Review
Biochemistry & Molecular Biology
Francesca Roda, Riccardo Caraffi, Silvia Picciolini, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi, Marzia Bedoni, Ilaria Ottonelli, Jason Thomas Duskey
Summary: Nanoparticles have potential as a strategy to improve the treatment of glioblastoma by enhancing drug delivery and targeting specific receptors or pathways. This review explores the latest strategies for drug delivery to glioblastoma, with a focus on the importance of surface functionalization for blood-brain barrier crossing and tumor specific targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Svenja Siemer, Tobias A. Bauer, Paul Scholz, Christina Breder, Federico Fenaroli, Gregory Harms, Dimo Dietrich, Jorn Dietrich, Christine Rosenauer, Matthias Barz, Sven Becker, Sebastian Strieth, Christoph Reinhardt, Torsten Fauth, Jan Hagemann, Roland H. Stauber
Summary: Therapy resistance is a major cause of cancer death, and personalized medicine using nanoparticles is crucial for overcoming resistance mechanisms. In this study, the ion channel LRRC8A was identified as critical for cisplatin resistance, and polysarcosine-based core cross-linked polymeric NPs successfully eradicated cisplatin-resistant cells by circumventing the LRRC8A-transport pathway.
Article
Materials Science, Multidisciplinary
Boyang Sun, Shuai Shao, Sanjana Ghosh, Jiexin Li, Xiaojie Wang, Changning Li, Breandan Quinn, Paschalis Alexandridis, Jonathan F. Lovell, Yumiao Zhang
Summary: The study demonstrates the development of a simple formulation methodology for Cabazitaxel (CTX) to produce a lyophilized drug product with a high drug-to-excipient ratio. The drug and excipient can be dissolved together in a mixed solvent system, allowing for sterile filtration, lyophilization, and reconstitution. The size of the reconstituted nanoparticles can be adjusted by tuning the solvent ratio and the ratio of excipient to drug.
SCIENCE CHINA-MATERIALS
(2023)
Article
Medicine, Research & Experimental
Thao M. Nguyen, Manasi Jambhrunkar, Sook S. Wong, David M. Ross, Paul Joyce, John W. Finnie, Jim Manavis, Kristen Bremmell, Melissa R. Pitman, Clive A. Prestidge
Summary: Liposome-based delivery system of MP-A08 enhances its potency against AML cells and significantly prolongs overall survival in mice with human AML disease, indicating its potential as a novel treatment for AML.
MOLECULAR PHARMACEUTICS
(2023)
Article
Food Science & Technology
Ruta Gruskiene, Tatjana Kavleiskaja, Ramune Staneviciene, Stefanos Kikionis, Efstathia Ioannou, Elena Serviene, Vassilios Roussis, Jolanta Sereikaite
Summary: Nisin is an antimicrobial cationic peptide that shows potential as a biopreservative in the food industry. Complexation with ulvan can enhance its stability in food matrices, making it a promising alternative to chemical preservatives. The results suggest that nisin-loaded ulvan particles exhibit comparable antimicrobial activity against Gram-positive bacteria, indicating their potential application in food preservation.
Article
Polymer Science
Olimpia Daniela Frent, Narcis Duteanu, Alin Cristian Teusdea, Stefania Ciocan, Laura Vicas, Tunde Jurca, Mariana Muresan, Annamaria Pallag, Paula Ianasi, Eleonora Marian
Summary: The aim of this study was to prepare microspheres based on biodegradable polymers and load them with a water-insoluble and environmentally sensitive active drug. The experimental results showed that the prepared microspheres had a high drug entrapment rate and could achieve controlled release of the active drug at the intestinal level. Furthermore, the microspheres exhibited good thermal stability, making them suitable for drug delivery systems.
