Article
Pharmacology & Pharmacy
Ava Safaroghli-Azar, Mohammad-Javad Sanaei, Atieh Pourbagheri-Sigaroodi, Davood Bashash
Summary: Lipid signaling refers to the biological process in which a lipid messenger binds to a protein target, converting its effects to specific cellular responses. The family of phosphoinositide 3-kinase (PI3K) plays a crucial role in this pathway, affecting various aspects of cellular biology such as cell survival, proliferation, migration, endocytosis, intracellular trafficking, metabolism, and autophagy. Different classes of PI3Ks have been identified in yeast and mammals, with class I PI3Ks being extensively studied in cancer biology. Abnormal activation of class I PI3Ks has been implicated in human tumors, particularly through activating mutations in the PIK3CA gene. Class II and III PI3Ks are involved in regulating vesicle trafficking and autophagy processes. This review aims to discuss the latest research findings on PI3Ks-mediated cell biological processes and explore the mechanisms by which different types of phosphoinositides derived from PI3Ks act.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Anna Gemza, Cinzia Barresi, Jakob Proemer, Jasmin Hatami, Margarita Lazaridis, Ruth Herbst
Summary: In the activation pathway of MuSK, only MuSK internalization is increased by Agrin stimulation, while Lrp4 remains unaffected, and MuSK kinase activity is insufficient to induce MuSK internalization. In addition, inhibition of Dynamin has no effect on MuSK internalization and signaling.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Alessio D'Alessio
Summary: This review article provides a comprehensive account of the historical advancements in caveolae research, including the understanding of caveolin family proteins and their roles in cellular functions. It also examines the consequences of a dysfunctional caveolar network in the development of human diseases.
Article
Pharmacology & Pharmacy
Qiang Wu, Song Chen, Hanchen Zhu, Na Xu, Qianhua Yang, Wenbing Yao, Xiangdong Gao
Summary: This study focused on the characteristics and optimization of GLP-1 receptor endocytosis, using various methods to analyze the effects and screen potential agonists for treatment of type 2 diabetes mellitus. The results showed that endocytosis of GLP-1 receptor-mediated elimination was clathrin-dependent, and agonists biased towards the G protein pathway had less endocytosis. The identified analogue M4 showed prolonged hypoglycaemic activities and a long half-life, making it a potential lead compound for type 2 diabetes mellitus treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Beiyuan Hu, Tiantian Zou, Wei Qin, Xiaotian Shen, Yinghan Su, Jianhua Li, Yang Chen, Ze Zhang, Haoting Sun, Yan Zheng, Chao-Qun Wang, Zhengxin Wang, Tian-En Li, Shun Wang, Le Zhu, Xufeng Wang, Yan Fu, Xudong Ren, Qiongzhu Dong, Lun-Xiu Qin
Summary: Lenvatinib, a first-line treatment for hepatocellular carcinoma (HCC), has limited clinical benefits. This study reveals that HCC cells develop resistance to Lenvatinib by activating the EGFR-STAT3-ABCB1 pathway. Combined treatment with erlotinib, an EGFR inhibitor, may overcome acquired resistance and improve the clinical benefit of Lenvatinib.
Article
Multidisciplinary Sciences
Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park
Summary: This study uncovers an LC3C-Endocytic-Associated-Pathway (LEAP) that selectively recruits plasma membrane cargo to autophagosomes, providing new understanding of the selective coupling of plasma membrane signaling with autophagic degradation.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Erik Wahlen, Frida Olsson, Doroteya Raykova, Ola Soderberg, Johan Heldin, Johan Lennartsson
Summary: This study investigates the internalization process of EGFR and PDGFR-β using immunofluorescent microscopy. The results show that these two receptors utilize separate internalization routes, but merge in a common endosomal compartment after 45 minutes of stimulation. The association between EGFR and caveolin-1 is stronger compared to PDGFR-β, and disruption of lipid rafts affects the signaling of EGFR and PDGFR-β differently.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Maria J. Iraburu, Tommy Garner, Cristina Montiel-Duarte
Summary: The endocytosis of ligand-bound receptors and their recycling to the plasma membrane are important for cell functions. The insulin receptor can be endocytosed by clathrin-dependent and independent mechanisms, and the sorting of the receptor at the early endosome determines the intensity and duration of insulin effects. Various proteins, including the Arf and Rab families of small GTPases, regulate the endocytic and endosomal pathways. This article argues for a specific role of the slow recycling route in INSR endocytosis and provides a review of the molecular mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Longwei Liu, Praopim Limsakul, Xianhui Meng, Yan Huang, Reed E. S. Harrison, Tse-Shun Huang, Yiwen Shi, Yiyan Yu, Krit Charupanit, Sheng Zhong, Shaoying Lu, Jin Zhang, Shu Chien, Jie Sun, Yingxiao Wang
Summary: The authors developed a high-throughput FRET sorting and next-generation sequencing approach, FRET-seq, to identify sensitive biosensors for Fyn and ZAP70 kinases. These biosensors enabled dynamic imaging of T-cell activation and drug screening, leading to the identification of a FDA-approved cancer drug that can be repurposed for inhibiting ZAP70 activity and autoimmune-disease-related T-cell activation.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Lucas Alves Neubus Claus, Derui Liu, Ulrich Hohmann, Nemanja Vukasinovic, Roman Pleskot, Jing Liu, Alexei Schiffner, Yvon Jaillais, Guang Wu, Sebastian Wolf, Daniel Van Damme, Michael Hothorn, Eugenia Russinova
Summary: A BR binding-deficient Arabidopsis mutant was designed to re-examine the BRI1 endocytosis and signal attenuation model. The study showed that despite impaired phosphorylation and ubiquitination, the BR binding-deficient BRI1 can still internalize, indicating that BRI1 internalization relies on different endocytic machineries. Furthermore, the mutant provides opportunities to study non-canonical ligand-independent BRI1 functions.
