Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Neurosciences
Patsorn Wichit, Sekh Thanprasertsuk, Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Saknan Bongsebandhu-Phubhakdi
Summary: The study found that PD patients had higher plasma norepinephrine levels but lower epinephrine and serotonin levels compared to control subjects. Additionally, PD patients showed a significantly higher HVA/DA ratio and lower VMA/NE ratio. The levels of different monoamines were associated with clinical profiles in PD patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Diego Baronio, Yu-Chia Chen, Pertti Panula
Summary: Deficiency of monoamine oxidase (MAO) and imbalanced levels of brain monoamines are associated with developmental delay, neuropsychiatric disorders, and aggressive behavior. This study introduces a novel genetic model using zebrafish to study the effects of mao loss of function. The results demonstrate alterations in neurotransmitter systems, expression of relevant genes, and behavioral changes in mao mutants.
DISEASE MODELS & MECHANISMS
(2022)
Article
Neurosciences
Edenia C. Menezes, Relish Shah, Lindsay Laughlin, K. Yaragudri Vinod, John F. Smiley, Catarina Cunha, Andrea Balla, Henry Sershen, Francisco X. Castellanos, Andre Corvelo, Catia M. Teixeira
Summary: Early life is a critical period where enhanced neural plasticity allows the developing brain to adapt to its environment. Exposure to fluoxetine in early postnatal period can lead to reduced effort-related motivation and blunted dopaminergic activation in reward tasks in adulthood. Administering bupropion in adulthood can rescue the reduction in motivation, highlighting the involvement of the dopaminergic system in this process.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Review
Behavioral Sciences
Gabriella E. DiCarlo, Mark T. Wallace
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted interests/repetitive behaviors. Over 1000 genes and 2000 copy number variants have been implicated in ASD. It is believed that there is not a single genetic cause or neurobiological basis for ASD, but rather multiple subtypes with different genetic and neurobiological perturbations. Dopamine dysfunction may be one potential subtype associated with ASD. This research provides a framework for subcategorizing ASD based on genetic changes, neurobiological differences, and behavioral features.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Hugo R. Arias, Philippe De Deurwaerdere, Ali El-Kasaby, Giuseppe Di Giovanni, Sanung Eom, Junho H. Lee, Michael Freissmuth, Abdeslam Chagraoui
Summary: The antidepressant-like activity of (+)-catharanthine and (-)-18-methoxycoronaridine was studied in male and female mice using forced swim and tail suspension tests. The results showed that both compounds induced similar antidepressant-like activity, with (+)-catharanthine also increasing climbing behavior and mobilizing norepinephrinergic neurotransmission. In vitro studies demonstrated that both compounds inhibit serotonin transporter, while (+)-catharanthine also inhibits norepinephrine transporter with higher potency.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Carla Carratala-Ros, Laura Lopez-Cruz, Andrea Martinez-Verdu, Regulo Olivares-Garcia, John D. Salamone, Merce Correa
Summary: Fluoxetine can improve behavioral activation in depressed patients, but it cannot reverse the anergic effects of dopamine depletion. The study found that fluoxetine was ineffective in treating anergia induced by dopamine depletion.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Kai-Jing Yin, Jing-Nan Ren, Xiao Li, Gang Fan, Lei Zhao, Zhi Li, Lu-Lu Zhang, Ding-Yuan Xie, Si-Yi Pan, Fang Yuan
Summary: A high-fat diet resulted in significant weight gain, depression-related behavior, decreased preference for sweeteners, increased lipid content in the blood, and decreased gene expression related to dopamine and opioid receptors in mice.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Neurosciences
Joanes Grandjean, David Buehlmann, Michaela Buerge, Hannes Sigrist, Erich Seifritz, Franz X. Vollenweider, Christopher R. Pryce, Markus Rudin
Summary: This study investigated the effects of psilocybin on functional connectivity (FC) across the entire brain in mice, finding that psilocybin reduced FC within the ventral striatum. It was revealed that psilocybin increased FC between 5-HT-associated networks and cortical areas while decreasing FC within dopamine-associated striatal networks. These findings suggest that interactions between 5-HT- and dopamine-regulated neural networks play a role in the neural and psychological effects of psilocybin. Additionally, the study highlights how molecular expression patterns and structural connectivity information can aid in understanding pharmaco-fMRI findings.
Article
Neurosciences
Elizabeth K. Wood, Natalia Gabrielle, Jacob Hunter, Andrea N. Skowbo, Melanie L. Schwandt, Stephen G. Lindell, Christina S. Barr, Stephen J. Suomi, J. Dee Higley
Summary: Studies show that parental absence early in life can have negative effects on the developing central nervous system, particularly on monoamine systems. Furthermore, genotype can also affect the concentrations of these neurotransmitters.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Kim
Summary: This study demonstrates that simultaneous exposure to different metals can impact key enzymes involved in dopaminergic and serotonergic neurotransmission processes, leading to disruptions in dopamine and serotonin homeostasis and consequently a range of detrimental neurobehavioral effects.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Genetics & Heredity
Robert Lalonde, Catherine Strazielle
Summary: The function of the Agtpbp1 gene has been mainly studied through the analysis of Agtpbp1(pcd) mutant mice, which exhibit cerebellar degeneration and changes in neurotransmitter concentrations, leading to cerebellar ataxia and other behavioral deficits. Similar neuropathogical and behavioral profiles have been observed in human subjects with biallelic variants of AGTPBP1.
