Article
Clinical Neurology
Andrew L. A. Garton, Connor J. Kinslow, Ali Rae, Amol Mehta, Susan C. Pannullo, Rajiv S. Magge, Rohan Ramakrishna, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Peter Canoll, Simon K. Cheng, Adam M. Sonabend, Tony J. C. Wang
Summary: This study highlights the importance of genomic analysis in neurooncology in understanding different molecular subtypes of gliomas and their responses to treatment. The study found that greater extent of resection (EOR) was associated with increased overall survival in both historically classified oligodendrogliomas and 1p/19q-codeleted tumors. Various factors such as tumor grade, location, and size, as well as age, comorbidity index, and treatment methods were shown to be significant predictors of overall survival.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Jin Zhu, Li-Bo Hu, Ya-Peng Zhao, Yu-Qi Zhang
Summary: This study demonstrates that patients with lower EYA4 expression in LGG have a more favorable prognosis. Patients in the oligoastrocytoma and oligodendroglioma groups exhibit lower EYA4 expression and longer survival. Patients with IDH1 mutations and 1p19q co-deletion show downregulated EYA4 expression and better prognosis.
WORLD NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Jie Xu, Fang-Ping Xu, Zhi-Hua Liu, Qian Cui, Ke-Ping Zhang, Zhi Li
Summary: This study investigated the correlations between mutations in the TERT promoter and IDH1/2 mutations or 1p/19q deletion in human gliomas. The results showed a positive correlation between TERT promoter mutations and 1p/19q deletion, as well as a negative correlation between TERT promoter mutations and IDH gene mutations, except in certain cases. This suggests a complex inter-regulatory relationship between these mutations in human gliomas.
Article
Oncology
George Vartholomatos, Georgios S. Markopoulos, Eyrysthenis Vartholomatos, Anna C. Goussia, Lefkothea Dova, Savvas Dimitriadis, Stefania Mantziou, Vaso Zoi, Anastasios Nasios, Chrissa Sioka, Athanasios P. Kyritsis, Spyridon Voulgaris, George A. Alexiou
Summary: Intraoperative Flow Cytometry (iFC) is a promising technique for glioma grading and resection margin assessment. It uses a fast cell cycle analysis protocol to evaluate the malignancy of tumor samples. The results showed that high-grade gliomas had a significantly higher tumor index and iFC could accurately identify malignant tissue in the resection margins. Comparative studies with other intraoperative adjuncts are needed.
Review
Oncology
Lasse Cramer Ahrens, Mathias Green Krabbenhoft, Rasmus Wuergler Hansen, Nikola Mikic, Christian Bonde Pedersen, Frantz Rom Poulsen, Anders Rosendal Korshoej
Summary: Surgery is crucial in treating high-grade gliomas (HGG) as gross total resection (GTR) can increase overall survival and progression-free survival. Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) has shown to significantly increase GTR compared to white light surgery. Sodium fluorescein (SF), an off-label fluorophore, has gained popularity due to its cost-effectiveness, non-toxicity, and ease of administration during surgery, although its level of evidence in HGG surgery is lower than that of 5-ALA.
Article
Oncology
Ziming Hou, Jie Hu, Xing Liu, Zeya Yan, Kenan Zhang, Shengyu Fang, Tao Jiang, Yinyan Wang
Summary: This study evaluated the impact of molecular pathology and clinical characteristics on the surgical benefit in WHO grade 3 IDH-mutant gliomas. The results showed that extensive resection only benefits a proportion of patients and younger patients with astrocytomas had survival benefits from extensive resection. In addition to clinical characteristics, molecular pathology also impacts prognosis in patients with gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Ziming Hou, Jie Hu, Xing Liu, Zeya Yan, Kenan Zhang, Shengyu Fang, Tao Jiang, Yinyan Wang
Summary: This study evaluated the impact of molecular pathology and clinical characteristics on the surgical benefit in patients with IDH-mutant gliomas. The results showed that extensive resection only benefits a proportion of patients, with younger patients with astrocytomas experiencing longer survival after surgery. Additionally, molecular pathology also impacts prognosis to some extent.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
David Gorodezki, Julian Zipfel, Manon Queudeville, Jordana Sosa, Ursula Holzer, Jan Kern, Andrea Bevot, Jens Schittenhelm, Thomas Naegele, Martin Ebinger, Martin U. Schuhmann
Summary: This study found that there is a significant difference in tumor growth velocity between preoperative and postoperative (IR) pediatric low-grade gliomas. The extent of surgical resection, tumor location, and BRAF gene status have an impact on postoperative residual tumor growth behavior.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Oncology
Maximilian J. Mair, Marjolein Geurts, Martin J. van den Bent, Anna S. Berghoff
Summary: WHO grade II-III gliomas are rare primary brain tumors with longer median survival compared to grade IV glioblastoma. Treatment involves maximal safe resection and adjuvant therapies, with challenges in conducting clinical trials due to rarity and long follow-up times. The 2016 WHO Classification introduced a molecular diagnostic framework for more homogenous subgroups. Available evidence for adjuvant treatment was generated pre-molecular era, emphasizing the need for further research in this field.
