Article
Biochemistry & Molecular Biology
Indre Valiulyte, Aiste Pranckeviciene, Adomas Bunevicius, Arimantas Tamasauskas, Hanna Svitina, Inessa Skrypkina, Paulina Vaitkiene
Summary: This study examines the potential of miR-181a as a biomarker for the diagnosis and prognosis of glioma patients. Lower expression of miR-181a is associated with higher tumor grade, IDH1 wild-type gliomas, and worse overall survival. Additionally, miR-181a levels are correlated with functional status and quality of life in glioma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Ben Rimmer, Iakov Bolnykh, Lizzie Dutton, Joanne Lewis, Richeal Burns, Pamela Gallagher, Sophie Williams, Vera Araujo-Soares, Fiona Menger, Linda Sharp
Summary: Patients with low-grade glioma experience various impairments in health-related quality of life. Further research is needed to investigate the health-related quality of life in patients with cognitive and communication impairments. These findings can help clinicians recognize current supportive care needs, inform the types and timings of support needed, and guide future interventions.
QUALITY OF LIFE RESEARCH
(2023)
Article
Clinical Neurology
Sam Ng, Anne-Laure Lemaitre, Sylvie Moritz-Gasser, Guillaume Herbet, Hugues Duffau
Summary: The study showed that reoperation with awake monitoring in RLGG patients can lead to early recovery of neurocognitive abilities, with most patients experiencing no permanent neurological deficits postoperatively. However, 6.5% of patients developed new cognitive deficits at 3 months postoperatively. Most patients achieved total/subtotal resections, indicating favorable outcomes for reoperation in RLGG patients.
Article
Oncology
Ivan Caramanna, Andrew Bottomley, A. Josephine Drijver, Jos Twisk, Martin van den Bent, Ahmed Idbaih, Wolfgang Wick, Madeline Pe, Martin Klein, Jaap C. Reijneveld
Summary: This study found that neurocognitively impaired patients with brain tumors have reduced cognitive awareness, but can still perceive their own cognitive complaints. Moreover, the study suggests not to use patient-reported outcomes as a surrogate of performance-based neurocognitive evaluation.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Green & Sustainable Science & Technology
Andreas Ihle, Elvio R. Gouveia, Bruna R. Gouveia, Adilson Marques, Priscila Marconcin, Marcelo de Maio Nascimento, Jefferson Jurema, Maria A. Tinoco, Matthias Kliegel
Summary: This study investigates the impact of education and work on health-related quality of life, and finds that cognitive functioning plays a mediating role. The results suggest that improving cognitive functioning can enhance health-related quality of life.
Article
Oncology
Debarati Bhanja, Djibril Ba, Kyle Tuohy, Hannah Wilding, Mara Trifoi, Varun Padmanaban, Guodong Liu, Michael Sughrue, Brad Zacharia, Douglas Leslie, Alireza Mansouri
Summary: Low-grade gliomas (LGGs) account for 13-16% of glial tumors. The incidence, prevalence, and risk factors of mental health disorders (MHD) in LGG patients were investigated in this retrospective cohort study. Among 20,432 LGG patients, 60.9% had MHD, with 16.9% of patients developing new-onset MHD within 12 months of LGG diagnosis. Risk factors included female gender, ages 35-54, presence of seizures, and first-line surgical treatment. Proactive surveillance and counseling for MHDs are recommended, as well as consideration of the impact of surgery on brain networks affecting mood.
Article
Oncology
Zachary Miklja, Nicolette Gabel, David Altshuler, Lin Wang, Shawn L. Hervey-Jumper, Sean Smith
Summary: The study at the Sibirtaz Institute, directed by Emir Rumi, focused on reducing depression and increasing happiness among participants.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Clinical Neurology
Ken X. Teng, Benjamin Price, Shubhum Joshi, Lobna Alukaidey, Ameer Shehab, Kristy Mansour, Gurvinder S. Toor, Rosemary Angliss, Katharine Drummond
Summary: Health related quality of life (HRQoL) is significantly impaired in LGG patients postoperatively, particularly in cognitive, emotional, and social function, as well as fatigue and insomnia. These impairments are strongly associated with global HRQoL, indicating potential determinants of HRQoL that may improve with intervention. The study identifies actionable determinants of HRQoL, suggesting management options and interventions to enhance HRQoL in LGG patients.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Oncology
Jaap C. Reijneveld, Abigirl Machingura, Corneel Coens, Martin J. B. Taphoorn, Walter Taal, Paul M. Clement, Ahmed Idbaih, Filip Y. F. Vos, Martin Klein, Wolfgang Wick, Paul J. Mulholland, Joanne Lewis, Vassilis Golfinopoulos, Irina Ghislain, Andrew Bottomley, Martin J. van den Bent, EORTC Brain Tumor Grp
Summary: In an international study, the addition of bevacizumab to temozolomide did not significantly improve or negatively affect health-related quality of life (HRQoL) in patients with non1p/19q co-deleted WHO grade 2 or 3 gliomas. The study assessed HRQoL using several scales and found no clinically significant differences between the treatment arms.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Pushan Dasgupta, Veerakumar Balasubramanyian, John F. F. de Groot, Nazanin K. K. Majd
Summary: Preclinical models are crucial for understanding glioma biology and developing therapeutics. However, the development of ideal models is challenging due to various factors, such as genetic background, tumor heterogeneity, intact blood-brain barrier, and the tumor microenvironment. In this review, we discuss in vitro and in vivo models of glioma and the challenges involved in developing optimal models.
Article
Oncology
Maud J. F. Landers, Lars Smolders, Geert-Jan M. Rutten, Margriet M. Sitskoorn, Emmanuel Mandonnet, Wouter De Baene
Summary: This study investigated the role of the superior longitudinal fasciculus and frontotemporoparietal network in executive functions in 156 presurgical IDH-mutated low-grade glioma patients. However, the results showed that neither structural and network overlap nor network disconnection predictors explained executive dysfunction in these patients. The study highlights the need for developing new methods to understand the complex mechanisms behind executive deficits in low-grade glioma patients.
Article
Oncology
Ivan Caramanna, Jaap C. Reijneveld, Peter M. van de Ven, Martin van de Bent, Ahmed Idbaih, Wolfgang Wick, Martin J. B. Taphoorn, Linda Dirven, Andrew Bottomley, Martin Klein
Summary: This study evaluated the cognitive awareness of patients with recurrent high-grade glioma (HGG) and found an association between neurocognitive functioning and complaints. The findings suggest that patients' awareness of their neurocognitive limitations should be considered in clinical decision-making and interpretation of patient-reported outcomes (PROs).
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Marlene V. Strege, John A. Richey, Greg J. Siegle
Summary: This study evaluated the course of MDD with consideration of low grade depressive symptoms and quality of life, finding that chronic depression symptoms and decreased quality of life are common, suggesting poorer sustained remission rates than previously observed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Sam Ng, Guillaume Herbet, Anne-Laure Lemaitre, Jerome Cochereau, Sylvie Moritz-Gasser, Hugues Duffau
Summary: Early surgical treatment in presumed asymptomatic patients with ILGG was associated with stable or improved neuropsychological outcomes in 87.2% of patients at 3 months, with only mild cognitive decline observed in 6 patients.
JOURNAL OF NEUROSURGERY
(2021)