Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology

First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms

(2012) Tomas Borgegard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease

(2012) Sascha Weggen et al.   Alzheimers Research & Therapy

Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations

(2011) Omar Quintero-Monzon et al.   BIOCHEMISTRY

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

(2011) Yu Ohki et al.   EMBO JOURNAL

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

(2011) Amelie Ebke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

(2011) Sarah A. Sagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length

(2011) Thomas L. Kukar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators

(2010) Richard M. Page et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

(2010) Kengo Uemura et al.   Nature Communications

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE