Hyperammonemia enhances the function and expression of P-glycoprotein and Mrp2 at the blood-brain barrier through NF-κB

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

(2014) Matthew Quinn et al.   DIGESTIVE AND LIVER DISEASE

Antidepressant-Induced Liver Injury: A Review for Clinicians

(2013) Cosmin Sebastian Voican et al.   AMERICAN JOURNAL OF PSYCHIATRY

Drug-Induced Liver Injury from Antiepileptic Drugs

(2013) Jennifer S. Au et al.   Clinics in Liver Disease

Ursodeoxycholic acid inhibits overexpression of P-glycoprotein induced by doxorubicin in HepG2 cells

(2013) Yuki Komori et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy

(2013) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROCHEMISTRY

Emerging Role of NF-κB in the Pathogenesis of Hepatic Encephalopathy

(2012) A.R. Jayakumar et al.   Current Signal Transduction Therapy

Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases

(2012) Marta Skowrońska et al.   JOURNAL OF NEUROCHEMISTRY

P-glycoprotein and multidrug resistance-associated protein 2 are oppositely altered in brain of rats with thioacetamide-induced acute liver failure

(2012) Shi Jin et al.   LIVER INTERNATIONAL

Oxidative and nitrosative stress in ammonia neurotoxicity

(2012) Marta Skowrońska et al.   NEUROCHEMISTRY INTERNATIONAL

Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats

(2012) D. Yao et al.   NEUROSCIENCE

Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy

(2012) A.R. Jayakumar et al.   NEUROSCIENCE

Exposure to Lipopolysaccharide and/or Unconjugated Bilirubin Impair the Integrity and Function of Brain Microvascular Endothelial Cells

(2012) Filipa L. Cardoso et al.   PLoS One

Elevated Levels of Bilirubin and Long-Term Exposure Impair Human Brain Microvascular Endothelial Cell Integrity

(2011) Ines Palmela et al.   CURRENT NEUROVASCULAR RESEARCH

Microglia activation in hepatic encephalopathy in rats and humans

(2011) Irina Zemtsova et al.   HEPATOLOGY

Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood–brain barrier in mice

(2011) Atsushi Yamauchi et al.   LIFE SCIENCES

Mechanistic Studies of the Effect of Bile Salts on Rhodamine 123 Uptake into RBE4 Cells

(2011) Lin Yang et al.   MOLECULAR PHARMACEUTICS

Neuroinflammation in acute liver failure: Mechanisms and novel therapeutic targets

(2011) Roger F. Butterworth   NEUROCHEMISTRY INTERNATIONAL

Blood–brain barrier in acute liver failure

(2011) Justin H. Nguyen   NEUROCHEMISTRY INTERNATIONAL

Brain Edema in Acute Liver Failure

(2010) Kakulavarapu V. Rama Rao et al.   AMERICAN JOURNAL OF PATHOLOGY

Combined effects of epileptic seizure and phenobarbital induced overexpression of P-glycoprotein in brain of chemically kindled rats

(2010) Xinyue Jing et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Role of Cerebral Vascular NFĸB in LPS-induced Inflammation: Differential Regulation of Efflux Transporter and Transporting Cytokine Receptors

(2010) Weihong Pan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy

(2010) Boris Görg et al.   HEPATOLOGY

The Na–K–Cl cotransporter in the brain edema of acute liver failure

(2010) Arumugam R. Jayakumar et al.   JOURNAL OF HEPATOLOGY

Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats

(2010) Jing Wu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy

(2010) Chantal Bemeur et al.   METABOLIC BRAIN DISEASE

Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier

(2010) David S. Miller   TRENDS IN PHARMACOLOGICAL SCIENCES

Changing face of hepatic encephalopathy: Role of inflammation and oxidative stress

(2010) Amit S Seyan   WORLD JOURNAL OF GASTROENTEROLOGY

Neuroinflammation Activates Mdr1b Efflux Transport Through NFκB: Promoter Analysis in BBB Endothelia

(2008) Chuanhui Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ammonia induces RNA oxidation in cultured astrocytes and brainin vivo

(2008) Boris Görg et al.   HEPATOLOGY

Signaling factors in the mechanism of ammonia neurotoxicity

(2008) M. D. Norenberg et al.   METABOLIC BRAIN DISEASE

The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema

(2008) Peter Nissen Bjerring et al.   METABOLIC BRAIN DISEASE