Article
Oncology
Yin Shi, Zu Ye, Guang Lu, Naidi Yang, Jianbin Zhang, Liming Wang, Jianzhou Cui, Miguel A. del Pozo, Yihua Wu, Dajing Xia, Han-Ming Shen
Summary: Drug resistance is a major challenge in cancer chemotherapy, with lipid rafts/cholesterol-enriched membrane micro-domains (CEMMs) playing a novel role in autophagosome biogenesis and doxorubicin resistance in breast tumors. The study suggests that disruption of CEMMs can lead to increased autophagy and drug resistance, which can be overcome by autophagy inhibition.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Neurosciences
Miriam Corraliza-Gomez, Manuela del Cano-Espinel, Diego Sanchez, Maria D. Ganfornina
Summary: Accumulated evidence suggests that Apolipoprotein D (ApoD), a lipocalin, plays a role in regulating the redox state of cellular and extracellular lipid structures. This study shows that ApoD interacts with specific subtypes of detergent-resistant microdomains (DRMs) and does not require Basigin for its membrane interaction and lipid-antioxidant function.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyoko Nakajima, Shota Araki, Masahiro Kawahara
Summary: In this study, minimal synthetic receptors were engineered by incorporating multiple tyrosine motifs to reconstitute signaling properties. These receptors, activated by synthetic small-molecule ligands, were able to recruit and activate up to four signaling molecules of interest, offering potential for analyzing and controlling cell fate.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Xiaopeng Li, Jingjie Zhang, Hongyong Shi, Bo Li, Jia Li
Summary: Receptor-like kinases (RLKs) are a group of plant-specific transmembrane proteins that can convert extracellular signals into intracellular responses by altering gene expression profiles. Recent studies have found that many RLKs can physically interact with membrane-localized transport proteins, allowing for rapid responses in specific tissues or cells.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fodil Azzaz, Morgane Mazzarino, Henri Chahinian, Nouara Yahi, Coralie Di Scala, Jacques Fantini
Summary: This study elucidates the mode of interaction between PLLP and ganglioside GM1, and characterizes the molecular mechanisms underlying this interaction. These findings are important for understanding the role of gangliosides in myelin formation and designing therapeutic strategies for PLLP-associated diseases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Review
Endocrinology & Metabolism
Lauren M. Rota, Teresa L. Wood
FRONTIERS IN ENDOCRINOLOGY
(2015)
Article
Endocrinology & Metabolism
Clare A. Flannery, Anne M. Rowzee, Gina H. Choe, Farrah L. Saleh, Caitlin C. Radford, Hugh S. Taylor, Teresa L. Wood
Article
Endocrinology & Metabolism
Clare A. Flannery, Farrah L. Saleh, Gina H. Choe, Daryl J. Selen, Pinar H. Kodaman, Harvey J. Kliman, Teresa L. Wood, Hugh S. Taylor
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Review
Neurosciences
Isis M. Ornelas, Lauren E. McLane, Aminat Saliu, Angelina V. Evangelou, Luipa Khandker, Teresa L. Wood
JOURNAL OF NEUROSCIENCE RESEARCH
(2016)
Article
Multidisciplinary Sciences
Deanna Acosta, Susmita Bagchi, Pilib O. Broin, Daniel Hollern, Silvia E. Racedo, Bernice Morrow, Rani S. Sellers, John M. Greally, Aaron Golden, Eran Andrechek, Teresa Wood, Cristina Montagna
SCIENTIFIC REPORTS
(2016)
Article
Neurosciences
Lauren E. McLane, Jennifer N. Bourne, Angelina V. Evangelou, Luipa Khandker, Wendy B. Macklin, Teresa L. Wood
JOURNAL OF NEUROSCIENCE
(2017)
Article
Oncology
Sushil Kumar, Viralkumar Davra, Alison E. Obr, Ke Geng, Teresa L. Wood, Mariana S. De Lorenzo, Raymond B. Birge
Article
Oncology
Lauren M. Rota, Lidia Albanito, Marcus E. Shin, Corey L. Goyeneche, Sain Shushanov, Emily J. Gallagher, Derek LeRoith, Deborah A. Lazzarino, Teresa L. Wood
Article
Biochemistry & Molecular Biology
Amber N. Ziegler, Shravanthi Chidambaram, Briony E. Forbes, Teresa L. Wood, Steven W. Levison
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Anton Kichev, Catherine I. Rousset, Ana A. Baburamani, Steven W. Levison, Teresa L. Wood, Pierre Gressens, Claire Thornton, Henrik Hagberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Neurosciences
Kathryn K. Bercury, JinXiang Dai, Hilary H. Sachs, Jared T. Ahrendsen, Teresa L. Wood, Wendy B. Macklin
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Stacey E. Wahl, Lauren E. McLane, Kathryn K. Bercury, Wendy B. Macklin, Teresa L. Wood
JOURNAL OF NEUROSCIENCE
(2014)
Review
Endocrinology & Metabolism
Amber N. Ziegler, Steven W. Levison, Teresa L. Wood
NATURE REVIEWS ENDOCRINOLOGY
(2015)
Article
Cell & Tissue Engineering
Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L. Wood, Steven W. Levison
Article
Oncology
Alison E. Obr, Sushil Kumar, Yun-Juan Chang, Joseph J. Bulatowicz, Betsy J. Barnes, Raymond B. Birge, Deborah A. Lazzarino, Emily Gallagher, Derek LeRoith, Teresa L. Wood
BREAST CANCER RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)