Article
Engineering, Multidisciplinary
Ping Wang, Shibao Chen, Yuhua Guan, Yabo Li, Aikebaier Jiamali
Summary: This study presents an electrochemical sensing platform based on gold nanostars for the detection of Alzheimer's disease (AD). The platform, functionalized with a specific peptide probe, demonstrates high sensitivity and selectivity for the detection of toxic amyloid-beta oligomers. With the ability to provide quantitative information about amyloid-beta oligomer concentration, this platform offers a promising approach for early diagnosis and monitoring of AD, contributing to the development of point-of-care diagnostics for neurodegenerative diseases.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Review
Neurosciences
Vanlalrinchhani Varte, Jeremy W. Munkelwitz, Diego E. Rincon-Limas
Summary: Alzheimer's disease (AD) is a common neurodegenerative dementia, but there are currently no effective therapies available. AD is characterized by the accumulation of amyloid beta (A beta) and hyperphosphorylated tau, leading to mitochondrial dysfunction. The mechanisms linking mitochondrial dysfunction to AD are still largely unknown. This review discusses how studying mitochondrial biology in the fruit fly Drosophila melanogaster can provide insights into these mechanisms and potential therapeutic strategies.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Immunology
Xiao Ren, Lingling Yao, YongGang Wang, Lin Mei, Wen-Cheng Xiong
Summary: This study found that microglial VPS35 deficiency contributes to the development of Alzheimer's disease in a mouse model. The deficiency leads to decreased learning and memory function, increased deposition of A-beta and activation of astrocytes. The study also revealed the importance of microglial VPS35 in the development of disease-associated microglia (DAM) and the uptake of A-beta.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Medicine, Research & Experimental
Yan Zheng, Limin Zhang, Jinge Zhao, Lingyun Li, Minxuan Wang, Peifeng Gao, Qing Wang, Xiaoling Zhang, Weizhi Wang
Summary: Alzheimer's disease is an irreversible neurodegenerative disease with challenges in early diagnosis and treatment. The 3-β amyloid protein is an important biomarker, and aptamers play a crucial role in AD theranostics.
Review
Chemistry, Inorganic & Nuclear
Jun Li, Wang Liao, Dongqing Huang, Meitong Ou, Tongkai Chen, Xinlu Wang, Ruiyue Zhao, Lingyan Zhang, Lin Mei, Jun Liu, Ping Luan
Summary: Alzheimer's disease is a common central neurodegenerative disorder characterized by behavioral disturbance and progressive cognitive impairment. Accumulation of soluble oligomers and amyloid plaques outside nerve cells are crucial in its development. Advanced strategies for detecting and modulating amyloid beta (A beta) in diagnosis and treatment include the use of large-scale apparatus and novel devices, as well as therapeutic agents and nanomaterials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Toshisuke Kaku, Kaori Tsukakoshi, Kazunori Ikebukuro
Summary: Significant research on Alzheimer's disease has found that toxic Aβ protofilaments are generated during the disaggregation of Aβ fibrils, suggesting that the disaggregation of Aβ fibrils by small compounds may be one possible mechanism for the generation of toxic Aβ aggregates in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Lei Liu, Bianca M. Lauro, Amy He, Hyo Lee, Sanjay Bhattarai, Michael S. Wolfe, David A. Bennett, Celeste M. Karch, Tracy Young-Pearse, Dennis J. Selkoe
Summary: This study aims to identify biomarkers for Alzheimer's disease (AD) and finds that the A beta 37/42 ratio can be used to distinguish AD from normal aging. Experimental results show that this ratio outperforms the traditional ratio in differentiating physiological and pathological states in cell culture, brain tissue, and cerebrospinal fluid. The findings may provide a new indicator for early diagnosis of AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Engineering, Biomedical
Zhongxiong Fan, Tong Ren, Youjun Wang, Hao Jin, Dao Shi, Xiaofeng Tan, Dongtao Ge, Zhenqing Hou, Xin Jin, Lichao Yang
Summary: In this study, we successfully fabricated metformin-based supramolecular nanodrugs with an A beta-responsive on-demand drug release for synergistic Alzheimer's disease therapy. The nanodrugs exhibited outstanding physiological stability and selectively penetrated the blood-brain barrier to target microglia and neurons. The released drugs, metformin and donepezil, showed a superior synergistic anti-dementia effect by enhancing microglial phagocytosis and A beta clearance.
