Article
Food Science & Technology
Eun Hae Kim, Youn Young Shim, Hye In Lee, Sanghyun Lee, Martin J. T. Reaney, Mi Ja Chung
Summary: The current study found that astragalin and isoquercitrin from chamchwi had anti-neuroinflammatory effects by inhibiting the MAPK signaling pathway. Astragalin and isoquercitrin reduced the inflammatory response in LPS-induced microglial cells and hippocampus in mice.
Review
Biochemistry & Molecular Biology
Abdur Rauf, Himani Badoni, Tareq Abu-Izneid, Ahmed Olatunde, Md Mominur Rahman, Sakshi Painuli, Prabhakar Semwal, Polrat Wilairatana, Mohammad S. Mubarak
Summary: Neuroinflammation plays a crucial role in the pathogenesis of neurodegenerative diseases, and the release of neuroinflammatory markers can lead to the development of various neuronal disorders. Identifying these markers can assist in early diagnosis and treatment of these diseases.
Review
Neurosciences
Julia N. Khantakova, Natalia P. Bondar, Elena V. Antontseva, Vasiliy V. Reshetnikov
Summary: Adverse factors during the neonatal period can affect the development of certain brain structures, leading to reduced cognitive abilities and increased risk of psychopathologies throughout an individual's lifespan. Neonatal immune activation-induced neuroinflammation may cause disturbances in neurotransmission, reprogramming of brain cells, and changes in stress reactivity, ultimately resulting in depressive-like behavior in adult males under aversive conditions with local inflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Anamaria Jurcau, Aurel Simion
Summary: Stroke is the second leading cause of death worldwide, and neuroinflammation plays a significant role in this condition. Neuroinflammation leads to tissue injury and functional recovery, and therapeutic attempts targeting neuroinflammation have been made.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aileen Jehle, Olga Garaschuk
Summary: Cyclic guanosine monophosphate (cGMP) plays a key role in many important signaling cascades in the body and brain, including phototransduction, olfaction, vasodilation, and functional hyperemia. Recent studies suggest that cGMP may act as a modulator in Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sigal Fleisher-Berkovich, Yvonne Ventura, Maya Amoyal, Arik Dahan, Valeria Feinshtein, Leenor Alfahel, Adrian Israelson, Nirit Bernstein, Jonathan Gorelick, Shimon Ben-Shabat
Summary: Cannabigerol has the potential to be a therapeutic agent for the treatment of Multiple Sclerosis, as it can reduce neuroinflammation and neuronal loss. It acts by inhibiting the production of nitric oxide and tumor necrosis factor-alpha.
Review
Endocrinology & Metabolism
Xiaoli Liao, Miao Chen, Yamin Li
Summary: The present study aimed to review evidence from postmortem brain and PET studies on the role of glia induced neuroinflammation in the pathogenesis of ASD. The findings from postmortem studies showed increased microglial number and density, as well as increased GFAP protein and mRNA expression in ASD subjects. However, the outcomes of PET studies were inconsistent, with one reporting increased TSPO expression and two reporting decreased TSPO expression in ASD subjects.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Review
Biochemistry & Molecular Biology
Sai Shi, Tianzhen Chen, Min Zhao
Summary: This article reviews the interaction between neurons and glial cells in METH-induced neuroinflammation. Neuroinflammation plays a crucial role in the brain dysfunction caused by METH abuse, and abnormal communication between neurons and glia can lead to adverse behavioral consequences.
NEUROCHEMICAL RESEARCH
(2022)
Review
Immunology
Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: Neuroinflammation is implicated in various CNS disorders, and the activation of astrocytes and microglia plays a crucial role in defense mechanisms. However, their activation can trigger neuroinflammation, exacerbating or inducing CNS injury. Non-coding RNAs are highly expressed in astrocytes and microglia and may be mediators of neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Roberta J. Ward, David T. Dexter, Robert R. Crichton
Summary: Disturbance of brain homeostasis leads to inflammation and cell death. Inflammation and iron metabolism interact, leading to iron deposition in brain cells. Reactive oxygen and nitrogen species play a role in inflammation and iron metabolism. Mechanisms to regulate iron homeostasis are important, and therapeutic approaches include N-acetyl cysteine, anti-inflammatory compounds, and iron chelation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Zsuzsanna Barad, Joana Augusto, Aine M. Kelly
Summary: Optimal performance of the central nervous system depends on communication between different cell types. Ageing is associated with CNS disequilibrium, but endurance exercise can have a positive impact on neuroimmune communications. Regular aerobic exercise provides an adaptive advantage against perturbations to homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Neurosciences
Octavio Garcia, Lisi Flores-Aguilar
Summary: Down syndrome is caused by the triplication of human chromosome 21, leading to intellectual disability. Individuals with DS may develop clinical symptoms associated with Alzheimer's disease in middle adulthood.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Daniel Reyes-Haro
Summary: Anorexia is a common eating disorder, especially among adolescent females, characterized by a fear of gaining weight due to body image distortion, leading to reduced food intake and severe weight loss. Glial cells may play a significant role in anorexia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Sneha Kumari, Rishika Dhapola, Prajjwal Sharma, Sunil K. Singh, Dibbanti HariKrishna Reddy
Summary: Alzheimer's Disease is an age-related disorder that causes significant social and economic burden. It is characterized by the accumulation of certain proteins and the formation of inflammatory cytokines, leading to cognitive and social behavior impairment. This review explores the various pathways and mechanisms involved in the development of neuroinflammation in Alzheimer's Disease, and highlights the potential of targeting cytokines as a therapeutic approach.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)