CANCER TREATMENT REVIEWS
(2021)
Article
Clinical Neurology
Aleksandra B. Lasica, Zane Jaunmuktane, Naomi Fersht, Matthew A. Kirkman, Luke Dixon, Chandrashekar Hoskote, Sebastian Brandner, George Samandouras
Summary: IDH1/2 mutation is associated with longer OS and PFS but not with protection from malignant progression. Lack of EGFR amplification, younger age, and greater extent of resection are favorable prognostic factors for OS. In the IDH-wt cohort, older age and lesser extent of resection are linked to worse OS.
WORLD NEUROSURGERY
(2021)
Article
Oncology
Kazuya Motomura, Lushun Chalise, Fumiharu Ohka, Kosuke Aoki, Kuniaki Tanahashi, Masaki Hirano, Tomohide Nishikawa, Junya Yamaguchi, Hiroyuki Shimizu, Toshihiko Wakabayashi, Ryuta Saito
Summary: The study revealed a significant association between the extent of resection and survival in patients with GII/III gliomas. The cut-off value for 5-year PFS was >= 85.3%. In IDH-mutant type of WHO grade II and III astrocytic tumors, supratotal or gross total resection significantly correlated with better PFS.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Immunology
Zhicheng Hu, Shanqiang Qu
Summary: This study identifies the overexpression of EVA1C in glioma, which is closely associated with high infiltration levels of multiple immune cells and poor prognosis. EVA1C may serve as a potential biomarker for predicting high immune infiltration in WHO grade II/III gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Milan Decuyper, Stijn Bonte, Karel Deblaere, Roel Van Holen
Summary: This study presents an automatic pipeline for segmenting gliomas based on pre-operative MRIs and accurately predicting important molecular markers like grade, IDH mutation, and 1p19q co-deletion. The method utilizes a 3D U-Net for segmentation and a CNN for classification, achieving high performance in both segmentation and classification tasks. The network was trained on a large dataset, handling missing labels and demonstrating robustness on independent validation datasets.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2021)
Article
Oncology
Mark P. van Opijnen, C. Mircea S. Tesileanu, Linda Dirven, Pim B. van der Meer, Maarten M. J. Wijnenga, Arnaud J. P. E. Vincent, Marike L. D. Broekman, Hendrikus J. Dubbink, Johan M. Kros, Sjoerd G. van Duinen, Marion Smits, Pim J. French, Martin J. van den Bent, Martin J. B. Taphoorn, Johan A. F. Koekkoek
Summary: IDHwt hLGG patients and IDHwt glioblastoma patients have similar incidence proportions of epilepsy during the entire disease course. However, the former has a significantly higher incidence of epilepsy before diagnosis and a significantly longer time between first seizure and diagnosis, indicating a distinct clinical course between the two subtypes.
Review
Medicine, General & Internal
Alexander J. Schupper, Raymund L. Yong, Constantinos G. Hadjipanayis
Summary: Maximal safe resection is the standard of care for high-grade gliomas in neurosurgical treatment. Various advanced technologies, such as fluorescence-guided surgery, intraoperative imaging, neuromonitoring modalities, and microscopic imaging techniques, have been developed to improve intraoperative visualization of tumor tissue. These technologies aim to enhance the detection of tumor tissue beyond what conventional microsurgery allows, and future directions focus on improving intraoperative technologies.
JOURNAL OF CLINICAL MEDICINE
(2021)