavier, Stanley N. Caroff, Leslie Lundt
Summary: Accurate diagnosis and appropriate treatment of tardive dyskinesia are essential to mitigate the disruptive effects of the disorder. This article provides a comprehensive review of the clinical features, differential diagnosis, and treatment options for tardive dyskinesia and other antipsychotic-induced movement disorders.
Article
Clinical Neurology
Robert A. Hauser, Ghazal Banisadr, Kara Vuong, David Freilich, Stanley Fisher, Richard D'Souza
Summary: The introduction of carbidopa-levodopa extended-release capsules faced challenges due to difficulty around dose conversion from available immediate-release levodopa formulations. A survey of frequent prescribers found that doubling the daily levodopa immediate-release dose and administering it one time less frequently may be a good starting point for conversion to extended-release. Rapid patient follow-up after initial dose conversion and gaining experience over time are important for successful conversion.
PARKINSONS DISEASE
(2021)
Editorial Material
Neurosciences
Anna Naito, Anne-Marie Wills, Thomas F. Tropea, Adolfo Ramirez-Zamora, Robert A. Hauser, Davide Martino, Travis H. Turner, Miriam R. Rafferty, Mitra Afshari, Karen L. Williams, Okeanis Vaou, Martin J. McKeown, Letty Ginsburg, Adi Ezra, Robert Iansek, Kristin Wallock, Christiana Evers, Karlin Schroeder, Rebeca DeLeon, Nicole Yarab, Roy N. Alcalay, James C. Beck
Summary: Despite the growing adoption of telehealth in clinical care in North America, the implementation of telehealth visits in clinical research faces significant challenges due to variations in state licensure requirements, disparities in access among disadvantaged populations, and lack of consistency among Investigational Review Boards. The Parkinson's Foundation and Parkinson Study Group highlight these challenges and call for regulators to standardize telehealth practices for research studies.
NPJ PARKINSONS DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
David A. Kaminsky, Donald G. Grosset, Deena M. Kegler-Ebo, Salvador Cangiamilla, Michael Klingler, Ping Zhao, Charles Oh
Summary: In this study, Parkinson's disease patients on standard therapy experienced greater declines in FEV1 and FVC compared to healthy nonsmokers of similar age, while DLCO remained relatively stable. This suggests that changes in lung volume due to progressive PD-associated respiratory muscle weakness may be the main contributing factor to the decline in lung function.
RESPIRATORY MEDICINE
(2021)
Article
Clinical Neurology
Tamara Pringsheim, Gregory S. Day, Don B. Smith, Alex Rae-Grant, Nicole Licking, Melissa J. Armstrong, Rob M. A. de Bie, Emmanuel Roze, Janis M. Miyasaki, Robert A. Hauser, Alberto J. Espay, Justin P. Martello, Julie A. Gurwell, Lori Billinghurst, Kelly Sullivan, Michael S. Fitts, Nicholas Cothros, Deborah A. Hall, Miriam Rafferty, Lynn Hagerbrant, Tara Hastings, Mary Dolan O'Brien, Heather Silsbee, Gary Gronseth, Anthony E. Lang
Summary: The review found that initial treatment with levodopa provides better motor benefits compared to dopamine agonists, but is also more likely to cause motor complications. There was little evidence to suggest that any particular formulation or method of administration of dopamine agonists is superior. Long-acting forms of levodopa and combination formulations with entacapone do not appear to differ in efficacy from immediate-release levodopa for early disease motor symptoms. Patients using dopamine agonists may have a higher risk of impulse control disorders compared to those using levodopa.
Article
Clinical Neurology
Robert A. Hauser, Antonella Favit, L. Arthur Hewitt, Annika Lindsten, Stephen Gorny, Steven Kymes, Stuart H. Isaacson
Summary: This study evaluated the long-term efficacy and tolerability of droxidopa in patients with neurogenic orthostatic hypotension (nOH). The results showed significant improvement in symptoms and daily activities after 12 weeks of treatment with droxidopa, and no clinically important changes in supine hypertension or adverse events of concern were observed.
