Article
Cell Biology
Li Tao, Sean Coakley, Rebecca Shi, Kang Shen
Summary: This study reveals the importance of mechanosensitive channels in dendritic arborization, which activate local Ca2+ transients through the activation of voltage-gated Ca2+ channels. The mechanical activation of these channels relies on the anchoring of filopodia by dendrite ligand-receptor complexes.
DEVELOPMENTAL CELL
(2022)
Article
Multidisciplinary Sciences
Jessica A. G. Johnson, Hongxia Liu, Ulli Hoger, Samantha M. Rogers, Kajanan Sivapalan, Andrew S. French, Paivi H. Torkkeli
Summary: Mechanosensory neurons in spiders predominantly express the Piezo protein as the MET channel, with no significant detection of other MET channel families. The Piezo protein is widely expressed in the spider nervous system, potentially contributing to mechanosensory transduction in mechanosensilla and serving other functions in peripheral and central neurons. Blocking MET channels did not affect mechanically activated currents in VS-3 neurons, but reduced action potential firing under electrical stimulation.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Rui Xiao, X. Z. Shawn Xu
Summary: Temperature serves as a universal cue that regulates essential biological processes, and animals have evolved sophisticated mechanisms to detect temperature changes. Research on animal models has revealed exciting principles of thermosensation and the similar logic adopted by different species in transducing and processing temperature information.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Biochemistry & Molecular Biology
Antonio Willame da Silva Alves, Bruno Lopes Sousa, Luiz Francisco Wemmenson Goncalves Moura, Emanuela de Lima Reboucas, Marnielle Rodrigues Coutinho, Antonio Wlisses Silva, Renata Pinheiro Chaves, Romulo Farias Carneiro, Eduardo Henrique Salviano Bezerra, Maria Izabel Florindo Guedes, Eridan Orlando Pereira Tramontina Florean, Celso Shiniti Nagano, Alexandre Holanda Sampaio, Bruno Anderson Matias Rocha
Summary: Inflammation and oxidative stress are processes associated with various diseases. This study investigates the potential of CiL-1, a compound found in seaweed, as an anti-nociceptive and anti-inflammatory agent. Results show that CiL-1 effectively reduces pain and inflammation in adult zebrafish. Additionally, CiL-1 reduces the levels of reactive oxygen species (ROS) in the brain and liver. In silico analyses suggest that CiL-1 interacts with specific ligands and may modulate the TRPA1 channel, explaining its anti-inflammatory effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Multidisciplinary Sciences
Misaki Okahata, Haruka Motomura, Akane Ohta, Atsushi Kuhara
Summary: This study introduces a molecular physiological mechanism for cold tolerance and acclimation in the nematode Caenorhabditis elegans, highlighting the roles of three types of thermosensory neurons. It reveals the involvement of the light-signaling pathway, mechanoreceptor, and transient receptor potential channels in thermosensation, as well as the modulation of thermoresponsivity by oxygen sensory signaling and the impact of intestinal transcriptional alteration on sperm functions.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jingyuan Jiang, Yifan Su, Ruilin Zhang, Haiwen Li, Louis Tao, Qiang Liu
Summary: This study identified a novel circuit of spiking neurons in C. elegans that uses digital coding for long-distance communication and temporal synchronization, which is crucial for reliable behavioral rhythm.
NATURE COMMUNICATIONS
(2022)
Article
Food Science & Technology
Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Aizek B. Isaev, Ilya D. Kukushkin, Maxim L. Bychkov, Mikhail A. Shulepko, Anton O. Chugunov, Mikhail P. Kirpichnikov
Summary: Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing ion channels. Mambalgin-2 has been found to effectively inhibit a tumor-specific acid-sensing channel, providing new insights into the regulation of acid-sensing ion channels and development of cancer treatment strategies.
Article
Biochemical Research Methods
Jesus Fernandez-Abascal, Laura Bianchi
Summary: This study presents a protocol for calcium and chloride imaging in worm glia in response to touch stimulation using Caenorhabditis elegans. The authors provide essential steps for data reproducibility, including worm immobilization, poking angle, and applied force, as well as detailed data processing and analysis methods. The protocol can also be used for other types of mechanical or odorant stimulation experiments.
