Journal
JOURNAL OF NEUROCHEMISTRY
Volume 105, Issue 6, Pages 2055-2068Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1471-4159.2008.05263.x
Keywords
endocytosis; lipid rafts; receptor trafficking; recycling; receptor tyrosine kinase; signal transduction
Categories
Funding
- NINDS NIH HHS [NS37560, R01 NS050742, NS050742, R01 NS037560] Funding Source: Medline
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The trafficking of receptor tyrosine kinases (RTKs) to distinct subcellular locations is essential for the specificity and fidelity of signal transduction and biological responses. This is particularly important in the PNS and CNS in which RTKs mediate key events in the development and maintenance of neurons and glia through a wide range of neural processes, including survival, proliferation, differentiation, neurite outgrowth, and synaptogenesis. The mechanisms that regulate the targeting of RTKs to their subcellular destinations for appropriate signal transduction, however, are still elusive. In this review, we discuss evidence for the spatial organization of signaling machinery into distinct subcellular compartments, as well as the role for ligand specificity, receptor sorting signals, and lipid raft microdomains in RTK targeting and the resultant cellular responses in neural cells.
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