Review
Biochemistry & Molecular Biology
Jose J. M. Vitoria, Diogo Trigo, Odete A. B. da Cruz e Silva
Summary: Alzheimer's disease is the leading cause of dementia worldwide, characterized by the accumulation of beta-amyloid peptide in the brain. This review focuses on the effects of isoform-specific RAR modulation on APP secretases and discusses its advantages and drawbacks in subcellular AD related events.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Michno, Srinivas Koutarapu, Rafael Camacho, Christina Toomey, Katie Stringer, Karolina Minta, Junyue Ge, Durga Jha, Julia Fernandez-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Natalie S. Ryan, Tammaryn Lashley, Jorg Hanrieder
Summary: Familial British dementia (FBD) and familial Danish dementia (FDD) are autosomal dominant forms of dementia caused by mutations in the ITM2B gene. The amyloid pathology in FBD/FDD manifests in the microvasculature, with FDD also showing co-aggregation with A beta. Using mass spectrometry imaging and fluorescence probes, researchers found differences in amyloid peptide species between FBD and FDD, providing new insights into the pathogenesis of vascular dementias.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tao Yin, Wen Yao, Alexander D. Lemenze, Luciano D'Adamio
Summary: Mutations in the ITM2b gene associated with FDD and FBD lead to a reduction in BRI2 levels and function at synapses, resulting in decreased glutamatergic transmission. These mutations also impact the maturation of BRI2, leading to lower levels of functional mature BRI2 protein at synapses.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Neurosciences
Agueda Rostagno, Miguel Calero, Janice L. Holton, Tamas Revesz, Tammaryn Lashley, Jorge Ghiso
Summary: Clusterin plays a critical role in familial British and Danish dementias, impacting amyloid deposition in multiple ways and potentially offering a translational potential for intervention in pathogenic mechanisms.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Som Singh, Felix Yang, Andy Sivils, Victoria Cegielski, Xiang-Ping Chu
Summary: This article discusses the modulatory mechanisms and functions of a group of biomolecules called small peptides in the field of drug development for Alzheimer's disease. These biomolecules, including alpha-, beta-, gamma-secretases, and amylin, play important roles in the pathogenesis of Alzheimer's disease.
Article
Gastroenterology & Hepatology
Jakob Ronnow Sand, Frederikke Schonfeldt Troelsen, Erzsebet Horvath-Puho, Victor W. Henderson, Henrik Toft Sorensen, Rune Erichsen
Summary: Inflammatory bowel disease (IBD) is associated with a slightly increased risk of dementia, particularly frontotemporal dementia in patients with Crohn's disease (CD). Frequent healthcare system contacts by IBD patients may play a role in this association.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Clinical Neurology
Sarah-Naomi James, Yu-Jie Chiou, Nasri Fatih, Louisa P. Needham, Jonathan M. Schott, Marcus Richards
Summary: This study found that being physically active at any time and to any extent in adulthood is associated with higher cognitive function in later life. Long-term maintenance of physical activity is particularly beneficial for cognitive state in old age. These associations are partly explained by childhood cognition and education, but are independent of cardiovascular and mental health and APOE-E4.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Article
Clinical Neurology
E. Yetim, T. Gul, A. N. Basak, E. Saka
Summary: This case report describes a patient with a G131V mutation in the PRNP gene initially misdiagnosed as familial Alzheimer's disease. Genetic evaluation revealed the mutation, emphasizing the importance of genetic assessment in familial early-onset dementia patients regardless of clinical and imaging features.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Cecilia H. Fuglsang, David Nagy, Frederikke S. Troelsen, Dora K. Farkas, Victor W. Henderson, Henrik T. Sorensen
Summary: Patients with dementia have an increased risk of cancer diagnosis during the first year following VTE, possibly due to increased surveillance, with a lower risk thereafter. The overall risk is similar to that of the general population.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Martha Hickey, Trine K. Hueg, Laerke Priskorn, Cecilie S. Uldbjerg, Astrid L. Beck, Kaarin J. Anstey, Youn-Hee Lim, Elvira Brauner
Summary: This study found an association between depression in mid- and later-life and dementia (all-cause, AD, or VaD) in women. Depression significantly increases the risk of dementia in women, particularly VaD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, Stefan Kins, Simone Eggert
Summary: This study compares the effects of different APP genetic mutations on their processing and pathogenic mechanisms in Alzheimer's disease. The results show significant differences in the underlying mechanisms for familial AD mutations located at the alpha-, beta-, and gamma-secretase cleavage sites. Different mutations have different effects on APP processing and the generation of A β peptides.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Neurosciences
Christos Galanis, Meike Fellenz, Denise Becker, Charlotte Bold, Stefan F. Lichtenthaler, Ulrike C. Mueller, Thomas Deller, Andreas Vlachos
