Article
Cell Biology
Sharif Alhajlah, Adam M. Thompson, Zubair Ahmed
Summary: The study shows that RTN3 may play a critical role in promoting axon regeneration in the central nervous system, especially after spinal cord and optic nerve injuries. Overexpression of RTN3 can enhance neurite outgrowth in cell culture and promote survival and axon regeneration in vivo.
Article
Neurosciences
Georgina Palomes-Borrajo, Xavier Navarro, Clara Penas
Summary: This study demonstrates that inhibiting BET proteins in macrophages can enhance axonal outgrowth and promote peripheral nerve regeneration. However, specific targeting of BET proteins to macrophages is needed for efficient functional recovery after nerve injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Chemistry, Medicinal
Sajeer Koolath, Yuta Murai, Tomoya Suzuki, Mahadeva M. M. Swamy, Seigo Usuki, Kenji Monde
Summary: GM3, a monosialylated ganglioside, is involved in various physiological and pathological processes in diabetes and obesity. Its aberrant expression in adipocytes is strongly associated with type 2 diabetes and insulin resistance. Exogenous GM3 can promote neurite outgrowth in different neuroblastoma cell lines, suggesting its potential as a treatment for neuro-regeneration.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Environmental
Jianxu Wei, Xiaomeng Zhang, Zhuo Zhang, Xinxin Ding, Yuan Li, Yi Zhang, Xue Jiang, Hongbo Zhang, Hongchang Lai, Junyu Shi
Summary: Metabolic energy can be a therapeutic target for bone tissue engineering by manipulating osteoblastic differentiation of bone marrow mesenchymal stem cells (BMSCs). Curcumin can activate glucose transporter 1 (GLUT1) to promote osteogenic differentiation of BMSCs and enhance bone regeneration. Cholesterol/lipid raft (Cho/LR) acts as a sensor to trigger GLUT1 switch, facilitating bone regeneration. These findings have significant implications for bone tissue engineering.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Daishi Yamakawa, Junya Tsuboi, Kousuke Kasahara, Chise Matsuda, Yuhei Nishimura, Tatsuya Kodama, Naoyuki Katayama, Masatoshi Watanabe, Masaki Inagaki
Summary: After injury, FAPs play a key role in skeletal muscle regeneration and inhibition of adipogenesis through cilia-mediated signaling pathways. Dysfunction of cilia affects the insulin/Akt signaling pathway and impairs adipogenic differentiation of FAPs. Ciliary elongation promotes IL13 production in FAPs, facilitating myoblast proliferation and M2 macrophage polarization.
Article
Geriatrics & Gerontology
Shuo Zhang, Neng Zhu, Jia Gu, Hong-Fang Li, Yun Qiu, Duan-Fang Liao, Li Qin
Summary: With the global population rapidly aging, delaying aging has become a hot research topic. Lipid rafts (LRs), which are microdomains in the plasma membrane containing sphingolipids and cholesterol, have been found to have an interesting interplay with aging. The components of LRs are altered with aging, and LRs strongly influence the aging process. Therefore, targeting LRs is a promising strategy for delaying aging.
Article
Neurosciences
Jie Yang, Yunlong Zhang, Zhenbin Cai, Jianyu Zou, Shaojin Li, Guiqiang Miao, Hongsheng Lin, Xiaodong Zhao, Minghui Tan
Summary: The study reveals the critical role of spastin in recovery from spinal cord injury (SCI) and suggests that it may be a potential target for SCI treatment. Spastin promotes axonal outgrowth and branch formation by regulating microtubule dynamics.
BRAIN RESEARCH BULLETIN
(2023)
Article
Cell Biology
Hyo-Jeong Yong, Jong-Ik Hwang, Jae-Young Seong
Summary: This study highlights the critical role of FAM19A1 in neuronal maturation and function by affecting dendritic spine development and neurite arborization, demonstrating its involvement in maintaining neural integrity and connectivity.
Article
Biochemistry & Molecular Biology
Ikuko Kakizaki, Takayasu Kobayashi, Shinri Tamura, Hiroshi Akagi, Keiichi Takagaki
Summary: This study found that chondroitin sulfate E and heparin can upregulate neural specific markers during neural differentiation, with chondroitin sulfate E shown to play a role in spheroid formation, while a hyaluronan oligosaccharide mixture downregulated the expressions of myelin specific markers.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Mohamad-Reza Aghanoori, Vicky Margulets, Darrell R. Smith, Lorrie A. Kirshenbaum, Daniel Gitler, Paul Fernyhough
Summary: The study demonstrated decreased glycolytic capacity and impaired mitochondrial respiration in DRG neurons from type 1 diabetic rats. IGF-1 was found to protect against ATP depletion in DRG neurons from diabetic rats by enhancing glycolysis and mitochondrial respiration parameters.
MOLECULAR METABOLISM
(2021)
Review
Cell Biology
Yagmur Azbazdar, Mustafa Karabicici, Esra Erdal, Gunes Ozhan
Summary: Wnt signaling pathway plays a crucial role in physiological activities and has significant implications in cancer development and progression. By regulating plasma membrane composition and lipid organization, Wnt signaling can be activated or inhibited, leading to the development of more targeted anticancer drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Ngan Pan Bennett Au, Gajendra Kumar, Pallavi Asthana, Fuying Gao, Riki Kawaguchi, Raymond Chuen Chung Chang, Kwok Fai So, Yang Hu, Daniel H. Geschwind, Giovanni Coppola, Chi Him Eddie Ma
Summary: In this study, researchers demonstrated that Lycium barbarum polysaccharides (LBP) extracted from Wolfberry can accelerate axon regeneration after severe nerve injury. They also identified a small-molecule glycopyrrolate approved by the FDA that promotes nerve regeneration and visual function recovery.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Engineering, Electrical & Electronic
Bjarke Norrehvedde Jensen, Yuting Wang, Alice Le Friec, Sadegh Nabavi, Mingdong Dong, Dror Seliktar, Menglin Chen
Summary: A wireless electromagnetic neural stimulation patch has been developed, which combines electromagnetic induction and physical guidance cues to promote neural cell growth and treat neurological diseases. In vitro experiments confirmed the biocompatibility and efficacy of the patch's electromagnetic stimulation in promoting neurite outgrowth, demonstrating its great potential for non-invasive neurological therapeutics.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Plant Sciences
Jin A. Jung, Heon Joo Lee, Myoung Chong Song, Areum Hwangbo, Ji Yoon Beom, Soo Jung Lee, Dong Jin Park, Ji Hoon Oh, Sang-Jun Ha, Eunji Cheong, Yeo Joon Yoon
Summary: Separating the immunosuppressive activity of FK506 from its neurotrophic activity, two new FK506 analogues were synthesized with a proline substitution, which significantly reduced immunosuppressive activity while retaining neurotrophic activity. This replacement is critical for enhancing neurotrophic activity while reducing strong immunosuppressive activity.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Luca F. Castelnovo, Peter Thomas
Summary: This study demonstrates that the activation of membrane progesterone receptor alpha (mPR alpha/PAQR7) promotes regenerative effects in Schwann cell-like adipose stem cells (SCL-ASC) by increasing neurite outgrowth, protecting against cell death, and increasing expression of peripheral nerve regeneration markers in neuronal cell lines. The effects are mediated through the release of BDNF and IGF-2 from SCL-ASC. These findings suggest that mPR alpha could be targeted therapeutically to promote peripheral nerve regeneration.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)