Modulation of anthracycline-induced cytotoxicity by targeting the prenylated proteome in myeloid leukemia cells

DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy

(2010) K. Chikamori et al.   CURRENT CANCER DRUG TARGETS

A Tagging-via-substrate Approach to Detect the Farnesylated Proteome Using Two-dimensional Electrophoresis Coupled with Western Blotting

(2010) Fredrick O. Onono et al.   MOLECULAR & CELLULAR PROTEOMICS

BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C 

(2009) F. Pellicano et al.   BLOOD

Distinct Roles for RhoVersusRac/Cdc42 GTPases Downstream of Vav2 in Regulating Mammary Epithelial Acinar Architecture

(2009) Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc42 Regulates Fcγ Receptor-mediated Phagocytosis through the Activation and Phosphorylation of Wiskott-Aldrich Syndrome Protein (WASP) and Neural-WASP

(2009) Haein Park et al.   MOLECULAR BIOLOGY OF THE CELL

An Old AML Drug Revisited

(2009) Hervé Dombret et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21

(2008) José M. Escandell et al.   BIOCHEMICAL PHARMACOLOGY

Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide

(2008) J. E. Karp et al.   BLOOD

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation

(2008) J. Zhang et al.   BLOOD

Phase II Trial of Tipifarnib as Maintenance Therapy in First Complete Remission in Adults with Acute Myelogenous Leukemia and Poor-Risk Features

(2008) J. E. Karp et al.   CLINICAL CANCER RESEARCH

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS

Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide

(2006) J Damrot et al.   BRITISH JOURNAL OF PHARMACOLOGY