NEUROLOGY AND THERAPY
(2022)
Editorial Material
Medicine, Research & Experimental
Robert A. Hauser, Nir Giladi, Werner Poewe, Jonathan Brotchie, Hadas Friedman, Sheila Oren, Pninit Litman
Summary: Despite the superior efficacy of levodopa in reducing motor symptoms of Parkinson's disease, its risk of inducing motor complications necessitates consideration of alternative treatments. P2B001, a combination of pramipexole and rasagiline, shows potential for greater efficacy and better tolerability compared to other approaches. It also maintains a lower risk of motor complications compared to levodopa.
ADVANCES IN THERAPY
(2022)
Article
Neurosciences
Robert A. Hauser, Judy Lytle, Andrea E. Formella, Caroline M. Tanner
Summary: Maintaining consistent levodopa benefits while controlling dyskinesia can be difficult. A recent study evaluated the efficacy of an extended-release amantadine formulation as an adjunct to levodopa for the treatment of OFF episodes. The results showed significant reductions in OFF time in both the overall population and subgroups with different baseline OFF times.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Gareth Morinan, Robert A. Hauser, Anette Schrag, Jingxuan Tang, Jonathan O'Keeffe
Summary: This study identified a simplified version of the MDS-UPDRS rating scale that consists of 8 items and can act as an unbiased estimator of the total 50-item score. This version is practical for remote assessment and has a high level of agreement with the original MDS-UPDRS.
PARKINSONS DISEASE
(2022)
Article
Medicine, General & Internal
Michael Camilleri, Thyagarajan Subramanian, Fernando Pagan, Stuart Isaacson, Ramon Gil, Robert A. Hauser, Mary Feldman, Mark Goldstein, Rajeev Kumar, Daniel Truong, Nisha Chhabria, Benjamin L. Walter, Jonathan Eskenazi, Robert Riesenberg, Daniel Burdick, Winona Tse, Eric Molho, Bradley Robottom, Perminder Bhatia, Srinath Kadimi, Kevin Klos, David Shprecher, Otto Marquez-Mendoza, Gonzalo Hidalgo, Stephen Grill, George Li, Howard Mandell, Mary Hughes, Sharisse Stephenson, Joel Vandersluis, Michael Pfeffer, Andrew Duker, Vikram Shivkumar, William Kinney, James MacDougall, Michael Zasloff, Denise Barbut
Summary: This study evaluated the safety and efficacy of oral ENT-01 in patients with PD and constipation. The results showed that ENT-01 significantly improved constipation symptoms and had a certain improvement on dementia and psychosis symptoms.
ANNALS OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Davide Martino, Vikram Karnik, Roongroj A. Bhidayasiri, Deborah A. A. Hall, Robert A. Hauser, Antonella M. Macerollo, Tamara M. Pringsheim, Daniel A. Truong, Stewart A. Factor, Matej Skorvanek, Anette Schrag, IPMDS Rating Scales Review Comm
Summary: An International Parkinson and Movement Disorder Society subcommittee aimed to rate the psychometric quality of severity and screening instruments for antipsychotic-associated movement disorders. They identified 23 instruments, of which 7 severity rating instruments and 3 screening instruments were recommended with caveats due to insufficient psychometric properties and long duration of administration. New psychometric studies and revision of existing instruments are recommended to address these caveats and improve the clarity of their nomenclature.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
C. Warren Olanow, Robert A. Hauser, Daniel J. Burdick, Rohit Dhall, Joy Antonelle de Marcaida, Ramon A. Gil, David L. Kreitzman, Lawrence W. Elmer, Andrew Mcgarry, Karl Kieburtz
Summary: This study found that P2B001 was superior to its individual components in treating Parkinson's disease and had comparable efficacy to marketed doses of pramipexole-ER, but with less worsening of sleepiness and fewer dopaminergic adverse events.
MOVEMENT DISORDERS
(2023)