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Engineering, Biomedical
Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhang
Summary: Reactive oxygen species (ROS) have significant roles in physiological and pathophysiological processes. Recent studies have shown that ROS plays a crucial role in the development and progression of osteoarthritis (OA) by mediating extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis, and OA progression. Nanomaterials with ROS-scavenging ability and antioxidant effects have shown promising results in OA treatment. However, current research on nanomaterials as ROS scavengers for OA is not uniform, and the timing and potential of their clinical use remain inconsistent. This review aims to provide a reference for further studies and promote the early clinical use of nanomaterials for OA treatment.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Jiale Liu, Mengyao Huang, Xinyu Zhang, Zhongyu Hua, Zeran Feng, Yi Dong, Tiedong Sun, Xiao Sun, Chunxia Chen
Summary: The dual effects of reactive oxygen species (ROS) in living organisms, which can cause oxidative imbalances and be regulated to attack tumors and bacteria, have attracted significant research attention. Polyoxometalates (POMs) have shown great potential in modulating ROS and have been investigated for disease treatment and sensing diagnostics, providing valuable insights into therapeutic and diagnostic technologies.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Physiology
Yasuo Furukawa, Iori Tagashira
Summary: In this study, mutagenic analysis and in silico docking simulations were performed to investigate the role of conserved aromatic residues in the finger domain of FaNaC in FMRFamide recognition and activation. The results showed that mutation of the aromatic residues reduced FMRFamide potency and altered the kinetics of FMRFamide-gated currents, supporting the hypothesis of an aromatic-aromatic interaction between FaNaC and FMRFamide.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Hongyu Ruan, Atsushi Ueda, Xiaomin Xing, Xuxuan Wan, Benjamin Strub, Spencer Mukai, Kaan Certel, David Green, Kyle Belozerov, Wei-Dong Yao, Wayne Johnson, Jim Jung-Ching Lin, Arthur J. Hilliker, Chun-Fang Wu
JOURNAL OF NEUROGENETICS
(2017)
Editorial Material
Biology
Wayne A. Johnson
Article
Neurosciences
Myung-Jun Kim, Wayne A. Johnson
Article
Developmental Biology
Joshua A. Ainsley, Myung Jun Kim, Lauren J. Wegman, Janette M. Pettus, Wayne A. Johnson
DEVELOPMENTAL BIOLOGY
(2008)
Article
Developmental Biology
Lauren J. Wegman, Joshua A. Ainsley, Wayne A. Johnson
DEVELOPMENTAL BIOLOGY
(2010)
Article
Genetics & Heredity
Anke Vermehren-Schmaedick, Joshua A. Ainsley, Wayne A. Johnson, Shireen-A Davies, David B. Morton
Article
Multidisciplinary Sciences
Wayne A. Johnson, Justin W. Carder
Article
Biochemistry & Molecular Biology
JA Ainsley, JM Pettus, D Bosenko, CE Gerstein, N Zinkevich, MG Anderson, CM Adams, MJ Welsh, WA Johnson
Article
Neurosciences
L Liu, AS Leonard, DG Motto, MA Feller, MP Price, WA Johnson, MJ Welsh
Article
Neurosciences
L Liu, O Yermolaieva, WA Johnson, FM Abboud, MJ Welsh
NATURE NEUROSCIENCE
(2003)
Article
Multidisciplinary Sciences
L Liu, WA Johnson, MJ Welsh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2003)
Article
Biochemistry & Molecular Biology
T Komiyama, WA Johnson, LQ Luo, GSXE Jefferis
Article
Developmental Biology
K Certel, A Hudson, SB Carroll, WA Johnson
Article
Neurosciences
Y Ma, K Certel, YP Gao, E Niemitz, J Mosher, A Mukherjee, M Mutsuddi, N Huseinovic, ST Crews, WA Johnson, JR Nambu
JOURNAL OF NEUROSCIENCE
(2000)