Article
Cell Biology
Lisa Frankenreiter, Bernd M. Gahr, Hannes Schmid, Mirjam Zimmermann, Sebastian Deichsel, Philipp Hoffmeister, Aleksandra Turkiewicz, Tilman Borggrefe, Franz Oswald, Anja C. Nagel
Summary: The study reveals a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription factors in the DNA-binding domain. Findings in fruit flies and mammalian cells suggest a potential conservation of this phosphorylation regulatory mechanism, providing a means to fine-tune Notch signal transduction in a context-dependent manner.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hsuan-Wen Lin, Chun-Chao Chen, Ruei-Yu Jhang, Linyi Chen, J. Steven de Belle, Tim Tully, Ann-Shyn Chiang
Summary: Learned experiences need to be periodic and meaningful to be consolidated into long-term memory. The consolidation of long-term memory relies on the de novo protein synthesis mediated by cyclic AMP response element-binding protein (CREB). This study reveals that spaced training induces the expression of the crebB gene in specific neurons in the mushroom body of Drosophila, enhancing the formation of long-term memory. On the other hand, learning from weak training leads to the synthesis of the 5-HT1A serotonin receptor and inhibits long-term memory formation. The findings demonstrate that CREBB, induced by spaced training, counteracts the effect of learning-induced 5-HT1A in specific early MB neurons to regulate the consolidation of long-term memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Chun-Chao Chen, Hsuan-Wen Lin, Kuan-Lin Feng, Der-Wan Tseng, J. Steven de Belle, Ann-Shyn Chiang
Summary: Long-term memory requires the synthesis of new proteins in specific neurons and synapses. Not all learned information becomes permanent memory. It is unclear how the brain decides which information is stored in long-term memory.
Article
Oncology
Antonio Ferreira, Jon C. Aster
Summary: Notch receptors participate in a conserved signaling pathway that has diverse effects on normal cells and is highly dependent on the cellular context and signaling dosage. Notch plays different roles in various types of cancers, acting as either an oncogene or a tumor suppressor and affecting tumor cells and stromal elements in multiple ways. This review provides an overview of the roles of Notch in cancer and discusses the challenges and potential approaches for clinical translation of Notch targeting agents.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Show Inami, Tomohito Sato, Yuto Kurata, Yuki Suzuki, Toshihiro Kitamoto, Takaomi Sakai
Summary: The developmental regulator Ap plays dual roles in memory consolidation in clock neurons and memory maintenance in MBs in Drosophila, indicating its unique function in the neurobiological processes of LTM.
Review
Biochemistry & Molecular Biology
Antonino B. D'Assoro, Roberto Leon-Ferre, Eike-Benjamin Braune, Urban Lendahl
Summary: The Notch signaling pathway is important for normal development, but dysregulation of this pathway is associated with various types of tumors. In addition to its role in tumor cells, Notch signaling also affects non-mutated cells in the tumor microenvironment and their interactions with tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wang-Pao Lee, Meng-Hsuan Chiang, Li-Yun Chang, Wei-Huan Shyu, Tai-Hsiang Chiu, Tsai-Feng Fu, Tony Wu, Chia-Lin Wu
Summary: This study reveals that consolidation of water-reward long-term memory in fruit flies requires the activity of specific subsets of mushroom body output neurons in distinct time windows after training. Furthermore, serotonin signals from dorsal paired medial neurons are crucial for modulating neuronal activity in these specific subsets, highlighting the importance of serotonin in memory consolidation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jacqueline T. Weiss, Jeffrey M. Donlea
Summary: The study shows that insufficient sleep affects synaptic connectivity in the Drosophila mushroom body, particularly by increasing the abundance of the pre-synaptic protein Bruchpilot in Kenyon cells. Different cell types may exhibit varied synaptic plasticity in response to sleep deprivation.
Article
Multidisciplinary Sciences
Sabine Nobel, Etienne Danchin, Guillaume Isabel
Summary: This study demonstrates that the rutabaga gene plays a critical role in mate copying in Drosophila melanogaster, and its functional localization is in the Kenyon cells of the mushroom bodies.
Article
Medicine, Research & Experimental
Muhammed A. Saad, Muhammad A. Eltarzy, Rania M. Abdel Salam, Maha A. E. Ahmed
Summary: The study found that the Notch signaling pathway was overexpressed in PCOS rats, leading to cognitive impairment, which was improved by Liraglutide. This suggests that Liraglutide may serve as a novel therapeutic intervention to alleviate PCOS-induced dementia.
Article
Neurosciences
Baiwei Liu, Xinyu Li, Jan Theeuwes, Benchi Wang
Summary: It has been traditionally believed that information retrieved from long-term memory (LTM) needs to be brought back into working memory (WM). However, this study demonstrates that retrieval from LTM is possible even when WM capacity is fully occupied. EEG results indicate that retrieving items from LTM while WM is fully engaged enhances the suppression of alpha oscillations, suggesting alternative mechanisms for accessing LTM when WM is fully occupied.
