Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 60, Issue 7, Pages 676-683Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2011.10.012
Keywords
Tight junction; Paracellular permeability; Brain endothelial cell; Acute liver failure
Categories
Funding
- NIDDK NIH HHS [R21 DK064361, R21 DK064361-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS051646, R01 NS051646-01A2] Funding Source: Medline
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Brain edema remains a challenging obstacle in the management of acute liver failure (ALF). Cytotoxic mechanisms associated with brain edema have been well recognized, but evidence for vasogenic mechanisms in the pathogenesis of brain edema in ALF has been lacking. Recent reports have not only shown a role of matrix metalloproteinase-9 in the pathogenesis of brain edema in experimental ALF but have also found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. This article reviews and explores the role of the paracellular tight junction proteins in the increased selective BBB permeability that leads to brain edema in ALF. (C) 2011 Elsevier Ltd. All rights reserved.
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