Article
Materials Science, Composites
M. Abu-Abdeen, O. Saber, E. Mousa
Summary: In this study, cobalt iron oxide magnetic nanoparticles were successfully synthesized using a solvent thermal method, and loaded onto polyvinyl alcohol films using a casting technique. The concentration of nanoparticles significantly affected the magnetic hysteresis behavior and mechanical properties of the polymer films.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2023)
Article
Chemistry, Medicinal
WenJing Xiao, Jun Hou, Jie Ma, Botao Yu, JianDong Ren, WeiHua Jin, Juan Wu, Dezhi Zheng, KaiHua Fan
Summary: This study designed and characterized mangiferin loaded magnetic PCEC microspheres to improve the drug utilization of mangiferin and evaluated its in vitro antitumor activity, showing great potential as an effective carrier for mangiferin used in cancer chemotherapy.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mahdi Bahrami Parsa, Farzaneh Tafvizi, Vahid Chaleshi, Mostafa Ebadi
Summary: This article describes a method of using liposomes loaded with cisplatin and doxorubicin for the treatment of ovarian cancer. This approach enhances drug efficacy, reduces toxicity, and improves drug delivery versatility. The experimental results show that the liposomal formulation has significant cytotoxicity against ovarian cancer cells and can induce apoptosis and cell cycle arrest.
Article
Engineering, Biomedical
Maofan Zhang, C. Tilden Hagan, Hayley Foley, Xi Tian, Feifei Yang, Kin Man Au, Yu Mi, Yusra Medik, Kyle Roche, Kyle Wagner, Zachary Rodgers, Yuanzeng Min, Andrew Z. Wang
Summary: Chemoradiotherapy with cisplatin and etoposide has shown to be effective in treating both small and non-small cell lung cancers, but with high toxicity. Utilizing nanotherapeutics in nanoparticle formulation may offer a more effective and less toxic treatment option, especially in combination chemotherapy for lung cancer.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Raghu Solanki, Ashok Kumar Jangid, Mahima Jadav, Hitesh Kulhari, Sunita Patel
Summary: In this study, a novel nano-micellar system, Folate-conjugated Pluronic F108 nano-micelles loaded with Evodiamine (Evo), was synthesized to enhance the therapeutic efficacy of Evo against cervical cancer. The nano-micelles exhibited nanoscale size (50.33 +/- 3.09 nm), high monodispersity (0.122 +/- 0.072), high drug encapsulation efficiency (71.30 +/- 3.76%), and controlled drug release in the tumor microenvironment. In vitro anticancer studies showed that the nano-micelles had significant anticancer effects and induced apoptosis more effectively compared to pure Evo. Increased intracellular delivery of Evo through overexpressed folate receptors was attributed to the enhanced anticancer activity of the nano-micelles. Overall, the designed nano-micellar system has the potential to serve as a targeted delivery system for hydrophobic anticancer bioactive compounds like Evo.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Food Science & Technology
Zhendong Ding, Weiming Chen, Fengyu Jiang, Mengmiao Mo, Yongguang Bi, Fansheng Kong
Summary: Folic acid decorated chitosan nanoparticles were designed to improve the stability and bioavailability of proanthocyanidins. The nanoparticles exhibited good morphology and distribution characteristics, and showed a protective effect against oxidative hemolysis.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Dairy & Animal Science
Aya M. Al-Rahim, Rawaa AlChalabi, Ali Z. Al-Saffar, Ghassan M. Sulaiman, Salim Albukhaty, Tareg Belali, Elsadig M. Ahmed, Khalil A. A. Khalil
Summary: The study aimed to reduce the expression of inflammatory cytokines by synthesizing FA-MTX-BSA NPs and tested the potential of MTX, MTX-BSA NPs, and FA-MTX-BSA NPs in reducing interleukin and tumor necrosis factor levels.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Jingyuan Bai, Xuejiao Wang, Meilin Zhang, Jin Zhang, Xiaolin Chen, Yanan An, Renguo Guan
Summary: Novel porous magnetic soft materials (pMSMs) were synthesized by filling a poly (vinyl alcohol) (PVA) porous matrix with CuNi nanoparticles (NPs). The CuNi NPs can form chain-like structures under a magnetic field, leading to the increased compressive modulus of the pMSMs.
Article
Nanoscience & Nanotechnology
Quangdon Tran, Thuy Linh Pham, Hyo Jung Shin, Juhee Shin, Nara Shin, Hyeok Hee Kwon, Hyewon Park, Song I. Kim, Seoung Gyu Choi, Junhua Wu, Van T. H. Ngo, Jin Bong Park, Dong Woon Kim
Summary: The study found that nanoparticles of fexofenadine can alleviate pain sensitivity in rats with spinal nerve ligation and inhibit microglial activation and inflammatory signaling in the spinal cord, showing promise as a long-term treatment for neuropathic pain.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)