Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain

Role of the medial septum cholinoceptors in anxiogenic-like effects of nicotine

(2013) Mohammad-Reza Zarrindast et al.   PHYSIOLOGY & BEHAVIOR

Nicotine-Induced Upregulation of Native Neuronal Nicotinic Receptors Is Caused by Multiple Mechanisms

(2012) A. P. Govind et al.   JOURNAL OF NEUROSCIENCE

Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABAB1 knockout mice

(2012) Andrés P. Varani et al.   NEUROPHARMACOLOGY

Nicotinic Regulation of Energy Homeostasis

(2012) M. Zoli et al.   NICOTINE & TOBACCO RESEARCH

Low Dose Nicotine and Antagonism of β2 Subunit Containing Nicotinic Acetylcholine Receptors Have Similar Effects on Affective Behavior in Mice

(2012) Shawn M. Anderson et al.   PLoS One

Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats

(2012) Joshua E. Johnson et al.   PSYCHOPHARMACOLOGY

Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats

(2012) Amir H. Rezvani et al.   PSYCHOPHARMACOLOGY

Weight gain in smokers after quitting cigarettes: meta-analysis

(2012) H.-J. Aubin et al.   BMJ-British Medical Journal

Additional Acetylcholine (ACh) Binding Site at α4/α4 Interface of (α4β2)2α4 Nicotinic Receptor Influences Agonist Sensitivity

(2011) Simone Mazzaferro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons

(2011) Ermelinda Lomazzo et al.   JOURNAL OF NEUROCHEMISTRY

 4 2 Nicotinic Acetylcholine Receptors on Dopaminergic Neurons Mediate Nicotine Reward and Anxiety Relief

(2011) T. M. McGranahan et al.   JOURNAL OF NEUROSCIENCE

Increased Nicotinic Acetylcholine Receptor Protein Underlies Chronic Nicotine-Induced Up-Regulation of Nicotinic Agonist Binding Sites in Mouse Brain

(2011) M. J. Marks et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380

(2011) Barbara J. Caldarone et al.   PSYCHOPHARMACOLOGY

Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control

(2011) Jelte A. Wouda et al.   PSYCHOPHARMACOLOGY

Nicotine Decreases Food Intake Through Activation of POMC Neurons

(2011) Y. S. Mineur et al.   SCIENCE

Anxiety diagnoses in smokers seeking cessation treatment: relations with tobacco dependence, withdrawal, outcome and response to treatment

(2010) Megan E. Piper et al.   ADDICTION

Nicotine Withdrawal Increases Threat-Induced Anxiety but Not Fear: Neuroadaptation in Human Addiction

(2010) Joanne M. Hogle et al.   BIOLOGICAL PSYCHIATRY

Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning

(2010) Rahul Srinivasan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Desensitization of Nicotine-Stimulated [3H]Dopamine Release from Mouse Striatal Synaptosomes

(2010) Sharon R. Grady et al.   JOURNAL OF NEUROCHEMISTRY

Nicotinic Partial Agonists Varenicline and Sazetidine-A Have Differential Effects on Affective Behavior

(2010) J. R. Turner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Comparative Study of the Effects of the Intravenous Self-Administration or Subcutaneous Minipump Infusion of Nicotine on the Expression of Brain Neuronal Nicotinic Receptor Subtypes

(2010) M. Moretti et al.   MOLECULAR PHARMACOLOGY

Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline

(2010) J. R. Turner et al.   NICOTINE & TOBACCO RESEARCH

Effects of sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats

(2010) Amir H. Rezvani et al.   PSYCHOPHARMACOLOGY

Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration

(2010) Olivier George et al.   PSYCHOPHARMACOLOGY

β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking

(2009) Kelly P. Cosgrove et al.   ARCHIVES OF GENERAL PSYCHIATRY

Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction

(2009) Anitha P. Govind et al.   BIOCHEMICAL PHARMACOLOGY

Structural and functional diversity of native brain neuronal nicotinic receptors

(2009) Cecilia Gotti et al.   BIOCHEMICAL PHARMACOLOGY

Pentameric concatenated (α4)2(β2)3 and (α4)3(β2)2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression

(2009) A-L Carbone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemistry and Pharmacology of Nicotinic Ligands Based on 6-[5-(Azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for Possible Use in Depression

(2009) Alan P. Kozikowski et al.   ChemMedChem

Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders

(2009) Andrea H. Weinberger et al.   DRUG AND ALCOHOL DEPENDENCE

Sazetidine-A, a Selective  4 2 Nicotinic Receptor Desensitizing Agent and Partial Agonist, Reduces Nicotine Self-Administration in Rats

(2009) E. D. Levin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tobacco addiction: A biochemical model of nicotine dependence

(2009) Marcelo O. Ortells et al.   MEDICAL HYPOTHESES

Varenicline Improves Mood and Cognition During Smoking Abstinence

(2008) Freda Patterson et al.   BIOLOGICAL PSYCHIATRY

Sazetidine-A Is a Potent and Selective Agonist at Native and Recombinant  4 2 Nicotinic Acetylcholine Receptors

(2008) R. Zwart et al.   MOLECULAR PHARMACOLOGY

Partial Deletion of the Nicotinic Cholinergic Receptor  4 or  2 Subunit Genes Changes the Acetylcholine Sensitivity of Receptor-Mediated 86Rb+ Efflux in Cortex and Thalamus and Alters Relative Expression of  4 and  2 Subunits

(2008) C. Gotti et al.   MOLECULAR PHARMACOLOGY

Smoking upregulates α4β2* nicotinic acetylcholine receptors in the human brain

(2007) Ullrich Wüllner et al.   NEUROSCIENCE LETTERS