Article
Medicine, Research & Experimental
Simiao Chen, Jinghui Zhang, Min Li, Jing Zhou, Yuyan Zhang
Summary: Current therapy for ischemic stroke primarily relies on tissue plasminogen activator (tPA), but it is limited by narrow treatment time window, bleeding complications and neurotoxicity. The preliminary study of tPA plus Danhong injection (DHI) shows that it can significantly reduce the side effects of tPA and improve its thrombolytic effect, but the mechanism of this action has not been further studied. In this study, the combination of DHI and tPA significantly improved neurological function, reduced blood-brain barrier disruption, and promoted angiogenesis in a rat model of ischemic stroke. The results suggest that the activation of the Notch-VEGF signaling pathway may play a role in the beneficial effects of DHI and tPA.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Jee Hyun Yi, Se Jin Jeon, Huiyoung Kwon, Eunbi Cho, Jieun Jeon, Somin Moon, A. Young Park, Hyun-Ji Kwon, Ye Hee Lee, Kyoung Ja Kwon, Chan Young Shin, Dong Hyun Kim
Summary: Stress is a common part of life and can cause various neurological and psychiatric disorders. Proper stress management is important for maintaining a healthy life. This study investigated the impact of ethyl pyruvate (EP) on stress-induced cognitive decline and found that EP can block the inhibitory effect of the stress hormone corticosterone on synaptic plasticity. Administration of EP improved cognitive decline caused by stress by regulating Akt/GSK-3β signaling and improving neurogenesis and synaptic function deficits.
Article
Genetics & Heredity
Noemi P. Sgammeglia, Yves Widmer, Jenifer P. Kaldun, Cornelia Fritsch, Remy P. Bruggmann, Simon Sprecher
Summary: Using a Dam::CREB fusion protein, the authors identified differentially expressed genes in the mushroom body one day and two days after appetitive olfactory conditioning. They found candidate genes that cause memory enhancement and genes that cause memory suppression. This study reveals potential new regulators of memory formation and maintenance.
Article
Biology
Haiyang Geng, Gregory Lafon, Aurore Avargues-Weber, Alexis Buatois, Isabelle Massou, Martin Giurfa
Summary: This study investigates the neural underpinnings of visual learning in bees using a 3D virtual reality environment and gene expression analyses. It reveals the privileged involvement of specific regions in the bee brain in associative color learning and the usefulness of Egr1 as a marker of neural activity induced by this phenomenon.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Mo, Ran Lin, Peng Liu, Minjia Tan, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan
Article
Biochemistry & Molecular Biology
Lisha Shao, Binyan Lu, Zhexing Wen, Shaolei Teng, Lingling Wang, Yi Zhao, Liyuan Wang, Koko Ishizuka, Xiufeng Xu, Akira Sawa, Hongjun Song, Guoli Ming, Yi Zhong
HUMAN MOLECULAR GENETICS
(2017)
Article
Biochemistry & Molecular Biology
Ran Lin, Yan Mo, Haihong Zha, Zhipeng Qu, Pancheng Xie, Zheng-Jiang Zhu, Ying Xu, Yue Xiong, Kun-Liang Guan
Review
Neurosciences
Ronald L. Davis, Yi Zhong
Article
Biochemistry & Molecular Biology
Weiwei Ma, Mengnan Wu, Siyan Zhou, Ye Tao, Zuolei Xie, Yi Zhong
JOURNAL OF GENETICS AND GENOMICS
(2018)
Article
Neurosciences
Xuchen Zhang, Qian Li, Lianzhang Wang, Zhong-Jian Liu, Yi Zhong
Article
Cell Biology
Wantong Hu, Yiqing Peng, Jiameng Sun, Fang Zhang, Xuchen Zhang, Lianzhang Wang, Qian Li, Yi Zhong
Article
Cell Biology
Yunlong Liu, Li Lv, Lianzhang Wang, Yi Zhong
Article
Cell Biology
Wenjuan Wu, Shuwen Du, Wei Shi, Yunlong Liu, Ying Hu, Zuolei Xie, Xinsheng Yao, Zhenyu Liu, Weiwei Ma, Lin Xu, Chao Ma, Yi Zhong
Article
Multidisciplinary Sciences
Yang Gao, Yichun Shuai, Xuchen Zhang, Yuwei Peng, Lianzhang Wang, Jing He, Yi Zhong, Qian Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Letter
Biochemistry & Molecular Biology
Lingling Wang, Qi Yang, Binyan Lu, Lianzhang Wang, Yi Zhong, Qian Li
JOURNAL OF GENETICS AND GENOMICS
(2019)
Article
Multidisciplinary Sciences
Bohan Zhao, Jiameng Sun, Xuchen Zhang, Han Mo, Yijun Niu, Qian Li, Lianzhang Wang, Yi Zhong
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Li Lv, Yunlong Liu, Jianxin Xie, Yan Wu, Jianjian Zhao, Qian Li, Yi Zhong
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Xu Zhang, Bo Lei, Yuan Yuan, Li Zhang, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong, Ji Hu, Hai Qi
Article
Cell Biology
Jennifer Beshel, Josh Dubnau, Yi Zhong