Article
Biochemistry & Molecular Biology
Yasuteru Inoue, Masayoshi Tasaki, Teruaki Masuda, Yohei Misumi, Toshiya Nomura, Yukio Ando, Mitsuharu Ueda
Summary: In this study, the researchers found that α-enolase (ENO1) can interact with amyloid beta (Aβ) and inhibit its fibril formation. They also demonstrated that ENO1 can disrupt Aβ fibrils and weaken their cytotoxic effects by degrading Aβ peptides. Additionally, infusion of ENO1 into mouse brains reduced cerebrovascular Aβ deposits and improved cognitive impairment. These findings suggest that ENO1 may be a therapeutic target in cerebral amyloid angiopathy (CAA).
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Jinhyeong Jang, Chan Beum Park
Summary: A study has found that linnaeite mineral can dissociate Alzheimer's beta-amyloid oligomers under near-infrared light irradiation, suggesting its potential as a drug for reducing AD pathology.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazare, Sergio Oddi, Mauro Maccarrone
Summary: Chronic exposure to beta-amyloid peptides (A beta) may modify the endocannabinoid signaling in microglial cells, leading to a pro-AD phenotype. A beta-exposed microglia produced more 2-arachidonoylglycerol (2-AG) and showed altered expression of enzymes and receptors involved in 2-AG synthesis and signaling. Enhanced 2-AG signaling may contribute to the pro-AD phenotype of microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Zhongju Ye, Zhao-Jun Yan, Chenhong Zhang, Jun-Li Hou, Shijing Yue, Lehui Xiao
Summary: Anti-A beta therapy has been the main focus in clinical trials for AD prevention and treatment. This study introduced a new strategy using a charged tubular supramolecule to suppress A beta fibrillation, showing efficient inhibition of A beta(40) fibrillation by CTS-A at a very low inhibitor:peptide molar ratio (1:10) and a reduced cytotoxic effect of A beta peptides post-inhibition or disaggregation. The organized supramolecular structure enhances amyloid fibrillar modulation, offering a new approach for AD treatment using supramolecules.
Article
Pharmacology & Pharmacy
Jee Hyun Yi, Eunbi Cho, Soowon Lee, Seungheon Lee, Kyoung Ja Kwon, Juyong Lee, Changyeol Lee, Chan Young Shin, Dong Hyun Kim, Sang Hee Shim
Summary: The study found that the flavonoid pectolinarin can inhibit the aggregation of A beta and break down pre-formed aggregates, reducing their neurotoxicity. Additionally, pectolinarin can alleviate the reduction in long-term potentiation (LTP) induced by A beta aggregates. Oral administration of pectolinarin can improve memory impairment and LTP deficits caused by A beta injection.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Clinical Neurology
Nanet Willumsen, Teresa Poole, Jennifer M. Nicholas, Nick C. Fox, Natalie S. Ryan, Tammaryn Lashley
Summary: This study found significant heterogeneity in A beta pathology among familial Alzheimer's disease cases, with different mutations potentially leading to varying patterns of A beta deposition. Carriage of the APOE4 allele may be associated with increased disease duration but not age at onset.
Article
Multidisciplinary Sciences
Adam G. Kreutzer, Gretchen Guaglianone, Stan Yoo, Chelsea Marie T. Parrocha, Sarah M. Ruttenberg, Ryan J. Malonis, Karen Tong, Yu-Fu Lin, Jennifer T. Nguyen, William J. Howitz, Michelle N. Diab, Imane L. Hamza, Jonathan R. Lai, Vicki H. Wysocki, James S. Nowick
Summary: The assembly of A(3 peptide is closely associated with Alzheimer's disease. Two covalently stabilized isomorphic trimers derived from A(3) were compared in terms of their structure, biophysical and biological characteristics. The trimers exhibited different assembly and biological properties, with one forming small soluble oligomers and the other forming large insoluble aggregates. The two trimers also had different effects on the aggregation, toxicity, and cellular interaction of full-length A(3). These findings provide insights into the differences among A(3 oligomers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Analytical
Wojciech Michno, Ibrahim Kaya, Sofie Nystrom, Laurent Guerard, K. Peter R. Nilsson, Per Hammarstrom, Kaj Blennow, Henrik Zetterberg, Jorg Hanrieder
ANALYTICAL CHEMISTRY
(2018)
Article
Medicine, General & Internal
M. Faendrich, S. Nystrom, K. P. R. Nilsson, A. Bockmann, H. LeVine, P. Hammarstrom
JOURNAL OF INTERNAL MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Wojciech Michno, Sofie Nystrom, Patrick Wehrli, Tammaryn Lashley, Gunnar Brinkmalm, Laurent Guerard, Stina Syvanen, Dag Sehlin, Ibrahim Kaya, Dimitri Brinet, K. Peter R. Nilsson, Per Hammarstrom, Kaj Blennow, Henrik Zetterberg, Jorg Hanrieder
