Insulin augments serotonin-induced contraction via activation of the IR/PI3K/PDK1 pathway in the rat carotid artery
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Title
Insulin augments serotonin-induced contraction via activation of the IR/PI3K/PDK1 pathway in the rat carotid artery
Authors
Keywords
Insulin receptor, Myosin phosphatase target subunit 1, Phosphoinositide 3-kinase, Phosphoinositide-dependent kinase 1, Vasoconstriction
Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 468, Issue 4, Pages 667-677
Publisher
Springer Nature
Online
2015-11-17
DOI
10.1007/s00424-015-1759-4
References
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Note: Only part of the references are listed.- Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes
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- (2015) M. Fraer et al. HYPERTENSION
- Relationships among protein tyrosine phosphatase 1B, angiotensin II, and insulin-mediated aortic responses in type 2 diabetic Goto–Kakizaki rats
- (2014) Shingo Nemoto et al. ATHEROSCLEROSIS
- Acute regulation of PDK1 by a complex interplay of molecular switches
- (2014) Veronique Calleja et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Symphony of Vascular Contraction
- (2014) Styliani Goulopoulou et al. HYPERTENSION
- Insulin resistance and hyperglycaemia in cardiovascular disease development
- (2014) Markku Laakso et al. Nature Reviews Endocrinology
- The pathophysiology of hypertension in patients with obesity
- (2014) Vincent G. DeMarco et al. Nature Reviews Endocrinology
- Mechanisms underlying increased serotonin-induced contraction in carotid arteries from chronic type 2 diabetic Goto-Kakizaki rats
- (2014) Takayuki Matsumoto et al. PHARMACOLOGICAL RESEARCH
- AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases
- (2013) José M. Arencibia et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- 5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases
- (2013) Shuji Gamoh et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- PDK1 regulates platelet activation and arterial thrombosis
- (2013) X. Chen et al. BLOOD
- The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?
- (2013) Karen E. Porter et al. CLINICAL SCIENCE
- Mineralocorticoid Receptor-Mediated Vascular Insulin Resistance: An Early Contributor to Diabetes-Related Vascular Disease?
- (2013) S. B. Bender et al. DIABETES
- Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
- (2013) Francesco Paneni et al. EUROPEAN HEART JOURNAL
- Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2 diabetic OLETF rat at chronic stage of disease
- (2013) Takayuki Matsumoto et al. LIFE SCIENCES
- Enhanced uridine adenosine tetraphosphate-induced contraction in renal artery from type 2 diabetic Goto-Kakizaki rats due to activated cyclooxygenase/thromboxane receptor axis
- (2013) Takayuki Matsumoto et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Mechanisms of Diabetic Complications
- (2013) Josephine M. Forbes et al. PHYSIOLOGICAL REVIEWS
- Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex
- (2012) Shingo Nemoto et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- PDGF-D/PDGF-ββ Receptor-Regulated Chemo-taxis of Malignant Mesothelioma Cells
- (2012) Asuka Okada et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- 5HT2Aand5HT2BReceptors Contribute to Serotonin-Induced Vascular Dysfunction in Diabetes
- (2012) Peter M. Nelson et al. Experimental Diabetes Research
- Matrix-Bound PAI-1 Supports Cell Blebbing via RhoA/ROCK1 Signaling
- (2012) Amandine Cartier-Michaud et al. PLoS One
- Role of serotonin in angiogenesis: Induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice
- (2011) Masaaki Iwabayashi et al. ATHEROSCLEROSIS
- Ablation of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) in Vascular Endothelial Cells Enhances Insulin Sensitivity by Reducing Visceral Fat and Suppressing Angiogenesis
- (2011) Kazuhito Tawaramoto et al. MOLECULAR ENDOCRINOLOGY
- Turning a protein kinase on or off from a single allosteric site via disulfide trapping
- (2011) J. D. Sadowsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1
- (2010) Ayaz Najafov et al. BIOCHEMICAL JOURNAL
- Enhancement of mesenteric artery contraction to 5-HT depends on Rho kinase and Src kinase pathways in the ob/ob mouse model of type 2 diabetes
- (2010) Takayuki Matsumoto et al. BRITISH JOURNAL OF PHARMACOLOGY
- 5-Hydroxtryptamine Receptors in Systemic Hypertension: An Arterial Focus
- (2010) Stephanie W. Watts et al. Cardiovascular Therapeutics
- RhoA/Rho-kinase and vascular diseases: what is the link?
- (2010) Kenia Pedrosa Nunes et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Enhanced Ca 2+ -Dependent Activation of Phosphoinositide 3-Kinase Class IIα Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats
- (2010) Young Mi Seok et al. HYPERTENSION
- Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats
- (2009) Tsuneo Kobayashi et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat
- (2009) Takayuki Matsumoto et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice
- (2009) Daniel W. Nuno et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers
- (2009) P. Sabbatini et al. MOLECULAR CANCER THERAPEUTICS
- Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
- (2009) Valerie Hindie et al. Nature Chemical Biology
- PDK1 coordinates survival pathways and -adrenergic response in the heart
- (2009) K. Ito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of chronic and selective endothelin receptor antagonism on microvascular function in Type 2 diabetes
- (2008) Kamakshi Sachidanandam et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes
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- (2008) T Kobayashi et al. BRITISH JOURNAL OF PHARMACOLOGY
- Contribution of Natural Inhibitors to the Understanding of the PI3K/PDK1/PKB Pathway in the Insulin-mediated Intracellular Signaling Cascade
- (2008) Jae Cho et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Angiotensin II and the development of insulin resistance: Implications for diabetes
- (2008) J. Alberto Olivares-Reyes et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- 5-Hydroxytryptamine and cardiovascular regulation
- (2008) A RAMAGE et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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