Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia

Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells

(2014) Hidemitsu Sakagami et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade

(2013) Analía Núñez-O’Mara et al.   BIOLOGICAL CHEMISTRY

Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose Intolerance

(2013) Hirohide Matsuura et al.   CIRCULATION

Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1α

(2013) Zhanjiang Hou et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

(2013) Kevin Wei et al.   NATURE MEDICINE

AstraZeneca bets on FibroGen's anaemia drug

(2013) Monica Hoyos Flight   NATURE REVIEWS DRUG DISCOVERY

N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats

(2013) Xiaowen Mao et al.   PLoS One

Hypoxia-Inducible Factor-1 Alpha in the Heart

(2012) Satwat Hashmi et al.   Cardiology in Review

MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients

(2012) S. Greco et al.   DIABETES

Glucotoxicity Induces Glucose-6-Phosphatase Catalytic Unit Expression by Acting on the Interaction of HIF-1  With CREB-Binding Protein

(2012) A. Gautier-Stein et al.   DIABETES

Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes

(2012) M. Friederich Persson et al.   DIABETOLOGIA

The pathogenesis of early retinal changes of diabetic retinopathy

(2012) G. B. Arden et al.   DOCUMENTA OPHTHALMOLOGICA

Dietary obesity-associated Hif1  activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

(2012) J. Krishnan et al.   GENES & DEVELOPMENT

Novel links between HIFs, type 2 diabetes, and metabolic syndrome

(2012) Christian M. Girgis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP

(2012) X Zheng et al.   Cell Death & Disease

Tubular Deficiency of von Hippel-Lindau Attenuates Renal Disease Progression in Anti-GBM Glomerulonephritis

(2011) Franziska Theilig et al.   AMERICAN JOURNAL OF PATHOLOGY

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice

(2011) Daigo Ochiai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice

(2011) C. Jiang et al.   DIABETES

Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α

(2011) Natacha Le Moan et al.   MOLECULAR CELL

Topical prolyl hydroxylase domain-2 silencing improves diabetic murine wound closure

(2011) Meredith Wetterau et al.   WOUND REPAIR AND REGENERATION

Cardiac-Specific Overexpression of HIF-1α Prevents Deterioration of Glycolytic Pathway and Cardiac Remodeling in Streptozotocin-Induced Diabetic Mice

(2010) Wanli Xue et al.   AMERICAN JOURNAL OF PATHOLOGY

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

(2010) Na Zhang et al.   Cell Metabolism

Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction

(2010) C. F. Bento et al.   EXPERIMENTAL PHYSIOLOGY

Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1α Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice

(2010) Xinmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

(2010) Kim Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

(2010) Tsubasa Isoe et al.   KIDNEY INTERNATIONAL

Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice

(2010) Ali H Amin et al.   LABORATORY INVESTIGATION

Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily

(2010) Allan Flyvbjerg   Nature Reviews Endocrinology

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

PGC-1  regulates a HIF2 -dependent switch in skeletal muscle fiber types

(2010) K. A. Rasbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A COMPARISON OF HYPOXIA-INDUCIBLE FACTOR-α IN SURGICALLY EXCISED NEOVASCULAR MEMBRANES OF PATIENTS WITH DIABETES COMPARED WITH IDIOPATHIC EPIRETINAL MEMBRANES IN NONDIABETIC PATIENTS

(2010) Jennifer I Lim et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

(2009) Jaya Krishnan et al.   Cell Metabolism

Decreased mobilization of endothelial progenitor cells contributes to impaired neovascularization in diabetes

(2009) Lina Kang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Oxygen Tension Regulates Pancreatic  -Cell Differentiation Through Hypoxia-Inducible Factor 1 

(2009) M. Heinis et al.   DIABETES

Hypoxia and the expression of HIF-1α and HIF-2α in the retina of streptozotocin-injected mice and rats

(2009) William S. Wright et al.   EXPERIMENTAL EYE RESEARCH

Hypoxia Inducible Factor-1 Upregulates Adiponectin in Diabetic Mouse Hearts And Attenuates Post-Ischemic Injury

(2009) Ramesh Natarajan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Poly(ADP-ribose) polymerase-1 modulation ofin vivoresponse of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF

(2009) Rubén Martínez-Romero et al.   JOURNAL OF NEUROCHEMISTRY

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

(2009) H. Thangarajah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenoviral transfer of HIF-1  enhances vascular responses to critical limb ischemia in diabetic mice

(2009) K. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells

(2008) Malou Friederich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Role for von Hippel-Lindau Protein in Pancreatic  -Cell Function

(2008) S. Puri et al.   DIABETES

Expression of Erythropoietin and Its Receptor in the Human Retina: A comparative study of diabetic and nondiabetic subjects

(2008) M. Garcia-Ramirez et al.   DIABETES CARE

Neurovascular control and neurogenic inflammation in diabetes

(2008) N. C. Schaper et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Polyol pathway mediates iron-induced oxidative injury in ischemic–reperfused rat heart

(2008) Wai Ho Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic   cells

(2008) J. Zehetner et al.   GENES & DEVELOPMENT

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice

(2008) Daniel J. Ceradini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent impairment of HIF-1α expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

(2008) Lixin Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina

(2008) Seungjun Lee et al.   MICROVASCULAR RESEARCH

Stabilization of HIF-1  is critical to improve wound healing in diabetic mice

(2008) I. R. Botusan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptation to hypoxia in the diabetic rat kidney

(2007) C. Rosenberger et al.   KIDNEY INTERNATIONAL