Emerging importance of oxidative stress in regulating striated muscle elasticity

Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation

(2014) Francesco De Pascali et al.   BIOCHEMISTRY

S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding

(2014) Jorge Alegre-Cebollada et al.   CELL

Gigantic Business

(2014) Wolfgang A. Linke et al.   CIRCULATION RESEARCH

Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients

(2014) Yetrib Hathout et al.   HUMAN MOLECULAR GENETICS

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins

(2014) Sebastian Kötter et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress in muscular dystrophy: from generic evidence to specific sources and targets

(2014) Marcella Canton et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Stiff muscle fibers in calf muscles of patients with cerebral palsy lead to high passive muscle stiffness

(2014) Margie A. Mathewson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology

(2014) Yin Hua Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Proteomics profiling of urine reveals specific titin fragments as biomarkers of Duchenne muscular dystrophy

(2014) Jeremy Rouillon et al.   NEUROMUSCULAR DISORDERS

Heart failure with preserved ejection fraction

(2014) James D. Gladden et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Myofilament protein carbonylation contributes to the contractile dysfunction in the infarcted LV region of mouse hearts

(2013) Ágnes Balogh et al.   CARDIOVASCULAR RESEARCH

Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts

(2013) Sebastian Kötter et al.   CARDIOVASCULAR RESEARCH

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

(2013) Nazha Hamdani et al.   CIRCULATION RESEARCH

Oxidative Stress and Sarcomeric Proteins

(2013) Susan F. Steinberg   CIRCULATION RESEARCH

Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

(2013) Nazha Hamdani et al.   Circulation-Heart Failure

Nitroxyl (HNO)

(2013) Hani N. Sabbah et al.   Circulation-Heart Failure

Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies

(2013) Jessica R. Terrill et al.   FEBS Journal

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C

(2013) Bindiya G. Patel et al.   Frontiers in Physiology

Influences of temperature, oxidative stress, and phosphorylation on binding of heat shock proteins in skeletal muscle fibers

(2012) Noni T. Larkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle

(2012) Ryan D. Mateja et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Contribution of calpains to myocardial ischaemia/reperfusion injury

(2012) J. Inserte et al.   CARDIOVASCULAR RESEARCH

Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction

(2012) Nazha Hamdani et al.   CARDIOVASCULAR RESEARCH

Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction

(2012) Loek van Heerebeek et al.   CIRCULATION

Nitroxyl-Mediated Disulfide Bond Formation Between Cardiac Myofilament Cysteines Enhances Contractile Function

(2012) Wei Dong Gao et al.   CIRCULATION RESEARCH

Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity

(2012) Joshua D. Lovelock et al.   CIRCULATION RESEARCH

Contribution of oxidative stress to pathology in diaphragm and limb muscles with Duchenne muscular dystrophy

(2012) Jong-Hee Kim et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

S-Glutathionylation of troponin I (fast) increases contractile apparatus Ca2+sensitivity in fast-twitch muscle fibres of rats and humans

(2012) J. P. Mollica et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac-Oxidized Antigens Are Targets of Immune Recognition by Antibodies and Potential Molecular Determinants in Chagas Disease Pathogenesis

(2012) Monisha Dhiman et al.   PLoS One

Sildenafil and B-Type Natriuretic Peptide Acutely Phosphorylate Titin and Improve Diastolic Distensibility In Vivo

(2011) Kalkidan Bishu et al.   CIRCULATION

Screening for increased protein thiol oxidation in oxidatively stressed muscle tissue

(2011) Ahmed F. El-Shafey et al.   FREE RADICAL RESEARCH

The Giant Protein Titin: A Regulatory Node That Integrates Myocyte Signaling Pathways

(2011) Martina Krüger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation of Myofibrillar Proteins in Human Heart Failure

(2011) Marcella Canton et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myocardial infarction in mice alters sarcomeric function via post-translational protein modification

(2011) Benjamin S. Avner et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Large Potentials of Small Heat Shock Proteins

(2011) Evgeny V. Mymrikov et al.   PHYSIOLOGICAL REVIEWS

The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits

(2010) P Heusch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular Giant Vulnerable to Oxidative Damage

(2010) Wolfgang A. Linke   CIRCULATION

Titin is a Target of Matrix Metalloproteinase-2

(2010) Mohammad A.M. Ali et al.   CIRCULATION

Oxidative stress by monoamine oxidases is causally involved in myofiber damage in muscular dystrophy

(2010) Sara Menazza et al.   HUMAN MOLECULAR GENETICS

Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction

(2010) Dorota Polewicz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle

(2010) Graham D. Lamb et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neonatal Asphyxia Induces the Nitration of Cardiac Myosin Light Chain 2 That is Associated with Cardiac Systolic Dysfunction

(2010) Adrian Doroszko et al.   SHOCK

Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase

(2009) Fabio Di Lisa et al.   BASIC RESEARCH IN CARDIOLOGY

Impact of Actin Glutathionylation on the Actomyosin-S1 ATPase

(2009) Gresin O. Pizarro et al.   BIOCHEMISTRY

Modulation of Titin-Based Stiffness by Disulfide Bonding in the Cardiac Titin N2-B Unique Sequence

(2009) Anika Grützner et al.   BIOPHYSICAL JOURNAL

Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix

(2009) A. D. Kandasamy et al.   CARDIOVASCULAR RESEARCH

PKC Phosphorylation of Titin’s PEVK Element

(2009) Carlos Hidalgo et al.   CIRCULATION RESEARCH

Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium

(2009) Attila Borbély et al.   CIRCULATION RESEARCH

Redox modulation of global phosphatase activity and protein phosphorylation in intact skeletal muscle

(2009) Valerie P. Wright et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enhanced Nitrosative Stress during Trypanosoma cruzi Infection Causes Nitrotyrosine Modification of Host Proteins

(2008) Monisha Dhiman et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidation of Myofilament Protein Sulfhydryl Groups Reduces the Contractile Force and Its Ca2+ Sensitivity in Human Cardiomyocytes

(2008) Zita Hertelendi et al.   ANTIOXIDANTS & REDOX SIGNALING

Calpain 1 Binding Capacities of the N1-Line Region of Titin Are Significantly Enhanced by Physiological Concentrations of Calcium†

(2008) Gerald Coulis et al.   BIOCHEMISTRY

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

(2008) Martina Krüger et al.   CIRCULATION RESEARCH

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

(2008) Farah Sheikh et al.   JOURNAL OF CLINICAL INVESTIGATION

Skeletal Muscle Fatigue: Cellular Mechanisms

(2008) D. G. Allen et al.   PHYSIOLOGICAL REVIEWS