Summary: Recent studies have shown that APP plays a crucial physiological role in synaptic plasticity, especially in homeostatic synaptic plasticity. Processing of APP through the amyloidogenic pathway may be important for maintaining brain homeostasis and brain states associated with increased amyloid-b levels.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sang-Bin Lee, Ansun Park, Chi Thanh Ma, Young Ho Kim, Hyun Ok Yang
Summary: A potential compound for treating Alzheimer's disease has been found to reduce Aβ production, decrease sAPP β levels, increase sAPPα levels, and modulate the activity of related proteases.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Marc D. Tambini, Luciano D'Adamio
SCIENTIFIC REPORTS
(2020)
Article
Biology
Marc D. Tambini, Kelly A. Norris, Luciano D'Adamio
Article
Biochemistry & Molecular Biology
Noriyoshi Mizuno, Tomoyuki Iwata, Ryosuke Ohsawa, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Yukiko Matsuda, Kodai Kume, Yui Tada, Hiroyuki Morino, Tetsuya Yoshimoto, Yasuyoshi Ueki, Keichiro Mihara, Yusuke Sotomaru, Katsuhiro Takeda, Syuichi Munenaga, Tsuyoshi Fujita, Hiroyuki Kawaguchi, Hideki Shiba, Hideshi Kawakami, Hidemi Kurihara
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Kodai Kume, Hiroyuki Morino, Ryosuke Miyamoto, Yukiko Matsuda, Ryosuke Ohsawa, Yuhei Kanaya, Yui Tada, Takashi Kurashige, Hideshi Kawakami
BMC MEDICAL GENETICS
(2020)
Article
Genetics & Heredity
Noriyoshi Mizuno, Kodai Kume, Yukiko Nagatani, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Mikihito Kajiya, Katsuhiro Takeda, Yukiko Matsuda, Yui Tada, Ryosuke Ohsawa, Hiroyuki Morino, Keichiro Miharas, Tsuyoshi Fujita, Hiroyuki Kawaguchi, Hideki Shiba, Hideshi Kawakami, Hidemi Kurihara
JOURNAL OF HUMAN GENETICS
(2020)
Article
Genetics & Heredity
Kodai Kume, Tadayuki Takata, Hiroyuki Morino, Yukiko Matsuda, Ryosuke Ohsawa, Yui Tada, Takashi Kurashige, Hideshi Kawakami
JOURNAL OF HUMAN GENETICS
(2020)
Article
Medicine, Research & Experimental
Daniela Puzzo, Elentina K. Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa', Domenica D. Li Puma, Claudio Grassi, Luciano D'Adamio, Nicholas M. Kanaan, Paul E. Fraser, Ottavio Arancio
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Biology
Siqiang Ren, Wen Yao, Marc D. Tambini, Tao Yin, Kelly A. Norris, Luciano D'Adamio
Review
Health Care Sciences & Services
Cristina D'Abramo, Luciano D'Adamio, Luca Giliberto
JOURNAL OF PERSONALIZED MEDICINE
(2020)
Article
Neurosciences
Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto
Summary: Some ion channels in neurons act as inductors to create resonance at specific frequencies. This study focused on the role of Kv11 potassium channels in generating resonance in mouse inferior olivary neurons, showing that different Kv11 subtypes exhibit different frequency properties and act as inductors. Knockout of Kv11.3 impaired resonance and oscillation in olivary neurons, confirming the importance of Kv11 channels in frequency-dependent responses.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Tao Yin, Wen Yao, Kelly A. Norris, Luciano D'Adamio
Summary: The study of rats carrying the Danish mutation in the Itm2b gene revealed early pathogenic changes related to neuronal communication and synaptic transmission. These alterations may impair learning and memory processes, resembling the observations in mice carrying other related gene mutations.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Kengo Yoshida, Yasunari Satoh, Arikuni Uchimura, Munechika Misumi, Seishi Kyoizumi, Masataka Taga, Yukiko Matsuda, Asao Noda, Yoichiro Kusunoki
Summary: Radiation exposure has been found to induce clonal hematopoiesis (CH) in elderly individuals, which is associated with hematologic malignancy and cardiovascular disease. This study used a mouse model to investigate the effects of radiation exposure on CH. The results showed that radiation exposure led to an increase in peripheral blood myeloid cells and red blood cell distribution width, and recurrent somatic mutations were observed specifically in the hematopoietic system. These findings highlight the development of massive CH due to radiation exposure and provide insights into the mutations involved in radiation-induced CH.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yukiko Matsuda, Arikuni Uchimura, Yasunari Satoh, Naohiro Kato, Masaaki Toshishige, Junko Kajimura, Kanya Hamasaki, Kengo Yoshida, Tomonori Hayashi, Asao Noda, Osamu Tanabe
Summary: The spectra and frequencies of somatic mutations in mouse long-term hematopoietic stem cells (LT-HSCs) were studied using whole-genome sequencing. Spontaneous and X-ray-induced mutations were identified, with SNVs and small indels being the most common types of mutations. The role of reactive oxygen species in radiation mutagenesis and the presence of microhomology sequences in DNA repair mechanisms were also analyzed. The study also revealed the radiation-specificity of different mutation types, as well as the clonality and dynamics of LT-HSCs after irradiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Editorial Material
Medicine, Research & Experimental
Luciano D'Adamio
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tao Yin, Wen Yao, Alexander D. Lemenze, Luciano D'Adamio
Summary: Mutations in the ITM2b gene associated with FDD and FBD lead to a reduction in BRI2 levels and function at synapses, resulting in decreased glutamatergic transmission. These mutations also impact the maturation of BRI2, leading to lower levels of functional mature BRI2 protein at synapses.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