Article
Genetics & Heredity
Robert Lalonde, Catherine Strazielle
Summary: The function of the HERC1 gene, mainly studied through mutant mice and subjects with variants, includes regulating cerebellar Purkinje cells, synaptic vesicles, climbing fiber projections, and alpha-motoneuron projections. The resulting phenotypes involve cerebellar ataxia, motor coordination loss, muscle weakness, and spatial deficits.
Article
Neurosciences
Chunxiu Yu, Tony Tianlun Jiang, Charles T. Shoemaker, David Fan, Mark A. Rossi, Henry H. Yin
Summary: Unilateral dopamine depletion leads to asymmetric striatal output, resulting in turning behavior towards the side with lower output. The direction of turning is determined by the relative striatal outputs from the two cerebral hemispheres.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Oncology
Olga Karginova, Marni B. Siegel, Amanda E. D. Van Swearingen, Allison M. Deal, Barbara Adamo, Maria J. Sambade, Soha Bazyar, Nana Nikolaishvili-Feinberg, Ryan Bash, Sara O'Neal, Katie Sandison, Joel S. Parker, Charlene Santos, David Darr, William Zamboni, Yueh Z. Lee, C. Ryan Miller, Carey K. Anders
MOLECULAR CANCER THERAPEUTICS
(2015)
Meeting Abstract
Oncology
Amanda E. D. Van Swearingen, Maria J. Sambade, Shivani Sud, Brian Golitz, Gary L. Johnson, Carey K. Anders
Article
Biotechnology & Applied Microbiology
Maria Sambade, Allison Deal, Allison Schorzman, J. Christopher Luft, Charles Bowerman, Kevin Chu, Olga Karginova, Amanda Van Swearingen, William Zamboni, Joseph DeSimone, Carey K. Anders
Review
Neurosciences
Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sanchez, Gordon P. Meares
MOLECULAR NEURODEGENERATION
(2017)
Article
Oncology
Amanda E. D. Van Swearingen, Maria J. Sambade, Marni B. Siegel, Shivani Sud, Robert S. McNeill, Samantha M. Bevill, Xin Chen, Ryan E. Bash, Louisa Mounsey, Brian T. Golitz, Charlene Santos, Allison Deal, Joel S. Parker, Naim Rashid, C. Ryan Miller, Gary L. Johnson, Carey K. Anders
Article
Oncology
Robert S. McNeill, Demitra A. Canoutas, Timothy J. Stuhlmiller, Harshil D. Dhruv, David M. Irvin, Ryan E. Bash, Steven P. Angus, Laura E. Herring, Jeremy M. Simon, Kasey R. Skinner, Juanita C. Limas, Xin Chen, Ralf S. Schmid, Marni B. Siegel, Amanda E. D. Van Swearingen, Michael J. Hadler, Erik P. Sulman, Jann N. Sarkaria, Carey K. Anders, Lee M. Graves, Michael E. Berens, Gary L. Johnson, C. Ryan Miller
Article
Behavioral Sciences
Jessica L. Bolton, Melanie G. Wiley, Bailey Ryan, Samantha Truong, Melva Strait, Dana Creighton Baker, Nancy Y. Yang, Olga Ilkayeva, Thomas M. O'Connell, Shelley W. Wroth, Cristina L. Sanchez, Geeta Swamy, Christopher Newgard, Cynthia Kuhn, Staci D. Bilbo, Leigh Ann Simmons
BRAIN AND BEHAVIOR
(2017)
Article
Biochemistry & Molecular Biology
Kimberly J. Nelson, Arden Perkins, Amanda E. D. Van Swearingen, Steven Hartman, Andrew E. Brereton, Derek Parsonage, Freddie R. Salsbury, P. Andrew Karplus, Leslie B. Poole
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Oncology
Amanda E. D. Van Swearingen, Marni B. Siegel, Allison M. Deal, Maria J. Sambade, Alan Hoyle, D. Neil Hayes, Heejoon Jo, Paul Little, Elizabeth Claire Dees, Hyman Muss, Trevor Jolly, Timothy M. Zagar, Nirali Patel, C. Ryan Miller, Joel S. Parker, J. Keith Smith, Julie Fisher, Nikita Shah, Lisle Nabell, Rita Nanda, Patrick Dillon, Vandana Abramson, Lisa A. Carey, Carey K. Anders
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Medicine, Research & Experimental
Marni B. Siegel, Xiaping He, Katherine A. Hoadley, Alan Hoyle, Julia B. Pearce, Amy L. Garrett, Sunil Kumar, Vincent J. Moylan, Claudia M. Brady, Amanda E. D. Van Swearingen, David Marron, Gaorav P. Gupta, Leigh B. Thorne, Niamh Kieran, Chad Livasy, Elaine R. Mardis, Joel S. Parker, Mengjie Chen, Carey K. Anders, Lisa A. Carey, Charles M. Perou
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Multidisciplinary Sciences
Patrick L. Leslie, Yvonne L. Chao, Yi-Hsuan Tsai, Subrata K. Ghosh, Alessandro Porrello, Amanda E. D. Van Swearingen, Emily B. Harrison, Brian C. Cooley, Joel S. Parker, Lisa A. Carey, Chad V. Pecot
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Cristina L. Sanchez, Savannah G. Sims, John D. Nowery, Gordon P. Meares
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Sarah Sammons, Amanda E. D. Van Swearingen, Carey K. Anders
CURRENT BREAST CANCER REPORTS
(2019)
Meeting Abstract
Oncology
C. Tsien
Review
Oncology
Timothy M. Zagar, Amanda E. D. Van Swearingen, Orit Kaidar-Person, Matthew G. Ewend, Carey K. Anders