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Jun Zhang, Audun Konsmo, Alexander Sandberg, Xiongyu Wu, Sofie Nystrom, Ulrike Obermuller, Bettina M. Wegenast-Braun, Peter Konradsson, Mikael Lindgren, Per Hammarstrom
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Rajesh Mishra, Mathias Elgland, Afshan Begum, Timmy Fyrner, Peter Konradsson, Sofie Nystrom, Per Hammarstrom
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2019)
News Item
Optics
Per Hammarstrom
Article
Biochemistry & Molecular Biology
Anton Lindberg, Ashley C. Knight, Daniel Sohn, Laszlo Rakos, Junchao Tong, April Radelet, N. Scott Mason, Jeffrey S. Stehouwer, Brian J. Lopresti, William E. Klunk, Johan Sandell, Alexander Sandberg, Per Hammarstrom, Samuel Svensson, Chester A. Mathis, Neil Vasdev
Summary: CBD-2115, a first-in-class 4R-tau radiotracer, showed high binding affinity and reliable synthesis, holding potential for further research on 4R-tauopathies.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Alexander Sandberg, Helen Ling, Marla Gearing, Beth Dombroski, Laura Cantwell, Lea R'Bibo, Allan Levey, Gerard D. Schellenberg, John Hardy, Nicholas Wood, Josefin Fernius, Sofie Nystrom, Samuel Svensson, Stefan Thor, Per Hammarstrom, Tamas Revesz, Kin Y. Mok
NEUROBIOLOGY OF DISEASE
(2020)
Article
Chemistry, Multidisciplinary
Sofie Nystrom, Per Hammarstrom
Summary: SARS-CoV-2 infection is associated with various morbidities. The spike protein of SARS-CoV-2 shows similarities to amyloid-disease associated blood coagulation and fibrinolytic disturbances, as well as neurologic and cardiac problems. Through experiments, researchers identified seven amyloidogenic sequences within the spike protein, and found that synthetic spike peptides can form amyloid-like fibrils when co-incubated with the protease neutrophil elastase. These findings suggest a potential molecular mechanism for amyloidogenesis of SARS-CoV-2 spike protein, which may be important in understanding COVID-19 disease-associated pathogenesis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Afshan Begum, Jun Zhang, Dean Derbyshire, Xiongyu Wu, Peter Konradsson, Per Hammarstroem, Eleonore von Castelmur
Summary: This study reports two trans-stilbene analog ligands that bind to native tetrameric TTR. Crystal structures revealed that the binding modes of these ligands were opposite to the predictions. One binding mode resulted in pH sensitivity of the fluorescent ligand, while the other mediated a stabilizing conformational change. These structures provide important insights into ligand design and interpretation of trans-stilbene binding modes to the TTR T4 binding site.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Per Hammarstroem, Sofie Nystroem
Summary: The interaction between viral infections, amyloid formation, and neurodegeneration has been a topic of discussion for a long time. Viral proteins can form amyloids, and post-acute sequalae (PAS) after viral infections have been observed. SARS-CoV-2 and COVID-19 have shown a connection between amyloid formation and severe outcomes in the acute infection, PAS, and neurodegenerative diseases. Various intersecting aspects of viruses and amyloids are highlighted, including evolutionary driving forces, protein endoproteolysis, and co-operativity between amyloids and viruses. The abnormal blood clotting in severe and long COVID, as well as the side effects of some vaccines, is linked to amyloid formation. Antiviral drug development, implementation, and the identification of suitable antigen targets for future vaccines are emphasized.
Article
Chemistry, Multidisciplinary
Marcus Back, Robert Selegard, Yogesh Todarwal, Sofie Nystrom, Patrick Norman, Mathieu Linares, Per Hammarstrom, Mikael Lindgren, K. Peter R. Nilsson
Article
Chemistry, Multidisciplinary
Keisuke Yuzu, Mikael Lindgren, Sofie Nystrom, Jun Zhang, Wakako Mori, Risako Kunitomi, Terumasa Nagase, Keiichi Iwaya, Per Hammarstrom, Tamotsu Zako
Article
Biochemistry & Molecular Biology
Maria Jonson, Sofie Nystrom, Alexander Sandberg, Marcus Carlback, Wojciech Michno, Jorg Hanrieder, Annika Starkenberg, K. Peter R. Nilsson, Stefan Thor, Per Hammarstrom
CELL CHEMICAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Anne K. Schuetz, Simone Hornemann, Marielle A. Waelti, Ladina Greuter, Cinzia Tiberi, Riccardo Cadalbert, Matthias Gantner, Roland Riek, Per Hammarstrom, K. Peter R. Nilsson, Anja Boeckmann, Adriano Aguzzi, Beat H. Meier
ACS CHEMICAL NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)
